Novartis Pharmaceuticals

This study tested the safety and effectiveness of the drug EGATEN (triclabendazole) in 301 people aged 6 and older with fascioliasis, a parasitic liver fluke infection. Participants received two doses of EGATEN 12 hours apart and were monitored for 90 days. The goal was to see if…

This study tested two injectable drugs, secukinumab and ustekinumab, in 119 adults with active psoriatic arthritis who had not responded to or could not tolerate TNFα inhibitors. The main goal was to see which drug better improved physical function over 28 weeks. Both drugs aim t…

This study tested an experimental drug called RHH646 in 82 adults with knee osteoarthritis. The goal was to see if the drug could help regrow cartilage in the knee and check for any side effects. Participants received either the drug or a placebo, and changes in cartilage were me…

This study tested a drug called eltrombopag in 20 Chinese adults with severe aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. The goal was to see if the drug could improve blood cell counts and reduce the need for transfusions. Participants…

This study tested an oral medication called DFV890 in 24 adults with coronary heart disease and high inflammation levels. Participants took the drug daily for 12 weeks to see if it could lower inflammatory markers like IL-6 and IL-18. The goal is to manage heart disease risk, not…

This study tested a treatment called tisagenlecleucel (a CAR-T cell therapy) in 98 adults with follicular lymphoma that had come back or stopped responding to other treatments. The therapy works by reprogramming a patient's own immune cells to find and attack cancer cells. The ma…

This study tested a combination of two anti-malarial drugs, cipargamin and KLU156, in 60 people aged 12 and older with uncomplicated Plasmodium falciparum malaria. The main goal was to see if the drugs could clear the malaria parasite from the blood by day 29 without the infectio…

This study tested an oral targeted drug called capmatinib in 36 Chinese adults with advanced non-small cell lung cancer that has a specific MET gene mutation (exon 14 skipping). The drug aims to block cancer growth by targeting this faulty gene. Researchers measured how many pati…

This study tested whether an eye injection called brolucizumab works as well as standard laser treatment for people with proliferative diabetic retinopathy, a serious eye problem caused by diabetes. About 689 adults with type 1 or 2 diabetes took part. The main goal was to see if…

This study looked at how safe and effective Xolair is for adults with chronic sinusitis and nasal polyps that don't get better with standard treatments. Researchers tracked side effects and symptom changes in 135 people using Xolair in everyday medical practice. The goal was to s…

This study tested a drug called ofatumumab in 99 Chinese adults with relapsing multiple sclerosis (RMS). The goal was to see if monthly injections could reduce the number of relapses and how safe the treatment is. Participants received the drug for 12 months, and researchers trac…

This study tested a drug called canakinumab in 14 Japanese adults with Adult-Onset Still's Disease, a rare inflammatory condition. Participants received injections every 4 weeks for at least 48 weeks. The goal was to see if the drug could reduce joint pain, fever, and inflammatio…

This study looked at the safety of the heart failure drug sacubitril/valsartan in Japanese children under 18 who had already finished a previous study. The goal was to collect more safety information and give these children access to the drug until a child-friendly version is ava…

This study looked at the long-term safety and effectiveness of the drug secukinumab in children with two types of juvenile idiopathic arthritis: juvenile psoriatic arthritis and enthesitis related arthritis. 55 children who had already completed a previous study continued taking …

This study tested a drug called alpelisib combined with hormone therapy (fulvestrant or letrozole) in 383 people with advanced breast cancer that has a specific genetic mutation (PIK3CA). The goal was to see how many patients were alive without their cancer getting worse after 6 …

This study tested a drug called inclisiran in 207 Chinese adults with high LDL (bad) cholesterol who were not taking other cholesterol medicines. Participants received either inclisiran or a placebo for 6 months, followed by 6 months where everyone got the drug. The goal was to s…

This study looked at whether people with chronic myeloid leukemia (CML) who have been on the drug nilotinib for at least 3 years can safely stop treatment and remain cancer-free. It also tested if adding another drug, asciminib, could help those who needed to restart medication t…

This study looked at how well ofatumumab works in 562 people with relapsing multiple sclerosis who switched from other MS drugs (fumarates or fingolimod) because their disease was still active. The main goal was to see how many relapses occurred per year. Researchers also tracked…

This study tested a drug called pelacarsen in 422 Black/African American and Hispanic patients with heart disease and high levels of Lp(a), a genetic risk factor. The goal was to see if the drug safely lowers Lp(a) levels after one year of treatment. Participants continued their …

This study tested two drugs—inclisiran (a shot) and bempedoic acid (a pill)—in 402 adults with high cholesterol and heart disease who were already on statins. The goal was to see which one lowers LDL (bad) cholesterol more. Results will help doctors choose the best treatment to c…

This study looked at how safe and effective Tabrecta is for people with a certain type of advanced lung cancer (MET exon 14 skipping mutation). It included 109 patients who took the drug and were followed for up to one year. The goal was to track side effects and how well the dru…

This study looked at over 2,600 people with multiple sclerosis to compare two drugs, Kesimpta and Ocrevus, using real-world insurance data. The goal was to see which one better prevents relapses and reduces healthcare visits and costs. Both drugs are already approved for MS, and …

This study tested two experimental drugs, DFV890 (a daily pill) and MAS825 (a single shot), to see if they could lower inflammation in 31 adults with coronary heart disease and a genetic blood condition called CHIP. The goal was to reduce markers like IL-6 and IL-18 that are link…

This early-phase study tested a new drug called siremadlin added to two existing medicines (venetoclax and azacitidine) for adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy. The study included 14 people whose cancer did not respond well …

This study tested a daily pill called remibrutinib in 144 adults with chronic spontaneous urticaria (long-term hives) that antihistamines couldn't control. The main goal was to check if the drug affects blood pressure over 12 weeks, while also seeing if it helps reduce hives. Par…

This study tested a new drug called VAY736 in 68 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. Participants had not responded well to or could not tolerate standard treatments. The goal was to see if VAY736 could help normalize liver enz…

This study tested a drug called iptacopan (LNP023) in 518 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants took either the drug or a placebo alongside their usual care. The goal was to see if iptacopan could reduce protein in the urine a…

This study observed 175 adults with HR+/HER2- advanced or metastatic breast cancer in the Middle East who received ribociclib combined with hormonal therapy. Researchers tracked side effects and how well the treatment controlled the cancer over 18 months. The goal was to understa…

This study tested an experimental drug called QAW039 in 675 adults and teens with asthma that wasn't well controlled by their current medications. Participants took either QAW039 or a placebo pill alongside their usual asthma treatments for 12 weeks. The main goal was to see if Q…

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA), a genetic condition that causes muscle weakness. Participants received either the therapy or a sham procedure. The goal was to see if the treatment impr…

This study looked at how well the eye medication Beovu (brolucizumab) works in everyday medical practice for people with wet age-related macular degeneration (AMD) or diabetic macular edema (DME). Researchers observed 572 patients who were already prescribed Beovu by their doctor…

This study looked at the safety of the drug LUTATHERA in 347 people with a type of cancer called neuroendocrine tumors. Researchers monitored patients for serious side effects like kidney problems, low blood counts, and certain blood cancers. The goal was to understand how safe t…

This study tested an experimental drug called LNA043, given as a shot directly into the knee, to see if it can help regrow cartilage in people with knee cartilage damage or osteoarthritis. About 142 adults took part, receiving either the drug or a placebo. The main goals were to …

This study tested the safety and best dose of a drug called crizanlizumab in children aged 2 to 18 with sickle cell disease who have had painful crises. The drug aims to reduce these pain episodes by blocking cells from sticking to blood vessels. 117 children received the drug fo…

This study looked at whether people with chronic myeloid leukemia (CML) could safely stop taking the drug nilotinib (Tasigna) if their cancer was already deeply suppressed. Participants had been on nilotinib for at least 2 years and had very low levels of leukemia cells. The goal…

This study looked at 781 adults with moderate to severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Participants either received the drug Secukinumab alone or combined with a lifestyle intervention (diet and exercise adv…

This study looked at how well the drug ribociclib works in Indian women with a certain type of advanced breast cancer (HR+, HER2-). Researchers collected data from medical records of 335 patients across 18 hospitals in India. The goal was to see how long the drug kept the cancer …

This study tested the drug nilotinib in 34 adults with advanced GIST that could not be removed by surgery. The goal was to see if the drug could shrink or stop the growth of tumors. While not a cure, the treatment helped control the disease in some patients, offering a potential …

This study looked at how well the drug ofatumumab (Kesimpta®) works in real-world Spanish clinics for people with relapsing multiple sclerosis. Researchers tracked 310 patients to see if the drug reduced the number of relapses (flare-ups of symptoms). The goal was to understand t…

This study looked at whether people with relapsing multiple sclerosis (MS) could safely switch from an IV infusion therapy to a self-injected drug called ofatumumab and still keep their MS under control. Over 100 adults took part, and after 12 months, most had no new or worsening…

This study tested a new combination of two drugs, KAF156 and lumefantrine, in 295 children aged 6 months to 18 years with uncomplicated malaria. The goal was to see if the treatment works well and is safe. The approach aims to provide a new option to fight malaria and reduce the …

This study followed 134 adults in Italy with active secondary progressive multiple sclerosis who were prescribed siponimod as part of their routine care. Over 36 months, researchers measured how many patients had a confirmed worsening of disability or thinking skills. The goal wa…

This study looked at the safety of Kesimpta, a drug for relapsing-remitting and active secondary progressive multiple sclerosis. It included 367 people who were using the drug for the first time. Researchers tracked any side effects or serious medical events that happened during …

This study tested an experimental drug called QAW039 in 704 adults and teens (12 years and older) whose asthma was not well controlled despite using standard inhalers. Participants took either QAW039 or a placebo pill on top of their usual asthma medicines for 12 weeks. The main …

This study looked at the safety and effectiveness of inclisiran sodium, a shot given under the skin, for Indian patients with high cholesterol. It included 65 adults who were already prescribed the drug by their doctor. The main goal was to track any side effects and see how much…

This study tested a drug called 177Lu-PSMA-617, which delivers radiation directly to prostate cancer cells. It involved 94 men in Japan with advanced prostate cancer that had stopped responding to hormone therapy. The goal was to see if the drug could shrink tumors and control th…

This study looked at the safety of a drug called crizanlizumab in 140 Indian patients aged 16 and older with sickle cell disease who have had painful crises. The drug is meant to reduce the frequency of these crises. Researchers monitored serious side effects and other adverse ev…

This study tested a drug called inclisiran in teenagers aged 12 to 18 with a rare genetic condition that causes extremely high cholesterol (homozygous familial hypercholesterolemia). The goal was to see if the drug safely lowers bad cholesterol (LDL-C) when added to their current…

This study looked at whether a lower starting dose (400 mg) of the drug ribociclib, combined with standard hormone therapy, is safe and effective for women with a certain type of advanced breast cancer (HR-positive, HER2-negative). The study included 376 women who had not receive…

This study tested a new malaria drug, KLU156, against the standard treatment Coartem in over 1,700 adults and children with uncomplicated malaria. The goal was to see if KLU156 works just as well and is safe. Results showed KLU156 is non-inferior to Coartem, offering a potential …

This study tested whether a combination of two blood pressure medicines (LCZ696 and amlodipine) works better than one medicine alone. It included 718 adults with mild to moderate hypertension that was not well controlled by LCZ696 alone. Participants received either the combo or …

This study tested adding the drug ruxolitinib to standard steroid treatment for children aged 28 days to under 18 years who had moderate to severe chronic graft-versus-host disease (cGvHD) after a stem cell transplant. cGvHD is a condition where donor immune cells attack the chil…

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who suffer from priapism—painful, unwanted erections lasting an hour or more. The goal was to see if the drug could reduce how often these episodes happen over 26 weeks. Participants reported their e…

This study tested a new inhaler (QMF149) against a standard one (MF Twisthaler) in 802 adults and teens with mild asthma that wasn't well controlled. The goal was to see if the new inhaler improved lung function and symptom control over 12 weeks. Participants took the medication …

This phase III trial tested whether the CAR-T cell therapy tisagenlecleucel works better than standard treatments for adults with aggressive B-cell non-Hodgkin lymphoma that came back after initial therapy. About 330 participants were randomly assigned to receive either the CAR-T…

This study tested a drug called secukinumab for people with giant cell arteritis, a condition where blood vessels become inflamed. The goal was to see if adding secukinumab to a steroid taper could help patients achieve remission faster and with less steroid use. About 354 adults…

This study tested an oral drug called asciminib in 199 adults with chronic myeloid leukemia (CML) whose cancer had not responded well to at least two previous treatments. The goal was to see how many patients achieved a major molecular response—a significant drop in leukemia-rela…

This study tested two experimental drugs, VAY736 and CFZ533, in 107 people with systemic lupus erythematosus (SLE). The goal was to see if these drugs could reduce disease activity and allow patients to lower their steroid use. The trial was completed and focused on safety, toler…

This study looked at the safety and effectiveness of the drug asciminib in 85 Indian adults with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP). Participants either had a specific gene mutation (T315I) or had already tried two or more othe…

This study tested a drug called atrasentan in 54 adults with IgA nephropathy, a kidney disease. All participants were already on standard treatments, including SGLT2 inhibitors. The goal was to see if adding atrasentan could reduce protein in the urine (a sign of kidney damage) b…

This study looked at whether a clinic focused on guideline-recommended heart failure medications helps patients get more of the right drugs. Researchers compared 342 patients who went to the special clinic to similar patients getting usual care. The goal was to see if more patien…

This study tested a new drug, inclisiran, to see how well it lowers 'bad' cholesterol (LDL-C) compared to a placebo and another drug called ezetimibe. The study included 350 adults with high cholesterol who were not taking any other cholesterol medications. Participants received …

This study tested a monthly injection of ofatumumab against other standard first-line medications for people newly diagnosed with relapsing multiple sclerosis (MS). The goal was to see which treatment better controls disease activity without relapses, new brain lesions, or worsen…

This study tested whether a hospital care pathway that includes the drug inclisiran can better lower LDL cholesterol in people who recently had a heart attack or unstable angina. About 400 participants with high cholesterol despite statin therapy were enrolled. The goal was to se…

This study tested a new intravenous drug called cipargamin in 254 adults and children with severe malaria. The goal was to find a safe and effective dose, especially for cases resistant to current treatments. The drug works by quickly clearing malaria parasites from the blood, in…

This study followed 42 children aged 6 to 17 with moderate to severe plaque psoriasis in China who were treated with Cosentyx (secukinumab) for up to 52 weeks. Researchers tracked side effects and how well the drug cleared skin symptoms. The goal was to see if Cosentyx is safe an…

This study looked at the safety of two doses of iscalimab in 206 people with Sjögren's syndrome who had already completed a previous study. The main goal was to track any side effects. Researchers also measured how much drug stayed in the blood and checked for signs of effectiven…

This study tested an oral medication called iptacopan in 52 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Participants switched from their usual intravenous treatments (eculizumab or ravulizumab) to iptacopan pills taken twice daily. The main goal …

This study tested an intravenous (IV) form of secukinumab in 65 adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). The goal was to see how the drug moves through the body and whether it is safe. Participants received multiple doses, and researchers monitored …

This study tested a drug called secukinumab in 137 Chinese adults with a form of spinal arthritis that doesn't show on X-rays (non-radiographic axial spondyloarthritis). The goal was to see if the drug reduces pain, stiffness, and improves function compared to a placebo after 16 …

This study tested two different schedules of the eye injection brolucizumab in 52 adults with wet age-related macular degeneration (AMD) whose vision was not fully controlled by previous treatment. The goal was to see which dosing plan works better and is safer over 52 weeks. Par…

This study tested a new anti-malarial drug called INE963 in 52 adults with uncomplicated P. falciparum malaria. The main goal was to see how quickly the drug clears malaria parasites from the blood. Researchers also checked the 28-day cure rate and drug safety. The study was comp…

This study tested an experimental drug called LRX712, given as injections into the knee, to see if it can help regrow cartilage in people with mild to moderate knee osteoarthritis. The trial involved 45 participants and compared the drug to a placebo over 8 weeks. The main goal w…

This study tested a new drug called XXB750 in 189 adults with resistant hypertension (high blood pressure that doesn't respond to standard treatments). Participants received different doses of the drug or a placebo as a shot under the skin, on top of their usual medications. The …

This study tested a drug called sacubitril/valsartan against an older drug, enalapril, in 922 adults with heart failure caused by Chagas disease. The goal was to see if the newer drug could reduce heart-related deaths, hospitalizations, and improve a key heart stress marker (NT-p…

This study looked at 107 adults in Switzerland with relapsing multiple sclerosis who were taking the drug Kesimpta (ofatumumab) as part of their normal medical care. The goal was to see how well the drug prevented new disease activity, such as relapses, new brain lesions, or wors…

This study tested a daily pill called asciminib in 56 adults with chronic myeloid leukemia (CML) whose cancer had not responded well to at least one or two prior treatments. The goal was to see if the drug is safe and helps control the disease. Participants took asciminib alone, …

This study looked at how well inclisiran (Leqvio®) and other cholesterol-lowering medicines work in real life for people with high cholesterol. About 1,868 adults took part, and researchers simply watched their usual care without giving any new treatments. The goal was to underst…

This study looked at health records of over 1,200 people with heart failure to compare two types of medication: sacubitril/valsartan versus ACE inhibitors or ARBs. The goal was to see which treatment better reduced the risk of death from heart problems or hospitalization due to h…

This study tested a new oral medication, iptacopan, in 34 adults with a rare kidney disease called atypical hemolytic uremic syndrome (aHUS) who had not received prior treatment. The goal was to see if the drug could improve blood counts and kidney function. Results showed that i…

This study tested whether a combination of two targeted drugs (dabrafenib and trametinib) could keep melanoma from coming back after surgery in people with high-risk, BRAF-mutated skin cancer. About 870 patients took either the drug combo or placebos for 12 months. The main goal …

This study tested the safety of two drugs, alpelisib and fulvestrant, in 40 men and postmenopausal women with a specific type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that had worsened after hormone therapy. The goal was to see how many people had side effec…

This study looked at how well and how safely the drug fingolimod (Gilenya) works for people in China with relapsing multiple sclerosis (RMS). It included 98 adults and children aged 10 to 65 who had not taken fingolimod before. Over 24 months, researchers measured the number of c…

This early-phase study tested a drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer. The goal was to find a safe dose and see if the combination helps control tumor growth. While not a cure, it aims to imp…

This study tested whether adding inclisiran to standard cholesterol-lowering therapy helps more high-risk patients reach their LDL (bad) cholesterol goals. About 1,770 adults with very high or high cardiovascular risk took part. Results showed that more patients on inclisiran ach…

This study tested whether adding the drug ribociclib to standard hormone therapy helps slow the growth of advanced breast cancer in Chinese women. The cancer type was hormone receptor positive and HER2 negative. 327 women took part, and the main goal was to see how long the cance…

This study tested a combination of two targeted drugs, dabrafenib and trametinib, in 40 Chinese adults with a specific type of advanced lung cancer (BRAF V600E mutation-positive NSCLC). The goal was to see if the drugs could shrink tumors. Participants took the drugs until their …

This study tested a medicine called inclisiran in 141 teenagers (ages 12–17) with a genetic condition that causes very high cholesterol. Participants received either inclisiran or a placebo for one year, then everyone received inclisiran for a second year. The goal was to see if …

This study tested two doses of secukinumab (a drug that calms the immune system) combined with a steroid taper in 381 adults aged 50+ with polymyalgia rheumatica (PMR), a condition causing severe muscle pain and stiffness. The goal was to see if secukinumab helps patients achieve…

This study tested the safety and effectiveness of brolucizumab eye injections in 66 adults with diabetic macular edema, a condition that causes vision loss in people with diabetes. Participants received injections over 40 weeks to see if their vision improved and to track any sid…

This study followed 72 adults in Taiwan with lupus nephritis who were taking Myfortic (mycophenolate sodium) for the first time. Over 12 months, researchers tracked side effects, serious events, and reasons for stopping the drug. The goal was to understand how safe this treatment…

This study reviewed medical records of 13 Korean children with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. Researchers wanted to see if adding eltrombopag to standard immunosuppressive therapy was safe and effective over 6 months. Th…

This study tested a targeted drug called capmatinib in 50 Indian adults with advanced non-small cell lung cancer that has a specific genetic change (MET exon 14 skipping mutation). The goal was to check how safe the drug is and how well it shrinks tumors. Participants could be ne…

This study looked at two versions of an experimental drug called ianalumab (VAY736) in 48 adults with rheumatoid arthritis. The goal was to check if the two versions are similar in how they work in the body and to see if they are safe. Participants received multiple doses of the …

This study tested a drug called secukinumab in 151 adults with newly diagnosed giant cell arteritis, a condition that causes inflamed arteries. Participants were in remission and taking steroids. The goal was to see if adding secukinumab could prevent the disease from coming back…

This study tested a one-time gene therapy called OAV101 in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had stopped taking other SMA medicines. The goal was to see if the treatment was safe and could help maintain or improve muscle function. Researchers monitor…

This study looked at whether people with chronic myeloid leukemia (CML) who had a deep response to the drug nilotinib could safely stop taking it without the cancer coming back. 215 adults who had been on nilotinib for at least two years were enrolled. The main finding was that m…

This study looked at whether a monthly injection of ofatumumab can stop or slow down multiple sclerosis (MS) in people who were diagnosed very early and had not yet taken any other MS medication. About 180 people with early relapsing-remitting MS received the drug for 18 months, …

This study tested whether adding eltrombopag to standard immunosuppressive therapy (r-ATG and cyclosporine) could improve blood cell counts in 36 East-Asian patients with severe aplastic anemia, a condition where the bone marrow fails to produce enough blood cells. The main goal …

This study tested a personalized treatment plan using the drug brolucizumab for people with a specific eye condition called polypoidal choroidal vasculopathy (PCV), which can cause vision loss. The trial involved 148 adults who had not received prior treatment for this condition.…

This study tested a new medicine called CFZ533 to see if it could prevent kidney transplant rejection as well as the standard drug tacrolimus. About 418 kidney transplant patients took part. The goal was to compare how many patients had rejection, lost their kidney, or died withi…

This study tested whether adding the experimental drug asciminib to the standard treatment imatinib helps people with chronic myeloid leukemia (CML) achieve a deeper molecular response (very low cancer levels). It included 104 adults who had been on imatinib for at least a year b…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to find where prostate cancer has returned in men with rising PSA levels after initial treatment. About 190 men with biochemical recurrence took part. The goal was to see how accurately the scan locates cance…

This study tested a special PET/CT scan using [68Ga]Ga-DOTA-TATE to see if it could better detect neuroendocrine tumors compared to standard imaging. 71 adults in Japan, including patients with known or suspected tumors and healthy volunteers, took part. The goal was to see how a…

This study tested a new PET imaging agent called [18F]CTT1057 to see how well it can find prostate cancer tumors. 195 men with high-risk prostate cancer who were scheduled for surgery received the PET scan, and the results were compared to tissue samples taken during surgery. The…

This study tested an experimental drug called DFV890 in 115 people with painful knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo. Participants were aged 50 to 80 and had moderate to severe pain.

This study tested the drug Xolair in 50 teenagers aged 12 to 17 who had severe seasonal allergies that standard treatments couldn't control. The goal was to see if Xolair is safe and helps ease their symptoms. Doctors monitored for side effects and overall improvement.

This study tested whether adding omalizumab to standard allergy medications (antihistamines and nasal sprays) could better control symptoms in 337 adults and teens with severe Japanese cedar pollinosis. Participants had severe symptoms despite current treatments. The study compar…

This study tested a drug called ligelizumab in 49 teenagers (ages 12 to 18) with chronic spontaneous urticaria, a condition causing long-term hives and itching. The goal was to see if adding ligelizumab to standard antihistamines could better control symptoms. Results focused on …

This study tested a drug called canakinumab in 49 children and young adults (ages 8-20) with sickle cell anemia to see if it could reduce their daily pain. Participants rated their pain on a scale of 0 to 10, and researchers compared changes over 8 to 12 weeks. The goal was to fi…

This study looked at whether Xolair (omalizumab) is safe and effective for Chinese teenagers with chronic spontaneous urticaria (long-lasting hives and itching) that don't get better with standard antihistamines. Fifty-five teens took part, receiving Xolair for 12 weeks and then …

This early-stage trial tested the safety of a new drug called NIO752 in 59 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants received multiple doses of the drug or a placebo injected into the spinal fluid. The …

This study looked at how people with multiple sclerosis felt about their first injection of either Kesimpta or a new under-the-skin version of Ocrevus. Researchers asked 134 adults about pain, redness, swelling, and itching at the injection site, as well as overall satisfaction. …

This study tested whether secukinumab, an injected drug, can reduce pain and improve function in adults with moderate to severe rotator cuff tendinopathy (shoulder tendon injury) who did not improve with standard treatments. 62 participants received either secukinumab or a placeb…

This study tested a single injection of NGI226 microparticles in 45 people with Achilles tendinopathy (mid-portion tendon pain). The goal was to see if the injection is safe and helps the tendon heal better than a placebo. Researchers measured side effects and changes in tendon s…

This early-stage study tested a new drug called XXB750 in 27 adults with heart failure (a weakened heart). The main goal was to see if the drug is safe and what side effects it might cause. Participants received either the drug or a placebo, and researchers monitored their health…

This study tested a monthly injection called erenumab in 557 Asian adults with chronic migraine (15+ headache days per month). Over 12 weeks, the drug reduced the number of migraine days compared to a placebo. The goal was to ease symptoms and improve daily life, not to cure migr…

This study observed 103 adults with relapsing multiple sclerosis who were taking Kesimpta (ofatumumab). Researchers used data from a patient support app to see how consistently people took their medication and how their symptoms and quality of life changed over time. The goal was…

This study looked at medical records of over 218,000 adults in England with a common type of breast cancer (HR+/HER2-). Researchers tracked which treatments patients received, how the disease progressed over time, and how healthcare resources were used. The goal was to better und…

This study observed 39 patients in Turkey who had high-risk stage III melanoma removed by surgery and were then treated with dabrafenib and trametinib. Researchers tracked how long patients stayed cancer-free and how long they took the medication. The goal was to see how well the…

This study looked at medical records of over 4,800 people with spinal muscular atrophy (SMA) to see how three approved treatments (onasemnogene abeparvovec, nusinersen, and risdiplam) are used in real life. Researchers tracked complications, medical equipment needs, and hospital …

This study examined medical records of 754 people with chronic myeloid leukemia (CML) in Japan to see which medications (called TKIs) they received, how often they switched or stopped treatment, and what healthcare costs were involved. The goal was to understand real-world treatm…

This study looked at 480 patients with a common type of advanced breast cancer (HR+, HER2-) to see how doctors actually use a class of drugs called CDK4/6 inhibitors in everyday practice. Researchers collected information on patient characteristics, treatment patterns, and outcom…

This study reviewed medical records of 1,480 adults with chronic-phase chronic myeloid leukemia (CML-CP) treated in U.S. community oncology clinics between 2016 and 2022. Researchers looked at which drugs were used, how doses were adjusted, and how well patients responded to trea…

This study observed over 2,400 women in Russia with a certain type of advanced breast cancer (HR+/HER2-). Researchers tracked which treatments doctors chose (like ribociclib, alpelisib, hormone therapy, or chemo) and how long they worked before needing a change. The goal was to u…

This study looked at how the drug ianalumab affects the salivary glands of people with Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. Researchers took small tissue samples (biopsies) from 21 adults to measure changes in immune cells and check for side effec…

This study looked at hospital records from 2015 to 2022 to find out how many people in France have a rare genetic condition called PROS. Researchers analyzed data from over 3,600 patients to understand their age, where they live, and what other health problems they have. The goal…

This study analyzed medical records from over 2,200 Medicare patients with chronic myeloid leukemia (CML) to see how they were treated in everyday practice. Researchers looked at which targeted drugs patients started, how often they switched treatments, and how much healthcare th…

This study used national health survey data to estimate how many US adults with high cholesterol might be eligible for the drug inclisiran, and how many heart attacks or strokes could be prevented over 10 years. Researchers analyzed information from over 1,300 participants to ide…

This study tested a new drug called TIN816 in 20 adults in the intensive care unit who had kidney injury from sepsis. The main goal was to see how the drug behaves in the body and whether it is safe. Researchers measured drug levels and watched for side effects. This was an early…

This study looked back at medical records of 606 people with secondary progressive multiple sclerosis (SPMS) in Russia who were taking the drug siponimod. The goal was to understand their age, gender, how long they had MS, and what treatments they used before siponimod. The study…

This study looked at how different levels of liver function affect the way the body processes the drug JDQ443. Researchers gave a single dose to 33 people with small cell lung cancer who had mild, moderate, or severe liver problems, and compared them to healthy volunteers. The go…

This study checked how well hospitals in Germany follow recommended treatments for people with heart failure after a serious episode. About 900 patients took part, and researchers looked at whether care matched official guidelines. The goal was to understand where care is strong …

This early-stage study tested the safety of a single dose of QCZ484 in 56 healthy adults and people with mild hypertension. Participants received either the drug or a placebo, and researchers monitored side effects and lab results. The goal was to see if the drug is safe enough f…

This study looked at pregnancy and baby outcomes in 13 women with sickle cell disease who were treated with Adakveo (crizanlizumab) during pregnancy or shortly before. Researchers tracked rates of miscarriage, stillbirth, and birth defects to better understand the drug's safety d…

This study did not test a new treatment. Instead, researchers looked at the medical records of over 6,000 prostate cancer patients who received a drug called 177Lu-PSMA-617. They wanted to understand who got the drug, what treatments they had before, and how long they lived. The …

This study looked at over 2,600 women in Germany with a common type of advanced breast cancer (HR+/HER2-). Researchers observed how long the cancer stayed under control when women received one of three first treatments: a combination of ribociclib plus hormone therapy, hormone th…

This study was done in India to learn more about a gene change called PIK3CA in people with a specific type of advanced breast cancer (HR-positive, HER2-negative). It also looked at how well the drug alpelisib worked for those with the gene change. About 595 people took part, but…

This study interviewed 28 adults who had sepsis-associated acute kidney injury to learn about their symptoms, daily impacts, and challenges with treatment. Researchers conducted 60-minute interviews to map the patient experience. The goal was to better understand what patients go…

This study looked at how well two cholesterol-lowering drugs, inclisiran and PCSK9 mAbs, work in real life for Chinese adults with high cholesterol. Researchers analyzed health records from nearly 12,000 patients across three databases. The goal was to see how much these drugs lo…

This study analyzed insurance claims from over 4,000 people with spinal muscular atrophy to see how three approved drugs (Zolgensma, Spinraza, and Evrysdi) are actually used in practice and what they cost. Researchers looked at dosing patterns, yearly costs, and overall healthcar…

This study examined over 1,200 men with advanced prostate cancer who received a radioactive drug called Lutetium-177. Researchers wanted to see what types of patients get this treatment, how many doses they receive, and how their PSA levels change. The goal was to understand how …

This study examined how the drug omalizumab is prescribed to adults with chronic urticaria (long-term hives) in China. Researchers analyzed electronic health records from 3,485 patients to see which doses were most common. The goal was to understand real-world treatment patterns,…

This study followed over 2,300 adults with moderate to severe plaque psoriasis to see how safe and effective the drug secukinumab is in everyday use. Researchers recorded side effects and how well the treatment cleared skin symptoms. The goal was to gather real-world evidence, no…

This study looked back at the medical records of 355 people in Turkey with myelofibrosis, a type of blood cancer, who were treated with the drug ruxolitinib for at least 3 months. Researchers collected information on patient characteristics, treatment patterns, and side effects t…

This study examined how CDK4/6 inhibitors, a type of targeted therapy, are actually used in hospitals across Portugal for advanced or metastatic breast cancer. Researchers looked at data from 16 public hospitals involving nearly 2,000 patients to understand treatment patterns, ho…

This study surveyed 335 healthcare professionals and MS patients/caregivers in Europe to see if they understood the safety steps for using Mayzent (siponimod). Participants answered questions about proper use, side effects, and risks. The goal was to measure knowledge and identif…

This study looked at blood and urine samples from 236 Japanese adults with chronic heart failure and reduced pumping ability. Researchers measured how certain biomarkers, like BNP, changed during treatment with sacubitril valsartan or enalapril. The goal was to better understand …

This study looked at how the body processes the drug remibrutinib in people with severe kidney disease compared to healthy people. Researchers measured drug levels in blood and urine to see if kidney problems change how the drug is handled. The goal is to help doctors decide the …

This study analyzed insurance claims from over 2,500 people with chronic myeloid leukemia (CML) to see how often side effects from tyrosine kinase inhibitors (TKIs) occur and how they lead to treatment changes or increased healthcare costs. The researchers looked at medical recor…

This study analyzed medical records of 213 children with spinal muscular atrophy (SMA) in the Czech and Slovak Republics to see how treatments are actually used in everyday practice. Researchers tracked motor skills, breathing, feeding, and other health measures over time. The go…

This study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis for 2 years to see how long they stayed on secukinumab treatment and how their quality of life changed. Researchers co…