Experimental radioactive therapy targets Hard-to-Treat cancers
NCT ID NCT05977322
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tested a radioactive drug called 177Lu-FF58 in 24 people with advanced pancreatic, gastroesophageal, or brain cancer. The drug seeks out and attaches to specific proteins on cancer cells to deliver radiation directly. The main goals were to check safety, find the right dose, and see if the drug could shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 177Lu-FF58 (a radioactive drug that targets specific proteins on cancer cells)
- What this could lead to
- If successful, this could point toward a new treatment option for advanced solid tumors that have few alternatives.
- What could go wrong
- This is a very early Phase 1 trial with only 24 participants, so safety and effectiveness are not yet known. The study was terminated, which may indicate challenges.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Novartis Investigative Site
Tel Aviv, 6423906, Israel
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Novartis Investigative Site
Nijmegen, 6500HB, Netherlands
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Novartis Investigative Site
L'Hospitalet de Llobregat, Catalonia, 08907, Spain
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Novartis Investigative Site
Madrid, 28034, Spain
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Novartis Investigative Site
Geneva, CH 1211, Switzerland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Blood and gut clues may flag pancreatic cancer risk early
- Can switching cancer therapy early extend life in stomach cancer?
- Can a new drug combo shrink Hard-to-Treat tumors?
- Can a pill outsmart Tumors' defenses?
- A sound wave that could expose hidden pancreatic cancer?