Cardiac rhythm disease

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study tests a new device called the VERAFEYE System, which creates a 3D model of the heart to guide doctors during catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). About 100 adults who are already scheduled for ablation will have the proc…

Researchers are testing the FARAFLEX Mapping and Pulsed Field Ablation System in people with atrial fibrillation who need a repeat ablation procedure. The trial compares the FARAFLEX system, which uses electrographic flow mapping and pulsed electric fields, against a control trea…

Researchers are testing a medical device that has not been approved or cleared by the U.S. FDA. The trial aims to see whether the device can help control a disease, possibly by reducing symptoms or slowing its course. Participants receive the device as part of the study, and the …

Researchers test whether adding superior vena cava isolation to standard pulmonary vein isolation helps people with persistent atrial fibrillation. About 340 participants aged 18 to 75 whose AFib has lasted less than a year and who are having their first catheter ablation join th…

Researchers in Denmark are testing whether a structured weight loss program can slow the progression of atrial fibrillation in people who are overweight or obese. The trial enrolls 480 adults with symptomatic paroxysmal or early persistent atrial fibrillation and a body mass inde…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This trial tests whether a 12-week remotely supervised exercise program can improve recovery in adults aged 50 to 75 who had catheter ablation for atrial fibrillation. Participants are randomly assigned to either the telerehabilitation group, which does aerobic, strengthening, an…

This trial tests whether giving naloxone during CPR helps people who have a cardiac arrest in the hospital. Naloxone is a drug that blocks opioid effects, and researchers want to see if it improves survival and recovery. About 850 adults who receive adrenaline during CPR will be …

This trial tests two ways of placing a pacemaker lead in the heart's left bundle branch area. One strategy aims to directly capture the heart's conduction system, while the other accepts capture of the nearby septal muscle. Researchers will compare how well the heart's pumping fu…

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This trial tests whether a small leadless pacemaker, the Aveir VR, can be safely implanted through the jugular vein in the neck instead of the usual route. Researchers will enroll 15 adults with slow heart rhythms who need ventricular pacing. The main goal is to see if the proced…

This trial compares two ways of placing a pacemaker lead in people who develop a slow heart rhythm after cardiac surgery. One method uses conventional right ventricular pacing, while the other uses left bundle branch area pacing, which aims to activate the heart more naturally. T…

This study tests a catheter-based procedure called Varipulse to treat paroxysmal atrial fibrillation (irregular heartbeat that comes and goes). Researchers want to see how well it works long-term when combined with different types of sedation. About 300 adults aged 18-80 with sym…

This trial tests whether the Sphere-9 catheter and Affera system can safely and effectively treat paroxysmal atrial fibrillation (PAF), a condition where the heart beats irregularly. Adults with PAF who have not been helped by or cannot take certain heart medications will receive…

This study compares two catheter ablation techniques for treating atrial fibrillation, a common heart rhythm problem. One method uses a single-shot device, while the other uses a focal dual-energy approach. The trial includes 268 adults with symptomatic atrial fibrillation who ar…

This trial tests whether apixaban, a blood thinner, can reduce the risk of stroke or blood clots in adults on dialysis who also have atrial fibrillation (an irregular heartbeat). Participants are randomly assigned to receive either apixaban or no oral anticoagulant, while continu…

This trial investigates whether a new technique called pulsed field ablation (PFA) can more effectively treat atrial fibrillation, a common heart rhythm problem. The procedure uses short electrical pulses to create precise lesions in the heart tissue, aiming to block faulty signa…

This trial tests whether a communication training program for emergency dispatchers can help them recognize cardiac arrest over the phone and guide callers to start CPR faster. The study involves about 987 adults who experience cardiac arrest outside of a hospital and call the SA…

This trial tests whether augmented reality (AR) can allow a technical expert to support doctors remotely during a heart procedure called catheter ablation for atrial fibrillation. Using a HoloLens headset and a remote connection, the expert may guide the procedure from a differen…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This trial tests whether a heart procedure called pulsed field ablation can be guided using only ultrasound, avoiding the use of X-rays (fluoroscopy), in people with paroxysmal atrial fibrillation. The study compares the success of completely isolating the pulmonary veins—a key s…

This trial tests whether a newer pacing method, called left bundle branch area pacing, is better than the standard right ventricular pacing for adults with permanent atrial fibrillation and a need for a pacemaker. The goal is to see if the newer technique reduces the risk of deat…

This trial tests whether a smartphone app that uses light to measure heart rhythm can reliably detect when atrial fibrillation (AF) spontaneously returns to a normal heartbeat. About 200 adults with AF scheduled for an electrical cardioversion will either receive standard care or…

This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the…

This study looks at two ways to treat atrial fibrillation (a common heart rhythm problem) in people aged 78 and older. One approach uses a procedure called catheter ablation to fix the heart's electrical signals, while the other uses medications to control heart rate or rhythm. R…

This study is testing two ways to perform a repeat ablation procedure in people with atrial fibrillation (an irregular heartbeat) that has returned after a first treatment. Both approaches use pulsed-field ablation to isolate the pulmonary veins, but one also adds ablation of the…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This trial tests whether adding a minimally invasive mitral valve repair (transcatheter edge-to-edge repair, or TEER) to standard catheter ablation improves outcomes for people with both atrial functional mitral regurgitation and atrial fibrillation. Participants are randomly ass…

This trial compares two standard IV medicines—verapamil and metoprolol—to see which controls rapid heart rate better in adults with atrial fibrillation who are otherwise stable. Patients receive one of the drugs in the emergency department, and their heart rate, blood pressure, a…

This phase 3 trial is testing an investigational drug called abelacimab in about 2,500 people with atrial fibrillation (an irregular heartbeat) who are at high risk for stroke but cannot take standard oral blood thinners. Participants will receive either abelacimab or a placebo, …

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standa…

This trial tests whether a procedure called pulsed field ablation can safely treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. About 30 people with frequent premature heartbeats or ventricular tachycardia will receive the treatment using a special…

This trial investigates whether a new pulsed field ablation system can safely and effectively treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The system uses short electrical pulses to destroy tiny areas of heart tissue causing the abnormal rh…

This trial tests whether adding tirzepatide (Mounjaro) to a structured lifestyle program reduces the return of atrial fibrillation within a year after catheter ablation in obese patients. About 710 participants with symptomatic AF and a BMI of 28 or higher (or 24 with other risk …

This study tests a device called the Globe Pulsed Field System, which uses short bursts of electric energy to destroy tiny areas of heart tissue that cause abnormal rhythms in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). The tria…

This trial tests whether adding a 3D holographic visualization tool, called EchoPixel Holographic Therapy Guidance, helps doctors perform two common heart procedures more accurately. The procedures are left atrial appendage occlusion (for atrial fibrillation) and mitral valve rep…

This trial compares a minimally invasive surgery that closes off a small heart pouch (the left atrial appendage) to standard blood-thinning medication in people with atrial fibrillation who have a high risk of bleeding. The goal is to see if the surgery can prevent strokes, major…

This study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…

This study tests whether wearable devices like smartwatches and ECG straps can help doctors remotely manage patients with both heart failure and atrial fibrillation. Participants use the devices to send real-time health data to their care team, who adjust medications and treatmen…

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This study aimed to see if a short course of the heart medication amiodarone could prevent atrial fibrillation (an irregular heartbeat) in adults after heart surgery. About 1 in 3 patients experience this complication. However, the study was withdrawn before enrolling any partici…

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a 'nudge' program—including text reminders, a medication calendar, and an action plan—to help 84 adults with atrial fibrillation take their blood thinners consistently. Participants will watch an educational video, create a daily pill-taking routine, and receive …

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This registry will follow 500 people with symptomatic atrial fibrillation who are scheduled for a heart ablation using the Globe Pulsed Field System. The goal is to see how well the device controls the heart rhythm over 12 months and to track any major side effects within the fir…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests whether a non-invasive ear stimulation, called low-level tragus stimulation, can reduce inflammation and early heart rhythm problems after pulsed field ablation for atrial fibrillation. Forty-six adults with atrial fibrillation will receive either active or sham …

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study compares a stepwise blood-thinning approach to the standard method in 424 patients with atrial fibrillation who are at high risk for stroke and need a heart device like a pacemaker. The stepwise plan involves stopping the blood thinner one day before surgery and restar…

This study tests whether a newer drug, Vernakalant, works better than the standard Amiodarone for treating atrial fibrillation (irregular heartbeat) that often occurs after heart surgery. About 50 adults who recently had heart surgery will receive one of the two drugs. The main g…

This study tests a non-invasive radiation treatment called STAR for people with a dangerous fast heart rhythm caused by heart scarring. Instead of using medications or a catheter procedure, a single targeted dose of radiation is delivered to the scarred area. The goal is to see i…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This study tests a new way to treat atrial fibrillation (AFib), a condition where the heart beats irregularly. Doctors will use pulsed field ablation (PFA) instead of heat or cold to create scars in the heart and block bad signals. They will also use a special 3D ultrasound syste…

This study tests a new way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a specific area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard procedure …

This study tests whether adding extra ablation to standard treatment can help people with persistent atrial fibrillation (a type of irregular heartbeat). About 350 adults will be randomly assigned to receive either standard ablation or standard ablation plus isolation of the left…

This study compares two heart procedures for people with persistent atrial fibrillation (AFib) lasting 6 months to 3 years. One group gets standard pulmonary vein isolation (PVI) ablation, while the other gets PVI plus an extra ablation on the Bachmann bundle. The goal is to see …

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. About 320 adults with AF will receive this procedure to see if it safely restores normal heart rhythm for at least a year. The goal is to reduce sympt…

This study follows 30 adults with paroxysmal atrial fibrillation (PAF) who have or will get a special pacemaker. The pacemaker can detect irregular heartbeats early and send a painless pacing pulse to stop them. It also sends data to doctors remotely. Researchers will check how w…

This study tests a new technique called Dynamic Voltage Mapping (DVM) to better identify scar tissue in the heart that causes ventricular tachycardia (VT), a life-threatening heart rhythm. The approach uses catheters to create a personalized electrical map, aiming to guide ablati…

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This study tests whether taking a daily probiotic capsule for 12 weeks can reduce the chance of atrial fibrillation (AF) returning in people who have just had a cardioversion (a procedure to restore normal heart rhythm). Fifty-six adults aged 40 and older with persistent AF will …

This study compares two CPR methods for newborns with cardiac arrest: a new technique that combines chest compressions with sustained lung inflation versus the standard 3:1 compression-to-ventilation ratio. Researchers will enroll 554 newborns across multiple hospitals to see whi…

This study tests whether mirabegron, a drug typically used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers wi…

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This study looks at whether giving volunteer community responders a small, portable defibrillator (about the size of a chocolate bar) helps them treat people having a cardiac arrest outside the hospital. Around 1,000 volunteers in Singapore will carry the device for up to a year …

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiat…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study tests whether staying alcohol-free for six months after a heart ablation procedure can reduce the return of atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 414 adults who drink at least three alcoholic beverages per week and are schedul…

This study tests a device that uses extreme cold to destroy small areas of heart tissue causing ventricular tachycardia, a fast and dangerous heart rhythm. Up to 130 people with recurrent VT will receive the procedure and be followed for 6 months. The goal is to see if the treatm…

This trial will enroll about 3,200 people with paroxysmal atrial fibrillation (AF) to see if using a smartwatch to continuously track AF burden can guide earlier and better treatment. Participants will be monitored with a wearable device, and if their AF burden is high, doctors w…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who have already had a catheter ablation. About 120 adults aged 20 to 75 will be randomly assigned to receive either acupunctur…

This early study tests a procedure that uses a catheter to ablate (destroy) a nerve near the heart, aiming to reduce signals that trigger ventricular tachycardia (VT), a dangerous fast heart rhythm. Ten adults with an implanted defibrillator (ICD) and recurrent VT will be enrolle…

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood th…

This study will test whether adding fexuprazan, a stomach acid reducer, to standard blood thinners can prevent upper gastrointestinal bleeding in people with atrial fibrillation. About 1,000 high-risk participants will be randomly assigned to receive either the combination therap…

This study compares two common heart rate-lowering drugs, verapamil and metoprolol, in 436 adults with paroxysmal atrial fibrillation (AF). It also tests whether using a smartwatch for self-care can reduce hospital visits and improve symptoms. The goal is to find better ways to m…

This study tests a device called CLAAS that closes a small pouch in the heart (left atrial appendage) to prevent strokes in people with atrial fibrillation. About 300 adults at high risk of stroke will get the device under conscious sedation (awake but relaxed). The goal is to se…

This study tests a new, small pacemaker that doesn't need wires (leads) to help people with a slow heartbeat. About 15 adults with certain heart rhythm problems will get the device to see if it's safe and works well. The pacemaker is placed directly in the heart to keep the beat …

This trial will test whether using smaller breaths (350ml) during CPR helps more people survive cardiac arrest compared to standard larger breaths (600ml). Paramedics will treat 1656 adults with presumed cardiac arrest. The main goal is to see if the smaller breaths lead to more …

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This study tests whether using special devices to precisely control breathing during CPR can help more people survive a cardiac arrest. About 852 adults who have a cardiac arrest in the hospital will be randomly assigned to either standard manual breathing help or breathing tailo…

This early study tests a new, wire-free pacemaker (ALPS) in 10 people with bradycardia (slow heart rate). The goal is to see if it is safe and works well. Participants will be monitored for device-related problems and how well the pacemaker controls their heart rhythm.

This study will compare different pulse field ablation systems used to treat atrial fibrillation (AF), a common heart rhythm problem. Over 1,100 patients will receive one of the standard treatments depending on the time period they are treated. Researchers will track whether AF r…

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard…

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes fewer major bleeding events while still preventing blood clots. Participants will be fol…

This study compares two ablation procedures for people with persistent atrial fibrillation (AF), a heart rhythm problem. Half of the 450 participants will get standard treatment (isolating the pulmonary veins), while the other half will get extra ablation lines in the heart. The …

This study looks at whether an implantable defibrillator (ICD) can reduce the risk of sudden cardiac death in people with non-ischemic dilated cardiomyopathy, a type of heart muscle disease not caused by blocked arteries. Researchers will use MRI scans to find heart scarring (fib…

This early study tests a new device that uses pulsed electric fields to treat atrial fibrillation (an irregular heartbeat) during planned heart surgery. Sixteen adults will receive the treatment and be followed for 6 months to check safety and whether the heart rhythm stays norma…

This study tests whether taking semaglutide (a drug used for diabetes and weight loss) before a standard heart procedure called catheter ablation can help prevent atrial fibrillation from coming back. The trial will include 240 adults with obesity and symptomatic atrial fibrillat…

This study looks at a device called AnchorMan that is placed in the heart to seal a small pouch where clots can form. It is for people with a type of irregular heartbeat (atrial fibrillation) who are at high risk for stroke. The main goal is to see how well the device gets covere…

This trial tests two different heart pacing leads—one without a hollow core (lumenless) and one with a stylet—to see which works better for left bundle branch pacing. About 288 people with slow heart rhythms will take part. Doctors will use continuous monitoring to guide the lead…

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or heart pump. Participants will receive either a standard implantable defibrillator (ICD) alone or an ICD plus a special pacing lead a…

This trial tests whether dapagliflozin, a drug typically used for diabetes, can reduce the return of atrial fibrillation after a heart ablation procedure. The study focuses on patients with persistent AF and increased epicardial adipose tissue (heart fat), which is linked to high…

This study tests a new shape-adaptive catheter that uses pulsed field ablation to treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. 35 adults with persistent AFib will receive the procedure under general anesthesia. Researchers will check for serious sid…

This study tests a procedure called pulsed field ablation in 70 people with atrial fibrillation who have already had a left atrial appendage occlusion to prevent stroke. The procedure uses electric pulses to destroy small areas of heart tissue causing the irregular rhythm. Resear…

This study compares two types of medicine for atrial fibrillation (AF), a condition causing irregular heartbeat. About 1,900 adults diagnosed with AF in the past year will be randomly assigned to take either dronedarone or a standard Class Ic drug (like flecainide). Researchers w…

This study compares two medical devices (Amplatzer Amulet and LAmbre) used to close a small pouch in the heart called the left atrial appendage. The goal is to reduce stroke risk in people with an irregular heartbeat (atrial fibrillation) who are at high risk for bleeding from bl…

This study tests a new CPR method called Bio-CPR, which synchronizes chest compressions with ventilation using a machine. Researchers will compare it to standard CPR in 408 adults who have a witnessed cardiac arrest. The goal is to see if this coordinated approach improves breath…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This study tests a temporary pacing technique to slow dangerously fast heart rates in people with atrial fibrillation who cannot use standard medications. Researchers will pace specific nerve fibers near the heart to see if it safely controls heart rate without permanent procedur…

This study looks at two ways to treat atrial fibrillation (AF) that comes back after a first ablation. Patients who still have symptoms despite medication will be randomly assigned to either a repeat ablation or a pacemaker with AV node ablation. The goal is to see which approach…

This study tests if burning extra spots outside the main heart veins can better control persistent atrial fibrillation (a type of irregular heartbeat). About 406 adults having their first ablation will be split into two groups: one gets standard vein isolation, the other gets add…

This study compares two heart procedures for people with paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. One group gets standard ablation to isolate the pulmonary veins, while the other also gets ablation of the superior vena cava using pulse…

This small study will test whether empagliflozin, a drug typically used for diabetes, can improve abnormal heart patterns in people with Brugada syndrome. Ten participants will take the drug daily for three months, and researchers will monitor their heart rhythms and any side eff…

This study tests a new procedure called pulsed field ablation (PFA) using the FARAPULSE system to treat people with paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 Chinese patients to see if the procedure can safely isolate the veins tha…

This study tests two heart ablation methods—right atrial only vs. bi-atrial—to see which better prevents fainting caused by reflex syncope. Fifty adults aged 18–60 with severe, recurrent fainting will be monitored with an implantable loop recorder. The goal is to find the most ef…

This study tests a new way to place an emergency IV line through the umbilical cord in newborns who need urgent resuscitation. The procedure aims to deliver adrenaline faster than the standard method. Researchers will enroll 26 full-term babies to see if the new technique can res…

Researchers are testing the Circle Safe System, a device that stimulates the phrenic nerve and records the diaphragm's electrical response during pulmonary vein ablation for atrial fibrillation. The study enrolls up to 50 adults scheduled for this procedure. All participants rece…

Researchers are testing whether continuous heart monitoring can lower unplanned hospital visits in adults with heart failure who have never shown signs of atrial fibrillation. One group receives a small monitor implanted under the chest skin, another uses a handheld device for we…

This study at Mayo Clinic will enroll 100 adults with atrial fibrillation who are taking the drug dofetilide. Researchers will compare a non-invasive magnetic heart scan (magnetocardiography, or MCG) with the standard ECG to see which better predicts safe drug dosing and heart co…

This trial tests whether a Doppler ultrasound patch placed on the neck can quickly and accurately detect when a cardiac arrest patient's heart starts beating again during emergency resuscitation. The patch's readings are compared to those from an arterial line, the gold standard …

This study tests whether an artificial intelligence software, SMD-AFECG, can predict the risk of atrial fibrillation (AF) within the next two hours using data from a single-lead electrocardiogram (ECG). Researchers will analyze nearly 800 ECG recordings from a hospital database, …

This study tests whether an artificial intelligence software called SMD-RVECG can predict the risk of atrial fibrillation with rapid ventricular response (a fast, irregular heart rhythm) within the next two hours. Researchers will analyze 348 existing single-lead electrocardiogra…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study will see if community pharmacies can effectively screen people aged 65 and older for atrial fibrillation, a heart condition that raises stroke risk. Trained pharmacists will use a small, portable ECG device to record a 30-second heart reading. If the result is abnormal…

This study tests a new way to find a hidden heart condition called cardiac amyloidosis in people with atrial fibrillation (AF). Researchers will use AI to analyze EKGs and CT scans to spot early signs of the disease. About 500 adults with AF and certain warning signs will be spli…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study looks at whether measuring a protein called S100B in the blood can help emergency doctors quickly tell if a person's fainting spell was caused by epilepsy or something else, like a heart problem. About 100 adults who come to the ER after losing consciousness will give …

This study tests if a smartphone app and a special bed mat can detect a type of fast heartbeat (supraventricular tachycardia) in children aged 0-10. Researchers will compare these methods to the standard hospital heart monitor. If successful, it could make diagnosis easier and le…

This study tests whether a simple bedside ultrasound of the inferior vena cava can detect low blood volume in shock patients as accurately as the standard invasive central venous pressure monitoring. Researchers will enroll 80 adults with shock from blood loss, infection, or othe…

This study tests a new technology that listens to your voice during short phone calls to detect atrial fibrillation, a common heart rhythm problem. Researchers will enroll 40 adults scheduled for a heart reset procedure (cardioversion) and compare voice recordings with standard h…

This study tests whether an artificial intelligence-enhanced ECG (SmartECG-AFrisk) can detect atrial fibrillation (AF) earlier than usual care in 1,230 adults with symptoms like palpitations or dizziness but no prior AF diagnosis. Participants are randomly assigned to either stan…

Researchers are testing whether mild electrical stimulation of a nerve in the ear can prevent atrial fibrillation, a common irregular heartbeat, after off-pump coronary artery bypass surgery. Adults scheduled for this heart surgery receive either the stimulation plus standard car…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study investigates whether screening older veterans (age 65 and older) who have a higher risk of atrial fibrillation—a condition where the heart beats irregularly—can reduce their chances of stroke, heart failure, or death. Participants selected for screening wear a small, w…

This trial tests whether two heart medications, metoprolol and amiodarone, can prevent new-onset atrial fibrillation (AFib) in people who develop minor rhythm issues after transcatheter aortic valve replacement (TAVR). About 198 participants will be randomly assigned to one of th…

This study tests whether the sedative drug dexmedetomidine can prevent new-onset atrial fibrillation (a fast, irregular heartbeat) in the days after mitral valve surgery. Researchers will randomly give 140 adults either the drug or a placebo during and after surgery. The goal is …

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

Researchers compare two pulsed-field ablation catheters, the Sphere-9 lattice-tip and the FARAPULSE pentaspline, in people with symptomatic persistent atrial fibrillation. All participants undergo pulmonary vein isolation, the only allowed ablation lesion set, and receive an impl…

Emergency medical services teams use defibrillator pads to shock the heart during out-of-hospital cardiac arrest. The VECTORS trial compares two standard pad placements: one with pads on the front and back of the chest, and one with pads on the front and side. Researchers will tr…

Researchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …

Researchers are testing a cardiac pulsed field ablation system that uses a spherical catheter to treat symptomatic, recurrent paroxysmal atrial fibrillation that has not responded to drugs. The trial enrolls 284 adults and randomly assigns them to either the investigational pulse…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This study compares two ways to sedate patients during a heart scan and electric shock treatment for atrial fibrillation. Currently, a cardiologist gives mild sedation for the scan, but an anaesthesiologist must give stronger sedation for the shock, causing delays. Researchers wa…

This study tests whether giving magnesium along with the standard drug metoprolol can quickly lower a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. About 196 adults in the emergency room will receive either magnesium or a placebo, plus metoprol…

This study compares two types of nerve blocks—Intertransverse Process Block and M-TAPA—for pain after laparoscopic gallbladder removal. Sixty adults will be randomly assigned to receive one of the blocks. The main goal is to see which block provides better pain relief and reduces…

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study will compare two types of nerve blocks—Transversalis Fascia Plane Block and M-TAPA—for controlling pain after laparoscopic inguinal hernia repair. Sixty adults aged 18–65 will be randomly assigned to receive one of the blocks before surgery. Researchers will measure pa…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study looks at 224 adults with a type of irregular heartbeat called paroxysmal atrial fibrillation who are getting a first-time heart procedure called pulsed-field ablation. Researchers want to see if using conscious sedation (being awake but relaxed) is safer than general a…

This study tests whether giving lidocaine through an IV can reduce diaphragm twitching and coughing during a procedure called pulse field ablation for atrial fibrillation. Sixty adults with AFib will be randomly assigned to receive lidocaine or a placebo (saline). The goal is to …

This study tests whether a four-week virtual yoga program can improve quality of life and reduce anxiety and depression in people going through IVF. About 80 participants will either take weekly yoga classes or continue with their usual care. Researchers will track changes in moo…

This study tests a simple mental exercise called episodic future thinking to help people with atrial fibrillation stick to their blood thinner medication. 68 participants will be split into two groups: one gets the future-thinking prompts plus usual care, the other gets usual car…

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

Researchers at Assiut University Children Hospital are studying how often children who come to the emergency department have an abnormal heart rhythm. The study includes children aged 1 month to 18 years who arrive with symptoms such as palpitations, chest pain, fainting, or trou…

This study will collect real-world information on the VERAFEYE system, a device that creates 3D images of the heart during procedures to treat atrial fibrillation (an irregular heartbeat) and to close the left atrial appendage (a small pouch in the heart). About 50 adults will ta…

Cardiac arrest survival in hospitals stays low, and staff on regular wards rarely face these emergencies. Researchers are studying a simulation-based self-training program that lets nurses, doctors, and assistants practice CPR without leaving their department. The study looks at …

This pilot study is testing whether wearable patch monitors can help detect heart problems early in adults undergoing treatment for breast cancer, blood cancers, or multiple myeloma. Participants will wear two patches—one that tracks heart rhythm continuously and another that rec…

This study tests whether artificial intelligence software can predict if atrial fibrillation will return within a year after a standard ablation procedure. Researchers will use the Volta AF-Xplorer II software to map abnormal electrical areas in the hearts of 125 people with pers…

This pilot study tests a web-based decision aid for Black and White patients with atrial fibrillation who need to choose whether to take blood thinners to prevent strokes. The tool explains risks and benefits and asks about personal preferences. The study will check if the tool i…

This study tests whether AI-generated avatar videos and a chatbot can better engage older Veterans in cardiovascular clinical trials compared to standard mailed letters. Veterans aged 65 and older with heart conditions will receive either a routine invitation or a link to a websi…

This study observes how supply chain problems affect the availability of intracardiac echocardiography (ICE) catheters, which are used during certain heart procedures. Researchers will track real-world procurement attempts, including delays, cancellations, and substitutions, to s…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This study investigates whether levels of a protein called neurofilament light chain (NFL) in the blood can predict neurological recovery in people who remain comatose after a cardiac arrest. Researchers will measure NFL at several time points over the first week in the ICU and c…

This observational study looks at how the blood thinner apixaban is processed in the bodies of Asian patients with atrial fibrillation. Researchers will analyze existing medical records and blood concentration data from about 200 patients to understand how factors like kidney fun…

About one in three people who have open-heart surgery develop an irregular heartbeat called postoperative atrial fibrillation (POAF), which raises the risk of stroke and other complications. This study is testing whether a blood marker called lipoprotein(a), or Lp(a), can identif…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

This observational study examines how antiplatelet medications affect platelet function in people over 80 with atrial fibrillation who have received a Watchman implant. Researchers will measure various markers of platelet reactivity before and after treatment to see if clotting r…

This trial investigates whether analyzing electrical signals from the heart during pulsed field ablation can tell doctors how well the catheter is touching tissue and whether the resulting scar will be permanent. About 60 people with paroxysmal atrial fibrillation will undergo th…

This study tests whether an artificial intelligence (AI) analysis of a simple electrocardiogram (ECG) can safely replace routine heart ultrasound (echocardiography) in managing atrial fibrillation (AF). About 1,724 adults with AF will be randomly assigned to either AI-ECG guided …

This study tests whether an artificial intelligence analysis of standard electrocardiograms (ECGs) can track heart muscle recovery in people with atrial fibrillation and mild heart failure who undergo catheter ablation. Researchers will follow 1,000 participants for a year, using…

This study investigates how often atrial fibrillation (AF), a type of irregular heartbeat, occurs in people with certain blood cancers who are starting a targeted cancer drug called a Bruton's tyrosine kinase inhibitor (BTKI). Researchers will follow 500 participants—400 starting…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study compares two types of heart ablation for people with persistent atrial fibrillation: pulsed field ablation and radiofrequency ablation. The goal is to see which one causes fewer stomach problems after the procedure. Twenty participants will be matched by age and health…

This study will compare five different pulsed field ablation systems used to treat atrial fibrillation (an irregular heartbeat). The goal is to see which system causes the fewest tiny clots (microemboli) that travel to the brain during the procedure. One hundred adults with atria…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at 128 adults having gallbladder surgery to see if using a low-flow (more eco-friendly) versus normal-flow sevoflurane anesthesia changes heart electrical signals linked to dangerous rhythms. Researchers will measure these signals before, during, and after surger…

This study will collect information on 1,200 emergency intubations across multiple hospitals in Taiwan. Researchers will track how often the tube is placed correctly on the first try and how often serious problems like low oxygen, low blood pressure, or cardiac arrest occur. The …

This study will create a digital twin of the heart for 1,000 people who have had a heart attack. The goal is to see if this computer model can better predict who is at risk for sudden cardiac death compared to the current standard method. Participants will undergo a cardiac CT sc…

This observational study will enroll 1,000 pregnant women and their fetuses to establish normal ranges for heart sounds and ECGs. The goal is to develop early warning systems for serious heart events in mothers, progression of fetal heart defects, and autoimmune-related fetal hea…

This study looks at whether re-sterilized (reprocessed) catheters work as well as new ones for heart ablation procedures. About 200 adults needing this treatment will be randomly assigned to get either a new or a reprocessed catheter. Researchers will compare how long the procedu…

This study explores whether drones can deliver automated external defibrillators (AEDs) faster than traditional ambulances in simulated cardiac arrest scenarios. Researchers will compare drone and ambulance response times in different city locations and traffic conditions. Twenty…

This study looks at how a new type of heart ablation (pulsed-field ablation) changes the heart's structure in people with atrial fibrillation. Researchers will use MRI scans before and 4 months after the procedure to measure scarring and function. About 39 adults with persistent …

This study will check how well heart failure and atrial fibrillation patients take their medicines after being admitted to the coronary care unit. Researchers will interview 250 adults to understand their medication beliefs and whether their prescriptions are appropriate. The goa…

This study looks back at medical records of 1500 adults hospitalized for acute myocarditis (heart muscle inflammation). The goal is to find out how often dangerous heart rhythms occur and what factors predict them. No new treatments are tested—researchers will use existing data t…

This observational study will follow 10,000 people with atrial fibrillation for 24 months. Researchers will use smartwatch data to measure how much time the heart is in AF (AF burden) and see if that predicts strokes or blood clots. The goal is to find a clear threshold where blo…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study looks at 421 people who are getting a heart device (ICD) to see if muscle health can help predict sudden cardiac death. Researchers will use AI to combine muscle scans, blood tests, and other data to build a risk prediction tool. No new treatments are tested—the goal i…

This study will test a new software system that measures tiny electrical signals in the heart after a procedure called pulsed field ablation, used to treat atrial fibrillation (an irregular heartbeat). Researchers will enroll 30 adults with AF who are already scheduled for ablati…

This study tests a drug called GC7 in 20 people who have had a cardiac arrest and been revived. The goal is to see if GC7 can reduce cell damage caused by the sudden return of blood and oxygen. Researchers will measure stress levels in blood cells and look for signs of improved r…

This study tests a machine learning device that uses heart tracings (ECG) to predict if a person will have another cardiac arrest after being revived. Researchers will first see if EMS providers find the device useful in simulated scenarios, then test its accuracy in 68 real pati…

This study will follow 300 people having planned coronary bypass surgery to see if the amount of belly fat they carry affects their risk of developing atrial fibrillation (a type of irregular heartbeat) after the operation. Before surgery, doctors will use ultrasound to measure t…

This study tests a new way to place a pacemaker lead in the heart's upper chambers. The goal is to see if pacing a specific area (Bachmann's bundle) can keep the heartbeat more natural and reduce the risk of atrial fibrillation. About 200 adults who need a pacemaker will take par…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study will test whether an artificial intelligence (AI) tool can better predict stroke risk in 1,000 people aged 65-95 with atrial fibrillation, compared to current methods. The AI analyzes health records and heart data to identify high-risk individuals early. The goal is to…

This study aims to see if artificial intelligence can predict serious heart rhythm problems, like atrial fibrillation, after high-risk surgeries. Researchers will record ECGs from 300 adults before surgery and analyze over 200 heart cycle parameters to find the best prediction me…

This study will measure various biomarkers in 200 people with certain heart rhythm problems (ventricular tachycardia, premature ventricular contractions, and AVNRT) who are scheduled for a catheter ablation procedure. The goal is to see if these biomarkers are linked to the speci…

This study tests a new questionnaire called PET (Patient Experience in Telehealth) to see if it accurately measures how patients feel about telemedicine visits. Researchers will ask 200 adults who had a telemedicine appointment at an Italian hospital to fill out the survey. The g…

This study will implant a small heart monitor under the skin of 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The device will track heart rhythms for up to three years to find hidden atrial fibrillation that standard tests might miss. …

This study will check if people with metastatic breast or colon cancer have antibodies that might also attack the heart. Researchers will collect blood samples and ECGs from 196 participants over 12 months. The goal is to see if these antibodies raise the risk of dangerous heart …

This study looks at how often colon damage (ischemia) happens in people who survive cardiac arrest and receive CPR. Researchers will perform a bedside colonoscopy 24-36 hours after CPR to check for colon injury. The goal is to better understand this complication and improve care …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study tests whether rinsing (flushing) ovarian follicles during egg retrieval can increase the number of mature eggs collected for IVF. In 75 women undergoing IVF, one ovary will be flushed and the other will not, and the egg yields will be compared. The goal is to see if th…

This study uses CT scans to compare heart fat and chamber size in people with and without atrial fibrillation (AF). Researchers will enroll 600 adults to see if fat distribution differs between those with normal rhythm, occasional AF, and persistent AF. No drugs or treatments are…

This study will follow about 3,500 adults in China who have atrial fibrillation (an irregular heartbeat) along with metabolic disorders like obesity, diabetes, or high cholesterol. Researchers want to learn how these combined conditions affect risks for stroke, heart failure, and…

This study looks at 460 adults who need a pacemaker but have never had atrial fibrillation. Researchers will compare three pacing approaches to see which one best reduces brief, device-detected atrial high-rate episodes over two years. The goal is to find out if pacing the heart'…

This study looks at whether measuring changes in exhaled carbon dioxide (a breath test) during a leg-raising maneuver can help predict if a critically ill patient needs more fluids. Doctors often struggle to balance giving enough fluids without causing harm from too much. The stu…

This study will follow 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (AF), a common heart rhythm problem. Researchers will track AF episodes, quality of life, hospitalizations, and deaths ov…

This study tests a small, sticky patch that records heart rhythms in hospitalized patients who need continuous monitoring. The patch sends data to a central system for real-time alerts and later review. Researchers want to see if it helps doctors make faster decisions about treat…

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…

This study will check progesterone levels in 659 women on the day of a frozen embryo transfer. The goal is to see how common low progesterone is and whether it is linked to lower pregnancy rates. Participants will have one extra blood draw, and their pregnancy outcomes will be tr…

This study tests whether a WhatsApp-based chatbot can help people recovering from atrial fibrillation ablation. About 76 adults will either use the chatbot to report symptoms and well-being for 3 months or receive standard hospital follow-up. The goal is to see if the chatbot is …

This study looks at whether getting a CT scan sooner after a person's heart stops outside the hospital and is revived can help them live longer. Researchers will review records from 5,000 adults treated at six hospitals in Taiwan. The goal is to find the best timing for CT scans …

This study looks at 5,000 patients who survived a cardiac arrest and were admitted to the intensive care unit (ICU). Researchers will use artificial intelligence to analyze past medical records and create a model that predicts how long a patient will stay in the ICU, their brain …

This study looks at 40 adults with atrial fibrillation and heart failure to see if lowering their resting heart rate from 100-110 bpm to a more normal level improves exercise ability and quality of life. Participants will do treadmill tests before and after either a cardioversion…

This study tests new MRI and CT imaging methods to better identify scar tissue in the heart that causes a dangerous fast heartbeat called ventricular tachycardia (VT). About 15 adults with VT and heart disease will get these scans. The goal is to see if the scans can clearly show…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will follow 1,100 people with atrial fibrillation who have a pulsed field ablation procedure. The goal is to find out which patient traits and procedure details make a repeat ablation more likely. Researchers will track heart rhythm problems and side effects for one ye…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …

This study looks at 700 people having their first heart ablation for atrial fibrillation to see if men and women have different heart structures and outcomes. Researchers will compare anatomy, procedure details, and how well the treatment works after 12 months. The goal is to und…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…

This study looks at 100 adults with frequent extra heartbeats (PVCs) to see if hidden heart inflammation (myocarditis) is the cause. Participants will get advanced heart scans and lab tests. The goal is to better understand the link and see if anti-inflammatory therapy helps thos…