Periodontitis

Researchers compare two ways to treat deep defects in the gums of people with advanced periodontitis. One approach cleans the pockets with minimally invasive non-surgical therapy, while the other uses a single flap surgical procedure. The trial measures gum attachment gain and us…

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin, improves the results of regenerative surgery for severe gum disease. Adults with stage III periodontitis and deep bone defects will receive standard surgery with a bone gra…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This trial looks at people who have both periodontitis (gum disease around natural teeth) and peri-implantitis (inflammation around dental implants). Researchers will measure three proteins in the fluid around teeth and implants before and after routine non-surgical therapy, whic…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin (Alb-PRF), to standard nonsurgical gum treatment improves healing of deep gum pockets in adults with periodontitis. Each participant has matched gum sites randomly assigned …

This trial tests whether a gel made from a patient's own blood, called injectable platelet-rich fibrin (I-PRF), can improve the results of a minimally invasive non-surgical treatment for advanced gum disease. Researchers will compare three approaches: the standard deep-cleaning p…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial asks whether daily caffeine intake can improve recovery after standard gum disease treatment. About 90 adults with periodontitis will receive non-surgical treatment and then be randomly assigned to avoid caffeine or consume low or moderate amounts for 6 months. Researc…

This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get o…

This trial tests whether a minimally invasive deep-cleaning technique (MINST) works better than the usual scaling and root planing for severe periodontitis in back teeth. Adults aged 18–35 with stage III/IV gum disease will have one molar treated with standard cleaning and anothe…

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with a…

This trial tests whether adding a small piece of connective tissue from the roof of the mouth to a standard gum-saving surgery helps repair deep bone defects caused by gum disease. Thirty adults with two or more deep gum pockets will receive the surgery on both defects, but only …

This study investigates whether a daily probiotic lozenge containing Limosilactobacillus reuteri can reduce inflammation and improve gum health in adults with severe periodontal disease. Researchers will also analyze participants' oral and gut bacteria to identify who is most lik…

This study tests whether a toothpaste and powder made from tinder fungus can improve gum health in people with advanced periodontitis. About 70 adults will use either the fungus product or a regular toothpaste alongside standard deep-cleaning treatment for 30 days. The main goal …

This study compares virgin coconut oil mouthwash to the standard chlorhexidine mouthwash as an add-on to deep cleaning for people with stage II periodontitis (gum disease). Over 30 days, researchers measure gum health indicators like pocket depth, bleeding, and inflammation. They…

This study follows 100 adults who received short dental implants (7 or 8 mm) in the back part of the upper or lower jaw. Researchers want to see how well these implants hold up over 5 years by measuring bone loss, stability, and overall success. The goal is to determine if shorte…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement o…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study looks at whether mobile health reminders can help people with gum disease keep their teeth cleaner after standard treatment. The trial will include 76 adults with gum disease affecting the roots of their back teeth. Participants will receive text or app reminders to im…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new gel that slowly releases medicine to treat advanced gum disease (periodontitis). The gel is placed directly into deep gum pockets to fight infection, reduce swelling, and help bone grow back. Researchers will study 80 people with severe gum disease to see i…

This study tests an injectable gel containing a bone-growth protein (BMP-2) to help regrow bone damaged by severe gum disease. The gel is designed to fight bacteria, reduce inflammation, and promote bone repair. Researchers will enroll 80 people with advanced periodontitis and bo…

This study tests an experimental drug called LP-005, given as an injection into the gums, for people with moderate-to-severe gum disease (periodontitis). About 100 adults aged 18-70 will receive either the drug or a placebo to see if it reduces gum inflammation, bleeding, and bon…

This early study will test whether using a miswak chewing stick (from the Salvadora persica plant) can reduce gum inflammation better than a regular toothbrush in people with moderate gum disease (periodontitis). Researchers will measure inflammatory markers in gum fluid from 24 …

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study compares two treatments for repairing bone damage from advanced gum disease. About 40 adults with deep gum pockets will receive either a combination of hyaluronic acid and polynucleotides (Regenfast) or enamel matrix proteins (Emdogain), both with a bone graft material…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study tests a new silk-reinforced collagen membrane designed to help regrow bone in the jaw for people with advanced gum disease (periodontitis). The membrane is placed during a dental procedure to guide bone regeneration. Researchers will measure bone fill and density using…

This study tests whether stem cells taken from donated teeth can be safely injected into the gums to treat periodontitis, a serious gum infection that damages tissue and bone. The goal is to help regrow lost gum and bone without the need for traditional surgery. The trial will en…

This study tests whether a special low-calorie diet that mimics fasting can improve the results of standard gum disease treatment in obese adults with severe periodontitis. The diet is given in three 5-day cycles around the treatment. Researchers will measure inflammation and gum…

This study tests whether using a laser along with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments on different sides of …

This trial tests whether adding a sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, to standard non-surgical gum treatment helps adults with periodontitis. 78 participants will receive one of three treatments and be checked after three months. The …

This study tests two different gum dressings—Ora-Aid and Coe-Pak—placed after a deep cleaning (scaling and root planing) in 25 adults with Stage 3 gum disease. Researchers will measure pocket depth, gum inflammation, plaque, and bacteria over 3 months to see which dressing helps …

This study tests whether a new mouthwash called Amphion can improve gum health when used after standard deep cleaning for periodontitis. Sixty adults with gum disease will receive either Amphion or a placebo mouthwash to use at home twice daily. The goal is to see if the mouthwas…

This study tests whether a gel made from the diabetes drug metformin can improve gum healing better than a standard antimicrobial gel (chlorhexidine) when used alongside deep cleaning. Sixty adults with moderate gum disease will be split into three groups: cleaning alone, cleanin…

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study compares three oral hygiene routines in 90 adults aged 60+ who have gum disease and mild cognitive impairment. One group uses a special light device (Lumoral) plus a manual toothbrush, another uses a powered toothbrush (Oral-B iO), and a control group uses a manual too…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study tests an artificial intelligence system called PerioAI V2.0 that creates a detailed 3D map of gum disease from dental scans. Researchers will enroll 80 adults with moderate-to-severe periodontitis who need gum surgery. The AI's map will be compared to what surgeons see…

This study aims to validate an Italian version of a widely used questionnaire for screening periodontitis (gum disease). Researchers will also develop an enhanced version with additional questions and test how accurately it identifies people with the condition. About 495 adults a…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study is developing a new, non-invasive saliva test that uses artificial intelligence to detect gum disease (periodontitis) early. Researchers will collect saliva from 200 adults—some with gum disease and some healthy—and analyze it with a special sensor. The goal is to see …

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

Researchers are testing whether dexamethasone, a steroid that reduces inflammation, works as well when taken by mouth as when given through a vein. The trial enrolls 40 adults with periodontitis who need two similar gum flap surgeries. Each participant has both surgeries and rece…

This study tests whether motivational interviewing, a patient-centered counseling approach, can improve outcomes of standard gum disease treatment (subgingival instrumentation) in 66 adults aged 30-50 with periodontitis. Participants will receive either motivational interviewing …

This study tests whether a special behavioral program can help people with gum disease who lack confidence in their oral hygiene. 78 adults with stage I-III periodontitis will get standard gum treatment plus either the behavioral program or regular instructions. Researchers will …

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study investigates whether non-surgical periodontal therapy (deep cleaning) can improve bite force distribution and chewing patterns in people with advanced periodontitis (Stage III or IV). Participants will receive standard gum treatment and be assessed using digital tools …

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study looks at whether inflammation from gum disease during pregnancy can affect the womb environment and lead to early delivery. Researchers will measure markers of inflammation and oxidative stress in saliva and amniotic fluid from 80 healthy pregnant women. The goal is to…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study looks at whether checking gum health 4 weeks after non-surgical treatment is better than waiting 8-10 weeks. Researchers will compare healing and pocket depth in 24 adults with advanced gum disease. The goal is to find the best time for follow-up to improve care.

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study looks at how people with gum disease (periodontitis) value their dental health and how their oral health beliefs relate to the severity of their condition. Researchers will ask 112 adults aged 30-50 to complete questionnaires and a clinical exam in one visit. The goal …

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study will measure certain proteins and antioxidants in the fluid from gum pockets in 21 adults with gum disease. Researchers will take samples before and after a deep cleaning procedure (scaling and root planing) to see how these markers change during healing over 3 months.…

This study looks at whether a deep dental cleaning (called non-surgical periodontal therapy) can change levels of a substance called asprosin in the blood of people who have both stable angina and gum disease. Asprosin is a protein that may play a role in heart health and inflamm…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study aims to see if the amount of plaque on teeth can predict how well non-surgical gum treatment works. Researchers will follow 100 adults with gum disease for 12 months after treatment, measuring pocket depth and other gum health signs. The goal is to understand if a simp…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This observational study looks at whether eating a diet that causes inflammation can make gum disease worse in people with metabolic syndrome. About 100 adults with metabolic syndrome will have their gum health checked and their diet analyzed using a special inflammation score. T…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study looks at whether standard gum treatment can improve heart health in people with stable angina. Researchers will measure certain blood markers before and after a routine dental cleaning. The study involves 60 adults, some with heart disease and some without. It aims to …

This study looks at how metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) might make gum disease worse. Researchers will measure gum inflammation in 100 adults and compare it to their metabolic health. The goal is to see if a simple gum measure…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque from 25 adults with advanced gum disease who have not yet started treatment. The goa…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…

This study compares levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of people with advanced gum disease versus those with healthy gums. Researchers aim to better understand the connection between gum inflammation and heart health. The…

This study will examine 60 adults with psoriasis to understand why they often have higher rates of gum disease. Researchers will measure immune-related proteins and stress hormones in saliva and gum fluid, and also ask about appearance-related anxiety. The goal is to uncover biol…