Promising combo aims to boost remission in follicular lymphoma
NCT ID NCT05994235
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial is testing a combination of two drugs—tazemetostat pills and mosunetuzumab injections—in 23 people with follicular lymphoma who have not yet received treatment. The goal is to see if the combination is safe and leads to a complete response (disappearance of cancer). Tazemetostat blocks a protein that helps lymphoma grow, while mosunetuzumab helps guide immune cells to attack the cancer. The study uses a newer, under-the-skin form of mosunetuzumab.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tazemetostat pills and mosunetuzumab injections
- What this could lead to
- If this combination works well, it could offer a more effective and convenient treatment option for people with newly diagnosed follicular lymphoma, potentially increasing the chance of complete remission.
- What could go wrong
- This is a small, early-phase trial with only 23 participants, so results may not apply to everyone. The drugs have not been tested together before, and there are risks like cytokine release syndrome and nerve-related side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Weill Cornell Medicine/NewYork-Presbyterian Hospital
New York, New York, 10065, United States
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