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Could some heart patients safely stop blood thinners after ablation?

NCT ID NCT07496281

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood thinners or switch to a single antiplatelet drug. The goal is to see if stopping blood thinners is as safe and effective as continuing them.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-vitamin K antagonist oral anticoagulant (NOAC) and single antiplatelet therapy (SAPT)
What this could lead to
If successful, this could show that some patients with atrial fibrillation and prior stents can safely stop blood thinners after successful ablation, reducing bleeding risk.
What could go wrong
This is a very small, early-phase trial with only 2 participants, so results may not apply broadly. Stopping blood thinners could increase the risk of stroke or heart attack.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 2 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2027

An estimate. Start dates often move.

Expected to finish

Mar 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Inclusion Criteria * Participants must meet all of the following criteria: * Age ≥18 years. * Documented history of atrial fibrillation (paroxysmal or persistent). * Successful catheter ablation for atrial fibrillation performed within the previous 3-6 months. * Maintenance of sinus rhythm after ablation, confirmed by follow-up electrocardiography or rhythm monitoring. * History of percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. * Completion of the recommended duration of dual antiplatelet therapy (DAPT) following PCI. * Currently receiving oral anticoagulation therapy with a non-vitamin K antagonist oral anticoagulant (NOAC). * Clinically stable and considered eligible for long-term antithrombotic therapy adjustment by the treating physician. * Ability to understand the study procedures and provide written informed consent. 2. Exclusion Criteria * Participants will be excluded if any of the following criteria are present: * Recurrent atrial fibrillation documented after the index ablation procedure requiring repeat ablation or antiarrhythmic escalation. * Presence of mechanical heart valve or moderate-to-severe mitral stenosis. * Indication for long-term anticoagulation independent of atrial fibrillation (e.g., venous thromboembolism, mechanical valve). * Recent acute coronary syndrome or PCI within the past 3 months. * Planned coronary revascularization or cardiac surgery. * History of intracranial hemorrhage or other major bleeding that contraindicates antithrombotic therapy. * Severe renal dysfunction (e.g., estimated glomerular filtration rate \<30 mL/min/1.73 m²). * Severe hepatic dysfunction associated with coagulopathy. * Known hypersensitivity or contraindication to aspirin or NOAC therapy. * Pregnancy or breastfeeding. * Life expectancy less than 1 year due to non-cardiovascular comorbidities. * Participation in another interventional clinical trial that may interfere with the study outcomes.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Ewha Womans University Mokdong Hospital

    Seoul, 07804, South Korea

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