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Zapping the heart: radiation may tame lethal rhythms

NCT ID NCT06593418

Disease control Sponsor: Corewell Health East Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiation to the heart area causing the problem. The goal is to find the lowest effective dose that reduces episodes of this dangerous rhythm and improves safety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must be 18 years or older. * Automatic implanted cardiac defibrillator present. * VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm. * Ejection fraction ≥20%. * At least one previous cardiac ablation for VT. * VT refractory despite antiarrhythmic medications. * Likely to live for 12 months in the absence of VT. * AICD in a position in the chest RT to be given without direct radiation. * Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT. * The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice. Exclusion Criteria: * Class IV heart failure * Abandoned leads. * Prior radiation therapy to the chest or upper abdomen. * Interstitial lung disease.

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Conditions

The condition(s) this trial relates to.

myocardial infarction ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial infarction Ventricular tachycardia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan, 48073, United States

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