Karolinska Institutet

This study tests if giving young children (ages 6 months to 3 years) a daily powder containing small amounts of 10 common food allergens (like milk, egg, and peanut) can safely cure their food allergies. 80 children with confirmed allergies will receive either the treatment or a …

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. The program focuses on increasing dai…

This study tests a new digital support system called Evira for treating childhood obesity. About 680 children aged 4 to 17 will use a special scale at home and a phone app to track weight and message their clinic. The goal is to see if adding this tool to standard lifestyle treat…

This study tests a new therapy called SAFETY for teens aged 10-17 who have recently attempted suicide. The therapy involves the teen and their family in learning skills to prevent another attempt. Researchers will compare SAFETY to standard care to see if it reduces suicide reatt…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study looks at whether treating certain hand fractures without surgery works as well as surgery. It involves 552 adults with a specific type of broken hand bone. Participants will either get immediate movement and rehab or surgery with screws or plates, then rehab. The main …

This study tests whether cooling the brain immediately after a cardiac arrest, using a special nasal device, helps more people survive with full brain function. About 1,000 adults aged 18-79 with a shockable heart rhythm will be randomly assigned to either rapid cooling followed …

This study tests if a supervised exercise program during chemotherapy can help eliminate breast cancer more effectively. 712 patients will either do high-intensity interval and resistance training or receive usual care. The main goal is to see if exercise increases the chance of …

This study compares two common tendon grafts used in ACL reconstruction: the semitendinosus (hamstring) and the quadriceps tendon. Researchers want to see which one provides better knee stability and function after surgery. The trial will enroll 200 active adults who plan to retu…

This study looks at two methods for treating deep cavities in the permanent teeth of children and teens aged 8 to 19. The goal is to see which approach better keeps the tooth alive and healthy, avoiding the need for a root canal. About 666 participants will be followed for up to …

This study looks at whether adding stair climbing to a brisk walking routine helps lower blood pressure more than brisk walking alone. Researchers will enroll 450 adults aged 35 and older who have high blood pressure, are overweight, and are not very active. Participants will be …

This study tests an internet-based therapy program for teens aged 13-17 who have hurt themselves without wanting to die. The program helps them learn to manage emotions and stop self-injury. About 341 teens will take part, and researchers will check if the therapy reduces self-ha…

This study tests whether replacing the thumb base joint with an artificial implant provides better pain relief and hand function than standard surgery (bone removal) for people with thumb osteoarthritis. 90 adults with painful thumb arthritis will receive the implant and be compa…

This study tests whether adding a digital treatment tool to standard obesity medication helps teenagers with obesity lose more weight than medication alone. About 40 teens aged 12-17 will be randomly assigned to either receive the digital tool plus medication or medication only, …

This study looks at 350 women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. Half will have surgery to remove endometriosis tissue before trying IVF, and the other half will go straight to IVF. The goal is to see which approach leads to more live bi…

This study tests a drug called eplerenone in 40 people who have both heart failure with reduced pumping function and severe chronic kidney disease. The goal is to see if the drug is safe and can be used in this high-risk group, who have been left out of previous studies. If succe…

This study tests a digital lifestyle program for adults aged 40-60 in Swedish primary care. Participants receive standard health advice plus app-based support for diet, exercise, alcohol, and smoking. The goal is to see if the program improves cholesterol and other heart health m…

This study tests whether internet-based cognitive behavioral therapy (iCBT) can improve quality of life and reduce ADHD symptoms, anxiety, depression, and stress in adults. Two hundred adults with ADHD in Sweden will be randomly assigned to receive iCBT right away or after a wait…

This study tests a culturally and language-adapted internet-based therapy (i-CBT) for Farsi/Dari-speaking migrants and refugees aged 15-29 who have symptoms of anxiety, depression, grief, or trauma. Participants will receive the therapy over 6-10 weeks, and researchers will compa…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who take the program to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. T…

This study tests whether a specially designed mobile app (HealthyMoms4MentalHealth) can improve mental well-being in pregnant women. About 440 women in early pregnancy will use the app, and researchers will measure changes in resilience and depression symptoms. The goal is to pro…

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

This study looks at whether women having robotic hysterectomy for non-cancerous conditions or endometrial cancer can safely go home the same day instead of staying overnight. About 300 women at three hospitals will be randomly assigned to either day-care or overnight stay. The ma…

This study tests a support program for 142 teens and young adults (ages 16-30) newly diagnosed with cancer. The program includes a meeting with a special team and a structured course called PRISM to build skills like stress management and goal setting. Participants fill out surve…

This study compares a new blended therapy (part computer, part therapist) to the standard prolonged exposure therapy for PTSD. Researchers want to see if the new approach works just as well for reducing PTSD symptoms. About 160 adults with PTSD will take part at clinics in Stockh…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study reviews medical records of 150 children who had cleft palate surgery. It compares those who received a standard painkiller (morphine) alone to those who also got a nerve block in the cheek area. The goal is to see if the nerve block reduces the need for morphine, lower…

This study tests an online therapy program (CBT) designed to help people who had a heart attack and still feel very anxious about their heart. The goal is to reduce fear, improve quality of life, and encourage physical activity. About 176 adults who had a heart attack at least 6 …

This study compares a newer type of talk therapy called metacognitive therapy (MCT) with the standard cognitive-behavioral therapy (CBT) for people with anxiety disorders. About 86 adults with generalized anxiety, social anxiety, or PTSD will receive one of the two treatments. Th…

This study tests whether a 5-day intensive exposure therapy can treat PTSD as well as the usual 15-week program. 140 adults with PTSD will be randomly assigned to either the fast or standard treatment. The goal is to see if the shorter format works, saves money, and is easier for…

This study compares two ways of giving a lung-opening medicine (surfactant) to premature babies with breathing problems. The newer method uses a soft mask placed in the throat instead of a breathing tube down the windpipe. Researchers want to see if the gentler method works just …

This study tests an online cognitive behavioral therapy program for children aged 8-17 with functional abdominal pain disorders (stomach pain with no clear physical cause). The goal is to see if the therapy can reduce pain and improve daily life. Researchers will also measure how…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a new, fast-paced therapy for teenagers with PTSD. Instead of weekly sessions over months, teens get a 5-day intensive treatment that combines talk therapy, eye movement therapy, physical activity, and parent support. The goal is to see if this approach is practi…

This study looks at whether a type of talking therapy (transdiagnostic cognitive behavioral therapy) can help people with long-term fatigue feel better. About 190 adults aged 18-67 with severe fatigue lasting at least 3 months will either get this therapy or usual care. The goal …

This study tests a stepped care model for children aged 8-16 who have trouble controlling anger or show defiant or aggressive behavior. It starts with a brief internet-based parenting support program (Step 1). If more help is needed, families can then choose from additional optio…

This study looks at whether giving people with generalized anxiety disorder the power to choose between two internet-based treatments helps them feel better and stick with the program. About 440 adults will either pick their preferred therapy or be assigned one randomly. The goal…

This study tests whether a therapist-guided online cognitive-behavioral therapy (CBT) program can reduce symptoms of body dysmorphic disorder (BDD) in children and teens aged 12-18. About 154 participants will receive the online treatment or a control, with follow-up at 6 months.…

This study tests a 10-week online therapy program for cancer survivors who still have anxiety or depression. About 400 people in Sweden will try different parts of the program to see which ones help most. The goal is to find the best way to support survivors' mental health after …

This study tests whether yoga-based exercises, done online or in person, can improve sleep, mood, and quality of life for people with chronic migraine or cluster headache. About 40 adults aged 18-65 with these conditions will participate. The goal is to see if adding yoga to stan…

This study tests whether an online, therapist-guided cognitive-behavior therapy can help children and teens with autism who also have obsessive-compulsive disorder (OCD). The goal is to reduce OCD symptoms and improve daily functioning. The study will include 220 participants and…

This study tests an online program called POET that helps teens aged 12-17 learn to manage their emotions. The goal is to reduce symptoms of anxiety, depression, and other mental health issues. Participants will be randomly assigned to receive POET or usual care, and researchers …

This study looks at whether putting fruit stands in schools helps students eat more fruit, and if adding a health-awareness campaign makes a bigger difference. About 300 Swedish students aged 7 to 19 will use a phone app to take pictures of their meals and snacks. The goal is to …

This observational study looks at children under 18 who have a tracheostomy (a breathing tube in the windpipe). Researchers want to find out how common feeding difficulties are in these children and whether those difficulties are linked to their quality of life. The study will in…

This study looks at whether the number of steps you take each day, tracked by your phone, can help predict how well you recover after non-cardiac surgery. Researchers will follow 264 adults having planned surgery and compare their step counts with how many days they spend at home…

This study watches 100 children under 18 with tracheostomies to see if serious airway problems can be predicted by symptoms parents or doctors notice. Kids get a routine camera exam of their airway, and researchers compare what was found with any symptoms reported beforehand. The…

This study looks at whether allowing people with severe psychiatric conditions to admit themselves to the hospital (instead of doctors deciding) can reduce forced hospital stays, improve symptoms, and boost quality of life. About 564 patients in Stockholm, Sweden, will try this a…

This study looks at 90 people with a heart condition called mitral valve prolapse who need surgery to fix a leaky valve. Researchers want to see if the surgery reduces dangerous heart rhythm problems and scarring in the heart muscle. Participants will have heart scans and wear a …

This study looks at how weight loss changes the way people with advanced cancer see themselves. Researchers will survey 800 patients from different countries to understand differences related to gender and location. The goal is to create better, fairer nutrition advice for cancer…

This study follows 91 people who had jaw joint surgery (arthroscopy or discectomy) for a displaced disc. Researchers want to see if the results seen at 6 months last for about 10 years. Participants will have a check-up and a jaw X-ray to measure pain, jaw opening, and joint wear…

This study looks at 300,000 surgical patients in Stockholm to see how the COVID-19 pandemic impacted their recovery. Researchers will track deaths, complications, and how long people stayed in the hospital. The goal is to understand the pandemic's effects on surgical care, not to…

This observational study aims to see if using a computer model to personalize the doses of standard TB drugs can help patients reach the right drug levels faster. About 30 adults with pulmonary tuberculosis will have their drug levels measured and doses adjusted based on the mode…

This observational study looks at how often serious anesthesia problems happen in children under 18 who have a tracheostomy and need a routine airway exam. Researchers will track complications and see if factors like age or ventilator use play a role. The goal is to better unders…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs of declining activity…

This study follows 1000 couples going through IVF to see if the bacteria and chemicals in their bodies affect their chances of having a baby. Researchers will collect samples from both partners and track outcomes like pregnancy, miscarriage, and live birth. The goal is to learn w…

This study looks at the best way to recover after surgery for a torn thumb tendon. About 380 people will be randomly assigned to either wear a cast for four weeks or start moving their thumb early. The goal is to see which approach lowers the risk of the tendon re-rupturing while…

This study looks at the best way to treat nerve injuries in the fingers. It compares two approaches: surgery to repair the nerve, or wearing a cast without surgery. The goal is to see which method helps restore feeling and hand function better after one year. About 166 adults wit…

This study looks at whether how active you are before surgery can help predict your risk of complications or death after the operation. Researchers will track 50,000 adults having planned non-cardiac surgery at two hospitals. The goal is to see if adding physical activity to stan…

This study aims to find out whether doctors trained in Advanced Trauma Life Support (ATLS) help more trauma patients survive compared to standard care. About 4,320 adult trauma patients in Indian hospitals will be included. The main goal is to see if ATLS training reduces deaths …

This study watches 600 people with or at risk for dementia with Lewy bodies (DLB) to learn how the disease starts and progresses. Researchers collect brain scans, spinal fluid, and thinking tests to find better ways to detect DLB early. No new treatments are tested; the goal is t…

This study looks at new blood tests to see if they can better measure how well bleeding treatments work in people with hemophilia who have developed inhibitors (antibodies that block standard treatment). About 20 patients will give blood samples before and after receiving bypassi…

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1500 people with newly diagnosed epilepsy and healthy controls. The goal is to find patte…

This study looks at whether doing a repeat kidney biopsy one year after starting treatment for lupus nephritis helps doctors make better treatment decisions. About 206 people with a first episode of lupus nephritis will be randomly assigned to either get the repeat biopsy or not.…

This study is testing a new blood test that looks for DNA from the donor heart to catch early signs of rejection in heart transplant patients. Researchers will compare the test results with standard heart biopsies to see if the blood test is accurate. The goal is to make monitori…

This study tests a method called Feedback Informed Treatment (FIT) in social services. 400 people receiving help for issues like substance use, family problems, or housing will regularly rate their progress and the care they get. The goal is to see if this feedback helps prevent …

This study looks at how much pollution and waste are created by two common ways to treat a broken hand bone: surgery or a cast/splint. Researchers will track 30 adults for a year, measuring things like carbon emissions and trash. The goal is to find out which treatment is better …

This observational study aims to understand how immune cells affect healing in diabetic patients with chronic foot ulcers. Researchers will compare blood and tissue samples from 40 patients whose ulcers are healing versus those that are not. The goal is to identify specific immun…

This study tests a simple questionnaire called Start-MSK that helps physiotherapists decide which treatment is best for each person with muscle or joint pain. 300 adults with pain in their neck, back, shoulders, hips, or knees will answer the questions and be grouped by their ris…

This study looks at how the brain and muscles change when one leg is unloaded for two weeks, mimicking spaceflight. Healthy adults will use crutches with a special shoe to keep one leg from bearing weight. Afterward, they walk on a treadmill in lunar gravity during a parabolic fl…

This study looks at how red blood cells (RBCs) from people with type 2 diabetes may harm the heart and blood vessels. Researchers will compare RBCs from 500 participants (healthy, with diabetes, or after a heart attack) in lab tests to understand the damage. The goal is to find n…

This study looks at whether beetroot juice, which contains natural nitrates, can safely lower blood pressure in the lungs of people with a serious type of pulmonary embolism (blood clot in the lung). The trial involves 36 adults who will receive either beetroot juice or a placebo…

This study aims to see if brain activity patterns can predict how well people with depression, insomnia, or social anxiety respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will use fMRI scans to measure moment-to-moment brain variability and compare …

This study explores whether women in war-torn Zaporizhzhia, Ukraine, can use a simple self-sampling kit at home to test for HPV, the virus that causes cervical cancer. Around 1,000 women aged 30-60 who haven't had a recent negative HPV test will receive a kit from their clinic, r…

This study looks at how stroke changes brain activity when people walk while doing another task, like listening or navigating. Researchers will measure brain signals and walking patterns in 50 adults who had a stroke at least 6 months ago. The goal is to better understand these c…

This study looks at whether planning workouts around menstrual cycle phases improves fitness in female athletes. About 111 women who exercise regularly will be split into three groups with different training schedules over three cycles. Researchers will measure changes in aerobic…

This study looks at whether a simpler form of CPR—using only chest compressions—works as well as standard CPR (compressions plus rescue breaths) for adults who collapse from cardiac arrest outside a hospital. About 3,260 people will take part, and the main goal is to see how many…

This study looks at whether internet-based exposure therapy can change how the brain processes pain in people with fibromyalgia. About 45 adults with fibromyalgia will undergo pain tests before and after 10 weeks of online therapy. The goal is to see if the treatment objectively …

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary tests and treatments in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if this approach lowers costs and improves care without …