Thyroid gland disorder

This study compares two ways of taking the drug pazopanib for people with advanced differentiated thyroid cancer that no longer responds to radioactive iodine. One group takes pazopanib continuously, while the other takes planned breaks and restarts the drug only if the cancer pr…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tested whether giving the drug lenvatinib before surgery helps remove advanced thyroid cancer more completely. 29 adults with invasive thyroid cancer took lenvatinib for a short time before their operation. The goal was to see if more patients could have clear or nearl…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study looked at whether a tea made from wild blackberry root could improve thyroid health in people with Graves' disease, an autoimmune condition that causes an overactive thyroid. Forty-two adults with newly diagnosed or relapsed Graves' disease drank either the blackberry …

This study offers ongoing treatment with alectinib or crizotinib to about 200 adults with ALK- or RET-positive cancer who were already benefiting from these drugs in a previous Roche trial. The main goal is to monitor safety and side effects as patients continue therapy after the…

This study tested a procedure called radiofrequency ablation, which uses heat to destroy small thyroid cancers. 27 adults with low-risk papillary thyroid microcarcinoma who did not want surgery or active monitoring took part. The goal was to see if the treatment could eliminate t…

This study looked at whether tocilizumab, a drug that calms the immune system, can help people with active moderate-to-severe thyroid eye disease that did not get better with steroids. Thirty-two adults received the drug every four weeks. Researchers measured improvements in eye …

This early-phase study tested a new radioactive drug called 177Lu-CTR-FAPI in 12 people with advanced solid tumors (breast cancer, sarcoma, or thyroid cancer) that had spread and no longer responded to standard treatments. The main goals were to see if the drug is safe and how it…

This study tested the drug sunitinib (Sutent) in 71 people with advanced thyroid cancer that had spread or could not be removed by surgery. The goal was to see if the drug could shrink tumors when standard treatments like radioactive iodine no longer work. Participants took sunit…

This study tested the drug cabozantinib in 41 adults with advanced differentiated thyroid cancer that no longer responds to radioactive iodine treatment. Participants took a 60 mg pill daily until their cancer worsened or side effects became too severe. The main goal was to under…

This study looked at whether playing active video games (exergaming) and following a Mediterranean diet could help people who had their thyroid removed due to cancer. 80 adults were split into four groups: one did exergaming, one followed the diet, one did both, and one had no ex…

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This study tested a patient decision aid—a short video—to help adults with hypothyroidism who were not getting enough thyroid hormone. The video explains the condition, the role of thyroxine, and factors that affect absorption. Researchers randomly assigned 236 patients to watch …

This study compared two ways to control bleeding during total thyroidectomy: using a device called LigaSure versus traditional knot tying. Researchers looked at whether LigaSure caused fewer injuries to the nerve that controls the voice box. The study involved 120 patients aged 1…

This study tested whether combining targeted drugs (trametinib and dabrafenib) with radioactive iodine can help shrink or control advanced thyroid cancer that has stopped responding to standard radioactive iodine treatment. The trial enrolled 40 adults with specific gene mutation…

This study tested a new medicine called MBX 2109, given once a week as a shot, in 64 adults with hypoparathyroidism. The goal was to see if it could safely help patients reduce their daily calcium and vitamin D pills while keeping blood calcium levels normal. The trial was comple…

This study looked at the safety of the drug lenvatinib in 50 people with advanced thyroid cancer that had stopped responding to radioactive iodine treatment. Researchers tracked side effects and how often patients needed to lower their dose. They also checked whether tumors shran…

This study tested a new hormone replacement therapy called North Star against the standard drug levothyroxine in 303 adults with hypothyroidism. The goal was to find the right dose of North Star to keep thyroid hormone levels normal. Participants were already stable on levothyrox…

This study tested a drug called batoclimab in 35 adults with Graves' disease whose thyroid hormone levels were still high despite taking standard antithyroid drugs. The goal was to see if batoclimab could help bring those levels back to normal or below over 24 weeks. Batoclimab w…

This study compared two radiation methods for people with early-stage breast cancer: a shorter, more focused radiation (accelerated partial breast irradiation) versus standard whole breast radiation. The goal was to see which causes fewer side effects like skin problems, breast s…

This early-phase study tested a combination of two experimental drugs (BGB-283 and PD-0325901) in 91 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and see if the drugs could shrink tumors. The trial is no…

This early-phase trial tested an experimental drug called AL2846 in 33 people with a type of thyroid cancer that no longer responds to standard treatments. The goal was to see if the drug could shrink tumors or slow the cancer's growth. Participants took the drug by mouth, and do…

This early-stage trial tested a new drug called CFT1946, alone or with other drugs, in 89 adults with solid tumors that have a BRAF V600 mutation, including melanoma, lung, colon, and thyroid cancers. The main goals were to check safety and find the best dose. The study is comple…

This study looked at 332 people with low-risk papillary thyroid cancer that had spread to neck lymph nodes. Researchers compared robotic surgery (done through small cuts in the armpit and breast) with traditional open surgery. They wanted to see if the robotic method removes canc…

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This study tested two daily doses (150mg vs 300mg) of the drug vandetanib in 81 adults with advanced medullary thyroid cancer that had spread or caused symptoms. The goal was to see which dose better shrinks tumors and how side effects compare. Patients took the drug for up to 24…

This phase 3 trial tested a daily oral drug called vandetanib (ZD6474) against a placebo in 331 people with advanced medullary thyroid cancer that could not be removed by surgery. The main goal was to see if the drug could delay tumor growth. Researchers also measured how many pa…

This study looked at whether an 8-week 5:2 intermittent fasting diet could help people with fatty liver disease. Eighty adults with excess liver fat followed the diet, eating normally for 5 days and restricting calories to 500 kcal on 2 non-consecutive days each week. Researchers…

This early-phase trial tested two drugs, vemurafenib and copanlisib, in 8 people with advanced BRAF-mutant thyroid cancers that had stopped responding to radioiodine therapy. The goal was to see if the combination could make tumors sensitive to radioiodine again and to find the s…

This study tested whether a special PET scan tracer called 18F-DOPA can better detect leftover medullary thyroid cancer in lymph nodes after surgery, compared to standard imaging. Twenty-four adults with elevated thyrocalcitonin levels (a sign of residual disease) received the tr…

This study tested a new rapid test that checks for thyroid cancer spread to neck lymph nodes in just minutes, instead of the usual days-long wait. Researchers studied 250 adults with suspected or known thyroid cancer, comparing the quick test to standard lab methods. The goal was…

This study tested an artificial intelligence (AI) system called Vision-LSTM to see if it could accurately diagnose a specific type of thyroid nodule (TI-RADS 4b) from ultrasound images. Researchers used images from 401 patients and compared the AI's performance to that of junior …

This study tested whether artificial intelligence (AI) can improve the accuracy of contrast-enhanced ultrasound for diagnosing thyroid nodules. Nearly 2,000 participants had both an ultrasound and a biopsy to confirm their diagnosis. Researchers compared how well doctors could id…

This study tested whether a computer program (deep learning) can predict if papillary thyroid cancer has spread to lymph nodes beyond the first draining node. During surgery, 131 adults with no signs of lymph node spread received injections of two dyes near the tumor. A camera re…

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study looked at two approaches to giving iodine supplements to pregnant women. One group received a daily iodine pill from 14 weeks until delivery. The other group had their urine iodine tested first; only those with low levels got iodine, while others got an iron pill. The …

This trial investigates whether placing a small piece of absorbable material (oxidized regenerated cellulose) over the nerves that control the voice box during total thyroidectomy can improve early voice quality. Thirty adults scheduled for thyroid surgery will be randomly assign…

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This study tested whether wearing virtual reality glasses during a fine needle biopsy of the thyroid could lower stress and pain in people with hyperthyroidism. 52 patients took part. Researchers measured stress and pain levels using questionnaires and checked vital signs. The go…

This study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…

This study tested whether a simple relaxation exercise, called progressive muscle relaxation (PMR), could help reduce pain and improve quality of life in people with thyroid cancer. Thirty-two patients undergoing chemotherapy were randomly assigned to do either PMR plus gentle st…

This study tested a new method called the 'Huaxi Tunnel Technique' to protect the recurrent laryngeal nerve during thyroid surgery. The technique uses a diluted epinephrine solution injected along the nerve to create a protective tunnel, reducing the risk of injury. The trial inv…

This study tested a special recovery program (ERAS) for people having thyroid surgery. The goal was to see if it could reduce pain, nausea, and time spent in the hospital compared to usual care. 143 adults took part, and the program focused on improving comfort and speeding up re…

This completed phase 3 trial tested whether a patient outreach program—regular phone calls every two weeks—could help people with advanced medullary thyroid cancer spend less time experiencing moderate-to-severe side effects from the drug vandetanib. The study enrolled 205 adults…

This study compares remimazolam, a newer sedative, to the standard drug propofol for anesthesia in 92 elderly patients (ages 60-75) undergoing thyroid surgery. The goal is to see if remimazolam provides smoother induction, stable vital signs, and faster recovery with fewer compli…

This study compared two types of thyroid surgery: one using a microscope and the standard approach. Researchers looked at blood loss, nerve damage, and low calcium levels after surgery in 74 patients with thyroid cancer or other thyroid conditions. The goal was to see if the micr…

This study tested whether doing gentle neck exercises for 10 days after thyroid surgery could reduce pain and improve quality of life. 93 adults who had their thyroid removed were split into two groups: one did the exercises, the other received standard care. Researchers measured…

This study tested whether spraying a blue dye called methylene blue onto tissues during thyroid surgery helps surgeons better see and protect the nerve that controls voice and the glands that regulate calcium. 136 adults with benign thyroid nodules took part. The goal was to redu…

This study tested whether adding dexmedetomidine to a standard nerve block (superficial cervical plexus block) improves pain control after thyroid surgery. Fifty-eight adults undergoing thyroid surgery were randomly assigned to receive the nerve block with or without dexmedetomid…

This study tested a new ultrasonic surgical system designed to cut and seal tissue during thyroid cancer surgery. Researchers compared its performance and safety to standard methods in 136 patients. The goal was to see if the new tool works just as well for helping surgeons remov…

This study tested whether applying oxidized regenerated cellulose and hyaluronic acid during thyroid surgery can prevent painful adhesions that often form after the procedure. 45 adults with benign goiter or thyroid cancer were enrolled. The goal was to see if these barriers redu…

This study tested whether using a virtual reality headset with relaxing hypnosis techniques could lower stress in people about to have their thyroid removed. Eighty-two adults used the headset for 30 minutes before and after surgery. Researchers measured anxiety levels to see if …

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study collects standard-of-care images from people with differentiated thyroid cancer who are treated with radioactive iodine (Iodine-131). The goal is to better understand how much radiation reaches healthy organs and what dose is needed to destroy thyroid tissue. By gather…

This pilot study tested whether a rapid lab test called frozen section analysis, done during thyroid surgery, can help surgeons decide how many lymph nodes to remove from the neck. The study included 66 adults with low-risk thyroid cancer and no signs of spread before surgery. Th…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…

This study tested whether a newer 3D imaging method (SPECT/CT) is as accurate as the standard 2D method for measuring how much the thyroid gland takes up a radioactive tracer. 27 people with underactive or overactive thyroids were scanned with both methods. The goal was to see if…

This small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study from the University of Pisa looked at how the thyroid cancer drug selpercatinib affects body composition. Fifteen adults on the drug had their lean mass and energy expenditure measured. The goal was simply to observe and gather data, not to test a new treatme…

This study looked at 220 adults with treated hypothyroidism to see if a thinner thyroid gland makes it harder to place a breathing tube during general anesthesia. Researchers measured thyroid thickness with ultrasound before surgery and recorded intubation difficulty. The goal is…

This completed study from Ankara City Hospital Bilkent examined 179 people with Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid. Researchers compared levels of reverse T3, a little-studied thyroid hormone, and inflammation markers in patients who were or…

This study looked at whether giving iodine supplements to pregnant women helps their children's brain development. Researchers tested 85 children at age 2 using a standard developmental assessment. The goal was to see if iodine, which is often low in French diets, makes a differe…

This study looked at 170 adults having thyroid surgery under general anesthesia to see if the blood pressure difference between the arm and leg changes when they are asleep. Researchers measured blood pressure in both limbs before and during anesthesia. The goal was to understand…

This pilot study tested a tool called CQUPLE, designed to help patients with low-risk thyroid cancer understand their treatment options and avoid overtreatment. Fifty patients were split into two groups: one received the CQUPLE decision aid and question list, while the other got …

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This pilot study tested whether routine genetic analysis of thyroid cancer samples could help surgeons decide how much of the thyroid to remove. Only 2 patients were enrolled. The goal was to see if a larger trial is possible, not to change treatment yet.

This completed study collected extra blood samples from 28 adults with thyroid disorders to help standardize thyroid-stimulating hormone (TSH) tests. Different labs often use different tests, making it hard to compare results. By analyzing these samples, researchers hope to make …

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study looked at 729 breast cancer patients who had surgery followed by radiation. Researchers checked their thyroid function before and after treatment to see how many developed an underactive thyroid (hypothyroidism). The goal was to find out which patients are at higher ri…

This study examined whether a marker of inflammation called interleukin-6 (IL-6) is linked to thyroid hormone problems in people with chronic kidney disease on dialysis. Researchers analyzed blood samples from 65 stable dialysis patients. The goal was to see if higher IL-6 levels…

This study looked at how changing the head position during thyroid surgery affects the optic nerve sheath diameter, which can indicate pressure inside the skull. Researchers measured this with ultrasound in 49 patients before and after positioning. They also tracked headache seve…

This completed study examined how immune cells (myeloid cells and their bone marrow progenitors) change in patients with newly diagnosed thyroid or colon cancer. Researchers measured inflammatory markers before and after exposing cells to agents that could 'train' them to fight t…

This study tested whether a parvovirus infection might trigger Graves' disease, an autoimmune condition affecting the thyroid. Researchers compared 52 people—half recently diagnosed with Graves' disease and half with thyroid nodules or goiter—by checking their blood for parvoviru…

This study tested a digital conversation aid to help patients and doctors make shared decisions about thyroid biopsy. Researchers enrolled 107 adults with thyroid nodules to see if using the tool during clinic visits was practical. The goal was to gather information for planning …

This study tested a special radioactive substance called 124-Iodine to see how much radiation each thyroid cancer spot in the body receives. The goal was to help doctors decide the right dose of standard treatment (131-Iodine) and avoid giving unnecessary radiation to patients wh…

This study looked at 50 adults having thyroid or parathyroid surgery to see how quickly the muscle relaxant rocuronium wears off. Doctors need the drug to be gone so they can monitor a nerve that controls the voice box during surgery. The goal was to find the best timing for givi…

This study looked at 558 people with congenital hypothyroidism, a rare thyroid condition found in newborns. Researchers examined their genes, medical images, and health records to find links between genetic changes and the type or severity of the disease. The goal is to improve e…

This study looked at 314 patients with small, early-stage papillary thyroid cancer who had surgery to remove half of the thyroid. During the operation, doctors checked nearby lymph nodes for hidden cancer spread. If cancer was found, the rest of the thyroid was removed in the sam…

This study looked at how much iodine breastfeeding mothers need each day. Seventeen healthy mother-infant pairs took different doses of iodine supplements for five days. Researchers measured iodine levels in urine, blood, and breast milk to figure out the right daily amount for b…