Cancer-killing virus injected directly into tumors combined with immunotherapy shows promise in hard-to-treat cancers
NCT ID NCT06340711
First seen Apr 25, 2026 · Last updated Apr 30, 2026 · Updated 2 times
Summary
This study tests a new combination treatment for people with advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to standard therapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into their tumor during a scope procedure, plus infusions of the immunotherapy drug pembrolizumab every 6 weeks. The goal is to see if this combination is safe and effective for tumors that are PD-L1-negative or have stopped responding to immunotherapy.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Email: •••••@•••••
Locations
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Abramson Cancer Center of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Weill Cornell Medicine/NewYork-Presbyterian Hospital
RECRUITINGNew York, New York, 10065, United States
Contact Email: •••••@•••••
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Conditions
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