University Of Chicago

This study tested a combination of three drugs (carfilzomib, lenalidomide, and dexamethasone) given before and after a stem cell transplant in 76 people newly diagnosed with multiple myeloma. The goal was to see how well this approach controls the cancer and improves response. Wh…

This study tested whether giving metoprolol, an FDA-approved beta-blocker, right after surgery and during hospital recovery can reduce heart damage in people with coronary artery disease. Researchers monitored daily blood tests for heart injury markers in 72 patients aged 50 and …

This study tested a combination of the drug lenalidomide with standard chemotherapy (EPOCH-R) in 55 people with aggressive B-cell lymphomas linked to the MYC gene. The goal was to find the safest dose and see how well the treatment controls the cancer. Results help doctors unders…

This study tested a 12-month program that provides remote support to older adults with type 2 diabetes. Participants received personalized goal setting, phone-based care management, and help connecting to community resources. The goal was to improve blood sugar control and qualit…

This study tested a combination of four drugs (elotuzumab, carfilzomib, lenalidomide, and dexamethasone) in 46 people newly diagnosed with multiple myeloma, a blood cancer. The goal was to see how many patients achieved a very deep response, meaning no cancer cells could be found…

This study tested a new combination of two drugs (belatacept and a proteasome inhibitor) in 5 highly sensitized kidney transplant candidates. The goal was to lower the antibodies that make it nearly impossible to find a compatible donor. The approach aims to increase the chance o…

This early-phase study tested whether removing a specific type of immune cell (regulatory T cells) before a stem cell transplant is safe and possible for people with multiple myeloma. Thirty participants received either standard transplant or transplant with T cell removal. The g…

This study tested a smartphone app called USeeBP to help African American adults with poorly controlled high blood pressure. 31 participants used the app alongside their usual care. The goal was to see if the app could improve home blood pressure readings and medication adherence…

This study tested whether adding two drugs (ixazomib and dexamethasone) to the standard maintenance drug lenalidomide could better control multiple myeloma that remains after a stem cell transplant. 42 adults who had already started lenalidomide maintenance were randomly assigned…

This study tested whether giving the immunotherapy drug pembrolizumab for one year after standard treatment could delay cancer recurrence in 100 patients with high-risk head and neck cancer. Half received pembrolizumab and half received a placebo. The main goal was to see how lon…

This early-stage study tested a new drug combination for men with a hard-to-treat type of prostate cancer that has spread. The goal was to see if adding relacorilant to the standard drug enzalutamide is safe and how the body handles it. 42 men took part in this phase 1 trial, whi…

This study tested a combination of three drugs (pomalidomide, dexamethasone, and carfilzomib) in 25 people whose multiple myeloma had returned or stopped responding to prior treatments. The goal was to find the safest dose and see how well the drugs worked together to control the…

This study looked at whether a type of diabetes medicine (SGLT2 inhibitors) helps people with severe heart failure who also have a mechanical heart pump (LVAD). 32 adults took the drug for 6 months. Researchers measured changes in heart size, weight, and kidney function. The goal…

This study tested a drug called pembrolizumab in 65 people with malignant mesothelioma, a rare cancer of the lining around the lungs or abdomen. The drug works by helping the body's immune system attack cancer cells. The goal was to see if it could shrink tumors or slow the disea…

This study looked at whether sleeping longer or keeping a regular sleep schedule can improve metabolic health and lower diabetes risk in overweight adults. Eighteen African American men and women who were short sleepers participated. Researchers measured changes in sleep patterns…

This early-phase study tested a combination of three drugs (selinexor, carfilzomib, and dexamethasone) in 52 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goal was to find the safest dose and identify side effects. Researchers …

This study tested whether adding metformin (a common diabetes drug) to standard chemotherapy could help people with advanced ovarian, fallopian tube, or primary peritoneal cancer. About 111 participants received either metformin or a placebo alongside chemo, then continued metfor…

This study tested whether taking a moderate dose of vitamin D (4,000 IU daily) could lower the chance of getting COVID-19 compared to a low dose (400 IU daily). Over 2,000 adults from the Chicago area and other US communities took part. Participants reported any COVID-19 infectio…

This study looked at whether taking moderate (4,000 IU) or high (10,000 IU) doses of vitamin D daily could lower the risk of getting COVID-19 compared to a low dose (400 IU). About 1,475 adults from the Chicago area took part for 9 months. Researchers tracked who got a confirmed …

This study tested whether Caplyta (lumateperone) can reduce symptoms of borderline personality disorder (BPD) in adults. Sixty people with BPD received either Caplyta or a placebo for 8 weeks. The goal was to see if Caplyta leads to greater improvement in BPD symptoms compared to…

This study looked at 70 women having robotic surgery for pelvic organ prolapse. It tested whether using a slightly lower gas pressure (12 mmHg instead of the usual 15 mmHg) during the operation would lead to less pain afterward. Researchers measured pain right after surgery and a…

This study tested whether taking fat from one part of the body and moving it to a breast that was damaged by radiation can help repair the tissue. Ten women who had radiation for breast cancer took part. The goal was to see if this fat transfer could make the skin softer and less…

This study tested a special cooling pillow pad called Moona to see if it could improve sleep quality in African American adults who are overweight or have obesity. 18 people took part, and researchers measured changes in how fast they fell asleep, how long they slept, and other s…

This study looked at whether Epidiolex, a prescription CBD oil, is safe and can help adults with obsessive-compulsive disorder (OCD), hair-pulling disorder, Tourette syndrome, or hoarding disorder. Only 4 people took part, and they received the drug for 2 weeks. Researchers track…

This small study tested whether an AI-powered virtual reality app could safely help people with inflammatory bowel disease (IBD) who also have mild to moderate anxiety or depression. Twenty-two adults with IBD used the app during a single session. The goal was to see if the appro…

This study looked at whether adding a common fiber supplement to peanut oral immunotherapy helps children with peanut allergy tolerate more peanut protein with fewer stomach issues. Twenty children aged 4 to 17 took part. The goal was to see if the fiber made the treatment safer …

This small study tested a single dose of psilocybin in 9 adults with both major depression and borderline personality disorder. Researchers measured changes in depression and BPD symptoms over time to see if the treatment was safe and helpful. The goal was to ease symptoms, not c…

This study observed 66 ICU patients on breathing machines to see if ultrasound could detect differences in diaphragm thickness during different machine settings. Researchers compared measurements when the machine fully controlled breathing versus when patients breathed on their o…

This study tested whether a special pain assessment tool (PAINAD) helps emergency room staff better manage pain in older adults with dementia who have hip pain. Researchers looked at how often the tool was used and whether it led to faster or better pain relief. The goal was to i…

This study collected information from 383 patients across global heart centers to understand how a newer pacing method called conduction system pacing (CSP) works in everyday practice. The goal was to learn about the benefits and risks of CSP for people with slow heartbeats or he…

This study looked at whether offering genetic counseling and testing remotely could help more childhood cancer survivors get the genetic services they need. About 391 survivors participated, and the study measured how many received testing or counseling, as well as changes in the…

This study looked at how daily rhythms affect fat cell genes and insulin response in 28 obese women scheduled for bariatric surgery. Researchers measured changes in insulin sensitivity before and 12 weeks after surgery. The goal was to understand how fat cells work, not to test a…

This study gathered information from routine medical care for 198 adults with atrial fibrillation who already had a device to close off a part of the heart (left atrial appendage occlusion) and then later underwent a heart ablation procedure. Researchers looked at patient details…

This study tested whether an educational video on safe catheter care could reduce bloodstream infections in adults starting home parenteral nutrition for intestinal failure. Researchers enrolled 25 first-time users and tracked infection rates. The goal was to see if simple video …

This study looked at whether teaching men with advanced prostate cancer about orchiectomy (surgery to remove the testicles) would make them more likely to choose it instead of staying on lifelong hormone therapy. 101 men who were already on hormone therapy for at least a year wer…

This study tested a program to improve sleep for 400 stroke patients in rehabilitation. The program trained nurses to reduce nighttime disruptions and screened patients for sleep apnea. The goal was to see if better sleep could improve recovery and daily function.

This study looked at ways to protect the right side of the heart after patients receive a mechanical pump (LVAD) for heart failure. Twenty adults who had LVAD surgery were monitored closely for several days. The goal was to find better methods to prevent right heart problems afte…