New triple-drug combo shows promise for hard-to-treat leukemia patients
NCT ID NCT05155709
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested a new drug called siremadlin added to two existing drugs (venetoclax and azacitidine) for adults with acute myeloid leukemia (AML) who are too frail for standard chemotherapy. The study included 14 people whose cancer did not respond well to initial treatment or who had high-risk features at diagnosis. The main goals were to find a safe dose and see if the combination could improve remission rates.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Novartis Investigative Site
Hong Kong, 999077, Hong Kong
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Novartis Investigative Site
Budapest, H-1083, Hungary
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Novartis Investigative Site
Beersheba, 8457108, Israel
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Novartis Investigative Site
Jerusalem, 9112001, Israel
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Novartis Investigative Site
Bologna, BO, 40138, Italy
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Novartis Investigative Site
Alor Star, Kedah, 05460, Malaysia
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Novartis Investigative Site
Kuala Selangor, 68000, Malaysia
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Novartis Investigative Site
Izmir, Balcova, 35340, Turkey (Türkiye)
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Oregon Health Sciences University
Portland, Oregon, 97239, United States
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Texas Oncology Sammons Cancer Center
Dallas, Texas, 78246, United States