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Could less be more? new trial tests lower epinephrine dose for cardiac arrest

NCT ID NCT07442071

Disease control Sponsor: Central Hospital, Nancy, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard dose. The main goal is to see if the lower dose leads to better neurological outcomes 28 days later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 4,336 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Male or female, aged ≥18 years. Out-of-hospital cardiac arrest for which resuscitation is decided by the SMUR team. Medical Out-of-hospital cardiac arrest. Affiliated with or beneficiary of a social security plan Exclusion Criteria: * Non-medical Out-of-hospital cardiac arrest (traumatic, drownings, electrocution, asphyxia, overdose, unknown cause). * Out-of-hospital cardiac arrest without advanced life support (Do Not Attempt Resuscitation order, body finding, the decision not to attempt advanced life support is at the physician's discretion). * Pregnant women, birthing or breastfeeding mothers * Adults under legal protection measure (such as guardianship, conservatorship) * Individuals deprived of liberty due to judicial or administrative decision

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Out-of-hospital cardiac arrest (OHCA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    26 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AP-HP Hôpital Necker

    Paris, France

  • Brigade de Sapeurs-Pompiers de Paris

    Courbevoie, France

  • CH Annecy

    Annecy, France

  • CH SUD Francilien

    Corbeil-Essonnes, France

  • CHRU Nancy

    Nancy, France

  • CHU Besancon

    Besançon, France

  • CHU Brest

    Brest, France

  • CHU Colmar

    Colmar, France

  • CHU Montpellier

    Montpellier, France

  • CHU Nice

    Nice, France

  • CHU Nimes

    Nîmes, France

  • CHU Poitiers

    Poitiers, France

  • CHU Rennes

    Rennes, France

  • CHU Rouen

    Rouen, France

  • CHU Tours

    Tours, France

  • Centre Hospitalier Universitaire De Nantes

    Nantes, France

  • Centre Hospitalier Universitaire De Toulouse

    Toulouse, France

  • Centre Hospitalier Universitaire Grenoble Alpes

    La Tronche, France

  • Centre Hospitalier Universitaire Reims

    Reims, France

  • Centre hospitalier Annecy Genevois Site Julien en GENEVOIS

    Saint-Julien-en-Genevois, France

  • Centre hospitalier de la Côte Basque

    Bayonne, France

  • Hopital Beaujon

    Paris, France

  • Hospices Civils De Lyon

    Lyon, France

  • La Pitié Salpêtrière

    Paris, France

  • Raymond Poincaré Hospital

    Paris, France

  • hôpital Lariboisière

    Paris, France

More trials for these conditions

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