New drug cocktail aims to boost stem cell transplant success in myeloma
NCT ID NCT01054196
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding lenalidomide (Revlimid) to the standard high-dose melphalan before an autologous stem cell transplant can improve outcomes for people with relapsed multiple myeloma. In the first phase, researchers find the safest dose of lenalidomide to combine with melphalan. In the second phase, they measure how long the response lasts. About 52 participants are enrolled, and after transplant, they continue on a standard low dose of lenalidomide to maintain the effect.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lenalidomide (Revlimid) and melphalan
What this could lead to
If successful, this could lead to a more effective preparative regimen for stem cell transplant, potentially extending remission in relapsed multiple myeloma.
What could go wrong
This is an early-phase trial with only 52 participants, so results may not apply broadly. Adding lenalidomide to high-dose chemotherapy also raises risks of severe side effects like low blood counts and infections.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Weill Cornell Medical College
New York, New York, 10065, United States