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New blood thinner may be safer after valve surgery

NCT ID NCT07434661

Disease control Sponsor: Meshalkin Research Institute of Pathology of Circulation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes fewer major bleeding events while still preventing blood clots. Participants will be followed for three months after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years at the time of enrolment * Open heart aortic or mitral valve repair or biological valve replacement in the last 10 days * Atrial fibrillation requiring anticoagulation (including pre-existing or post-operative atrial fibrillation), * Informed consent from either the patient or a substitute decision-maker. Exclusion Criteria: * Mechanical valve replacement * Antiphospholipid syndrome (triple positive) * Severe renal failure (Cockcroft-Gault equation; creatinine clearance \<15 ml/min) * Known significant liver disease (Child-Pugh classification B and C) * Left ventricular thrombus * Ongoing bleeding, hemorrhagic disorders, or bleeding diathesis * Known contraindication for any DOAC or VKA * Women who are pregnant, breastfeeding, or of childbearing potential * Follow-up not possible

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic valve surgery Atrial fibrillation (AF) Mitral valve annuloplasty Mitral valve repair Mitral valve surgery Valve disease, heart Valve replacement surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • "E.Meshalkin National Medical Research Center" of the Ministry of Health of the Russian Federation

    Novosibirsk, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.