C-Section bleeding mystery: scientists track Oxytocin's every move
NCT ID NCT05488457
First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 3 times
Summary
This study looks at how the drug oxytocin works in women having a C-section. Oxytocin is used to help the uterus contract and prevent heavy bleeding after delivery, but it doesn't always work. Researchers will measure oxytocin levels in the blood and compare them to how well the uterus tightens. The goal is to understand why some women don't respond to the standard dose. About 100 women having planned or unplanned C-sections will take part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * 18-50 years old * intrauterine pregnancy * term (\>39 weeks gestation or 37-39 weeks gestation with fetal or maternal medical indication for delivery) pregnancy * non-emergent (scheduled or unscheduled) cesarean delivery Exclusion Criteria: * allergy or contraindication to oxytocin * inability to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Stanford University
NOT_YET_RECRUITINGStanford, California, 94305, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A single class may help new mothers avoid Long-Term pain after C-Section
- Could a 20% lower anesthetic dose make C-Sections safer?
- Can a single dose extend Post-Cesarean pain relief?
- Could having a partner present during emergency C-Sections improve Mothers' mental health?
- When pain strikes during C-Section: what Women's stories reveal
- Which drug stops Post-Birth bleeding better? a Head-to-Head test