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Heart surgery anesthesia showdown: sevoflurane vs propofol

NCT ID NCT02851433

Disease control Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the anesthetic sevoflurane protects the heart better than propofol during aortic valve replacement surgery. 82 patients were randomly assigned to receive either sevoflurane or propofol during and after surgery. The researchers measured troponin levels, a marker of heart stress, to see which anesthetic caused less damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sevoflurane (inhaled anesthetic) and Propofol (intravenous anesthetic)
What this could lead to
If sevoflurane proves better at protecting the heart during surgery, it could become the preferred anesthetic for valve replacement, reducing heart damage.
What could go wrong
This is a small, completed Phase 4 trial with only 82 participants, so results may not apply to all patients. The benefit is measured by a lab marker (troponin), not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

82 people

The number who actually took part.

Started

Oct 2015

Finished

Sep 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who have provided informed written consent. * Aortic valve replacement via sternotomy or thoracotomy, under Cardiopulmonary bypass (CPB). * Anterograde cardioplegia with cold blood Exclusion Criteria: * Adults under guardianship. * Patients without national health insurance cover. * Epileptics. * Heart grafted patients. * Patients under 18 years and pregnant or beast-feeding women. * Aortic dissections and vascular surgery. * Contra-indications to treatment with Sevoflurane: hypersensitivity to halogen-based anaesthetic agents, myopathy, personal or family history of malignant hyperthermia, hyper-eosinophilia, liver disease, icterus or unexplained fever after anaesthesia with a halogen-based anaesthetic agent * Contra-indications to treatment with Propofol: known hypersensitivity to propofol or one of the constituents of the specific form used, hypersensitivity to peanuts or soja. * pre-operative LVEF\<35%. * Coronary artery bypass graft alone or associated. * Mitral valve replacements. * Warm cardioplegia.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery

Contacts and locations

Locations

  • CHU Dijon Bourgogne

    Dijon, 21079, France

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