ACUTE KIDNEY INJURY

This early-stage study tests whether adding the iron-binding drug MEX-CD1 to dialysis fluid can safely remove extra iron in adults with sepsis-related acute kidney injury in the ICU. Fourteen participants will each receive two 24-hour dialysis sessions—one standard and one with t…

This study tests whether giving sodium bicarbonate (baking soda) to critically ill patients with metabolic acidosis and acute kidney injury can reduce serious kidney problems, including death or need for dialysis, within 90 days. About 660 adults in intensive care will receive ei…

This study tests a new drug, QRX3, in 3,000 adults with chronic kidney disease (CKD) whose kidney function is declining. The goal is to see if QRX3 can slow that decline and reduce protein in the urine. Participants must have an eGFR below 60 and a slow rate of decline (less than…

This study tests whether N-Acetylcysteine can protect kidney function in adults with solid tumors who are receiving cisplatin-based chemotherapy. Participants will take either N-Acetylcysteine or a placebo for seven days around their chemo session. Researchers will measure kidney…

This study tests whether giving amino acids (protein building blocks) through a vein can help prevent or reduce acute kidney injury in adults on ECMO life support. About 40 intensive care patients will receive either amino acids or a placebo. The goal is to see if this simple tre…

This study tests a newer blood thinner, nafamostat mesylate, against the standard citrate for patients with sepsis and severe kidney injury who need continuous dialysis. The goal is to see if the newer drug works just as well or better at preventing death, ongoing kidney failure,…

This study looks at whether giving fluids and a blood pressure medication early can prevent kidney injury in adults with septic shock, a life-threatening infection. About 100 participants will receive a standard treatment plan. Researchers will measure kidney function and blood p…

This study compares two common antibiotic combinations to see which one is less likely to harm the kidneys of hospitalized adults with serious infections. About 852 participants will be randomly assigned to receive either vancomycin plus piperacillin/tazobactam or vancomycin plus…

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Standard fluids can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the standard one in 220 adult…

This study tests whether giving an amino acid infusion during and after heart surgery can lower the risk of acute kidney injury in children. About 30 children at high risk for kidney problems will receive either the amino acid or a placebo for up to 72 hours. Researchers will als…

This study tests whether giving a short infusion of amino acids during heart surgery can help prevent acute kidney injury, a common complication. Researchers will enroll 130 adults having elective heart surgery with a bypass machine. Half will receive standard care, and the other…

This study tests whether aminophylline, a drug usually used for asthma, can prevent kidney damage in children receiving cisplatin chemotherapy. About 24 children will be randomly assigned to receive either aminophylline or a placebo alongside their standard hydration protocol. Re…

This study looks at 130 adults with sepsis to see if a kidney ultrasound (renal resistance index) and a urine test can predict acute kidney injury before it happens. Researchers will measure these markers right after sepsis diagnosis and track who develops kidney problems. The go…

This study looks at whether blood electrolyte levels can predict kidney damage in stroke patients who undergo a clot removal procedure. Researchers will review medical records of 250 adults treated between 2018 and 2026. The goal is to find new ways to identify patients at higher…

This study watches 120 critically ill adults without kidney injury at ICU entry to see if their fluid balance in the first 48 hours is linked to developing acute kidney injury (AKI). Researchers track fluids hourly and check kidney function for 7 days. The goal is to find better …

This study tests whether showing anesthesiologists a computer-calculated risk score for acute kidney injury (AKI) helps them take steps to prevent it. About 25,500 adults having non-emergency surgery will take part. Doctors will either see the risk score alone, the score plus an …

This study will collect information from up to 100,000 critically ill patients in intensive care units (ICUs) around the world who receive continuous kidney dialysis (CRRT). The goal is to understand how different hospitals use this treatment and how it affects patient outcomes. …

This study looks at whether combining two common blood markers—uric acid/albumin ratio and lactate—can help predict which older sepsis patients will develop kidney injury, need blood pressure support, or die within 28 days. Researchers will follow 80 patients aged 65 and older in…

This study looks at whether a protein in the blood called uromodulin can help predict how well the kidneys will recover in adults with sepsis-related acute kidney injury. Researchers will measure uromodulin levels at the start, after one week, and at hospital discharge in 30 pati…

This study tests a structured program to help family members make difficult decisions about starting emergency dialysis for a loved one with acute kidney injury in the ICU. About 100 family members will be randomly assigned to receive either the program or standard care. Research…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having heart bypass or valve surgery will take part. Researchers will measure kidney injury markers and track how much fluid patients…

This study aims to create a simple risk score for older adults (60+) who develop rhabdomyolysis after lying on the floor for over an hour following a fall. Researchers will review medical records from 1,000 patients to find which factors best predict serious outcomes like kidney …

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study looks at whether the way you sleep before heart surgery is connected to your risk of confusion (delirium) and kidney injury after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to better understand t…

This study looks at 3,000 adults having planned heart surgery to find out if things like genes, blood markers, and even voice recordings can help predict serious complications such as kidney injury, delirium, or bleeding. Researchers will collect samples and data before, during, …

This study will check if a new scoring system called STARZ can predict kidney injury in newborns within the first week of life. Researchers will enroll 140 babies in the NICU and compare the STARZ score to standard tests. The goal is to catch kidney problems early so doctors can …

This study looks at whether a special ultrasound technique called VExUS can help doctors manage fluids better in ICU patients with acute kidney injury. About 100 adults in intensive care will be observed and some will have their treatment guided by VExUS. The goal is to see if th…