Centre Hospitalier Universitaire Dijon

This early-phase study tested a new way to deliver chemotherapy directly to liver tumors in 15 people with cirrhosis and liver cancer that could not be surgically removed. The treatment involved injecting a mix of the drug idarubicin and a special oil into the liver's main artery…

This study tested whether adding the cholesterol-lowering drug pravastatin to the standard cancer drug sorafenib helps people with advanced liver cancer live longer. It involved 474 adults with Child-Pugh A cirrhosis who could not have curative treatments. The goal was to see if …

This study tested whether using an early PET scan after two rounds of chemotherapy could help doctors choose the right treatment for people with advanced Hodgkin lymphoma. Patients whose scan showed a good response got a milder chemo, while those with less response continued stro…

This study tested a new way to treat high lactate levels in patients with shock. High lactate can be caused by low oxygen to tissues or other problems, and knowing the cause helps doctors choose the right treatment. The study used a special CO2 measurement to guide care and compa…

This study looked at 83 people with diabetes-related eye damage. It compared having laser treatment in one session versus four sessions to see which approach better prevents vision loss from swelling. The goal was to find a more effective and convenient way to manage the disease.

This study tested a special heating cable (Thermowire) to warm chemotherapy liquid directly inside the body during a procedure called HIPEC. The goal was to avoid using a complex external pump, which could lower risks and costs. The trial included 13 patients scheduled for HIPEC …

This study tested whether citrate or heparin is better at keeping dialysis catheters working longer in ICU patients with sudden kidney failure. 405 adults were randomly assigned to receive one of the two lock solutions. The goal was to see which solution helped the catheter stay …

This study tested whether the anesthesia drug sevoflurane protects the heart more than propofol during planned aortic valve replacement. Researchers measured a heart stress marker (troponin) in 82 adults undergoing surgery. The goal was to see if combining sevoflurane before and …

This study looked at whether a team of nurses, doctors, and pharmacists providing close follow-up for two years after a stroke or heart attack is better than standard care. The goal was to see if this approach improves quality of life and reduces hospital readmissions. Over 850 a…

This study tested a drug called sirolimus in 16 people with a rare condition causing parts of their body to grow too much due to a PIK3CA gene change. The goal was to see if sirolimus could stop or slow this overgrowth. Participants took the drug and were monitored with scans and…

This study tested a new cognitive assessment tool (CASP) for stroke patients, including those with language difficulties. Researchers enrolled 263 participants to see if the test is reliable and valid. The goal is to help doctors evaluate thinking skills in all stroke patients, n…

This study tested a new genetic test (exome sequencing) to find the cause of severe epilepsy with developmental delays in 15 children whose standard tests were normal. The goal was to see if this advanced approach could identify more genetic causes, helping families get clearer a…

This study looked at whether a special PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a condition that causes inflammation in blood vessels. Researchers compared the scan results to the standard method, a biopsy of the temporal artery, in 70 patien…

This study tested a computer program that automatically adjusts cochlear implant settings to improve hearing for people who have one implant and a hearing aid in the other ear. Nine adults with severe hearing loss took part. The goal was to see if the new settings helped them hea…

This study looked at whether adding a painkiller (tramadol) to a local anesthetic given through a small tube near the chest wound can reduce the need for morphine after heart surgery. 160 adults having heart surgery through a breastbone incision took part. The goal was to see if …

This study tested whether a non-invasive brain stimulation technique called TMS can help smokers quit. The treatment targets a brain area linked to cravings. Researchers gave 88 adults who had failed other quit attempts a series of TMS sessions, plus maintenance sessions to preve…

This study tested a new method to adjust cochlear implants in 18 adults who have profound deafness in one ear but some hearing (with or without a hearing aid) in the other ear. The goal was to improve how well they understand speech in noisy environments by using a computer algor…

This study tested whether playing virtual reality games on a tablet could help frail elderly people improve their motor and thinking skills during rehabilitation. 37 participants aged 65 and older took part. The goal was to see if this fun, game-based training works better than s…

This study looked at how well patients walk and how much pain they feel after a procedure to open blocked leg arteries using special drug-coated balloons. 293 adults took part. The goal was to see if these balloons help people move better and hurt less.

This study tested whether Korean hand acupuncture (manupuncture) can reduce pain in women with endometriosis. 74 women were randomly assigned to receive either real acupuncture or a placebo treatment. The goal was to see if this gentle, non-drug approach could help manage pain th…

This study tested whether low-frequency magnetic brain stimulation (rTMS) could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 adults who were highly dependent on nicotine and wanted to quit received either real or fake rTMS over two we…

This study tested whether a full-body compression bandage could help reduce fluid buildup in patients with severe sepsis or septic shock in the ICU. 64 adults on breathing machines were enrolled within 24 hours of admission. Researchers tracked daily fluid balance and checked sur…

This study tested whether using no opioids during heart surgery could lower the need for morphine afterward and reduce complications. 110 adults having heart surgery with a heart-lung machine took part. The approach aimed to control stress and inflammation with other drugs, avoid…

This study looked at 72 people with lumbar spinal stenosis (a narrowing in the lower back that causes pain and trouble walking). All had surgery to relieve pressure on nerves. The goal was to see if their posture improved after surgery, not just their pain. Researchers used speci…

This study looked at 748 adults having retina or vitreous eye surgery to see if taking blood thinners (anticoagulants or antiplatelet drugs) increases the risk of dangerous bleeding during or after the operation. Doctors did not change their usual practice; they simply observed w…

This study looked at 40 adults with lumbar spinal stenosis (a common cause of back pain) to see if surgery improves how they walk. Researchers measured walking speed before and after surgery using a 6-minute walk test. The goal was to find a simple, objective way to measure the b…

This study looked at 62 adults with severe pneumonia to see how fat (lipid) metabolism differs between COVID-19 and other causes. Researchers measured cholesterol and other fat-related substances in the blood. The goal was to better understand links between obesity, inflammation,…

This study followed 356 adults with lupus over time to learn how the disease impacts their quality of life. Participants filled out questionnaires about their symptoms, fatigue, mood, and daily activities. No new treatments were tested; the goal was simply to gather information t…

This study looked at 202 people who had surgery for a detached retina, a condition where the light-sensitive layer at the back of the eye pulls away. The goal was to understand why some patients regain good vision while others do not. Researchers used advanced eye scans (OCT) and…

This study looked at how arachidonic acid, a type of fat, is processed in artery plaques of people with and without diabetes. Researchers collected plaque samples from 204 patients undergoing carotid surgery. They wanted to see if differences in fat metabolism make plaques more l…

This study looked at 982 people who had a heart attack to see if things like air pollution, noise, and nearby parks or water affect their recovery over one year. Researchers used home addresses to measure environmental exposures. The goal was to understand how these factors influ…

This study observed 101 ICU patients to see if stopping tube feeding before removing a breathing tube affects stomach fullness. Researchers used ultrasound to measure stomach volume, aiming to find ways to reduce the risk of inhaling stomach contents. The goal was to improve how …

This study looked at over 8,700 pregnant women with inflammatory bowel disease (Crohn's or colitis) to see how well doctors follow guidelines when using antiTNFα drugs during pregnancy. Researchers checked for complications in both mothers and babies up to one year after birth. T…

This study explored whether a fast type of genome sequencing (called exome sequencing) can quickly and accurately diagnose genetic problems in unborn babies with ultrasound abnormalities. Researchers tested 149 pregnant women whose fetuses had two or more abnormalities seen on ul…

This study tested whether monitoring pupil size during heart surgery helps doctors give just the right amount of pain medicine. 50 adults having planned heart surgery were included. The goal was to see if this approach reduces the total dose of a strong opioid called sufentanil, …

This study looked at 165 patients in the intensive care unit after major abdominal or urinary surgery. Doctors used lung ultrasound to measure fluid in the lungs and see if it could predict who would develop severe breathing problems. The goal was to learn if this simple test cou…

This study looked at whether the liquid used to keep dialysis catheters open (heparin or citrate) can leak into the bloodstream. It involved 76 adults with acute kidney failure who needed dialysis. Researchers measured blood clotting and calcium levels before and after injecting …

This study looked at 67 women who experienced domestic violence to see if a special center (Maison des Femmes) that offers medical, social, and legal help in one place leads to less post-traumatic stress than a regular shelter. Researchers measured PTSD symptoms at the first visi…

This completed study looked at 543 people who survived severe COVID-19 lung failure (ARDS) to see if their social and economic background affected their recovery. Researchers measured lung function, mental health, and quality of life six months after leaving the ICU. The goal is …

This study analyzed data from 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to measure how often a serious eye infection called endophthalmitis occurred within 28 days after the injection. No new treatments …

This study looked at whether a rapid genome sequencing test can quickly find the genetic cause of birth defects seen on ultrasound in unborn babies. The goal was to deliver results in less than 7 days, compared to the usual 3-4 weeks. Researchers studied 184 pregnancies to see if…

This study tested whether using simulation (like role-play or practice scenarios) can help adults with insulin-dependent diabetes learn to use the FreeStyle Libre glucose monitor. 27 patients who had already completed standard diabetes education took part. The goal was to see if …

This study looked at whether measuring muscle thickness in the thigh and breathing muscles with ultrasound before heart or lung surgery can help predict problems after surgery. Researchers enrolled 301 patients aged 65 and older. They found that less muscle mass may be linked to …

This study looked back at medical records of 65 people who had a cardiac arrest (heart stopped) and were treated with a heart-lung machine. The goal was to find factors that might predict who survives. Researchers checked things like how long the heart was stopped, initial heart …

This study looked at 198 patients who received a sutureless aortic valve to see if they developed heart rhythm problems after surgery. Sutureless valves are faster to implant but have a metal frame that may cause electrical issues in the heart. The goal was to better understand t…

This study looked at why obese women may have trouble during labor. Researchers took blood and uterine tissue samples from 38 women having C-sections. They studied how certain cells and chemicals affect the uterus's ability to contract, hoping to better understand delivery proble…

This study looked at 103 diabetic adults starting chemotherapy to see if a continuous glucose monitor (Freestyle Libre) could better track dangerous blood sugar highs and lows. Researchers wanted to find out if this device could help doctors manage diabetes more closely during ca…

This study looked at 39 hospitalized COVID-19 patients to measure their immune system's T-cell response. The goal was to find out if a strong immune reaction makes symptoms worse. Researchers measured specific immune cells and chemicals in the blood to understand why some patient…

This study looked at stress levels and healthcare use among parents of 60 infants at high risk for cerebral palsy after leaving the NICU. Researchers tracked how stress changed over time and how satisfied parents were with follow-up care. The goal is to improve support for famili…

This study looked at a type of immune cell called regulatory T cells in people with giant cell arteritis (Horton's disease), a condition that causes inflamed blood vessels. Researchers wanted to see if these cells are not working properly, which could explain why the disease happ…

This study examined whether certain immune cells in the blood of pregnant women hospitalized for preterm labor could predict if they would deliver within a week. Researchers measured specific markers on monocytes and lymphocytes from blood samples. The goal was to find a better w…

This study looked for new genes that cause a rare condition called syndromic congenital neutropenia, where children have low infection-fighting white blood cells along with other birth defects. Researchers used advanced DNA sequencing on 25 participants to find the genetic causes…

This study looked at 34 older adults (ages 60-90) who had fallen recently to see if ankle muscle strength is related to balance. Researchers measured ankle strength and balance using special tests. The goal is to find better ways to screen for fall risk and design exercises to st…

This study looked at whether improving blood sugar control can help a protein called apoC1 work better to manage cholesterol in people with type-1 diabetes. Researchers compared 160 patients with poorly controlled diabetes to 80 healthy controls. They measured blood samples to se…

This study examined how COVID-19 lockdowns impacted over 1,300 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers looked at changes in medication use, lifestyle habits, and stress levels. The goal was to understand the health risks …

This study looked at 770 adults who had pancreas surgery to see if measuring a different enzyme (lipase) in surgical drains could better detect a common complication called pancreatic fistula. Currently, doctors use the enzyme amylase, but it can be misleading. The goal was to fi…

This study tested a short, fast step test designed to measure anaerobic fitness in 44 people with coronary artery disease. The goal was to see if the test is safe, doable, and useful for creating better exercise programs. Participants completed the test while doctors watched for …

This study examined whether malnutrition makes it harder for foot sores to heal in people with type 1 or 2 diabetes. Researchers followed 75 patients with foot lesions that had lasted 1 to 24 months. The goal was to see if those who were malnourished had slower healing, which cou…

This study looked at how certain immune cells, called T CD8 lymphocytes, might be involved in Horton's disease (a type of blood vessel inflammation). Researchers collected blood samples and temporal artery biopsies from 30 newly diagnosed patients before treatment. The goal was t…

This study aims to develop and validate a test that uses time estimation to detect early emotional disorders in people with neurological diseases. Researchers first need to establish normal reference values by testing 150 healthy volunteers aged 20 to 92. The test measures how em…

This study checked the dental health of 110 adults with schizophrenia in Côte d'Or, France. Participants had a mouth exam, a blood test for vitamin C, and answered questions about their dental care and eating habits. The goal was to understand their current dental status, not to …

This study looked at how certain immune cells (T cells) work in people with autoimmune hemolytic anemia, a condition where the body attacks its own red blood cells. Researchers compared 27 patients to healthy volunteers to learn more about the disease. The goal was to gather know…

This study looked at whether sleep apnea causes early damage to tiny blood vessels in the eye. Researchers used a special eye scan (OCT-angiography) to compare the retinas of 166 adults with and without sleep apnea. The goal was to see if this quick, non-invasive test could revea…

This study looked at how the energy factories (mitochondria) inside certain immune cells change in patients with severe infections in the ICU. Researchers compared 36 patients with and without sepsis to understand why some patients' immune cells become dormant, making infections …

This study tested a new questionnaire to understand how people with schizophrenia feel about their oral health. Researchers asked 59 patients to fill out surveys about their teeth and quality of life. The goal is to create a reliable tool that can help design better dental preven…

This study looked at 39 people with syndromic poikiloderma, a rare skin condition that also affects other parts of the body. Researchers used advanced genetic tests to find new genes that cause the disorder. The goal was to improve diagnosis, help families understand their geneti…

This study tested whether virtual reality (VR) is safe and tolerable for people with a leg amputation and for healthy volunteers during walking tasks. Researchers measured how many participants could complete the VR walking exercises without problems. The goal is to see if VR can…

This study looked at whether nutritional status affects the risk of death in adults aged 70 and older with COVID-19. Researchers compared death rates between those with good and poor nutrition. The goal was to understand if undernutrition makes older patients more vulnerable to s…

This study looked at whether a person's psychological profile (type A or B personality) is linked to foot wounds in type 2 diabetes. Researchers compared 66 adults with diabetes—some with foot wounds, some without—using a simple questionnaire. The goal was to understand how perso…

This study looked at how families of children with rare developmental disorders feel about advanced genetic testing. Researchers surveyed and interviewed over 500 parents to understand their preferences about receiving unexpected genetic results. The goal is to help doctors bette…

This study looked at how well the Cor-Knot® device works during heart valve surgery. The device automatically ties knots in the threads that hold the new valve in place, which may reduce the time the heart is stopped during surgery. Researchers collected information from over 550…

This study looked at how often dangerously low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers monitored 29 residents using continuous glucose monitors and compared that to standard finger-prick tests. The goal was to find hidde…

This study looked at how tasting fatty acids changes levels of digestive hormones and other markers in the blood. Researchers compared healthy adults, people with type 2 diabetes, and obese individuals without diabetes. They also measured each person's ability to detect a specifi…

This study checked if having a dedicated center for ECMO (a machine that helps the heart and lungs) lowers the chance of dying. Researchers looked back at records of 172 adult patients in Dijon, France, over 10 years. They compared death rates before and after the center opened t…

This completed study examined the link between dietary fatty acids and colorectal cancer risk in 551 adults aged 45 and older. Researchers measured fatty acids in abdominal fat and red blood cells to see if certain fats increase cancer risk. The study did not test a treatment but…

This study looked at hospital records of over 4 million children aged 0 to 5 in France to find out how often physical abuse happens and what leads to it. Researchers used two large national databases to identify cases of abuse and compare them with other hospitalized children. Th…

This study looked at 50 adults who had a recent ischemic stroke and received a clot-busting drug called rt-PA. Researchers measured levels of a brain protein called BDNF in their blood to see if it increased after treatment. They also checked patients' recovery of thinking, movem…

This study tested a new rocking chair prototype designed to stimulate the body's balance system (vestibular system) in 30 healthy adults. The goal was to see if the chair could make people consciously feel movement and trigger eye reflexes, which could help screen for balance pro…

This study looked at how immune cells change in people with clogged arteries. Researchers compared blood samples from 61 heart surgery patients with and without artery plaque. They used a new method to measure cell changes that might help understand heart disease better.

This study looked at whether a new genetic test called high-throughput exome sequencing can find the cause of multiple birth defects in fetuses when standard exams cannot. Researchers studied 100 fetuses with at least two malformations and compared the new test to usual methods. …

People with long-term mental disorders often die 20 years earlier than others, mainly from heart disease. This study looks at how patients and their caregivers can work together to lower heart risks. Researchers talked to 127 people, including patients, caregivers, and doctors, t…

This study looked at 278 adults on a heart-lung machine (VA ECMO) to find early warning signs of dangerous bleeding. Researchers collected patient details, medical history, and lab results to identify which factors made major bleeding more likely. The goal is to help doctors prev…

This study tested a new plan to find and treat a serious complication called an anastomotic leak after colorectal cancer surgery. The plan used a blood test for C-reactive protein (CRP) to spot patients at high risk. 105 patients with high CRP levels after surgery were included. …

This study looked at fluid samples from the eyes of 137 people to understand what happens at a molecular level during retinal detachment. Researchers compared samples from people with retinal detachment to those having other eye surgeries. The goal was to identify changes in fats…

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic shock or other types of shock. The goal was to understand how this fluid changes during sepsis, which may explain why severe swelling occurs. Researchers measured component…

This study looked at 598 people who had surgery to remove colorectal cancer. Researchers wanted to learn when and where the cancer might come back after five years. The goal is to help doctors create better follow-up plans to improve survival.

This study looked at how doctors and nurses think about therapeutic patient education (TPE) for people with schizophrenia. Researchers interviewed 21 caregivers to find out what helps or hinders using TPE in mental health care. The goal is to improve how these programs are put in…

This study looked at whether GLP-1 agonist drugs (like liraglutide) can reduce fat buildup in the hearts of people with type 2 diabetes. 42 adults over 50 with diabetes and at least one heart risk factor were enrolled. Researchers used MRI scans to measure heart fat before and af…

This study looked at the sticky layer (biofilm) that forms inside breathing tubes of ICU patients on ventilators. Researchers wanted to see if the biofilm's structure and germs are linked to a higher chance of developing pneumonia. The study involved 61 adults who had been on a v…

This study looked at how being socially or economically vulnerable affects patients in intensive care units (ICUs). Researchers followed 1,417 patients in France to see if those with fewer resources had worse health when admitted and poorer recovery. The goal is to use this infor…

This study examined how psychological and ethical support affected the mental health of over 4500 hospital professionals during the COVID-19 crisis. Researchers measured stress levels using a standard questionnaire. The goal was to understand what support worked best and how it c…

This study aims to understand why dapagliflozin, a diabetes medication, can increase bad cholesterol levels in people with type 2 diabetes. Researchers will track how the body produces and removes cholesterol in 28 patients over 6 months. The findings could help doctors choose th…

This study looked at two different ways to treat sudden bleeding under the retina in people with age-related macular degeneration (AMD). One approach was surgery followed by anti-VEGF injections, and the other was a gas bubble injection followed by anti-VEGF injections. The goal …

This study looked at how patients in intensive care, their family members, and hospital staff decide who should be the main contact person. The goal was to see if these groups use different criteria. Researchers surveyed 150 patients and 150 relatives to find out. The results cou…

This study compared two advanced embryo culture systems used in IVF to see which one helps embryos grow better. Researchers looked at how many embryos successfully implanted in the womb. The goal is to improve success rates for people struggling with infertility.

This study looked at whether the COVID-19 lockdowns in France caused delays in treating diabetic foot ulcers, leading to more amputations. Researchers analyzed over 3 million hospital stays of diabetic patients from 2017 to 2020. They compared amputation rates before, during, and…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature infants born before 29 weeks. The goal was to see if higher …

This study looked at 26 very premature babies (born before 32 weeks) to see if a non-invasive light monitor (NIRS) could detect changes in a key heart vessel (the ductus arteriosus) as well as ultrasound does. Researchers compared NIRS readings of oxygen in the brain and kidneys …

This study looked at how often vein congestion (backed-up blood in veins) happens in intensive care patients and whether it leads to organ problems like kidney or liver failure. Researchers observed 185 adults in the ICU, checking for signs of congestion using ultrasound and othe…

This study reviewed the records of 1772 adults who had heart surgery with a heart-lung machine. Researchers compared those who received opioid-free anesthesia (using lidocaine and other drugs) to those who got standard opioid anesthesia. The goal was to see if avoiding opioids le…

This study aimed to find out how often fatigue happens after a stroke and what might cause it, including the effects of early treatments. Researchers followed 126 adults who had a recent stroke. The goal was to help doctors better understand and address this common, disabling sym…

This study looked at 552 adults who had planned colorectal surgery to see if a blood test called procalcitonin could detect infections earlier than the standard C-reactive protein (CRP) test. The goal is to catch complications like internal infections sooner, which could lead to …

This study examined blood samples from 300 people to see if depression is linked to faster cell aging. Researchers measured telomere length and stress levels in white blood cells. The goal was to find genetic markers that could help doctors better understand the severity and phys…

This study looked at whether giving water through a feeding tube can help stabilize blood flow in ICU patients on breathing machines, compared to standard IV saline. 50 adults with low blood pressure were included. The goal was to see how water affects heart function and to gathe…