Karolinska Institutet

This study looks at whether a single dose of the HPV vaccine can prevent infection with several types of HPV in young adult women. Researchers are tracking 150,000 women in Sweden born between 1994 and 1999 who received one vaccine dose. The goal is to see how well one dose works…

This study tests a treatment using donated fetal stem cells given through an IV to infants with a severe form of osteogenesis imperfecta (brittle bone disease). The goal is to see if it is safe and can reduce fractures and improve bone strength. Some babies may receive the cells …

This study tests whether a brief online version of Parent-Child Interaction Therapy can help reduce disruptive behaviors in children aged 2-7. Twenty parents will complete a 10-week online program and answer weekly questionnaires. The goal is to see if the approach is practical a…

This study tests if giving local anesthesia during the pushing phase of labor can lower the risk of perineal tears (including serious ones) in women having their first vaginal birth. About 1,350 first-time mothers will take part. The goal is to see if a simple numbing injection c…

This study tests whether a fun, play-based training program using special three-wheeled running bikes can help children aged 2-5 with cerebral palsy move better and be more active. Over 12 weeks, kids will join group play sessions and do exercises at home. The goal is to improve …

This study tests whether adding in-home decluttering help to group cognitive-behavioral therapy (CBT) can reduce hoarding symptoms in adults. About 90 participants in Sweden will receive group CBT, with some also getting hands-on decluttering support at home. The goal is to see i…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 …

This study aimed to compare different treatments for jaw muscle or joint pain in children aged 7 to 14. The treatments included mouthguards, jaw exercises, and anti-inflammatory medication. However, the study was withdrawn before any participants were enrolled, so no results are …

This study tests an online therapy program for teenagers aged 13 to 17 who have hurt themselves on purpose (nonsuicidal self-injury). The therapy, called IERITA, helps teens learn to manage their emotions. The study will see if the program is practical and helpful, with the goal …

This study compares two types of wrist fusion surgery for people with advanced wrist arthritis (SNAC or SLAC). The goal is to see if one surgery provides better grip strength and function than the other. 64 adults with grade 2-3 arthritis will be randomly assigned to one of the t…

This study compares two internet-based cognitive behavioral therapy programs for people with generalized anxiety disorder. About 400 adults will receive one of two 10-week online treatments targeting either intolerance of uncertainty or unhelpful beliefs about worry. Researchers …

This study looks back at 65 adults who had one of two surgeries for a painful jaw joint condition (TMJ disc displacement). The goal is to see which surgery better improves mouth opening, reduces pain, and helps the jaw work better. Researchers also check recovery speed, side effe…

This study tests a new online program called Tiny Heroes, designed to help parents reduce anxiety in their young children (ages 3-6) who have mild to moderate worries or fears. The program is a type of cognitive behavioral therapy delivered over the internet, and parents complete…

This study checks whether two methods for measuring nerve function in the fingers give consistent results over time. Ten healthy adults were tested twice, two weeks apart. The goal is to make sure these methods are reliable before using them in larger studies.

This study tests whether giving women structured online contraceptive advice when they buy the morning-after pill at a pharmacy helps them start using a regular, effective birth control method. About 600 women in Sweden will use a smartphone app to get counseling and report back …

This study looks at whether it's possible to compare two types of cognitive-behavioral therapy (CBT) for anxiety disorders in regular psychiatric care. One approach is a general therapy that works for many anxiety types, while the other is customized for a specific disorder. The …

This study looks at why people with post-COVID syndrome feel tired and have trouble exercising. Researchers will compare how 62 people with long COVID and healthy volunteers respond to different types of exercise, including moderate walking, intense intervals, and strength traini…

This study tests a program called Little ACF, designed to help parents of children aged 1-2 years strengthen their parenting skills and support their child's emotional development. About 670 parents from child health clinics will be randomly assigned to either the program or usua…

This study tests a method to improve workplace health by focusing on positive factors like fairness and leadership, rather than just fixing problems. About 45 municipal employees will set goals and track progress using a tool called Goal Attainment Scaling. Researchers want to se…

This study tests whether a brief information session can help people with risky alcohol use feel more comfortable seeking help. Many avoid help due to shame or fear of consequences, even though effective treatments exist. Researchers will measure changes in participants' willingn…

This study tests a 10-week online education program for women aged 18-40 with functional hypothalamic amenorrhea (a condition where periods stop due to stress, low weight, or exercise). The goal is to see if the program is easy to use and helpful, before testing it in a larger st…

This study aimed to create a website that helps people in Sweden decide whether to join cancer screening programs for breast, colorectal, and ovarian cancer. The goal was to provide clear, balanced information so people can make choices based on facts, not fear. The study was wit…

This study planned to test two new methods for spotting acute kidney injury (AKI) early in adults having elective heart surgery. Researchers wanted to see if these methods could predict AKI better than current tests. However, the study was withdrawn before any participants were e…

This study looks at whether using snus (including newer nicotine pouches) is linked to heart disease, poor metabolism, and mental health issues, separate from smoking. Researchers are analyzing health data from over 30,000 Swedish adults, including CT scans and blood tests, to co…

This study tests a 10-week online health program for adults with long-term spinal cord injury. Participants attend weekly video sessions on exercise, diet, and stress, and wear an activity monitor. Researchers compare them to a waitlist group to see if the program improves lifest…

This study follows 7,500 men aged 50-74 to see if advanced screening methods—like a blood test, biomarkers, and MRI—can reduce deaths from prostate cancer. Participants were invited for screening or acted as controls. Researchers track who develops cancer, who dies from it, and h…

This study looks at whether having a resuscitation order other than 'full code' is linked to a higher risk of death in critically ill patients. Researchers will analyze data from 1500 ICU patients, considering factors like age, sex, and frailty. The goal is to see if the increase…

This study looks at large DNA changes in 10,000 people with rare genetic disorders or brain conditions. Researchers will map the exact location of these changes and study how they affect gene activity. The goal is to improve genetic testing and find new targets for treatments.