Experimental lung cancer drug MGY825 tested in early trial
NCT ID NCT05275868
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested an investigational drug called MGY825 in 41 adults with advanced non-small cell lung cancer that has specific genetic changes (NFE2L2/KEAP1/CUL3 mutations). The main goal was to check the drug's safety and find the right dose. The study was terminated early, so only limited safety and dosing information is available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MGY825
What this could lead to
If successful, this could point toward a new treatment option for a specific genetic subtype of advanced lung cancer.
What could go wrong
This was a very early, small Phase 1 trial that was terminated, so results are limited. The drug may not prove effective or safe in larger studies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Sloan Kettering
New York, New York, 10017, United States
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Memorial Sloan Kettering Onc. Dept
New York, New York, 10017, United States
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NYU School of Medicine
New York, New York, 10015, United States
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Novartis Investigative Site
Frankfurt am Main, Hesse, 60590, Germany
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Novartis Investigative Site
Cologne, North Rhine-Westphalia, 50937, Germany
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Novartis Investigative Site
Essen, 45147, Germany
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Novartis Investigative Site
Chuo Ku, Tokyo, 104 0045, Japan
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Novartis Investigative Site
Seoul, 03080, South Korea
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Novartis Investigative Site
Madrid, 28050, Spain
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Novartis Investigative Site
Geneva, CH 1211, Switzerland
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Novartis Investigative Site
Sankt Gallen, 9007, Switzerland
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Uni Of TX MD Anderson Cancer Cntr
Houston, Texas, 77030, United States
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Wash U School of Medicine
St Louis, Missouri, 63110, United States