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PET scans could spare hodgkin patients from extra chemo

NCT ID NCT01358747

Disease control Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using an early PET scan after two rounds of chemotherapy can help doctors choose the right treatment for people with advanced Hodgkin lymphoma. Patients whose scan showed a good response got a milder chemo, while those with less response continued stronger treatment. The goal was to see if this approach works as well as giving everyone the stronger chemo, with fewer side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Start date

May 2011

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with a first diagnosis of classical Hodgkin lymphoma according to world health organization (WHO) criteria excluding nodular lymphocyte predominant subtype * Age of 16 to 60 years * No previous treatment for Hodgkin lymphoma * Ann Arbor stages: IIB with mediastinum/thorax ≥0.33 or extra nodal localization III IV * Baseline 18-FDG PET scan (PET0)(F-FDG Positon Emission Tomography) performed before any treatment with at least one hypermetabolic lesion * Eastern Cooperative Oncology Group (ECOG) performance status \< 3 * With a minimum life expectancy of 3 months * Having previously signed a written informed consent * The patient must be covered by a social security system (in France) Exclusion Criteria: * Pregnant or lactating women * Men and women of childbearing potential not practicing an adequate method of contraception during the study treatment and at least 3 months after the last study drug administration * Any history of cancer or cancer treatment during the last 5 years with the exception of non-melanoma skin tumors or stage 0 (in situ) cervical carcinoma * Uncontrolled infectious disease, including active HBV (hepatitis B virus) infection defined by either detection of HBs Antigen or presence of anti HBs antibody without detectable anti HBc antibody. * HIV (Human immunodeficiency virus), HCV (hepatitis C virus) or HTLV (Human T-lymphotropic virus) serology positivity * Abnormal liver (bilirubin \> 2,5 N) function unless abnormalities are due to AHL 2011 Protocol Version n°1.2\_ 09/02/11\_approved on March 11, 2011 EudraCT n°2010-022844-19 4 / 73 Hodgkin lymphoma * Abnormal renal (Creatinin \> 150 μmol/L) function unless abnormalities are due to Hodgkin lymphoma * Leukopenia \< 2 G/l or thrombopenia \<100 G/l unless abnormalities are due to Hodgkin lymphoma * Severe cardio-pulmonary, or metabolic disease interfering with normal application of protocol treatment: * Left Ejection Ventricular Fraction \<50% * Respiratory insufficiency prohibiting bleomycin use * Uncontrolled diabetes mellitus leading to impossibility to perform PET scan * Impossibility to perform a baseline PET (PET0) before randomization and treatment beginning * Incapable person

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hodgkin's lymphoma

Contacts and locations

Locations

  • AZ Delta

    Roeselare, 8800, Belgium

  • AZ Groeninge

    Kortrljk, 8500, Belgium

  • Az Sint Jan

    Bruges, 8000, Belgium

  • CH Antibes

    Antibes, 06606, France

  • CH Avignon - Hopital Duffaut

    Avignon, 84902, France

  • CH Chambéry

    Chambéry, 73000, France

  • CH Chartres - Hopital Louis Pasteur

    Le Coudray, 28630, France

  • CH Dubos

    Pontoise, 95300, France

  • CH Jacques-Coeur

    Bourges, 18020, France

  • CH Lens

    Lens, 62307, France

  • CH Marc Jacquet

    Melun, 77011, France

  • CH Meaux

    Meaux, 77100, France

  • CH Mulhouse - Hopital Muller

    Mulhouse, 68070, France

  • CH Sud Francilien

    Corbeil-Essonnes, 91106, France

  • CH Valence

    Valence, 26953, France

  • CH Victor Dupouy

    Argenteuil, 95107, France

  • CH Yves Le Foll

    Saint-Brieuc, 22027, France

  • CH d'Arras

    Arras, 62022, France

  • CH de Bourg en Bresse

    Bourg-en-Bresse, 01012, France

  • CH de Bretagne Atlantique

    Vannes, 56017, France

  • CH de Dunkerque

    Dunkirk, 59385, France

  • CH de Pau

    Pau, 64046, France

  • CH de Troyes

    Troyes, 10003, France

  • CH de Versaille - Hopital Mignot

    Le Chesnay, 78157, France

  • CH de la région d'Annecy

    Pringy, 74370, France

  • CH du Dr Duchenne

    Boulogne-sur-Mer, 62200, France

  • CH tourelle Peltzer

    Verviers, 4800, Belgium

  • CHG Béziers

    Béziers, 34500, France

  • CHR Metz - Hopital Bon Secours

    Metz, 57038, France

  • CHR de la Source

    Orléans, 45067, France

  • CHU Angers

    Angers, 49033, France

  • CHU Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU Caremeau

    Nîmes, 30029, France

  • CHU Dijon - Hopital du Bocage

    Dijon, 21079, France

  • CHU Haut Leveque - Centre François Magendie

    Pessac, 33600, France

  • CHU Hotel Dieu

    Nantes, 44093, France

  • CHU Lyon Sud

    Pierre-Bénite, 69495, France

  • CHU Nice - Hopital de l'Archet

    Nice, 06202, France

  • CHU Reims - Hopital Robert Debré

    Reims, 51092, France

  • CHU Saint-Eloi

    Montpellier, 34295, France

  • CHU de Caen-Côte de Nacre

    Caen, 14000, France

  • CHU de Limoge - Hopital Dupuytren

    Limoges, 87042, France

  • CHU de Strasbourg-Hopital de Hautepierre

    Strasbourg, 67200, France

  • CHU du Mans

    Le Mans, 72037, France

  • CRLC Val D'Aurelle

    Montpellier, 34298, France

  • Centre Antoine lacassagne

    Nice, 06189, France

  • Centre Catherine de Sienne

    Nantes, 44000, France

  • Centre François Baclesse

    Caen, 14076, France

  • Centre Henri Becquerel

    Rouen, 76000, France

  • Centre Hospitalier Wallonie Picarde

    Tournai, 7500, Belgium

  • Centre Léon Bérard

    Lyon, 69373, France

  • Ch Brive

    Brive-la-Gaillarde, 19312, France

  • Chd Vendee

    La Roche-sur-Yon, 85925, France

  • Chru Lille

    Lille, 59037, France

  • Chu Mont Godinne

    Yvoir, 5530, Belgium

  • Clinique Mathilde

    Rouen, 76100, France

  • Clinique ST Pierre

    Ottignies, 1340, Belgium

  • Clinique St Joseph

    Mons, 7000, Belgium

  • Clinique Victor HUGO

    Le Mans, 72015, France

  • Clinique de la Sauvegarde

    Lyon, 69337, France

  • Clinique du Parc

    Castelnau-le-Lez, 34170, France

  • Clinique sud Luxembourg

    Arlon, 6700, Belgium

  • Grand hôpital de Charleroi

    Charleroi, 6000, Belgium

  • Hopital Américain de Paris

    Neuilly-sur-Seine, 92200, France

  • Hopital Antoine Beclere

    Clamart, 92140, France

  • Hopital Bicetre

    Le Kremelin Bicetre, 94275, France

  • Hopital Cochin

    Paris, 75679, France

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Necker

    Paris, 75743, France

  • Hopital Saint Louis

    La Rochelle, 17019, France

  • Hopital Saint-Louis

    Paris, 75475, France

  • Hopital Soint-Antoine

    Paris, 75012, France

  • Hopital de Bayonne

    Bayonne, 64100, France

  • Hopital de la Pitié Salpétrière

    Paris, 75651, France

  • Hopital de la conception

    Marseille, 13385, France

  • Hopitaux Civil de Colmar - Hopital Pasteur

    Colmar, 68024, France

  • Hôpital Bretonneau

    Tours, 37044, France

  • Hôpital Erasme

    Brussels, 1070, Belgium

  • Hôpital Jolimont

    Haine-Saint-Paul, 7100, Belgium

  • Hôpital Morvan- CHU Brest

    Brest, 29609, France

  • Hôpital ST Antoine

    Paris, 75012, France

  • Hôpital St Jean

    Perpignan, 66046, France

  • Hôpital d'instruction des Armées Percy

    Clamart, 92141, France

  • Hôpital de Chalon

    Chalon-sur-Saône, 71100, France

  • Institut Bergonié

    Bordeaux, 33076, France

  • Institut Calmettes

    Marseille, 13273, France

  • Institut Curie - Hopital Claudius Régaud

    Paris, 75248, France

  • Institut Curie - Hopital Huguenin

    Saint-Cloud, 92210, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut de Cancérologie Lucien Neuwirth

    Saint-Priest-en-Jarez, 42271, France

  • Polyclinique Bordeaux Nord Aquitaine

    Bordeaux, 33077, France

  • Pontchaillou

    Rennes, 35033, France

  • RHMS

    Baudour, 7331, Belgium

  • Ucl Bruxelles

    Brussels, 1200, Belgium

  • ZNA Stuivenberg

    Antwerp, 2060, Belgium

  • chu Ambroise Paré

    Mons, 7000, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.