New pill shows promise in slowing rare thyroid cancer

NCT ID NCT00410761

Completed Disease control Sponsor: Genzyme, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested a daily oral drug called vandetanib (ZD6474) against a placebo in 331 people with advanced medullary thyroid cancer that could not be removed by surgery. The main goal was to see if the drug could delay tumor growth. Researchers also measured how many patients had their tumors shrink. The study is now complete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Vandetanib (also called ZD6474 or ZACTIMA), a once-daily oral tablet

What this could lead to

If successful, this could provide a new treatment option to slow tumor growth in people with advanced medullary thyroid cancer.

What could go wrong

This is a phase 3 trial, but results may not apply to all patients. Side effects from vandetanib can be serious, and the drug may not improve overall survival.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Medullary familial medullary thyroid carcinoma medullary thyroid gland carcinoma thyroid cancer Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID CANCER

Contacts and locations

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Locations

Anderson Cancer Center Site Number : 13

Houston, Texas, 77030, United States
Dana Farber Cancer Institute Site Number : 2

Boston, Massachusetts, 02115, United States
Faculdade de Medicina de Ribeirao Preto - USP- Site Number : 2302

Ribeirão Preto, São Paulo, 14048-900, Brazil
Fletcher Allen Health Care Site Number : 21

Burlington, Vermont, 05401, United States
Hospital De Clinicas De Porto Alegre- Site Number : 2301

Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
Investigational Site Number 10

St Louis, Missouri, 63110, United States
Investigational Site Number 1001

St Leonards, 2065, Australia
Investigational Site Number 11

New Haven, Connecticut, 06510, United States
Investigational Site Number 1101

Brussels, 1000, Belgium
Investigational Site Number 1102

Leuven, 3000, Belgium
Investigational Site Number 1201

Moncton, E1C6Z8, Canada
Investigational Site Number 1202

London, N6A 4L6, Canada
Investigational Site Number 1203

Calgary, T2E7C5, Canada
Investigational Site Number 1204

Sherbrooke, J1H 5N4, Canada
Investigational Site Number 1205

Toronto, M5G2M9, Canada
Investigational Site Number 13

Houston, Texas, 77030, United States
Investigational Site Number 14

Rochester, Minnesota, 55905, United States
Investigational Site Number 1401

Mumbai, 400012, India
Investigational Site Number 1402

Vellore, 632004, India
Investigational Site Number 15

Jacksonville, Florida, 32224, United States
Investigational Site Number 1501

Seoul, South Korea
Investigational Site Number 1601

Pécs, 7624, Hungary
Investigational Site Number 17

Lexington, Kentucky, 40536-0298, United States
Investigational Site Number 1701

Gliwice, 44-101, Poland
Investigational Site Number 1702

Poznan, 60-355, Poland
Investigational Site Number 1703

Warsaw, 02-781, Poland
Investigational Site Number 18

Chicago, Illinois, 60637, United States
Investigational Site Number 1801

Bucharest, Romania
Investigational Site Number 19

Charleston, South Carolina, 29425, United States
Investigational Site Number 1901

Vienna, 1901, Austria
Investigational Site Number 2

Boston, Massachusetts, 02115, United States
Investigational Site Number 2001

Halle, 06120, Germany
Investigational Site Number 2002

Essen, 45122, Germany
Investigational Site Number 2005

Würzburg, 97080, Germany
Investigational Site Number 21

Burlington, Vermont, 05401, United States
Investigational Site Number 2101

Basel, 4031, Switzerland
Investigational Site Number 2102

Bern, CH-3010, Switzerland
Investigational Site Number 22

Portland, Oregon, 97239, United States
Investigational Site Number 2301

Porto Alegre, 90035-003, Brazil
Investigational Site Number 2302

Ribeirão Preto, 14048-900, Brazil
Investigational Site Number 2402

Mexico City, 14000, Mexico
Investigational Site Number 2403

Ciudad Madero, Mexico
Investigational Site Number 2404

México, 06726, Mexico
Investigational Site Number 2501

Pisa, 56124, Italy
Investigational Site Number 2502

Milan, Italy
Investigational Site Number 2503

Naples, 80131, Italy
Investigational Site Number 2504

Siena, 53100, Italy
Investigational Site Number 2505

Roma, 00161, Italy
Investigational Site Number 2506

Catania, Italy
Investigational Site Number 2601

Lisbon, 1099-023, Portugal
Investigational Site Number 2602

Coimbra, 3000-75, Portugal
Investigational Site Number 2701

Odense C, 5000, Denmark
Investigational Site Number 2801

Villejuif, 94800, France
Investigational Site Number 2802

Bordeaux, 33076, France
Investigational Site Number 2803

Lyon, 69373, France
Investigational Site Number 2901

Utrecht, Netherlands
Investigational Site Number 2902

Groningen, Netherlands
Investigational Site Number 3

Little Rock, Arkansas, 72205, United States
Investigational Site Number 3001

Madrid, 28041, Spain
Investigational Site Number 3002

Pamplona, 31008, Spain
Investigational Site Number 3003

Madrid, 28040, Spain
Investigational Site Number 3101

Uppsala, 75185, Sweden
Investigational Site Number 3102

Stockholm, 17176, Sweden
Investigational Site Number 3301

Obninsk, 249036, Russia
Investigational Site Number 3401

Belgrade, 11000, Serbia
Investigational Site Number 3402

Belgrade, Serbia
Investigational Site Number 3601

Prague, 15006, Czechia
Investigational Site Number 6

Cincinnati, Ohio, 45267-0589, United States
Investigational Site Number 7

Detroit, Michigan, 48201, United States
Investigational Site Number 8

San Francisco, California, 94115, United States
Investigational Site Number 9

Aurora, Colorado, 80010, United States
Investigational Site Number : 1101

Anderlecht, 1070, Belgium
Investigational Site Number : 1102

Leuven, 3000, Belgium
Investigational Site Number : 1201

Moncton, New Brunswick, E1C6Z8, Canada
Investigational Site Number : 1202

London, Ontario, N6A 4L6, Canada
Investigational Site Number : 1203

Calgary, Alberta, T2E7C5, Canada
Investigational Site Number : 1204

Sherbrooke, Quebec, J1H 5N4, Canada
Investigational Site Number : 1205

Toronto, Ontario, M5G2M9, Canada
Investigational Site Number : 1401

Mumbai, 400012, India
Investigational Site Number : 1402

Vellore, 632004, India
Investigational Site Number : 1501

Seoul, 03080, South Korea
Investigational Site Number : 1601

Pécs, 7624, Hungary
Investigational Site Number : 1701

Gliwice, 44-101, Poland
Investigational Site Number : 1702

Poznan, Greater Poland Voivodeship, 60-355, Poland
Investigational Site Number : 1703

Warsaw, Masovian Voivodeship, 02-781, Poland
Investigational Site Number : 1901

Vienna, 1901, Austria
Investigational Site Number : 2001

Halle, 06120, Germany
Investigational Site Number : 2002

Essen, 45122, Germany
Investigational Site Number : 2005

Würzburg, 97080, Germany
Investigational Site Number : 2101

Basel, 4031, Switzerland
Investigational Site Number : 2102

Bern, CH-3010, Switzerland
Investigational Site Number : 2404

México, 06726, Mexico
Investigational Site Number : 2501

Pisa, 56124, Italy
Investigational Site Number : 2502

Milan, Italy
Investigational Site Number : 2503

Naples, 80131, Italy
Investigational Site Number : 2504

Siena, 53100, Italy
Investigational Site Number : 2505

Roma, 00161, Italy
Investigational Site Number : 2506

Catania, Italy
Investigational Site Number : 2601

Lisbon, 1099-023, Portugal
Investigational Site Number : 2701

Odense C, 5000, Denmark
Investigational Site Number : 2801

Villejuif, 94800, France
Investigational Site Number : 2802

Bordeaux, 33076, France
Investigational Site Number : 2803

Lyon, 69373, France
Investigational Site Number : 2901

Utrecht, Netherlands
Investigational Site Number : 2902

Groningen, Netherlands
Investigational Site Number : 3001

Madrid, 28041, Spain
Investigational Site Number : 3002

Pamplona, Navarre, 31008, Spain
Investigational Site Number : 3003

Madrid, 28040, Spain
Investigational Site Number : 3101

Uppsala, 75185, Sweden
Investigational Site Number : 3102

Stockholm, 17176, Sweden
Investigational Site Number : 3301

Obninsk, 249036, Russia
Investigational Site Number : 3401

Belgrade, 11000, Serbia
Investigational Site Number : 3402

Belgrade, Serbia
Investigational Site Number : 3601

Prague, 15006, Czechia
Mayo Clinic- Site Number : 14

Rochester, Minnesota, 55905, United States
Mayo Clinic- Site Number : 15

Jacksonville, Florida, 32224, United States
Medical University of South Carolina- Site Number : 19

Charleston, South Carolina, 29425, United States
Oregon Health & Science University- Site Number : 22

Portland, Oregon, 97239, United States
The University Of Chicago Site Number : 18

Chicago, Illinois, 60637, United States
The University Of Kentucky Site Number : 17

Lexington, Kentucky, 40536-0298, United States
USCF / Mt Zion Medical Center Site Number : 8

San Francisco, California, 94115, United States
University Arkansas Site Number : 3

Little Rock, Arkansas, 72205, United States
University Of Cincinnati Site Number : 6

Cincinnati, Ohio, 45267-0589, United States
University Of Colorado Health Sciences Center Site Number : 9

Aurora, Colorado, 80010, United States
Washington University School Of Med Site Number : 10

St Louis, Missouri, 63110, United States
Wayne State University / Harper Hospital Site Number : 7

Detroit, Michigan, 48201, United States
Yale University School Medicine Site Number : 11

New Haven, Connecticut, 06510, United States