Novartis Pharmaceuticals

This study allows participants who benefited from remibrutinib in previous Novartis trials to continue taking the medication for up to three years. It aims to collect long-term safety data on the drug. The study is open to people with skin or allergy conditions who cannot access …

This study will observe how well the drug asciminib works and how safe it is for people in China newly diagnosed with a type of blood cancer called chronic myeloid leukemia. It will follow 200 patients in a real-world setting, not a tightly controlled clinical trial, to see how t…

This early-stage study aims to check if a new drug called HJB647 is safe for people with chronic heart failure. About 12 participants will receive either the drug or a placebo for three days while doctors monitor for side effects. The main goal is to understand how the body proce…

This study aims to understand the best long-term treatment plans for children and teenagers with two specific types of juvenile arthritis (ERA and JPsA) who are taking the medication secukinumab. Researchers will use existing German patient registry data to track 100 young patien…

This study is testing a drug called asciminib in children and teenagers (ages 1 to under 18) with a specific type of chronic blood cancer called Philadelphia-positive chronic myeloid leukemia (CML). The goal is to see if the drug is safe and effective for kids, including those ne…

This study aims to gather real-world evidence on the safety and effectiveness of a one-time spinal injection gene therapy (ITVISMA®) for people with Spinal Muscular Atrophy (SMA). It will follow 36 U.S. participants, aged 2 and older, for at least a year after their treatment to …

This small, early-stage study aims to check if adding a new drug called pelabresib to a standard medication (ruxolitinib) is safe for Japanese adults with myelofibrosis, a rare and serious bone marrow cancer. It will involve about 6 participants who are already taking a stable do…

This study aims to see how well the drug iptacopan works for people with paroxysmal nocturnal hemoglobinuria (PNH) in everyday Italian clinics. It will follow about 50 adult patients for up to two years to see if the treatment helps raise their hemoglobin levels and allows them t…

This study is testing whether adding a new drug called pelabresib to the standard treatment (ruxolitinib) works better for adults with myelofibrosis, a serious bone marrow cancer. It will enroll 460 patients who have not yet tried JAK inhibitor drugs. The main goals are to see if…

This study is testing a medication called secukinumab to see how well it works and how safe it is for Chinese adults with moderate-to-severe hidradenitis suppurativa (HS), a painful skin condition. It will follow 36 participants for about one year, comparing two different dosing …

This study aims to monitor the safety and effectiveness of the drug Iptacopan (Fabhalta®) in real-world medical settings in Korea. It will follow about 21 adult patients who have been diagnosed with either Paroxysmal Nocturnal Hemoglobinuria (PNH, a rare blood disease) or C3 Glom…

This study aims to see if a new once-daily inhaler containing three medicines (QVM149) works better and is as safe as a common twice-daily inhaler for controlling asthma in teenagers. It will involve about 304 participants aged 12 to 18 whose asthma is not fully controlled on the…

This study is testing whether adding a new drug called ianalumab to standard platelet-boosting medications is safe and tolerable for adults with primary immune thrombocytopenia (ITP). Researchers want to see if this combination helps improve platelet counts and allows patients to…

This study is testing whether an investigational drug called zigakibart can slow the progression of IgA nephropathy, a kidney disease. It will involve 32 adults who will receive the drug for two years while researchers check their kidney tissue and function. The main goal is to s…

This study is testing a new combination of drugs for children and young adults (ages 1-30) whose acute lymphoblastic leukemia (ALL) has come back or hasn't responded to other treatments. The goal is to see if adding a new targeted drug (asciminib) to a lower-dose chemotherapy and…

This early-stage study aims to understand how a drug called pelabresib is processed in the body of people with advanced cancer who also have liver problems. It will compare drug levels in people with normal liver function to those with moderate or severe liver impairment. The goa…

This study aims to understand how a specific treatment for metastatic prostate cancer is used in real-world medical practice. It will observe about 750 patients who have already received the drug, collecting data on their treatment patterns, side effects, and health outcomes. The…

This early-stage study aims to understand how a new cancer drug called pelabresib interacts with three common medications: a diabetes drug, a sedative, and a birth control pill. Researchers will enroll 24 adults with advanced cancers who have run out of standard treatment options…

This study aims to understand how doctors in China actually prescribe the drug omalizumab for adults with chronic hives (urticaria) in everyday practice. It will review the health records of about 2,500 patients to see what doses are used, how long treatment lasts, and what other…

This study aims to understand if secukinumab, a standard treatment for moderate-to-severe hidradenitis suppurativa (a painful skin condition), has any effect on the progression of plaque in the heart's arteries. It will follow 34 adults who are already at high risk for heart dise…

This study aims to understand how advanced breast cancer is actually treated in China by analyzing the medical records of 14,000 patients. It will look at which drugs are used first, how long treatments last, and what side effects patients experience. The goal is to gather real-w…

This study will observe 83 adults with a rare kidney disease called C3 glomerulopathy (C3G) who are already taking the approved drug iptacopan. Researchers will review patients' medical records from before and after starting the medication to understand who gets treated and how t…

This study looks back at real-world data to see how well patients in Japan with high cholesterol stick to their prescribed injection treatments over one year. It compares two different injectable medications, inclisiran and evolocumab, to see which one patients are more likely to…

This study aims to understand how chronic myeloid leukemia (CML) has been treated in Kuwait over the last ten years. Researchers will look at the medical records of 400 adult patients to see what treatments they received, how other health conditions affected their care, and what …

This study aims to understand if a specific CAR-T cell therapy (tisagenlecleucel) could be linked to patients developing a second, different type of T-cell cancer later on. It will analyze existing tissue and blood samples from about 30 people who received the therapy and were la…