Novartis Pharmaceuticals

This study tested a drug called canakinumab to see if it could help control the symptoms of Adult-Onset Still's Disease (AOSD), a rare inflammatory condition. Fourteen Japanese patients received a subcutaneous injection every four weeks for at least 48 weeks. The main goal was to…

This study tested whether the drug eltrombopag could help Chinese adults with severe aplastic anemia, a serious blood disorder, when other treatments had failed. Twenty participants took the drug daily for up to a year, with doctors checking if their blood cell counts improved. T…

This study tested whether regular eye injections of a medication called brolucizumab could work as well as or better than standard laser treatment for people with proliferative diabetic retinopathy, a serious eye complication of diabetes that can cause vision loss. Nearly 700 par…

This study tested whether a lower starting dose of the drug ribociclib (400 mg) works as well as the standard dose (600 mg) when combined with hormone therapy for advanced breast cancer. It involved 376 women whose cancer had spread or returned and who hadn't received prior treat…

This study tested if adding a medication called secukinumab to a standard steroid taper helps people with newly diagnosed giant cell arteritis stay in remission longer. It involved 151 adults whose disease symptoms were under control. The goal was to see if the drug could delay o…

This study tested whether adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder, could safely switch from their standard injection treatment to a new oral medication called iptacopan. Fifty-two patients who were already doing well on their current treatment…

This study tested two different schedules for giving an eye injection called brolucizumab to people with 'wet' age-related macular degeneration (AMD) who were already receiving treatment. The goal was to see if starting with a series of three injections (a 'loading' phase) was be…

This study tested a one-time treatment called tisagenlecleucel, a type of CAR-T cell therapy, in adults whose follicular lymphoma had returned or stopped responding to other treatments. Doctors collected and reprogrammed each patient's own immune cells to better find and attack t…

This study monitored patients with relapsing or progressive multiple sclerosis (MS) who were taking Kesimpta injections for two years. The main goal was to track side effects and see how well the drug worked at preventing relapses and slowing disability. Researchers followed 367 …

This study tested if a personalized schedule for brolucizumab eye injections works as well as a standard schedule for people with a serious eye disease called PCV. The goal was to control the disease and preserve vision while potentially giving patients fewer injections. It invol…

This study tested whether adding an experimental pill called QAW039 to standard asthma medications could help patients whose asthma is not well controlled. Over 12 weeks, researchers measured if the drug improved lung function, reduced daytime symptoms, and decreased the need for…

This study tested whether adding a drug called secukinumab to standard steroid treatment helps people with polymyalgia rheumatica (PMR) who recently had their symptoms return. About 381 adults aged 50+ received either secukinumab or a placebo injection alongside a tapering steroi…

This study tested the safety and effectiveness of two drugs, dabrafenib and trametinib, given together to Chinese patients with advanced non-small cell lung cancer that has a specific genetic change called BRAF V600E. The goal was to see if this combination could shrink tumors an…

This study tested two experimental drugs, VAY736 and CFZ533, in people with active lupus to see if they are safe and can help control the disease. Over 100 participants were randomly assigned to receive either one of the drugs or a placebo for 28 weeks, followed by a period where…

This study tested a new antibody drug called CFZ533 to see if it could prevent organ rejection in kidney transplant patients as well as or better than the standard medication, tacrolimus. It involved 418 adults who had recently received a transplant or were maintaining a transpla…

This study tested whether the drug nilotinib could help control advanced gastrointestinal stromal tumors (GIST) in adults who had not yet received treatment for their metastatic disease. It enrolled 34 patients to take nilotinib daily and measured if their tumors shrank or stoppe…

This study tested the safety and correct dosing of a drug called crizanlizumab in children aged 2 to 18 with sickle cell disease. The goal was to see if the drug, given as a monthly infusion, could safely reduce the frequency of painful vaso-occlusive crises. Researchers studied …

This study followed 127 adults for two years to see how well they stayed on a prescribed drug called secukinumab, which treats several related inflammatory conditions. Researchers tracked whether patients continued treatment and measured changes in their symptoms, pain, and quali…

This study tested a new drug called gevokizumab when added to standard cancer treatments. It involved 167 adults with advanced colorectal, gastroesophageal, or kidney cancer that had spread. The main goals were to find a safe and effective dose and to see if the combination could…

This study tested whether a new daily pill called DFV890 could safely reduce specific markers of inflammation in the blood of people with coronary heart disease. About 24 adults who had a prior heart attack and high inflammation levels took either the drug or a placebo for 12 wee…

This study tested whether a new drug called LRX712, injected directly into the knee joint, could help regrow damaged cartilage in people with mild to moderate knee osteoarthritis. It was a small, early-stage trial involving 45 participants who received either the drug or a placeb…

This study tested if a specific care plan using a newer cholesterol-lowering drug called inclisiran works better than standard care for people recovering from a recent heart attack. About 400 participants, who still had high cholesterol despite taking standard medication, were as…

This study observed 72 patients in Taiwan with lupus nephritis (kidney inflammation from lupus) who were newly prescribed Myfortic. The main goal was to monitor the drug's safety and side effects over 12 months of routine use. Researchers also tracked whether patients' kidney fun…

This study compared two heart failure medicines in people whose heart damage was caused by Chagas disease. It tested if a newer drug (sacubitril/valsartan) was better than a standard one (enalapril) at preventing hospital stays and death from heart problems. The goal was to find …

This study tested whether switching to the drug ofatumumab could better control multiple sclerosis in patients whose current treatments were no longer working effectively. It followed 562 adults with relapsing MS for 96 weeks after they switched from specific older medications. T…

This study tested whether a new oral medication called RHH646 could help regrow cartilage in the knees of people with mild to moderate osteoarthritis. Over 80 participants took the drug or a placebo for one year while researchers used MRI scans to measure changes in knee cartilag…

This study tested how well and how safe the drug ofatumumab was for adults in China with relapsing multiple sclerosis (RMS). All 99 participants received the drug as a monthly injection they could give themselves at home after initial clinic visits. Researchers tracked how often …

This study tested whether adding the drug atrasentan helps control IgA nephropathy, a kidney disease that causes scarring, in patients already taking standard protective medications. Fifty-four adults with the disease tried atrasentan and a placebo in different orders to see whic…

This study looked at how well the drug ribociclib worked in real-world settings for 335 Indian women with advanced breast cancer. Researchers analyzed medical records from 18 hospitals to understand how long the treatment kept the cancer from worsening and what side effects patie…

This study tested the safety of a new drug, NIO752, given as an injection into the spinal fluid for people with progressive supranuclear palsy (PSP), a rare and serious brain disorder. The main goal was to see if the treatment was safe and how the body processes it. About 59 part…

This study tested whether a drug called crizanlizumab could reduce the frequency of painful, prolonged erections (priapism) in men with sickle cell disease. 36 male participants aged 12 and older, who experienced frequent priapism episodes, received the drug by IV infusion for on…

This study continued testing an experimental drug called iscalimab in people with Sjögren's syndrome who had already taken it in a previous trial and seemed to benefit. For about a year, 206 participants received regular injections of one of two doses to closely monitor safety an…

This study tested a new experimental malaria drug called INE963. It involved 52 adults with uncomplicated malaria to see how quickly a single oral dose could clear the malaria parasites from their blood and to check if it was safe. The goal was to find an effective dose for a sim…

This study looked back at medical records to see how safe and effective a drug called eltrombopag was when used with standard therapy in Korean children with severe aplastic anemia. It involved 13 children who were newly diagnosed and followed their progress over 6 months. The go…

This study tested a new injectable drug called inclisiran to see how well it lowers 'bad' cholesterol (LDL-C) in people with high cholesterol who were not taking any other cholesterol medications. It involved 350 adults and directly compared inclisiran's effects to both a placebo…

This study observed 39 patients in Turkey with high-risk melanoma who had surgery to remove their cancer. Doctors then gave them a two-drug combination (dabrafenib and trametinib) to try to prevent the cancer from coming back. The main goal was to see how long patients stayed can…

This study tested if two different versions of the same drug, called ianalumab (VAY736), are equally safe and behave the same way in the body. It involved 48 people with active rheumatoid arthritis who were already on standard treatment. The main goal was to check for side effect…

This large, completed Phase 3 trial tested whether a personalized cell therapy called tisagenlecleucel (a type of CAR-T) works better than standard chemotherapy and stem cell transplant for adults with aggressive B-cell non-Hodgkin lymphoma that returned or didn't respond to init…

This study tested whether an injectable drug called secukinumab could help adults with moderate-to-severe shoulder tendon pain that hadn't improved with standard treatments like physical therapy and pain relievers. Over 24 weeks, researchers compared the drug to a placebo injecti…

This study tested whether adding a drug called eltrombopag to standard treatment could help patients with severe aplastic anemia. It involved 36 East-Asian adults and children who had not received prior treatment for this serious blood disorder. The goal was to see if the combina…

This study looked back at the medical records of 606 people in Russia with secondary progressive multiple sclerosis (SPMS) who were treated with the drug siponimod. The goal was to understand the real-world effects of this treatment on disability progression and relapse rates. Re…

This study aimed to understand and compare the experiences of people with Multiple Sclerosis (MS) who were starting one of two different injectable treatments. It focused on side effects at the injection site, like pain or redness, and how satisfied patients were with the process…

This large, completed Phase 3 trial tested whether the drug iptacopan (LNP023) could help control IgA nephropathy, a serious kidney disease. It involved 518 adults with the condition who were already on standard care. The main goals were to see if the drug could reduce harmful pr…

This study tested if two experimental drugs, DFV890 (a daily pill) and MAS825 (a single injection), could safely reduce specific markers of inflammation in the blood of people with coronary heart disease and a genetic blood condition (CHIP). About 31 adults who had a prior heart …

This study tested an injectable drug called ligelizumab to see if it could better control chronic, unexplained hives in teenagers. It involved 49 adolescents aged 12 to 18 who still had bothersome hives despite taking standard allergy pills. Participants received either a high do…

This study directly compared two cholesterol-lowering medications—Inclisiran (given as two injections) and Bempedoic Acid (taken as a daily pill)—in 402 adults with heart disease who still had high cholesterol despite taking maximum statin therapy. The goal was to see which drug …

This study tested the safety and effectiveness of the drug capmatinib for Indian adults with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called a MET exon 14 skipping mutation. About 50 patients took capmatinib pills twice daily for 24 weeks. Th…

This study tested whether adding the drug ruxolitinib to standard steroid treatment could help children with moderate to severe chronic graft vs host disease (cGvHD). cGvHD is a serious complication where donor immune cells attack the patient's body after a stem cell transplant. …

This study tested if a new combination inhaler (QMF149) worked better than a standard inhaler (MF) for people whose mild asthma was not well controlled. Over 800 adults and teenagers used one of the inhalers daily for 12 weeks. Researchers measured lung function and asthma sympto…

This study checked the safety of crizanlizumab, a medication that helps reduce painful crises in sickle cell disease. It involved 140 Indian patients aged 16 and older who had experienced these painful episodes before. Researchers monitored patients for side effects while they re…

This study checked if a new drug called remibrutinib affects blood pressure in adults with chronic hives that standard allergy pills don't control. For 12 weeks, 144 participants took the drug while wearing a portable blood pressure monitor. The main goal was to see if the drug c…

This study tested a new drug called TIN816 in 20 hospitalized adults with kidney injury caused by a severe bloodstream infection (sepsis). The main goal was to see how the drug moves through the body and to check its safety. Patients in intensive care received either TIN816 or a …

This study tested whether adding an investigational pill called QAW039 to standard asthma treatments could improve lung function and symptoms in people whose asthma was not well-controlled. Over 700 adults and teens took either the new pill or a placebo (dummy pill) for 12 weeks …

This study tested a new drug called VAY736 for adults with autoimmune hepatitis, a condition where the body's immune system attacks the liver. It was for patients whose disease was not fully controlled by standard medications or who couldn't tolerate them. Researchers compared di…

This study monitored the safety and effectiveness of Xolair in adults with chronic sinusitis and nasal polyps who weren't fully helped by standard nasal sprays. It followed 135 Korean patients in their regular doctor's visits for 24 weeks to track any side effects and see if thei…

This study tested a drug called inclisiran in teenagers (ages 12-17) with a rare, severe genetic condition that causes very high cholesterol from birth. The goal was to see if the drug was safe and effective at lowering 'bad' cholesterol (LDL-C) when added to their current standa…

This study looked back at medical records of 1,249 patients with a weakened heart to compare two types of medications. Researchers wanted to see if a newer drug combination (sacubitril/valsartan) worked better than older standard drugs at preventing heart-related deaths and hospi…

This study observed how well an eye injection called brolucizumab worked in everyday medical practice for patients with two common causes of vision loss: 'wet' age-related macular degeneration (AMD) and diabetic macular edema (DME). It followed 572 patients in Germany for up to t…

This study compared the effectiveness and safety of two injectable biologic drugs, secukinumab and ustekinumab, in adults with active psoriatic arthritis. It focused on patients whose symptoms were not adequately controlled by a common first-line biologic treatment. Over 28 weeks…

This study tested whether patients with a specific type of leukemia (CML) who had achieved a very deep remission could safely stop their daily medication, nilotinib. It enrolled 163 adults who had been successfully treated for at least 3 years. The main goal was to see how many p…

This study tested a new intravenous drug called cipargamin for treating severe malaria, a life-threatening disease. It involved 254 adults and children with severe malaria and aimed to find a safe and effective dose. The goal was to develop a new treatment option, especially as r…

This study tested whether patients with a specific type of chronic leukemia could safely stop their daily medication, nilotinib, after it had successfully controlled their disease for a long time. It involved 215 adults whose cancer was in a stable phase and who had achieved a ve…

This study followed 109 patients with advanced non-small cell lung cancer who had a specific genetic change (MET exon 14 skipping). After the drug Tabrecta was approved, researchers tracked everyone who took it for up to one year. The main goals were to monitor side effects, see …

This study aimed to understand how the experimental drug ianalumab works in people with Sjögren's syndrome, an autoimmune disease that causes severe dryness. Researchers gave the drug to 21 patients and took small saliva gland samples to see how it affected immune cells. The main…

This study tested whether people with relapsing multiple sclerosis could safely switch from receiving intravenous (IV) antibody treatments every 6 months to monthly self-injections of ofatumumab. The research followed 111 participants for 12 months to see if the new treatment mai…

This study tested if a medication called secukinumab, given as an injection, could help control symptoms of active inflammatory back arthritis (non-radiographic axial spondyloarthritis) in Chinese adults. For the first 16 weeks, some participants received the drug and others rece…

This was the first study in humans to test a new experimental drug called QCZ484, which is being developed to help control high blood pressure. Researchers gave single injections to 56 healthy volunteers and people with mild hypertension to check if it was safe and to see how the…

This study followed children with juvenile psoriatic arthritis or enthesitis-related arthritis for up to four years to see how well and how safely a medication called secukinumab worked over the long term. The 55 participants had already completed a previous study and chose to co…

This study looked back at whether a specialized clinic for heart failure medication worked better than standard care. Researchers compared 342 patients who went to a clinic focused on giving the right heart medicines to similar patients who got usual care. They checked if patient…

This study looked at the safety and real-world effectiveness of an injectable medication called Xolair (omalizumab) for Chinese teenagers with chronic spontaneous urticaria (CSU), a condition causing persistent, itchy hives. It involved 55 adolescents whose hives were not adequat…

This study tested a new injectable drug called XXB750 for people with resistant high blood pressure, meaning their blood pressure stays high despite taking three or more standard pills. Over 20 weeks, researchers compared different doses of XXB750 to a placebo (a dummy injection)…

This study tested the safety and effectiveness of the drug fingolimod (Gilenya) in Chinese adults and teens with relapsing multiple sclerosis (RMS). About 100 participants took the daily pill for two years while doctors tracked their relapses and side effects. The goal was to see…

This study tested whether starting a monthly injection called ofatumumab right after an MS diagnosis could help control the disease. It involved 119 adults newly diagnosed with relapsing-remitting MS and 61 healthy people for comparison. Researchers tracked participants for 18 mo…

This study monitored the safety of sacubitril/valsartan, a heart failure medication, in 8 Japanese children who had completed a previous trial. It allowed these children to continue receiving the medication while researchers tracked any side effects. The goal was to provide conti…

This study tested whether a new malaria drug called KLU156 works as well as the current standard treatment, Coartem. It involved 1720 adults and children with uncomplicated malaria. The goal was to see if taking KLU156 once daily for three days clears the infection safely and eff…

This study checked the safety of a two-drug combination (alpelisib and fulvestrant) for people in India with advanced breast cancer that has a specific genetic change (PIK3CA mutation) and has worsened after hormone therapy. It involved 40 men and post-menopausal women. The main …

This study tested whether adding the drug ribociclib to standard hormone therapy helps control advanced breast cancer longer in Chinese women. It involved 327 premenopausal and postmenopausal women with hormone receptor-positive, HER2-negative breast cancer that had spread or ret…

This study tested whether a single injection of experimental particles called NGI226 could help heal painful Achilles tendons. Researchers compared the injection to a placebo in 45 people with chronic tendon pain that hadn't improved with standard treatments. The main goals were …

This study looked at how well the multiple sclerosis drug ofatumumab (brand name Kesimpta) worked for 310 patients in regular Spanish clinics. It aimed to see if the drug effectively reduced relapses and was safe when used outside of controlled trials. Researchers collected infor…

This study observed 42 children and teenagers in China with moderate to severe plaque psoriasis who were prescribed the medication Cosentyx. It aimed to collect real-world safety information and see how well the drug worked to clear or nearly clear their skin over one year. The s…

This study tested a pill called asciminib for adults with chronic-phase chronic myeloid leukemia (CML) who had already tried at least two other standard treatments and either didn't respond well or couldn't tolerate them. The main goal was to find the best daily dose and schedule…

This study tested whether a monthly injection called erenumab could safely reduce the number of migraine days for adults with chronic migraine. Over 550 participants were randomly assigned to receive either the real injection or a placebo shot for 12 weeks. The main goal was to s…

This study tested a new drug called inclisiran to see if it could safely lower 'bad' cholesterol (LDL-C) in Chinese adults. The 207 participants had elevated cholesterol but a low-to-moderate risk for heart disease and were not taking other cholesterol medications. For the first …

This study tested whether adding a new drug called asciminib to the standard treatment imatinib could help patients with chronic myeloid leukemia (CML) achieve a deeper level of disease control. It involved 104 adults whose CML was not fully controlled by imatinib alone. Particip…

This study tested whether adding a second blood pressure medication (amlodipine) to an existing drug (LCZ696) works better than using LCZ696 alone. It involved 718 adults with mild-to-moderate high blood pressure that wasn't fully controlled on just LCZ696. The goal was to see if…

This study tested a new oral medication called asciminib for adults with chronic-phase chronic myeloid leukemia (CML) who had already tried at least two other standard treatments. It specifically included patients with a hard-to-treat genetic mutation (T315I). The main goals were…

This study tested a two-step approach to help people with chronic myeloid leukemia (CML) live without daily medication. First, it tried reducing the dose of their standard drug (nilotinib). If that didn't work, it tested adding a new drug (asciminib) to try again. The goal was to…

This study tested whether a new two-drug combination (Cipargamin + KLU156) works as well as the standard malaria treatment (Coartem). It involved 60 adolescents and adults with uncomplicated malaria. Researchers measured how quickly and completely the drugs cleared the malaria pa…

This study compared a monthly self-injected medication called ofatumumab against standard first-line MS therapies in people newly diagnosed with relapsing multiple sclerosis. The goal was to see which treatment was better at keeping the disease quiet—preventing relapses, stopping…

This study tested if an injectable drug called secukinumab could help control giant cell arteritis, a serious inflammatory disease of blood vessels. It involved 355 patients and compared the drug against a placebo, with both groups also taking a tapering course of steroids. The m…

This study tested a single-dose gene therapy called OAV101 in children and teens (ages 2 to 18) with spinal muscular atrophy (SMA) type 2. The goal was to see if the treatment could safely improve muscle movement and function. It was a large, late-stage trial where some participa…

This study tested a drug called inclisiran in teenagers with a genetic condition that causes very high cholesterol. For the first year, some participants received the drug and others received a placebo, while all continued their standard cholesterol medications. The main goal was…

This study observed 134 adults in Italy with active secondary progressive multiple sclerosis (MS) who were newly starting the drug Mayzent (siponimod) as part of their regular care. Over three years, researchers tracked whether the drug helped slow the worsening of physical and m…

This study observed how well new cholesterol-lowering treatments work in everyday medical practice. It followed 1,871 adults with high cholesterol who were starting either a new pill, a new injectable drug called inclisiran, or inclisiran alongside a blood-filtering procedure. Th…

This study tested a single spinal injection of a gene therapy called OAV101 in children and teens (ages 2 to 18) with spinal muscular atrophy (SMA) who had previously stopped other SMA treatments. The main goal was to see if the one-time treatment was safe and well-tolerated. Res…

This study tested whether adding the drug alpelisib to standard hormone therapy could help control advanced breast cancer that had a specific genetic change (PIK3CA mutation) and had worsened despite prior treatments. It involved 383 men and women whose cancer was hormone-recepto…

This early-stage study tested the safety and side effects of a new drug called XXB750 for people with chronic heart failure. It involved 27 participants who received either the drug or a placebo via injection. The main goal was to see how well the drug was tolerated and how it mo…

This study tested a new type of PET scan designed to find and pinpoint prostate cancer tumors more accurately. It involved 195 men with newly diagnosed, high-risk prostate cancer who were scheduled for surgery. Researchers compared the scan results directly to tissue samples from…

This study tested a new type of PET/CT scan to see if it could better detect neuroendocrine tumors compared to standard imaging. It involved 71 people in Japan, including patients with confirmed or suspected tumors and healthy volunteers. The main goal was to see how accurate the…

This study tested a new type of PET scan, using a tracer called [18F]CTT1057, to see how well it could find and locate returning prostate cancer in men whose PSA levels were rising after initial surgery or radiation. About 190 men participated, each receiving the new scan and a s…

This study tested whether adding an injectable medication called omalizumab could help people with severe Japanese cedar pollen allergies who still suffer despite using standard allergy medicines like nasal sprays and antihistamines. The 12-week trial involved 337 adults and adol…

This study tested an experimental oral medicine called DFV890 to see if it could safely reduce pain and inflammation in people with painful knee osteoarthritis. About 115 participants, aged 50-80, took either the medicine or a placebo pill for 12 weeks. Researchers measured chang…

This study tested whether monthly injections of a drug called canakinumab could reduce the daily pain and inflammation experienced by children and young adults with sickle cell anemia. For 24 weeks, 49 participants aged 8-20 received either the drug or a placebo (dummy shot) to s…

This study looked at the safety and effectiveness of the drug Xolair in teenagers with severe seasonal allergies that weren't controlled by standard allergy medicines. It involved 50 participants aged 12 to 18 and observed them for up to 24 weeks. The main goal was to see what si…

This study looked back at how doctors in Portugal actually prescribed and adjusted specific breast cancer medications in real hospital settings. Researchers analyzed drug use data from 16 public hospitals between 2018 and 2023 to understand treatment patterns, how long patients s…

This study aimed to understand how well the available treatments work for children with spinal muscular atrophy (SMA) in everyday life, not just in clinical trials. Researchers looked back at the medical records of 213 children in the Czech and Slovak Republics to see their treat…

This study aimed to estimate how many adults in the United States might be eligible for a cholesterol-lowering drug called inclisiran. Researchers used national survey data to model the potential number of heart attacks, strokes, and other cardiovascular events that could be prev…

This early-stage study aimed to understand how a new drug called remibrutinib is processed by the body in people with severe kidney impairment. It involved 16 participants—half with poor kidney function and half healthy—to measure drug levels in their blood and urine. The goal wa…

This observational study followed 2,424 Russian women with advanced breast cancer to understand how different treatments work in real-world settings. Researchers tracked patients already receiving standard medications like ribociclib, alpelisib, hormone therapy, or chemotherapy a…

This study looked at how well German heart failure clinics followed established treatment guidelines for patients with weakened heart muscles after a serious health episode. Researchers collected data from 899 patients across different types of clinics to compare care quality. Th…

This study looked back at the health records of nearly 12,000 adults in China with high cholesterol. Researchers wanted to see how well two newer types of injectable cholesterol medicines worked for people in everyday life, outside of a controlled trial. They compared the effecti…

This study looked back at the medical records of 355 people in Turkey who were treated for myelofibrosis, a type of bone marrow cancer. The goal was to understand the real-world use of the drug ruxolitinib, including patient characteristics, treatment patterns, and side effects. …

This study followed 2,376 adults with moderate-to-severe plaque psoriasis for 5 years to understand how different treatments work in real-world settings. Researchers compared the safety and effectiveness of the drug secukinumab against other approved therapies like biologics, pil…

This study analyzed Medicare claims data from 2,298 patients with chronic myeloid leukemia (CML) to understand how treatments work in real-world settings. Researchers examined treatment patterns, medication adherence, healthcare costs, and outcomes for patients receiving differen…

This study looked at how side effects from common CML drugs affect patients' treatment plans and healthcare costs. Researchers analyzed insurance claims data from over 2,500 adult patients taking these medications. The goal was to understand how often side effects lead to treatme…

This study looked back at medical records to understand how doctors in Japan treat chronic myeloid leukemia (CML) with targeted drugs called TKIs. It followed 754 patients to see which drugs they used, how often they switched or stopped treatment, and what the associated healthca…

This study was a survey to see if doctors, nurses, and patients with multiple sclerosis (MS) received and understood important safety information about the drug Mayzent. It involved 335 healthcare professionals and patients/caregivers in several European countries and Canada. The…

This study looked back at health records to understand how a newer prostate cancer drug, 177Lu-PSMA-617, was used in real-world practice. Researchers analyzed data from 6,448 patients to see who received the drug, how long they lived, and how their cancer markers changed. The goa…

This study interviewed 28 people who experienced sepsis-related kidney injury and their caregivers to learn about their experiences. Researchers conducted hour-long interviews to understand symptoms, treatment challenges, and how the condition affects daily life. The goal is to g…

This study observed over 2,600 women in Germany with advanced breast cancer to compare how different first-line treatments work in real-world settings. Researchers tracked patients receiving either a combination drug (ribociclib plus hormone therapy), hormone therapy alone, or ch…

This study analyzed French national hospital records from 2015-2022 to understand how common PIK3CA-Related Overgrowth Spectrum (PROS) disorders are in France. Researchers examined data from over 3,600 patients to learn how often these genetic conditions occur, how they're manage…

This study aimed to understand how three different treatments for spinal muscular atrophy (SMA) are actually used in the real world and what they cost the healthcare system. Researchers analyzed anonymous insurance claims data from over 4,100 patients who received one of the trea…

This study observed how a targeted radiation drug was used to treat men with advanced prostate cancer in real-world medical settings. It followed 1,247 patients to understand their characteristics, how they were treated, and their outcomes. The goal was to gather knowledge about …

This study looked back at the medical records of nearly 1,500 adults with a type of chronic leukemia to understand how they were treated in everyday cancer clinics. Researchers analyzed which medications were used, how patients responded, what side effects occurred, and how long …

This study observed how well a specific drug combination (alpelisib plus fulvestrant) worked for Indian patients with a certain type of advanced breast cancer that has a specific genetic mutation (PIK3CA). It also aimed to find out how common this mutation is among Indian patient…

This study aimed to understand how the body processes a drug called secukinumab when given through an IV (intravenous) line, and to check its safety. It involved 65 adults with either giant cell arteritis (GCA) or polymyalgia rheumatica (PMR), two painful inflammatory conditions.…

This completed study looked at how people in Australia with relapsing multiple sclerosis (MS) used a treatment called Kesimpta (ofatumumab) in their daily lives. It tracked if patients took their doses on time and explored how the treatment affected their fatigue, work productivi…

This study looked back at the real-world experiences of 4,805 people with spinal muscular atrophy (SMA) who received one or more of three modern drug treatments. It aimed to understand how often patients needed hospital care or special medical equipment before and after starting …

This study aimed to understand how liver problems affect how the body processes a single dose of an experimental lung cancer drug called JDQ443. It compared 33 people with varying levels of liver impairment to healthy individuals, measuring drug levels in the blood over several d…

This study aimed to monitor the safety of the drug LUTATHERA after it was approved for use. It observed 347 patients with a specific type of neuroendocrine tumor who received the drug in real-world medical settings. The main goal was to track the occurrence of certain serious sid…