ACUTE KIDNEY INJURY

This study tests if ambrisentan, a drug already used for lung blood pressure, can help people with hepatorenal syndrome—a serious kidney problem that can happen in advanced liver disease. About 54 adults will get either ambrisentan or the standard treatment terlipressin while in …

This study tests an experimental drug called Auxora in 150 adults with acute kidney injury and breathing problems. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive and recover without needing a ventilator or kidn…

This study tests whether a proactive fluid management plan helps critically ill patients with acute kidney injury who are on dialysis. The plan aims to keep fluid levels balanced by preventing and treating fluid buildup. About 150 adults in the ICU will be randomly assigned to ei…

This study tests a device called the Selective Cytopheretic Device (SCD) in 10 ICU patients with acute kidney injury and hepatorenal syndrome. The device filters certain white blood cells from the blood for 7 days to see if it improves kidney function and blood circulation. The m…

This study tests whether a blood pressure medication (angiotensin receptor blocker) can prevent major heart problems and kidney disease in patients who had acute kidney injury while in the intensive care unit. About 508 adults aged 18–75 who have recovered enough to leave the ICU…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study tests a new urine test that measures a protein called L-FABP to see if it can predict kidney injury within 2 days after heart or blood vessel procedures that use contrast dye. About 450 adults at higher risk for kidney problems will provide urine samples before and aft…

This study planned to test two new methods for spotting acute kidney injury (AKI) early in adults having elective heart surgery. Researchers wanted to see if these methods could predict AKI better than current tests. However, the study was withdrawn before any participants were e…

This study tests a simple, non-invasive ear stimulation technique to prevent acute kidney injury in people having heart surgery with a heart-lung machine. About 152 adults will receive either real or fake stimulation before and after surgery. The goal is to see if this approach r…

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which may damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo to see if …

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study planned to use a biomarker test called NGAL to predict which critically ill children would develop severe kidney injury. It aimed to help doctors decide when to start or stop certain treatments. However, the study was withdrawn before any patients were enrolled, so no …

This study is collecting information on a new dialysis machine called CARPEDIEM, designed specifically for critically ill infants with kidney problems. Researchers will track how well the machine works, how long filters last, and how many babies recover kidney function. The goal …

This study was designed to track the long-term health of hospitalized patients in China who experienced acute kidney injury (AKI). Researchers wanted to see how often AKI leads to chronic kidney disease, heart problems, or death. However, the study was withdrawn before enrolling …

This study looks at how often kidney injury happens in newborns in intensive care units around the world. Researchers will review medical records from about 4,000 babies to find risk factors and improve future care. No new treatments or medications are given—this is an observatio…

This study looks back at data from 343 heart surgery patients who had a blood purification device (oXiris) added to the heart-lung machine. Earlier results showed the device reduced acute kidney injury by about 12% in the first week. Now researchers will check if it also affects …

This study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (sudden kidney damage) happens during a hospital stay. Researchers will also check if patients who had kidney injury are more likely to die or be readmitted. The goal is …

This study tests whether a real-time computer alert that predicts acute kidney injury (AKI) can help doctors step in early to prevent or reduce kidney damage. About 180 hospitalized adults at risk for AKI will be randomly assigned to either standard care or early kidney specialis…

This study planned to see if two monitoring tools—an ultrasound probe in the esophagus and a skin sensor that measures oxygen levels—could help doctors predict kidney injury early in children having heart surgery. The goal was to find a faster way to spot kidney problems during t…

This study looks at how to better assess fluid status in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different methods, including physical exams and bioimpedance, t…

This study looks at whether a substance called UDP-glucose in urine can help doctors find kidney injury earlier in children who have had heart surgery. Current tests often miss early signs, leading to delays in care. Researchers will collect urine samples from 305 children aged 8…

This study aims to find the right cutoff value for a lab test called ProNephro AKI (NGAL) that helps identify ICU patients at risk for moderate to severe acute kidney injury. Researchers will collect blood and urine from 800 adult ICU patients and track their kidney function over…

This study planned to test whether giving doctors machine-learning risk alerts could reduce serious complications after surgery, like unplanned ICU stays or kidney injury. It was designed for high-risk patients, but the study was withdrawn before any participants were enrolled. N…

This study follows 420 children in the pediatric intensive care unit (PICU) who are at risk for acute kidney injury. Researchers use a biomarker test (NGAL) and a kidney stress test to predict which children will become fluid overloaded and need dialysis. The goal is to improve h…

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…

This study aimed to analyze medical records to see if preventing acute kidney injury during heart surgery is worth the cost in the UK. It planned to compare patients who had kidney injury after surgery with those who did not. However, the study was withdrawn before enrolling any …

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or too much fluid in their body and are treated with the Carpediem system. Doctors will use the machine as they normally would and collect information on survival and kidney recovery. The goal is…

This study looks at whether special monitors can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients. About 30 adults in the ICU with acute kidney injury or end-stage kidney failure will take part. The goal is to…