Weill Medical College Of Cornell University

This study tests a combination of four drugs (daratumumab, clarithromycin, pomalidomide, and dexamethasone) in people with multiple myeloma whose cancer returned or didn't respond after previous treatment with daratumumab. The goal is to see if this combo can shrink tumors more e…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) before prostate removal surgery is safe and effective for men with high-risk prostate cancer. Sixteen men with aggressive prostate cancer (Gleason score 8 or higher or signs of spread) will receive ra…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with a certain type of esophageal cancer. The trial involves 42 adults whose cancer has not spread far but is locally advanced. The main goal is to see if t…

This study tests whether giving two immunotherapy drugs (botensilimab and balstilimab) before surgery can help shrink colorectal cancer tumors in 26 adults. The drugs aim to boost the immune system to attack the cancer. Researchers are checking how well the tumors respond and wha…

This study tests a combination of three drugs—daratumumab, pomalidomide, and dexamethasone—in 15 adults with AL amyloidosis whose disease has returned or not responded after prior treatment including daratumumab. The goal is to see if this triple therapy leads to more complete re…

This pilot study tests whether high doses of a radioactive sugar (FDG) can safely treat advanced cancers that no longer respond to standard therapies. FDG is taken up by cancer cells because they use a lot of glucose, and the radiation may kill them. The study involves 30 adults …

This study tests a new approach for men with intermediate-risk prostate cancer. First, doctors use a procedure called irreversible electroporation (IRE) to destroy cancer cells with electrical pulses. Then, they follow up with precise MRI-guided radiation. The goal is to see if t…

This early-phase study tested a new treatment approach for people with advanced liver cancer that can be surgically removed. Participants were to receive focused radiation therapy along with two immunotherapy drugs (tremelimumab and durvalumab) to help the immune system fight the…

This study tests whether combining an experimental targeted radiation drug (177Lu-J591) with hormone therapy (ketoconazole) can prevent prostate cancer from spreading in high-risk patients. About 55 men whose PSA is rising despite hormone treatment, but who have no visible metast…

This study tests whether replacing a standard immune-suppressing drug with tocilizumab can prevent graft failure and graft-versus-host disease in blood cancer patients receiving a special type of bone marrow transplant. About 21 adults with high-risk blood cancers are participati…

This study tests whether combining two drugs—tazemetostat (a pill) and mosunetuzumab (an injection)—is safe and effective for people with follicular lymphoma who have not yet been treated. The goal is to see if the combination can improve the number of patients whose cancer disap…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and rituximab or obinutuzumab) in people with untreated mantle cell lymphoma, a type of blood cancer. About 37 participants will receive the treatment for about a year, then continue on a lower dose to ke…

This study tested a combination of four drugs (carfilzomib, clarithromycin, lenalidomide, and dexamethasone) in 74 adults with newly diagnosed multiple myeloma, a type of blood cancer. The goal was to see how well the treatment worked and if it was safe. Patients received the dru…

This study tests adding lenalidomide to the standard chemotherapy (melphalan) given before a stem cell transplant for people whose multiple myeloma has returned. The goal is to find the safest dose and see if it improves how long the cancer stays under control. About 52 participa…

This study is testing a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the highest dose that can be given safely without severe side effects. About 50 participants will rec…

This study tests a new approach for people with untreated CLL. Instead of giving three drugs to everyone, patients start with two oral medications (zanubrutinib and venetoclax). Only those who still have signs of cancer after 16 cycles get a third drug (obinutuzumab) to boost res…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study looks at whether a central outreach program can help more people at high risk for lung cancer get a low-dose CT scan. About 2000 adults aged 50-80 who smoke or used to smoke will be invited to get screened. The goal is to catch lung cancer early, when it's easier to tr…

This study tests a tablet-based app called COPPEhR designed to help older adults (50+) living with HIV for at least 15 years feel more socially connected and less lonely. About 68 participants will use the app or a tablet without the app for 9 months. Researchers will measure if …

This study tests whether injecting methotrexate directly into the nail area can improve nail psoriasis symptoms like pitting, crumbling, and discoloration. One adult with at least three affected fingernails is enrolled. Each nail is scored on severity, and the treatment's safety …

This early-stage study tests whether a medicine called phenylbutyrate is safe and tolerable for children with certain genetic conditions that cause seizures and developmental delays. The trial includes 50 children with STXBP1 or SLC6A1 disorders. Researchers will monitor side eff…

This study looks at two different radiation schedules for postmenopausal women with early-stage breast cancer. One group gets 5 daily doses, the other gets 3 doses every other day. The goal is to see which schedule causes less scarring (fibrosis) in the breast. 350 women will be …

This study tests whether using a FitBit and a mobile app after surgery for stomach, liver, colon, or other GI cancers can help prevent patients from being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will be randomly assigned to …

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study tests a behavioral program called Moving Well for people waiting for knee replacement surgery. The goal is to see if it can lower anxiety and depression before the operation. About 79 adults aged 50 and older who are scheduled for surgery are taking part.

This study tests a program that uses short videos and a health coach to help people aged 60 and older with a type of heart failure (HFpEF) manage their condition better. Fifty participants will try the program, and researchers will measure changes in self-care skills after 90 day…

This study compares two radiation schedules for women with early-stage breast cancer: the standard 15 sessions over 3 weeks versus an experimental 10 sessions over 2 weeks. The goal is to see if the shorter schedule is just as effective at controlling cancer and causes similar or…

This study compares two shortened radiation schedules for men whose prostate cancer has come back after surgery. One group gets 20 treatments over 4 weeks, the other gets 5 treatments over 2 weeks. The main goal is to see if the shorter course causes similar or fewer bowel and ur…

This study looks at whether older adults with a specific type of heart disease (cardiac amyloidosis) feel better when they stop taking a common heart medication called a beta-blocker. Twenty participants will each go through two periods—one on the drug and one off—to compare thei…

This study looks at whether older adults (age 60+) with a type of heart failure called HFpEF can safely stop taking beta-blockers to feel better and have a better quality of life. About 240 participants will either gradually reduce their beta-blocker dose or continue it for 4 mon…

This study looks at whether a shorter, more intense course of radiation (accelerated radiation therapy) is safe and tolerable for women with breast cancer who have already had chemotherapy and surgery. About 88 participants will receive the accelerated radiation to the breast and…

This study is for people with GLUT1 deficiency syndrome, a rare genetic condition that makes it hard for the brain to get enough sugar for energy, often causing seizures and movement problems. The trial will replace the patient's own red blood cells with healthy donor cells to se…

This study aims to understand people's experiences with statin side effects and create educational materials to help new users separate real drug effects from nocebo effects (negative expectations). About 30 adults with heart risk factors will share their views through surveys an…

This study involves 55 women with chronic pelvic pain to develop a questionnaire that captures their full experience. Researchers will interview participants to understand symptoms and impacts, then test the questionnaire for clarity and completeness. The goal is to create a reli…

This study collects kidney tissue from 100 adults with ADPKD who are already scheduled for kidney removal surgery. Researchers will analyze the genetic mutations in cyst cells to better understand why cysts form and why the disease affects people differently. The goal is to learn…

This study tests a new PET scan method that looks at two things at once: oxygen levels and cell growth in high-grade brain tumors. The goal is to see if these scans can help doctors understand which tumors might resist standard treatment. Only 8 adults with suspected high-grade g…

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study looks at how often children develop delirium—a temporary state of confusion—after a stem cell transplant. Researchers will track over 1,000 children to find out what puts them at risk and how delirium affects their hospital stay and recovery. The goal is to use this in…

This study tests whether a personalized approach called N-of-1 trials can help older adults (65+) with a type of heart failure (HFpEF) feel more confident about continuing or stopping their beta-blocker medication. Twenty participants will go through a tailored trial to see how t…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study checks if drinking caffeine changes blood pressure or heart rate in people taking the antifungal medication terbinafine for nail fungus. Researchers will monitor 52 adults before and after they start the drug. The goal is to understand possible side effects, not to tes…

This study looks at whether using MRI to guide radiation therapy for breast cancer is as good as the standard CT-guided method. It involves 17 women aged 50 or older with early-stage breast cancer who have had breast-conserving surgery. The goal is to compare how well each method…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…