Karolinska Institutet

This phase 3 trial tests whether giving personalized doses of tamoxifen (based on how each person processes the drug) helps more women with hormone-sensitive breast cancer stay on treatment and have better outcomes. Currently, 30-50% of patients stop tamoxifen early due to side e…

This study tests a 10-week psychoeducational program for women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress, low energy, or lifestyle factors. About 70 women will either join the program or receive usual care. Researchers will track …

This study tests a new way to help families prevent and manage childhood obesity. It combines two proven programs: one for all first-grade students and their families, and another for parents of children who are already overweight or obese. The goal is to improve teamwork between…

This study looks at 40 adults aged 16-50 with a single-chamber heart (Fontan circulation) to understand how muscle size and strength relate to their heart and lung function. Researchers will measure oxygen use, muscle mass, and quality of life. The goal is to find out if muscle t…

This study looks at how well a program to spot family violence works in child health services. Researchers will check if parents are asked about violence, how neighborhood factors affect this, and what nurses think about asking. About 90,000 parents and nurses in Stockholm will t…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously took part in a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to understand what participants liked or disliked about e…

This study will observe 400 adults with sepsis and unstable blood pressure to learn how their heart and blood vessels are affected. Participants will have heart ultrasounds, blood tests, and circulation checks within 72 hours of hospital admission. The main goal is to see if diff…