Drug cocktail slashes melanoma recurrence risk in High-Risk patients

NCT ID NCT01682083

First seen Apr 24, 2026 · Last updated May 09, 2026 · Updated 3 times

Summary

This study tested whether a combination of two targeted drugs (dabrafenib and trametinib) could keep melanoma from coming back after surgery in people with high-risk, BRAF-mutated skin cancer. About 870 patients took either the drug combo or placebos for 12 months. The main goal was to see if the treatment lengthened the time before the cancer returned or death occurred. Results showed the drug combo significantly reduced the risk of recurrence compared to placebo.

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Contacts and locations

Locations

  • Novartis Investigative Site

    Birmingham, Alabama, 35243, United States

  • Novartis Investigative Site

    Tucson, Arizona, 85724, United States

  • Novartis Investigative Site

    San Francisco, California, 94115, United States

  • Novartis Investigative Site

    San Francisco, California, 94143, United States

  • Novartis Investigative Site

    Aurora, Colorado, 80045, United States

  • Novartis Investigative Site

    Lake Worth, Florida, 33461, United States

  • Novartis Investigative Site

    Orlando, Florida, 32806, United States

  • Novartis Investigative Site

    Tampa, Florida, 33612, United States

  • Novartis Investigative Site

    Atlanta, Georgia, 30322, United States

  • Novartis Investigative Site

    Atlanta, Georgia, 30341, United States

  • Novartis Investigative Site

    Lutherville-Timonium, Maryland, 21093, United States

  • Novartis Investigative Site

    Boston, Massachusetts, 02114, United States

  • Novartis Investigative Site

    Boston, Massachusetts, 02115, United States

  • Novartis Investigative Site

    Ann Arbor, Michigan, 48019, United States

  • Novartis Investigative Site

    Winston-Salem, North Carolina, 27157, United States

  • Novartis Investigative Site

    Columbus, Ohio, 43210, United States

  • Novartis Investigative Site

    Portland, Oregon, 97123, United States

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    Pittsburgh, Pennsylvania, 15232, United States

  • Novartis Investigative Site

    Nashville, Tennessee, 37203, United States

  • Novartis Investigative Site

    Dallas, Texas, 75390, United States

  • Novartis Investigative Site

    Capital Federal, Buenos Aires, C1426ANZ, Argentina

  • Novartis Investigative Site

    Buenos Aires, C1125ABD, Argentina

  • Novartis Investigative Site

    Gateshead, New South Wales, 2290, Australia

  • Novartis Investigative Site

    North Sydney, New South Wales, 2060, Australia

  • Novartis Investigative Site

    Tweed Heads, New South Wales, 2485, Australia

  • Novartis Investigative Site

    Westmead, New South Wales, 2145, Australia

  • Novartis Investigative Site

    Greenslopes, Queensland, 4120, Australia

  • Novartis Investigative Site

    Woolloongabba, Queensland, 4102, Australia

  • Novartis Investigative Site

    Adelaide, South Australia, 5000, Australia

  • Novartis Investigative Site

    Box Hill, Victoria, 3128, Australia

  • Novartis Investigative Site

    Heidelberg, Victoria, 3084, Australia

  • Novartis Investigative Site

    Melbourne, Victoria, 3004, Australia

  • Novartis Investigative Site

    Nedlands, Western Australia, 6009, Australia

  • Novartis Investigative Site

    Graz, 8036, Austria

  • Novartis Investigative Site

    Linz, A-4010, Austria

  • Novartis Investigative Site

    Salzburg, A-5020, Austria

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    Vienna, 1090, Austria

  • Novartis Investigative Site

    Wels, A-4600, Austria

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    Brussels, 1200, Belgium

  • Novartis Investigative Site

    Leuven, 3000, Belgium

  • Novartis Investigative Site

    Liège, 4000, Belgium

  • Novartis Investigative Site

    Wilrijk, 2610, Belgium

  • Novartis Investigative Site

    Curitiba, Paraná, 81520-060, Brazil

  • Novartis Investigative Site

    Ijuí, Rio Grande do Sul, 98700, Brazil

  • Novartis Investigative Site

    Edmonton, Alberta, T6G 1Z2, Canada

  • Novartis Investigative Site

    Hamilton, Ontario, L8V 5C2, Canada

  • Novartis Investigative Site

    Oshawa, Ontario, L1G 2B9, Canada

  • Novartis Investigative Site

    Ottawa, Ontario, K1H 8L6, Canada

  • Novartis Investigative Site

    Toronto, Ontario, M5G 2M9, Canada

  • Novartis Investigative Site

    Québec, Quebec, G1J 1Z4, Canada

  • Novartis Investigative Site

    Brno, 656 53, Czechia

  • Novartis Investigative Site

    Prague, 100 34, Czechia

  • Novartis Investigative Site

    Prague, 128 08, Czechia

  • Novartis Investigative Site

    Zlín, 76275, Czechia

  • Novartis Investigative Site

    Arhus C, 8000, Denmark

  • Novartis Investigative Site

    Herlev, 2730, Denmark

  • Novartis Investigative Site

    Odense, 5000 C, Denmark

  • Novartis Investigative Site

    Bordeaux, 33075, France

  • Novartis Investigative Site

    Boulogne-Billancourt, 92100, France

  • Novartis Investigative Site

    Brest, 29609, France

  • Novartis Investigative Site

    Dijon, 21079, France

  • Novartis Investigative Site

    Grenoble, 38043, France

  • Novartis Investigative Site

    Lille, 59037, France

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    Marseille, 13385, France

  • Novartis Investigative Site

    Montpellier, 34295, France

  • Novartis Investigative Site

    Nice, 06202, France

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    Paris, 75014, France

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    Paris, 75475, France

  • Novartis Investigative Site

    Pierre-Bénite, 69495, France

  • Novartis Investigative Site

    Reims, 51092, France

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    Rennes, 35042, France

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    Toulouse, 31059, France

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    Tours, 37044, France

  • Novartis Investigative Site

    Villejuif, 94805, France

  • Novartis Investigative Site

    Freiburg im Breisgau, Baden-Wurttemberg, 79104, Germany

  • Novartis Investigative Site

    Heilbronn, Baden-Wurttemberg, 74078, Germany

  • Novartis Investigative Site

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Novartis Investigative Site

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Novartis Investigative Site

    Ulm, Baden-Wurttemberg, 89081, Germany

  • Novartis Investigative Site

    Munich, Bavaria, 80337, Germany

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    Nuremberg, Bavaria, 90419, Germany

  • Novartis Investigative Site

    Regensburg, Bavaria, 93053, Germany

  • Novartis Investigative Site

    Würzburg, Bavaria, 97080, Germany

  • Novartis Investigative Site

    Darmstadt, Hesse, 64297, Germany

  • Novartis Investigative Site

    Marburg, Hesse, 35033, Germany

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    Wiesbaden, Hesse, 65199, Germany

  • Novartis Investigative Site

    Hanover, Lower Saxony, 30625, Germany

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    Schwerin, Mecklenburg-Vorpommern, 19049, Germany

  • Novartis Investigative Site

    Bochum, North Rhine-Westphalia, 44791, Germany

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    Cologne, North Rhine-Westphalia, 50937, Germany

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    Essen, North Rhine-Westphalia, 45147, Germany

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    Mainz, Rhineland-Palatinate, 55131, Germany

  • Novartis Investigative Site

    Magdeburg, Saxony-Anhalt, 39120, Germany

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    Kiel, Schleswig-Holstein, 24105, Germany

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    Lübeck, Schleswig-Holstein, 23538, Germany

  • Novartis Investigative Site

    Erfurt, Thuringia, 99089, Germany

  • Novartis Investigative Site

    Gera, Thuringia, 07548, Germany

  • Novartis Investigative Site

    Berlin, 10249, Germany

  • Novartis Investigative Site

    Athens, 11527, Greece

  • Novartis Investigative Site

    Thessaloniki, 54622, Greece

  • Novartis Investigative Site

    Thessaloniki, 56429, Greece

  • Novartis Investigative Site

    Ramat Gan, 52621, Israel

  • Novartis Investigative Site

    Rome, Lazio, 00167, Italy

  • Novartis Investigative Site

    Genoa, Liguria, 16132, Italy

  • Novartis Investigative Site

    Bergamo, Lombardy, 24127, Italy

  • Novartis Investigative Site

    Milan, Lombardy, 20133, Italy

  • Novartis Investigative Site

    Milan, Lombardy, 20141, Italy

  • Novartis Investigative Site

    Candiolo, Piedmont, 10060, Italy

  • Novartis Investigative Site

    Pisa, Tuscany, 56126, Italy

  • Novartis Investigative Site

    Padova, Veneto, 35128, Italy

  • Novartis Investigative Site

    Shizuoka, 411-8777, Japan

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    Tokyo, 104-0045, Japan

  • Novartis Investigative Site

    Amsterdam, 1066 CX, Netherlands

  • Novartis Investigative Site

    Amsterdam, 1081 HV, Netherlands

  • Novartis Investigative Site

    Groningen, 9713 GZ, Netherlands

  • Novartis Investigative Site

    Leeuwarden, 8934 AD, Netherlands

  • Novartis Investigative Site

    Maastricht, 6229 HX, Netherlands

  • Novartis Investigative Site

    Nijmegen, 6525 GA, Netherlands

  • Novartis Investigative Site

    Rotterdam, 3015 GD, Netherlands

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    Auckland, 0622, New Zealand

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    Ålesund, 6026, Norway

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    Oslo, 0310, Norway

  • Novartis Investigative Site

    Gdansk, 80-215, Poland

  • Novartis Investigative Site

    Konin, 62-500, Poland

  • Novartis Investigative Site

    Poznan, 60-693, Poland

  • Novartis Investigative Site

    Warsaw, 02-781, Poland

  • Novartis Investigative Site

    Chelyabinsk, 454087, Russia

  • Novartis Investigative Site

    Moscow, 115478, Russia

  • Novartis Investigative Site

    Moscow, 143423, Russia

  • Novartis Investigative Site

    Ryazan, 390011, Russia

  • Novartis Investigative Site

    Saint Petersburg, 191014, Russia

  • Novartis Investigative Site

    Saint Petersburg, 197758, Russia

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    Saint Petersburg, 198255, Russia

  • Novartis Investigative Site

    Volgograd, 400138, Russia

  • Novartis Investigative Site

    Badalona, 08916, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Barcelona, 08036, Spain

  • Novartis Investigative Site

    Donostia / San Sebastian, 20014, Spain

  • Novartis Investigative Site

    Las Palmas de Gran Canaria, 35016, Spain

  • Novartis Investigative Site

    Madrid, 28034, Spain

  • Novartis Investigative Site

    Madrid, 28041, Spain

  • Novartis Investigative Site

    Madrid, 28046, Spain

  • Novartis Investigative Site

    Palma de Mallorca, 07198, Spain

  • Novartis Investigative Site

    Pamplona, 31008, Spain

  • Novartis Investigative Site

    Santander, 39008, Spain

  • Novartis Investigative Site

    Valencia, 46014, Spain

  • Novartis Investigative Site

    Gothenburg, SE-413 45, Sweden

  • Novartis Investigative Site

    Lund, SE-221 85, Sweden

  • Novartis Investigative Site

    Stockholm, SE-171 76, Sweden

  • Novartis Investigative Site

    Uppsala, SE-751 85, Sweden

  • Novartis Investigative Site

    Basel, 4031, Switzerland

  • Novartis Investigative Site

    Chur, 7000, Switzerland

  • Novartis Investigative Site

    Zurich, 8091, Switzerland

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    Taoyuan, 33305, Taiwan

  • Novartis Investigative Site

    Northwood, Middlesex, HA6 2RN, United Kingdom

  • Novartis Investigative Site

    Exeter, EX2 5DW, United Kingdom

  • Novartis Investigative Site

    Glasgow, G12 0YN, United Kingdom

  • Novartis Investigative Site

    Guildford, GU2 7XX, United Kingdom

  • Novartis Investigative Site

    Leeds, LS9 7TF, United Kingdom

  • Novartis Investigative Site

    London, NW3 2QG, United Kingdom

  • Novartis Investigative Site

    London, SW3 6JJ, United Kingdom

  • Novartis Investigative Site

    London, W1G 6AD, United Kingdom

  • Novartis Investigative Site

    Manchester, M20 4BX, United Kingdom

  • Novartis Investigative Site

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Novartis Investigative Site

    Norwich, NR4 7UY, United Kingdom

  • Novartis Investigative Site

    Preston, PR2 9HT, United Kingdom

  • Novartis Investigative Site

    Southampton, SO16 6YD, United Kingdom

Conditions

Explore the condition pages connected to this study.