Weill Medical College Of Cornell University

This early-stage study tests a gene therapy for people with alpha-1 antitrypsin deficiency, a condition that can damage the lungs. The treatment uses a single IV dose to help the body make a protective protein. Researchers are checking safety and whether it works in 16 adults wit…

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver. Participants receive treatment before and after surgery to remove liver tumors. The goal is to see if these combinations ch…

This early-stage study tests whether adding an experimental drug (TVB-2640) to the standard drug enzalutamide (Xtandi) is safe for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About 30 men will take part to find the best dose and wa…

This study tests whether adding a radiation-delivering drug (225Ac-J591) to standard immunotherapy (pembrolizumab) and hormone therapy works better for men with advanced prostate cancer that has spread and stopped responding to treatment. About 52 men will participate. The goal i…

This study is for people whose breast cancer has come back after previous lumpectomy and radiation. It tests whether a second round of targeted radiation can allow them to keep their breast instead of needing a mastectomy. The main goal is to see if this approach is safe and does…

This study tests two treatments given before surgery for stages IB to III non-small cell lung cancer. One group gets immunotherapy (cemiplimab) plus chemotherapy; the other gets immunotherapy plus targeted radiation. After surgery, all participants continue immunotherapy for a ye…

This study tests a new combination treatment for people with advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to standard therapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into their tumor during a scope …

This study tests whether inviting friends, family, or coworkers to join a weight loss program helps Black or Hispanic adults with obesity lose more weight. About 264 participants will be assigned to a lifestyle program either alone or with up to two social network members. The go…

This study is testing whether a liver transplant can help people with colorectal cancer that has spread only to the liver and cannot be surgically removed. About 20 adults aged 18 to 65 with stable or shrinking liver tumors will receive a liver transplant and be tracked for cance…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or with one prior ICSI cycle. Researchers will measure how well the treated gametes fertilize and how the embryos develop. The study plans to enro…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. The goal is to see if more grafts lower the risk of death, stroke, heart attack, or needing another procedure. About 4,300 adults with coronary artery disease wi…

This study aims to find out if using multiple arteries for heart bypass surgery is better than using just one artery in women with coronary artery disease. About 2,300 women will be randomly assigned to one of the two surgical approaches. Researchers will track heart-related even…

This early-stage study tests a new vaccine called dAd5GNE in 150 people with cocaine dependence. The vaccine aims to train the immune system to block cocaine from reaching the brain, reducing its effects. The main goal is to check safety, but researchers will also measure if the …

This early-stage trial is testing whether special cells from human umbilical veins are safe to use alongside standard surgery for simple anal fistulas. The study will enroll 39 adults who are already scheduled for fistulotomy. Researchers will monitor for side effects over two we…

This study compares two blood-thinner strategies after heart bypass surgery in 700 people with chronic coronary disease. One group takes ticagrelor plus low-dose aspirin for one month, then aspirin alone; the other takes only aspirin. The goal is to see if the short dual therapy …

This study looks at whether limiting eating to an 8-hour window each day, combined with a healthy diet and exercise, can reduce fat in the liver. Researchers will compare this approach to standard lifestyle advice alone in 40 adults with non-alcoholic fatty liver disease. The goa…

This study is testing whether a special type of PET/MRI scan (68Ga-DOTATATE) can better detect certain brain tumors, like meningiomas, and tell the difference between tumor regrowth and changes from past treatment. About 200 adults with these tumors will get the scan, and doctors…

This study is testing whether a special type of scan called PSMA-PET CT can accurately rule out serious prostate cancer in men who are currently on active surveillance (monitoring the cancer without immediate treatment). Researchers will enroll 200 men with low or favorable inter…

This pilot study tests whether adding spiritual care to regular cancer care improves spiritual well-being and readiness to make future medical plans in Black patients with advanced cancer. About 64 participants will receive spiritual care interventions in outpatient settings. The…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of the usual weeks of daily sessions, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can rapidly imp…

This study tests a program called EMPOWER to help family members who make decisions for critically ill patients. The goal is to reduce symptoms of grief and post-traumatic stress. About 172 participants will be followed for up to a year to see if the program helps compared to sup…

This study tests a device called IVS3 that uses intense visual stimulation to help people with chronic stroke improve arm movement. Researchers want to see if the device is easy to use and tolerable in a rehab center. About 25 adults who had a stroke at least 6 months ago will pa…

This study tests whether a 9-week therapy called Engage & Connect can increase brain activity related to positive social experiences, which may help reduce suicidal thoughts. Researchers will use brain scans and computer tasks to measure changes in 128 adults aged 50-80 with depr…

This study tests whether calcium carbonate, a common supplement, can safely improve contractions during labor for first-time mothers. About 60 women will receive the supplement alongside standard care. The goal is to see if it shortens labor and reduces the need for cesarean sect…

This study tests a program called Living Healthy to see if it improves mood and well-being for home health aides. About 100 aides will take part in an 8-week program that includes health education and positive thinking. Some will also get a peer coach—another aide trained to offe…

This study is testing whether a mobile app called Maya Perinatal Cognitive Behavioral Skills App is easy and helpful for pregnant people and new parents up to 12 months after birth. Participants will complete 12 app modules that teach practical skills to manage anxiety, stress, a…

This study tests a new type of talk therapy called Engage & Connect for new mothers with postpartum depression. The therapy is delivered online over 9 weeks and aims to reduce depression by improving social connections and reward processing. The study will enroll 60 mothers who a…

This study tests whether adding non-opioid pain medicines (acetaminophen and ketorolac) can better control pain and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly a…

This study tests a digital program on an iPad that combines brain-training games with learning practical thinking strategies. The goal is to see if it can improve mood, memory, and daily function in people who have had a stroke. Researchers will enroll 70 adults who had a first s…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and compare genetic patterns in airway cells to better understand how lung diseases deve…

This study is testing whether an artificial intelligence tool can help doctors make better decisions for people undergoing in vitro fertilization (IVF) or other fertility treatments. Researchers will analyze data from 4,000 patients to see if the AI can accurately predict things …

This study collects leftover tumor tissue from surgery or autopsy from 500 people with central nervous system (CNS) tumors. Researchers will use the tissue to create lab models and test how different drugs work. The goal is to learn more about these tumors and find better treatme…

This study tests a training program called PICT for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to notice pain signs and talk about them with doctors. About 440 caregivers will take part to see if the training improves pai…

This study follows children and adults with genetic developmental and epileptic encephalopathy (DEE) for up to 10 years. Researchers will track development, seizures, and quality of life through in-person visits, virtual check-ins, or online surveys. The goal is to better underst…

This study looks at whether offering genetic testing for inherited cancer risks (like BRCA1/2) during routine pregnancy or fertility care is practical and acceptable. About 550 pregnant or preconception patients will be offered the screening alongside standard prenatal tests. The…

This study looks at whether digital devices like smartwatches and blood pressure cuffs can help detect high blood pressure and other pregnancy risks in refugee women. About 75 pregnant refugees will use these tools at home and complete surveys. The goal is to see if this approach…

This study looks at how young women (ages 18-44) newly diagnosed with breast cancer decide on surgery. Researchers are testing a web tool called CONSYDER that gives helpful information and improves talks with surgeons. About 800 participants will fill out surveys before and after…

This study is testing a special shoe called NUSHU that has sensors to measure how people with Parkinson's disease walk and keep their balance. The shoe can also give gentle vibrations to help with walking problems. Researchers want to see if the shoe is comfortable and easy to us…

This study uses cardiac MRI to examine heart and lung damage in 510 COVID-19 survivors who had severe symptoms. Researchers aim to link imaging findings with ongoing symptoms like shortness of breath and fatigue. The goal is to better understand why some people have lasting probl…