Novartis Pharmaceuticals

This early-phase study aimed to test the safety, side effects, and best dose of an experimental drug called QEQ278 in adults with advanced solid tumors. It enrolled 30 participants with specific advanced cancers (lung, kidney, esophageal, or head/neck) that had progressed despite…

This study aimed to test if a drug called capmatinib, given before and after surgery, could help people with certain types of non-small cell lung cancer that have specific genetic changes. The goal was to see if the drug could shrink tumors before surgery and prevent the cancer f…

This study tested a drug called ensovibep, given as an injection, to treat adults with early COVID-19 symptoms who were not in the hospital. The main goals were to see if the drug could reduce the amount of virus in the body and, more importantly, prevent people from needing to g…

This early-stage study tested a new gene-editing treatment for people with severe sickle cell disease. Doctors collected patients' own blood stem cells, used CRISPR technology to edit a gene to boost protective fetal hemoglobin, and then transplanted the cells back after chemothe…

This early-stage study tested two different drug combinations (TNO155 with either spartalizumab or ribociclib) in adults with advanced solid tumors, including lung, head and neck, and colorectal cancers. The main goal was to find safe doses and understand side effects, not to cur…

This early-stage study tested two different drug combinations for adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS), two serious blood and bone marrow cancers. The main goal was to find safe doses and see how well the combinations were tolerated…

This study tested whether adding an experimental drug called LTP001 to standard treatments could help people with pulmonary arterial hypertension, a serious lung and heart condition. About 47 participants took either LTP001 or a placebo pill daily for 24 weeks while continuing th…

This study tested a new, dissolvable tablet version of a common malaria medicine (artemether-lumefantrine) for the smallest patients: newborns and infants weighing less than 11 pounds. Researchers wanted to see if the right amount of medicine got into babies' bodies, if it was sa…

This study aimed to gather more information about the long-term safety and effectiveness of the experimental drug LTP001 for people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It was designed as a follow-up for 31 people who had completed an ea…

This early-stage study tested a new radioactive cancer treatment called [177Lu]Lu-FF58 in patients with advanced pancreatic, stomach, or brain cancers. The main goal was to find a safe dose and see how the body handles the drug. Researchers also used a special imaging scan to see…

This study tested whether combining two targeted drugs, alpelisib and olaparib, works better than standard chemotherapy for women with a specific type of advanced ovarian cancer that has stopped responding to platinum-based treatments. The trial enrolled 358 women whose cancer ha…

This was an early-stage study to test the safety and find the right dose of a new drug called JBH492. It involved 25 patients whose chronic lymphocytic leukemia or non-Hodgkin's lymphoma had returned or did not respond to previous treatments. The main goal was to see how much of …

This early-stage study aimed to find safe doses for several single drugs and drug combinations in adults with lower-risk myelodysplastic syndrome (MDS), a bone marrow disorder. The trial enrolled 33 participants to test the safety and tolerability of these treatments. It was term…

This study tested whether adding an experimental drug called sabatolimab to standard treatments could help control a serious blood and bone marrow disorder called myelodysplastic syndrome (MDS). It involved 39 adults with intermediate to very high-risk MDS. The trial was terminat…

This was a first-in-human study to test the safety and find the right dose of a new immunotherapy drug called FAZ053. It was given alone and in combination with another drug, PDR001, to 154 adults with advanced solid tumors that had stopped responding to standard treatments. The …

This study tested whether adding an experimental drug called MBG453 to the standard treatment (azacitidine) could help adults with higher-risk forms of myelodysplastic syndromes (MDS) or a related blood cancer (CMML-2). The main goal was to see if the combination helped patients …

This study aimed to see if a drug called ligelizumab is safe and effective for controlling food allergies over three years. It involved 163 people with food allergies who had already completed a previous ligelizumab trial. Researchers tested whether the treatment could help some …

This early-stage study aimed to find a safe dose of a new drug called WVT078, given alone and with another drug called WHG626, for people with advanced multiple myeloma. It involved 56 patients whose cancer had returned or stopped responding to at least two standard treatments. T…

This study tested the safety and effectiveness of an experimental drug called MBG453 when combined with two existing drugs (azacitidine and venetoclax) for adults newly diagnosed with acute myeloid leukemia (AML) who were too frail for standard intensive chemotherapy. It aimed to…

This study aimed to test the safety and find the right dose of a three-drug combination (ribociclib, topotecan, and temozolomide) for children and young adults whose cancers had returned or did not respond to standard treatments. It focused on aggressive cancers like neuroblastom…

This study aimed to confirm if a computer model could accurately predict when a standard drug (hydroxyurea) would stop working for patients with polycythemia vera, a type of blood cancer. It observed 76 adult patients in Germany who were starting the drug for the first time. The …

This study aimed to test the safety and initial effectiveness of a new drug, sabatolimab, when combined with two existing drugs (azacitidine and venetoclax) for adults with high-risk MDS who could not receive intensive chemotherapy or a stem cell transplant. The trial was termina…

This study tested a drug called sabatolimab, alone or with another drug, for people with acute myeloid leukemia (AML). The goal was to see if it could prevent the cancer from coming back in patients who had a small amount of leftover disease after a stem cell transplant. The tria…

This study aimed to test if a new injectable drug called XXB750 could help control heart failure. It was compared against a placebo (dummy treatment) and an existing pill. The trial was stopped early because more patients getting the new drug experienced worsening heart failure, …

This study tested an oral drug called iptacopan in people with two rare autoimmune blood disorders: immune thrombocytopenia (ITP) and cold agglutinin disease (CAD). The goal was to see if the drug could safely help control the diseases by improving patients' platelet or red blood…

This study tested an oral drug called QBW251 to see if it could help adults with bronchiectasis, a chronic lung condition. The goal was to see if the drug could improve lung function, reduce mucus, and lower the amount of harmful bacteria in the lungs. The trial was stopped early…

This was an early safety study for a new drug called DFF332, designed to block a protein that helps certain cancers grow. It was tested alone and in combinations with other cancer drugs in adults with advanced kidney cancer and other tumors driven by specific genetic changes. The…

This study tested an experimental cell therapy called PHE885 for adults with multiple myeloma that has returned or stopped responding to multiple standard treatments. Researchers collected immune cells from participants, genetically modified them to target cancer cells, and reinf…

This large, late-stage trial aimed to see if adding a new immunotherapy drug (spartalizumab) to two existing targeted drugs (dabrafenib and trametinib) could better control advanced melanoma with a specific BRAF gene mutation. It involved 568 previously untreated patients whose c…

This study tested several experimental treatments for idiopathic pulmonary fibrosis (IPF), a serious lung scarring disease. It involved 46 participants who received either a treatment or placebo for 26 weeks while researchers measured lung function and quality of life. The trial …

This study tested two experimental drugs, canakinumab and LNA043, given as injections directly into the knee joint of people with painful knee osteoarthritis. The goal was to see if these drugs could reduce pain, improve function, and potentially protect or even regrow knee carti…

This early-stage study aimed to find a safe dose and schedule for a new two-drug combination (VOB560 and MIK665) for patients whose non-Hodgkin lymphoma, acute myeloid leukemia, or multiple myeloma had returned or stopped responding to other treatments. The drugs were designed to…

This study tested whether adding an experimental drug called MBG453 to standard chemotherapy could better control a serious blood and bone marrow disorder called myelodysplastic syndrome (MDS). It involved 127 adults with intermediate to very high-risk MDS who were not candidates…

This was an early safety study of a new oral drug called MGY825 for adults with advanced non-small cell lung cancer that had spread or could not be removed by surgery. The main goals were to find a safe dose and see how the body processes the drug. The study also looked for early…

This large, late-stage trial tested whether adding an anti-inflammatory drug called canakinumab to standard first-line treatment (chemotherapy plus an immunotherapy drug) could better control advanced non-small cell lung cancer. It involved 673 patients who had not received prior…

This study tested whether adding an experimental drug called siremadlin to two standard leukemia drugs could improve treatment responses for adults with acute myeloid leukemia (AML) who are too frail for intensive chemotherapy. It aimed to find a safe dose and see if the three-dr…

This study aimed to test how a chewable asthma drug called fevipiprant is processed by the body in children aged 6 to 12. It was a short, 8-day trial to find the right dose for kids for future studies. However, the drug's development program was discontinued, so this study was te…

This early-stage study aimed to find safe doses and combinations of drugs for adults with advanced or spreading colorectal cancer that has a specific BRAF V600 genetic change. The trial tested several different drug pairings to see how well patients tolerated them and to gather e…

This study aimed to monitor the real-world safety of the drug alpelisib, combined with fulvestrant, in adults with a specific type of advanced breast cancer that had worsened after prior hormone therapy. It planned to track side effects like high blood sugar and jaw bone problems…

This study aimed to see if anti-inflammatory drugs could help slow cognitive decline in people with early Alzheimer's disease or mild memory problems due to Alzheimer's. It tested one drug in a small group of participants who also showed signs of body-wide inflammation. The trial…

This early-stage study aimed to find a safe dose of the experimental drug VAY736, given alone or with other cancer drugs, for adults with several types of Non-Hodgkin Lymphoma that had returned or stopped responding to standard treatments. The main goal was to check for side effe…

This study tested whether adding one or two new drugs (NIS793 and spartalizumab) to standard chemotherapy could better control advanced pancreatic cancer that had spread. It enrolled 164 adults with newly diagnosed metastatic pancreatic cancer who had not received prior treatment…

This was an early, first-in-human study to test a new radioactive imaging agent called [68Ga]-FF58. The goal was to see if it could safely and effectively highlight specific aggressive cancers (like glioblastoma and pancreatic cancer) during PET scans. The study was terminated ea…

This study tested whether an experimental drug called TIN816 could prevent acute kidney injury in adults undergoing major heart surgery. About 98 patients at risk for kidney problems were randomly assigned to receive either TIN816 or a placebo. The trial was terminated early and …

This study tested whether an injectable drug called secukinumab could reduce pain and improve movement in adults with persistent, painful shoulder tendon problems. It compared the drug against a placebo (dummy) injection, both given alongside standard painkillers and physical the…

This study aimed to understand how satisfied migraine patients were with a treatment called erenumab in real-world settings. Researchers followed 37 adults in the Gulf region who had recently started the treatment, asking them to complete online surveys over 12 weeks. The goal wa…

This study tested an investigational drug called QUC398 to see if it could reduce pain and slow cartilage loss in people with painful knee osteoarthritis. About 101 participants received either the drug or a placebo injection every four weeks for 12 weeks. The main goal was to me…

This study tested whether a drug called secukinumab, given as an injection, could reduce pain and improve movement in adults with persistent, painful shoulder tendon problems. About 60 participants with moderate-to-severe pain that hadn't improved with standard treatments like ph…

This study tested an experimental drug called BLZ945 in people with ALS (amyotrophic lateral sclerosis). The main goal was to see if the drug could safely reduce inflammation from specific brain cells (microglia) and to find the right dose. Researchers used special brain scans (P…