App-Alerted volunteers may boost cardiac arrest survival
NCT ID NCT07589504
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal is to see if faster help from nearby citizens leads to more people surviving at 30 days, 6 months, and 1 year.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 5,200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients (≥18 years) with confirmed out-of-hospital cardiac arrest managed by the regional emergency medical services (118 system) in Emilia-Romagna between 1 January 2018 and 31 December 2025. Patients are identified through EMS dispatch databases and national health information systems and include cases in which a First Responder was activated via the DAE RespondER system. The study population reflects a real-world, unselected cohort of OHCA patients treated within an integrated regional emergency care system.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * Confirmed out-of-hospital cardiac arrest (OHCA) * Emergency medical services activation with Advanced Life Support dispatch (Code Red Advanced Blue) * OHCA confirmed by return code 2-3-4 and/or NSIS codes (C0208 or C0205) * Event occurring between 1 January 2018 and 31 December 2025 * Activation of the regional emergency medical system (Emilia-Romagna 118 system) Exclusion Criteria: * Age \<18 years * Cardiac arrest not confirmed after EMS assessment * Cases with return code \<2 (misclassified as cardiac arrest)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Carlo Alberto Pizzardi Major Hospital
Bologna, Emilia-Romagna, Italy
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