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Could a gentle electric field heal the heart? new study tests Pulsed-Field ablation for persistent AF

NCT ID NCT07675395

Disease control Sponsor: Taipei Veterans General Hospital, Taiwan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent AF and use the FARAPULSE system to isolate the pulmonary veins and modify additional heart tissue. They will measure changes in heart size, function, and scarring using echocardiograms, MRI, and invasive pressure readings before and after the procedure, and track whether participants stay free of AF for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pulsed-field ablation using the FARAPULSE system (FARAWAVE catheter)
What this could lead to
If successful, this could show that pulsed-field ablation not only treats atrial fibrillation but also helps reverse structural damage to the heart, potentially improving long-term outcomes.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. The procedure carries risks like bleeding, heart damage, or recurrence of abnormal heart rhythms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of persistent atrial fibrillation * Left atrial anteroposterior (AP) diameter greater than 4 cm and less than 6 cm * Anti-arrhythmic medications (except amiodarone) discontinued for at least 5 half-lives before the procedure * No use of beta-blockers or diuretics before or after the ablation procedure * Willing and able to provide written informed consent Exclusion Criteria: * Paroxysmal atrial fibrillation * Previous left atrial surgery or catheter ablation procedure, including left atrial appendage closure * Atrial fibrillation due to reversible causes, such as thyroid disorders, acute alcohol intoxication, or other major surgeries within the 90 days preceding the procedure * Myocardial infarction, acute coronary syndrome, percutaneous coronary intervention, or coronary artery bypass grafting within 90 days of the procedure * Known presence of cardiac thrombus * Stroke or transient ischemic attack within the last 90 days * Any other anatomical or comorbid condition that, in the investigator's opinion, could limit the patient's ability to participate in the clinical trial, comply with follow-up requirements, or impact the scientific validity of the clinical trial results

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Conditions

The condition(s) this trial relates to.

atrial fibrillation Atrial Remodeling persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation (AF) Atrial remodeling Persistent atrial fibrillation Pulsed field ablation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

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