New hope for tough thyroid cancers? cabozantinib trial shows promise

NCT ID NCT05660954

Completed Disease control Sponsor: Grupo Espanol de Tumores Neuroendocrinos Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug cabozantinib in 41 adults with advanced differentiated thyroid cancer that no longer responds to radioactive iodine treatment. Participants took a 60 mg pill daily until their cancer worsened or side effects became too severe. The main goal was to understand how the drug affects certain biomarkers in the blood and to measure tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cabozantinib
What this could lead to: If successful, this could provide a new treatment option for patients with advanced thyroid cancer that no longer responds to radioactive iodine.
What could go wrong: This is a small, early-phase trial with only 41 participants and no comparison group, so results may not apply broadly. Cabozantinib can cause side effects like fatigue, diarrhea, and high blood pressure.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma neoplasm thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFERENTIATED THYROID CANCER

Contacts and locations

Locations

Complejo Asistencial Universitario de Salamanca

Salamanca, Salamanca, 37007, Spain
Complexo Hospitalario Universitario A Coruña

A Coruña, A Coruña, 15006, Spain
Hospital Clínic de Barcelona

Barcelona, Barcelona, 08036, Spain
Hospital Clínico San Carlos

Madrid, Madrid, 28040, Spain
Hospital General Universitario Morales Meseguer

Murcia, Murcia, 30008, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Ramón y Cajal

Madrid, Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron

Barcelona, Barcelona, 08035, Spain

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