New drug combo aims to stall prostate cancer spread in High-Risk patients

NCT ID NCT00859781

First seen Apr 10, 2026 · Last updated May 15, 2026 · Updated 7 times

Summary

This study tests whether combining an experimental targeted radiation drug (177Lu-J591) with hormone therapy (ketoconazole) can keep prostate cancer from spreading in men whose cancer has returned after initial treatment. About 55 men with high-risk, castration-resistant prostate cancer but no visible metastases will receive the combination. The main goal is to see how many remain free of new cancer spots on scans for 18 months.

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Contacts and locations

Locations

  • Cedars Sinai

    Los Angeles, California, 90048, United States

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Indiana University Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana, 46202, United States

  • The University of Kansas Cancer Center

    Westwood, Kansas, 66205, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • USC/Norris Comprehensive cancer center

    Los Angeles, California, 90089, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

  • Weill Cornell Medical College

    New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.