Cancer-killing virus plus immunotherapy shows promise for hard-to-treat stomach cancers
NCT ID NCT06340711
First seen Apr 25, 2026 · Last updated Jun 09, 2026 · Updated 9 times
Summary
This study tests a new treatment for advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to standard immunotherapy. The treatment combines a virus (OBP-301) that is injected directly into the tumor with an immunotherapy drug (pembrolizumab) given through an IV. The goal is to see if this combination is safe and effective for people whose tumors are PD-L1-negative or have stopped responding to immunotherapy. About 27 participants will receive up to 5 virus injections and pembrolizumab infusions every 6 weeks for up to 2 years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Abramson Cancer Center of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Weill Cornell Medicine/NewYork-Presbyterian Hospital
RECRUITINGNew York, New York, 10065, United States
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Conditions
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