Weill Medical College Of Cornell University

This study compares two blood thinner strategies in 700 people with chronic heart disease who are having bypass surgery. One group takes ticagrelor plus low-dose aspirin for one month, then aspirin alone; the other takes only low-dose aspirin. The goal is to see if the short dual…

This early-phase study tests a gene therapy called AAVrh.10hFXN for heart disease caused by Friedreich's ataxia, a rare genetic disorder. The treatment delivers a working gene to help heart cells function better. About 25 people aged 12 to 50 with mild to moderate heart issues wi…

This early-phase study tests whether special cells from human umbilical veins are safe to use during surgery for simple anal fistulas. The cells are placed in the fistula tract after a standard fistulotomy to help healing. The study involves 39 adults and focuses on short-term sa…

This study tests a new way to deliver radiation therapy for men with high-risk prostate cancer. Using advanced imaging (PSMA PET/MR), doctors can precisely target the tumor and give a stronger dose to the most aggressive areas. The goal is to improve the chance of staying cancer-…

This study is testing whether training religious leaders to teach their communities about blood pressure can help lower average blood pressure levels. About 24,000 adults aged 35 and older from 20 communities in Tanzania will take part. The main goal is to see if communities wher…

This study tests whether tirzepatide, a once-weekly injection for weight loss, is practical and acceptable for 30 postmenopausal women who have had hormone receptor-positive breast cancer and are obese. Participants will take the drug for 6 months with monthly check-ins, and rese…

This study looks at whether using a biosynthetic mesh during robotic anti-reflux surgery can lower the chance that a hiatal hernia returns. About 200 adults with GERD who are already scheduled for surgery will be randomly assigned to receive either the standard repair or repair w…

This study looks at a surgery that reconnects nerves in the voice box to help people with both vocal cords paralyzed breathe easier. It involves 15 adults aged 18 to 70 whose paralysis hasn't improved for at least 6 months. The main goal is to measure changes in breathing symptom…

This study tests two treatments given before surgery for stage IB-III non-small cell lung cancer. One group gets immunotherapy (cemiplimab) plus chemotherapy, the other gets immunotherapy plus targeted radiation. After surgery, all participants continue immunotherapy for a year. …

This study tests whether adding targeted radiation and immunotherapy to standard hormone therapy can turn a woman's own breast tumor into a personalized vaccine. About 100 postmenopausal women with HR+ breast cancer will receive letrozole plus either radiation alone or radiation …

This study is for women with a common type of advanced breast cancer (HR+ HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a targeted drug, can help keep the cancer from growing longer. About 102 participants will be r…

This study tests a new vaccine, dAd5GNE, in 150 people with cocaine dependence. The vaccine aims to train the immune system to block cocaine from reaching the brain, reducing its effects. The main goal is to check safety, but researchers will also measure cocaine use and antibody…

This study is testing whether a liver transplant can help people with colorectal cancer that has spread only to the liver and cannot be removed by surgery. About 20 adults aged 18-65 with stable or shrinking liver tumors for at least 6 months will receive a transplant. Researcher…

This study is for adults with mild to moderate Crohn's disease who are already on or about to start an IL-23 therapy. Researchers want to see if adding the antifungal drug fluconazole helps patients respond better to their standard treatment. The trial will compare the combinatio…

This study tests whether placing a small balloon-like stent in the uterus after surgery to remove a septum (a wall of tissue) can prevent internal scar tissue from forming. Scar tissue can cause problems with fertility and periods. The trial will involve 320 women and compare sta…

This study tests if eating only during an 8-hour window each day, along with a healthy diet and exercise, can reduce liver fat in people with non-alcoholic fatty liver disease. About 40 adults will be split into two groups: one follows the time-restricted eating plan plus standar…

This study compares two common heart procedures—stenting and bypass surgery—in 600 minority patients with blocked heart arteries. The goal is to see which approach leads to better survival and quality of life. Participants will be randomly assigned to one procedure and followed o…

This early-phase study tests a new combination of two drugs that deliver radiation directly to prostate cancer cells. The goal is to find the safest dose that can be given together. About 42 men with advanced prostate cancer that has stopped responding to hormone therapy will tak…

This study tests a new way to help people with HIV in rural Uganda. Traditional healers will be trained to offer HIV testing, counseling, and support to take medication regularly. The goal is to see if this extra help, alongside regular clinic care, can help more people achieve a…

This study looks at two common ways to restore blood flow in women with blocked heart arteries: stenting (a less invasive procedure) and bypass surgery (open-heart surgery). Researchers want to see which approach leads to better survival and quality of life. About 600 women will …

This study is for people with a serious heart condition called ventricular tachycardia that hasn't improved with standard treatments. Researchers want to see if giving a single, lower dose of radiation is just as safe and effective as splitting the dose into three smaller treatme…

This study tests a program called I-TRANSFER-HF for people with heart failure who need home care after leaving the hospital. The program combines early nurse visits at home with quick follow-up doctor appointments to prevent patients from returning to the hospital within 30 days.…

This study is for men with advanced prostate cancer that has spread and is no longer controlled by standard hormone therapy. It tests whether adding a targeted radiation drug (225Ac-J591) to immunotherapy (pembrolizumab) and an androgen-receptor inhibitor works better than the im…

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where low blood cell counts increase the risk of developing blood cancers like leukemia. Participants receive injections every three weeks for up to 48 weeks. …

This study is for people with breast cancer that has spread to the brain. It tests a drug called pembrolizumab (an immunotherapy) combined with precise radiation to one brain tumor. The goal is to see if this combo can make the immune system attack other untreated tumors in the b…

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these treatments change the immune environment inside the liver tum…

This study tests a new drug combination (polatuzumab vedotin plus chemotherapy) in 20 adults with Richter's transformation, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. Participants receive up to six 21-day cycles of treatment and are monitored for s…

This study compares a standard prostate cancer surgery to a newer technique that spares more surrounding tissue. The goal is to see if the newer approach can maintain cancer control while improving urinary function, sexual function, and reducing complications like penile shorteni…

This study aims to improve the heart health of home health aides, a group that often has poor cardiovascular health. Participants will work with a trained peer coach over 10 weeks to learn healthy habits and positive thinking. The program is based on the American Heart Associatio…

This study tests whether support from community health workers through phone calls and telehealth can help people with dangerously high blood pressure avoid major heart problems. About 3,620 adults who come to the emergency room with very high blood pressure will either get this …

This study tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and lutetium Lu 177 dotatate (a radioactive drug that kills cancer cells)—in 18 adults with Merkel cell carcinoma. The goal is to see if the combination can shri…

This study compares two types of bowel surgery for people with Crohn's disease who need part of their intestine removed. The goal is to see if a newer technique, called Kono-S, is better at preventing the disease from coming back than the standard method. About 600 adults with Cr…

This study tests a new treatment for advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to standard immunotherapy. The treatment combines a virus (OBP-301) that is injected directly into the tumor with an immunotherapy drug (pembrolizumab) gi…

This study tests whether a simple technique called "double voiding" (urinating twice in a row) can reduce urinary tract infections (UTIs) in kidney transplant recipients. UTIs are common after transplant and can lead to serious complications. The study will follow 438 adults at o…

This study is for women whose breast cancer has come back after previous lumpectomy and radiation. It tests whether a second, targeted radiation treatment can allow them to keep their breast instead of needing a mastectomy. The study will enroll 120 participants and closely monit…

This early-stage study tests a gene therapy for people with alpha-1 antitrypsin deficiency, a condition that can damage the lungs. The treatment is given once through a vein and aims to produce a special protein that protects the lungs. Researchers will check safety and measure p…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. Researchers want to see if multiple grafts lower the risk of death, stroke, heart attack, or needing another procedure. About 4,300 adults with coronary artery d…

This study compares two types of heart bypass surgery in 2,300 women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which approach reduces the risk of heart attac…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain tumors will get an extra PET scan (FES PET/CT) before their standard radiation planning. Researchers will compare this scan wit…

This study tests whether a radioactive tracer called [Cu64]DOTATATE can help surgeons find meningioma tumors during surgery using a special probe. About 20 adults with suspected or confirmed meningioma will receive the tracer before surgery. The goal is to see if this method impr…

This study aims to see if a special MRI scan can accurately diagnose jaw muscle pain, known as masticatory myofascial pain syndrome. Researchers will compare MRI results from 90 adults with and without jaw pain. The goal is to develop a more objective way to identify this conditi…

This study is testing whether a special PET/MRI scan using a radioactive tracer called 68Ga-DOTATATE can better detect certain brain tumors (like meningioma) and tell the difference between tumor regrowth and changes from past treatment. About 200 adults with these tumors will ge…

This study is testing whether a special type of PET scan (PSMA-PET CT) can accurately rule out dangerous prostate cancer in men who are currently monitoring their low- or intermediate-risk cancer without active treatment. Researchers will compare scan results to yearly biopsies i…

This study tests whether playing a specially designed video game can help teens ages 15-20 use birth control more consistently and avoid unplanned pregnancy. About 850 participants will be randomly assigned to play the game or a control activity. Researchers will track changes in…

This study tests a 10-session program called RISE-HP, where trained peer coaches use cognitive behavioral techniques and education to help people with hypersensitivity pneumonitis feel better day-to-day. The goal is to improve quality of life and see if the program is practical. …

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests whether a drug called leronlimab is safe for people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. It also looks at whether the drug can reduce inflammation in the brain. Twenty volunteers aged 50 and older will receive weekly injections f…

This study tests whether adding non-opioid pain medicines like acetaminophen (Tylenol) and ketorolac (Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years with acute respiratory fa…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. The study will enroll 10 participants aged 40-79 who have had a stroke at least one month ago and have significant a…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This study tests whether a 9-week therapy called Engage & Connect can change brain activity related to reward processing and reduce suicidal thoughts in depressed adults aged 50-80. Researchers will use brain scans (fMRI) to measure changes in brain networks before and after ther…

This study tests a therapy called PATH-Pain in 100 older adults (60+) who have mild memory problems, depression, and chronic pain. The therapy helps people cope with pain and mood issues to improve thinking, depression, and daily function. Participants are compared to those recei…

This study tests a mobile app called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The app teaches emotion regulation skills to help reduce suicide risk. Researchers will measure changes in brain activity, self-r…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study tests whether a procedure called embolization (blocking off abnormal veins in the pelvis) can reduce chronic pelvic pain in women. About 40 women with pelvic varicose veins and severe pain for over 6 months will be randomly assigned to either get the procedure or just …

This study tests a new type of talk therapy called Engage & Connect for new mothers with postpartum depression. The therapy is delivered remotely over 9 weeks and focuses on reducing feelings of isolation and improving how the brain processes social rewards. The study will enroll…

This study is testing a mobile app called MAYA that teaches coping skills for anxiety and depression. Researchers want to see if adults aged 40 and older with anxiety or mood disorders find the app helpful and easy to use. Participants will use the app for about 20 minutes, twice…

This study tests if a gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 people who are at least 3 months past their stroke and have significant fatigue. Participants will use a headset device daily, wi…

This study tests whether using a brain scan (fMRI) to guide magnetic stimulation (rTMS) can better treat depression that hasn't improved with medication. About 348 adults aged 22-65 with major depression will receive rTMS, and researchers will track changes in depression scores. …

This study tests a program called Living Healthy to see if it improves mood and mental health for home health aides. About 100 aides will take part in an 8-week program that includes health education and positive thinking. Some will also get support from a trained peer coach. The…

This study tests whether a device that provides intensive visual stimulation (IVS3) is easy to use and well-tolerated by people recovering from a stroke. Researchers will enroll 25 adults who had a stroke at least 6 months ago and have moderate arm weakness. Participants will use…

This study tests two types of spiritual care for people with advanced cancer. Researchers want to see if these programs improve spiritual well-being and reduce hospital visits. About 288 patients from religious communities will take part.

This study tests whether one-on-one coaching from a trained peer (someone who also has rheumatoid arthritis) can lower anxiety and depression in adults with RA. 250 participants will meet weekly with a coach for 9 weeks and complete surveys. The goal is to see if this support imp…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes a day, twice a week, for six weeks…

This study tests a special bracelet that vibrates gently when it senses nail-biting. Ten adults who bite their nails will wear the bracelet for 12 weeks and track their progress with a phone app. The goal is to see if the vibration helps reduce nail-biting and improve nail health…

This study tests an 8-week group program that teaches mind-body skills like meditation, guided imagery, and relaxation techniques to help medical and graduate students manage mood symptoms. Researchers will enroll 60 students aged 18 or older who have mild anxiety or depression. …

This study tests a new therapy that treats PTSD and chronic pain together in 12 virtual sessions. It is for adults who have both conditions. The goal is to see if this combined approach is practical and helpful for reducing symptoms.

This study is testing whether N-Acetylcysteine (NAC), an antioxidant, can help people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will give different doses of NAC or a placebo to 95 adults aged 21-60 with ME/CFS. They will measure brain chemicals…

This study tests whether spiritual care interventions can improve spiritual well-being and readiness for advance care planning in Black patients with advanced cancer. About 64 participants will be recruited from outpatient clinics. The goal is to see if a larger trial is possible…

This study compares two types of talk therapy—exposure therapy and interpersonal therapy—for treating PTSD caused by military sexual trauma. About 208 survivors will be randomly assigned to one of the two therapies to see if they are equally effective. The goal is to offer more t…

This study tests a training program called PICT for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to notice signs of pain and communicate better with doctors. About 440 caregivers will take part, and the goal is to reduce ca…

This study looks at whether giving a TAP block—a numbing injection in the belly wall—before surgery works better than giving it after surgery to control pain and reduce opioid use. Researchers will track pain scores and opioid amounts in 150 adults having elective abdominal or we…

This study compares two types of nerve blocks—PENG and femoral—for pain relief in people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they arrive. Researchers will measure pain scores before and after the bloc…

This study looks at how the dietary supplement L-Phenylalanine changes levels of a natural chemical (phenylpropionic acid) and gut fungi in healthy adults. Researchers will measure these changes in stool, swabs, and blood over time. The goal is to understand the link between diet…

This study tests whether the medicine propranolol can help infants born with a heart condition called Tetralogy of Fallot grow new heart muscle cells. About 40 babies under 60 days old will receive propranolol, and researchers will examine heart tissue removed during surgery to s…

This study is collecting tissue samples from 25 adults with rectal cancer who are receiving standard short-course radiation before surgery. The goal is to understand how radiation changes the immune system at the cellular level. Participants will provide biopsies and imaging befo…

This study looks at how long different numbing medications work during skin surgery. Researchers will test 35 adults by checking when feeling returns after the injection. The goal is to find out if the amount of medicine affects how long numbness lasts, especially on sensitive ar…

This study looks at whether offering online genetic testing services and support to close relatives of people with BRCA mutations helps more of them get tested compared to usual care. About 820 first-degree relatives (parents, siblings, children) will take part. The goal is to se…

This study collects tissue samples, medical data, and family histories from 1,120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers aim to discover new genes and immune system clues that could lead to better prevention and targeted treatments. …

This study collects tumor samples from 400 breast cancer patients at key moments—diagnosis, surgery, and if the cancer returns or spreads. Researchers will grow mini-tumors in the lab and analyze genes and immune cells to better understand the disease. The goal is to gather knowl…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and understand how gene changes in airway cells lead to disease. Participants must be 18…

This study looks at whether offering genetic testing for inherited cancer risk (like BRCA1/2) during routine pregnancy or fertility care is practical and well-received. About 550 pregnant or preconception patients will be offered the screening alongside standard prenatal tests. T…

This study aims to develop a better way to measure how the brain uses sugar (glucose) for energy. Researchers will use advanced MRI-like scans at 3 or 7 Tesla strength in 20 healthy volunteers and people with Glut1 deficiency, a rare condition that affects brain fuel. Participant…

This study looks at how young women (ages 18-44) newly diagnosed with early-stage breast cancer decide on surgery. Researchers are testing a web-based tool called CONSYDER that gives helpful information and improves talks with surgeons. About 800 participants will fill out survey…

This study tests whether connecting an ambulance to a remote children's emergency doctor via a simple video call can improve care for seriously ill children in low-resource settings. Researchers in Karachi, Pakistan will compare health outcomes for 900 children who either receive…

This study is watching and recording what happens to 200 men who receive focal (targeted) treatments for prostate cancer, such as high-intensity focused ultrasound or cryotherapy. The goal is to learn how these treatments affect cancer grade, PSA levels, and patient quality of li…

This study is testing whether an artificial intelligence tool can better predict outcomes for people undergoing in vitro fertilization (IVF) or other fertility treatments. Researchers will use the AI to analyze ultrasound images and count early-stage eggs, aiming to make assessme…

This study will test whether digital health devices, like smartwatches and blood pressure cuffs, can help detect high blood pressure and related pregnancy risks in refugee women. About 75 pregnant refugee women in New York City will use these tools at home and complete surveys. T…

This study explores whether signs of Parkinson's disease can be found in the gut's nervous system and microbiome during a routine screening colonoscopy. Researchers will compare gut tissue and stool samples from people with Parkinson's, those at risk, and healthy volunteers aged …

This study tests a lab method to separate sperm that produce boys from those that produce girls. Up to 2,000 couples undergoing IVF or insemination will use the selected sperm. The goal is to see if the method reliably leads to embryos and babies of the desired sex.

This study aims to improve techniques for freezing and thawing ovarian tissue, as well as maturing eggs in the lab. It includes up to 300 females aged 0-45 who are at risk of early menopause due to cancer treatment, surgery, or other medical reasons. The goal is to help these ind…

This study collects leftover tumor tissue from brain surgery or autopsy to learn more about central nervous system tumors. Researchers will create cell lines and models to test how different drugs work. Up to 500 people of all ages with suspected or confirmed brain tumors can joi…

This study follows children and adults with genetic developmental and epileptic encephalopathy (DEE) to understand how the disease progresses. It does not test any treatment or drug. Instead, researchers will measure changes in development, communication, motor skills, seizures, …