Karolinska Institutet

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes is just as effective fo…

This study compares two plant-based diets for people with advanced chronic kidney disease: one that limits potassium-rich foods and one that does not. The goal is to see if a more liberal diet causes dangerous high potassium levels. Thirty participants will follow their assigned …

This study tests a 10-week psychoeducational program designed to help women with Functional Hypothalamic Amenorrhea (FHA) restore their menstrual cycles and hormone balance. Seventy women aged 18-42 will either join the program or receive standard care. Researchers will track whe…

This phase 3 trial tests whether adjusting tamoxifen doses based on individual metabolism can reduce the number of breast cancer patients who stop treatment early due to side effects. About 1,100 premenopausal or perimenopausal women with hormone-sensitive breast cancer will rece…

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests a 6-month lifestyle program for adults 60 and older who have a higher risk of dementia. The program includes nutrition advice, exercise, brain games, and social activities. Half of the 80 participants will follow a structured program with a coach, while the other…

This study tests a new way to help families prevent and manage childhood obesity. It combines two programs: one for all first-grade students and their families, and another for parents of children who are already overweight or obese. The goal is to see if this combined approach h…

This study tests whether letting patients give themselves sedation medication (propofol) by pressing a button during a colonoscopy leads to higher satisfaction than standard sedation given by a doctor. About 40 adults scheduled for colonoscopy will be randomly assigned to either …

This study tests whether weekly yoga-based movements, done online or in person, can improve sleep and quality of life for adults with chronic migraine or cluster headache. About 80 participants will be randomly assigned to yoga or usual care. The goal is to see if this gentle exe…

This study tests a digital tool called RECapp that helps patients recover after surgery for esophageal or stomach cancer. The app lets patients track symptoms, get personalized self-care advice, and know when to contact their healthcare team. 250 adults in Sweden will use the app…

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests a shortened version of Parent-Child Interaction Therapy (PCIT) that uses videos and 360-degree virtual reality films to help parents manage disruptive behavior in children aged 2-7. Fifteen families will receive up to 10 therapy sessions. Researchers will measure…

This study tests whether an 8-week digital lifestyle program can reduce depression and anxiety in migrants in Sweden. The program focuses on physical activity, sleep, diet, and social connection. 240 adults with moderate distress will be randomly assigned to the program or a wait…

This study will observe 400 adults with sepsis (a severe infection) who need medication to keep their blood pressure up. Researchers will check their heart function and blood vessel health within the first 72 hours. The goal is to see if certain patterns of heart and blood vessel…

This study looks at how well a program to identify family violence works in child health services. Researchers will check if parents are asked about violence, how neighborhood factors affect this, and what nurses experience. About 90,000 parents and many nurses in Stockholm will …

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy and cognitive-behavioral therapy. The goal is to understand how patients view each treatment, helping doctors choose a…

This study will test a device called Q-NRG+ to see if it can accurately measure how much energy critically ill babies under 10 kilograms use. About 80 infants in the pediatric ICU will be observed. The goal is to see if this method works well in very small patients, which could h…

This study will follow 4,000 young adults (ages 15-39) diagnosed with cancer to understand how different treatments impact their fertility, pregnancy, and children's health. Researchers will collect data from European medical records to identify risks and improve fertility preser…

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, movement, and decision-making in 600 people with bipolar disorder, major depression, and healthy volunteers using smartwatches and computer …

This study looks at medical records of 10,000 adults who had gallbladder surgery and were found to have stones in the common bile duct. It compares complication rates between hospitals that have ERCP (a procedure to remove bile duct stones) available and those that do not. The go…

This study looks at people who have a groin hernia on each side, but only one side causes pain. Doctors want to know if it is better to repair both hernias at once or just the painful one. The trial will follow 2,200 adults in Sweden to compare long-term pain, complications, and …

This study tests a new website designed to help 11-12 year olds and their parents learn about the HPV vaccine. The goal is to see if the tool is easy to use and helpful in real school settings, especially in areas where fewer people get vaccinated. About 100 students and their fa…

This study will follow 3,000 young women (ages 15-39) diagnosed with cancer to understand how treatments like chemotherapy and immunotherapy affect their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preserva…

This study looks at how much time young children (0-5 years) and their parents spend on screens, and how child health nurses address this topic. About 300 parents and nurses will complete surveys and interviews. The goal is to better understand screen habits and improve advice fo…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

This study will review medical records of 500 adults in Stockholm to find patterns that may appear before a criminal act in people who later get a forensic psychiatric evaluation. Researchers will compare those who committed crimes with similar patients who did not. The goal is t…

This study follows 200 patients with colorectal cancer and liver tumors found at the same time. Researchers compare different surgery sequences to see which helps patients complete their full treatment plan. The goal is to create a guide for doctors to choose the best surgical ap…

This study looks at how muscle function impacts circulation and quality of life in 40 adults (ages 16-50) with a single-chamber heart, a condition where the heart lacks a chamber to pump blood to the lungs. Researchers will measure muscle mass, strength, oxygen uptake, and heart …

This study looks at whether a four-session therapy called Brief Cognitive Behaviour Therapy (BCBT) is acceptable and practical for adults hospitalized after a suicide attempt or at high risk. About 32 participants will receive the therapy plus usual care, and researchers will int…