ACUTE KIDNEY INJURY

This study tests whether SGLT2 inhibitors, drugs already used for diabetes and chronic kidney disease, can help people with acute kidney disease (AKD). AKD occurs after a sudden kidney injury and can lead to permanent kidney damage. The trial will include 264 adults with AKD, wit…

This study tests whether a stem cell therapy called Amimestrocel can help people with acute kidney injury (sudden kidney failure). About 50 adults aged 18-75 will receive the treatment to see if it lowers creatinine levels and reduces the need for dialysis. The goal is to control…

This study tests a special blood filter (HA380) in 40 very ill adults who need dialysis or a heart-lung machine. The filter is designed to remove harmful inflammatory substances from the blood. Researchers want to see if using the filter is practical and if it can reduce time on …

This study tests a modified dialysis method for ICU patients with acute kidney injury. The goal is to see if a special citrate-based protocol reduces the need for extra electrolytes like potassium and magnesium. About 43 adults will take part, and researchers will compare the new…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 participants will receive either the drug or a placebo daily while in the hospital. The main goal is to see if the drug helps improve kidney function compared to …

This study tests whether a personalized care plan, based on a patient's risk of future kidney problems and delivered through digital tools, can improve health after acute kidney injury. About 6,000 adults leaving Alberta hospitals will be randomly assigned to receive either the t…

This study tests whether stem cells from donated fat tissue can help prevent kidney injury from getting worse in people who have been severely hurt in an accident or burn. About 70 adults in intensive care will receive the stem cells to see if it is safe and helps their kidneys r…

This study is testing whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care can improve outcomes for patients with heart failure and sudden kidney injury. Researchers will compare recovery, need for dialysis, and symptom relief between those wh…

This study tests if cilastatin protects the kidneys as well as the standard drug thiosulfate in women with ovarian cancer who receive heated chemotherapy during surgery. About 90 women aged 18-75 will be randomly assigned to one of the two drugs. The main goal is to see how many …

This study looks at whether a simple urine test (furosemide stress test) can help doctors decide when to safely stop continuous kidney dialysis in ICU patients with acute kidney injury. The goal is to reduce complications from prolonged dialysis, such as infections and heart issu…

This study looks at whether using a lower sodium concentration (140 mmol/l) in dialysis fluid can prevent dangerous fluid buildup in ICU patients with acute kidney injury, compared to the standard higher level (145 mmol/l). About 158 adults on a slow, daily dialysis method will b…

This study tests whether giving a stomach acid drug (pantoprazole) early to trauma patients with severe bleeding can reduce kidney injury. About 100 adults will be randomly assigned to receive the drug early or at the usual time. Researchers will measure kidney damage using urine…

This study tests a device called the Selective Cytopheretic Device (SCD) in ICU patients with severe acute kidney injury who need dialysis. The goal is to see if adding SCD treatment to standard dialysis improves survival and reduces the need for long-term dialysis. About 339 adu…

This study tests a drug called Niyad as a blood thinner for people undergoing continuous kidney dialysis who cannot use the standard drug heparin because of bleeding risk. About 70 adults will be randomly assigned to receive Niyad or a placebo during dialysis. The goal is to see …

This study tests whether giving a protein called albumin after a liver transplant can lower the risk of acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets enough albumin to keep blood levels above 30 g/L for five days, while t…

This study tests if giving two medicines—tranexamic acid and desmopressin—before surgery can reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see if these…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to see which approach is safer and works better. About 50 hospitaliz…

This study tests whether a treatment made from a patient's own white blood cells can help the kidneys recover faster after heart surgery. About 98 adults who develop acute kidney injury within 48 hours after surgery will receive either the cell therapy or a placebo. The goal is t…

This study tests whether a special care program helps adults recover from acute kidney injury (sudden kidney damage) better than usual care. About 2,145 participants will be randomly assigned to either the program or standard follow-up. The goal is to see if the program leads to …

This study tests whether giving extra fluids through an IV before and after a new type of heart procedure (pulsed field ablation) can prevent kidney injury in people with atrial fibrillation. About 290 adults will be randomly assigned to receive either standard care or extra flui…

This study tests whether a virtual home hospital program with remote monitoring can help adults recovering from acute kidney injury spend more days at home and avoid repeat hospital visits. About 354 participants will receive either usual care or a digital health package that inc…

This study looks at 250 ICU patients with acute kidney injury who need dialysis. Many have too much fluid in their body, which can harm recovery. The trial compares a faster fluid removal rate (2 ml/kg/h) with a slower one (0-1 ml/kg/h) to see which helps patients get off breathi…

This study looks at 450 adults with multiple myeloma who have a type of kidney damage called light chain cast nephropathy. Researchers want to see if plasma exchange or a drug called daratumumab helps the kidneys recover better than other treatments. The goal is to improve surviv…

This study tests whether using a very small amount of contrast dye during heart X-rays is safe for people who already have acute kidney injury. About 32 hospitalized adults will be randomly assigned to get the heart scan right away or wait until their kidney function improves. Th…

This study tests a device called JuxtaFlow that helps protect the kidneys during heart surgery. People with kidney problems who need heart surgery are at higher risk for kidney damage afterward. The device gently reduces pressure inside the kidney to help it work better during th…

This study tests whether starting kidney dialysis earlier, rather than waiting, helps people with severe heart shock who are on a heart-lung machine (ECMO). About 408 adults with both heart and kidney failure will be randomly assigned to early or standard dialysis. The main goal …

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The goal is to see if adding this device to standard care helps improve blood gas levels and reduce complications. About 99 adults wit…

This study monitors children (weighing at least 22 pounds, up to age 22) who have acute kidney injury caused by sepsis and are treated with the QUELIMMUNE device. The device filters blood to help kidneys recover. Researchers will track whether these children develop new bloodstre…

This study tests if briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with heart failure. About 240 adults with heart failure who need a heart catheterization will be randomly assigned to receive either the cuf…

This study looks at whether giving a lower dose of continuous dialysis (CRRT) to critically ill patients with sudden kidney failure is safe and works as well as the standard dose. About 100 adults in the ICU who need dialysis will be randomly assigned to receive either the standa…

This study looks at whether SGLT2 inhibitors (a type of diabetes drug) can prevent acute kidney injury caused by contrast dye used during heart procedures like angiography or stenting. Researchers will analyze data from 4,000 patients to compare kidney function before and after t…

This study is testing a new ultrasound technique called Shear Wave Elastography to see if it can detect acute kidney injury early in people who have had vascular surgery. Researchers will compare the kidney stiffness measurements of 50 healthy volunteers and surgery patients. The…

This study looks at whether a simple bedside ultrasound measurement, called the renal resistive index (RRI), can detect acute kidney injury earlier than usual methods in high-risk patients admitted to a surgical intensive care unit. Researchers will enroll 100 adults with conditi…

This study looks at whether a blood test called cystatin C can find kidney injury earlier than the usual test in people with chronic kidney disease who receive contrast dye for CT scans or heart procedures. About 100 adults will be enrolled, and their kidney function will be chec…

This study is testing a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsy samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to t…

This study tests whether giving theophylline, a drug used for asthma, soon after birth can prevent kidney injury in newborns with HIE (a lack of oxygen to the brain) who are treated with cooling therapy. About 30 infants will receive the drug to see if it is safe and to plan a la…

This study tests whether the drug LSALT peptide can prevent or reduce acute kidney injury in 240 adults having heart surgery that uses a heart-lung machine. Participants receive either the drug or a placebo before surgery, and doctors monitor kidney function for a week. The goal …

This study tests whether cilastatin, a drug already used for other purposes, can prevent acute kidney injury in hospitalized patients who must take medications known to harm the kidneys. About 700 adults receiving certain antibiotics, chemotherapy, or contrast dyes will receive e…

This study tests whether giving a concentrated salt solution (hypertonic saline) right after heart transplant can prevent or lessen acute kidney injury. About 74 adults who have a heart transplant will be randomly assigned to receive either the salt solution or a placebo. The mai…

This study tests whether melatonin, a natural sleep hormone, can prevent kidney injury caused by the antibiotic vancomycin. Researchers will give melatonin to 300 hospitalized adults aged 18-75 who are starting vancomycin therapy. The goal is to see if melatonin reduces the risk …

This study is testing an AI-powered tool that helps emergency room doctors detect and manage acute kidney injury (AKI) earlier. Researchers will roll out the tool at three hospitals and track whether it improves care and outcomes for up to 200,000 adult patients. The goal is to s…

This study examines whether starting continuous dialysis (CRRT) earlier in critically ill patients with severe kidney injury improves survival. Researchers will analyze data from over 50,000 patients from multiple ICUs in Sweden, comparing those who started dialysis early versus …

This study tests whether using a special ultrasound (VExUS) to guide fluid management during lung surgery can lower the risk of kidney injury and lung complications. About 230 adults having video-assisted lung surgery will be enrolled. The goal is to see if this approach leads to…

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 participants with CF, both during routine clinic visits and during hospital stays for lung flare-ups. They will look for earl…

This study looks at whether new markers in blood and urine can better predict kidney injury after kidney removal surgery than current standard tests. About 60 adults scheduled for surgery will provide samples before and after the procedure. The goal is to find faster, more accura…

This study aims to understand how inflammation from infections or major surgery can harm the kidneys. Researchers will measure certain proteins in urine, blood, and sputum from 100 ICU patients with sepsis, after surgery, or after poisoning. The goal is to find early markers that…

This study looks at how to improve follow-up care for people who have had acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin) to see which better measures kidney function after AKI. They will also interview patients about their experience…

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary tests and treatments in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if this approach lowers costs and improves care without …

This study is collecting blood and urine samples from 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze genes, proteins, and immune cells to find patterns that predict disease progression, complications, or response to t…

This study is observing 420 adults undergoing emergency non-cardiac surgery to see if their hemoglobin level before the operation is linked to developing acute kidney injury afterward. Researchers will also track how long patients stay in the hospital. The goal is to better under…

This study looks at patients on a heart-lung machine (ECMO) who also need kidney dialysis. It compares two ways to connect the dialysis machine: directly into the ECMO circuit or using a separate line. The goal is to see which method keeps the dialysis filter working longer and c…

This study looks at a new way to monitor kidney transplant health by measuring tiny bits of kidney-specific DNA in the blood. Researchers will test 30 adults with end-stage kidney disease before and after their transplant surgery. The goal is to tell the difference between DNA fr…

This study compares two types of continuous dialysis (CVVHD and CVVHDF) in 80 ICU patients with acute kidney injury. The goal is to see if one method removes waste (urea) from the blood as well as the other. Results will help doctors choose the best approach for kidney support in…

This study looks at 1000 adults in Latin American ICUs who need dialysis for sudden kidney failure. Researchers want to understand how care differs between countries and what affects patient survival. The goal is to gather data to improve future treatment, not to test a new drug …

This study tests whether a computer algorithm can accurately predict acute kidney injury (AKI) in children admitted to the intensive care unit (ICU). Researchers will enroll 800 children and use the tool to generate risk scores, but doctors won't see the results—so care remains u…

This study explores whether a special type of MRI, called manganese-enhanced MRI (MEMRI), can help detect early signs of heart and kidney problems in people with various kidney diseases, including acute kidney injury, chronic kidney disease, and kidney transplant. Researchers wil…

This study tests whether a non-invasive light sensor placed on the skin over the kidney can predict acute kidney injury after lung transplant surgery. About 80 adult lung transplant patients will be monitored during surgery. The goal is to see if low oxygen levels in the kidney, …

This study is testing whether adding blood and urine tests (biomarkers) to a computer risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). About 800 adults at high risk will be enrolled at two hospitals. Researchers will collect…

This study looks at whether taking creatine for a week can reduce kidney stress and keep thinking sharp after exercising in hot conditions. Twenty healthy, active adults will take either creatine or a placebo, then cycle in a heated room. Researchers will measure urine markers of…

This study tests a teaching program for families of children with acute kidney injury (AKI) while in the hospital. Researchers want to see if the program helps parents and kids understand AKI better, which could lead to improved care. About 25 children aged 1 to 18 with AKI will …

This study looks at whether giving less fluid during heart surgery, combined with a blood-saving technique, increases the risk of kidney injury. Researchers will measure kidney damage markers in the urine of 100 adults having elective bypass surgery. The goal is to understand if …

This study is observing 2,000 children (0-16 years old) from hospitals around the world to see how often kidney injury happens after non-heart surgery. Researchers will track kidney function with blood and urine tests to find early warning signs. The goal is to better understand …

This study tracks 230 adults having planned heart surgery to see if drops in blood pressure during the operation lead to serious problems like confusion, kidney damage, stroke, or death within 30 days. Researchers will monitor blood pressure and use of medicines to raise it, then…

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam versus vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury using more sensitive markers than standard…