Palsy

This study tests a fun, game-based training program that teaches children with cerebral palsy how to breathe better and improve their posture. The program includes exercises like blowing out candles and floating boats, along with visual and audio cues. Researchers want to see if …

This study investigates whether a program of functional progressive resistance training—exercises like sit-to-stand, step-ups, and stair climbing with gradually increasing resistance—can improve bone mineral density and balance in children with cerebral palsy. The trial includes …

This study tests a drug called Angiotensin II for patients who develop dangerously low blood pressure after heart bypass surgery. About 329 adults will receive the drug along with standard treatments, and their outcomes will be compared to similar patients from the past. The goal…

This phase III trial tests whether giving tranexamic acid continuously for 24 hours after hip surgery can reduce blood loss in non-ambulatory children with cerebral palsy. About 52 children aged 4 to 16 will be randomly assigned to receive either the drug or a placebo. The goal i…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests a surgical procedure to release tight muscles in the forearm of children with cerebral palsy who have a fixed elbow rotation (pronation deformity). The surgery cuts two pronator muscles to allow the arm to turn outward more easily. Researchers will measure change…

This study tests whether a special type of electrical stimulation, called reciprocal neuromuscular electrical stimulation, can improve balance and quality of life in children aged 6 to 10 with hemiparetic cerebral palsy. The 32 participants will receive either the electrical stim…

This study will test whether a gentle brain stimulation technique called tDCS, combined with task-oriented training and virtual reality, can improve movement and brain activity in 150 children with spastic cerebral palsy. Participants will be randomly assigned to receive either r…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This study tests whether a virtual reality (VR) home exercise program can help stroke survivors improve arm and hand function. Forty-eight adults who had a stroke at least 3 months ago will either use a VR headset to practice daily activities at home or receive standard therapy. …

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can reduce spasticity (muscle stiffness) in adults with cerebral palsy. Forty participants aged 16 and older with stable, one-sided motor disability will receive the implant. Re…

This study tests whether combining spinal cord stimulation with physical therapy can improve arm and hand movement in people with cervical spinal cord injury. Forty participants will receive either real stimulation or a sham version during 20 therapy sessions over 6-8 weeks. Rese…

This study compares two rehabilitation approaches—virtual reality exercises and motor-cognitive dual-task training—in 14 children aged 7-14 with brachial plexus birth injury, a condition where arm nerves are damaged during birth. Each child will do their assigned program for 12 w…

This study tests a wearable robotic exoskeleton called Bambini Teens in 20 children aged 5 to 14 with cerebral palsy. The device assists leg movement during walking training. Researchers will check if it is safe and easy to use, and if it improves walking speed after six 30-minut…

This pilot study will test a small screw placed in the hip bone to help correct a wide hip angle (coxa valga) in 50 children with cerebral palsy who have early hip subluxation. The goal is to see if the screw can guide bone growth and improve hip alignment, potentially preventing…

This study tests whether combining balance exercises with thinking tasks (like math or memory games) and gentle head movement stimulation can help children with diplegic cerebral palsy improve their walking and coordination. Fifty-four children aged 6 to 12 will do these exercise…

This study tests whether videos recorded by parents at home can help doctors detect early signs of cerebral palsy in very preterm infants (born before 29 weeks). Researchers will compare the accuracy of family-led recordings to standard professional assessments. If successful, th…

This study tests whether adding short mindfulness sessions (5-10 minutes) before physical therapy can reduce anxiety, depression, and body image concerns in people with non-flaccid facial paralysis. Twenty-four adults with conditions like Bell's palsy or Ramsay Hunt syndrome will…

This study will test whether a structured aquatic therapy program can improve balance in children aged 5 to 12 with spastic diplegic cerebral palsy. Fifty participants will be split into two groups: one receiving water-based therapy and the other continuing standard land-based ph…

This study looks at whether plyometric (jumping) exercises on the less affected leg can improve strength, movement control, and balance in children aged 6-10 with hemiplegic cerebral palsy. Forty children will either get standard physical therapy alone or standard therapy plus pl…

This study tests whether low-energy shockwave therapy can improve facial nerve function in people with chronic Bell's palsy. Forty-two adults aged 45 to 55 will receive the treatment on specific points along the facial nerve. The goal is to reduce facial muscle weakness and impro…

This small study tests whether wearing a rigid leg cast (from thigh to ankle) during treadmill training can safely improve how children with cerebral palsy walk. Six children aged 7 to 14 will take part in a 4-week walking program. Researchers will use motion cameras and muscle s…

This study tests whether watching movements in person (live) or on video helps children with spastic diplegia improve their balance and walking. About 45 children aged 4 to 7 with mild spasticity will participate. The goal is to see which method works better for improving stabili…

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This study looks at whether a wearable garment called TheraTogs can help children and teens with cerebral palsy improve their balance and walking. Twelve participants will be tested with and without the garment to see if it makes an immediate difference. The goal is to find a sim…

This study looks at whether special balance exercises (vestibular rehabilitation) can help children aged 8 to 12 with spastic diplegia, a type of cerebral palsy, stand steadier and use less energy when walking. Researchers will measure trunk sway and heart rate during walking. Th…

This trial tests whether adding a structured home exercise program to regular clinic-based physical therapy helps people aged 40-50 with sub-acute stroke walk better and do daily activities. 72 participants will either get clinic rehab alone or clinic rehab plus home exercises li…

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This small pilot study will test whether a non-immersive virtual reality system called Rehametrics is practical and enjoyable for children with cerebral palsy aged 4 to 10. Ten participants will do balance and walking exercises using the system. The main goal is to see if kids co…

This study compares augmented reality (AR) and virtual reality (VR) during music therapy for people with cerebral palsy aged 15 to 35. Participants will use a Meta Quest 3 headset to reach for musical cubes, repeat note sequences, and play virtual instruments. The goal is to see …

This study looks at whether letting children with cerebral palsy walk sooner after calf surgery helps their foot movement and motor skills. Forty-two children aged 4 to 14 will either get a cast for 3 weeks or a brace right away, plus physical therapy. Researchers will check thei…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study will test whether different types of electrical acupuncture can help adults recover from Bell's palsy, a condition that causes sudden facial paralysis. One hundred participants will receive either low-frequency continuous or intermittent electrical pulses over 4 weeks.…

This study tests whether a personalized robotic telerehabilitation program can help people recover arm movement after a stroke. Seventy participants will use a wearable robotic device with virtual reality exercises at home for 4 weeks, supervised remotely. The goal is to see if t…

This study tests whether a virtual reality exercise program, done at home with telehealth coaching, can help children with cerebral palsy become more physically active. 130 kids aged 10 to 17 will either play seated arm exercise games using a VR headset for 12 weeks or continue t…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can safely reduce chronic musculoskeletal pain in adults with cerebral palsy. Thirty-two participants will use either the active device or a sham (inactive) version at home for 30 days. Researcher…

This study tests a non-invasive brain stimulation technique called rTMS to improve motor function in 60 children with cerebral palsy. The treatment uses magnetic pulses to enhance brain plasticity and movement recovery. Researchers will measure brain activity changes to see if th…

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This study tests whether combining functional electrical stimulation (gentle electrical pulses to help muscles move) with circuit training can improve balance, posture, and walking in children with cerebral palsy. Forty-six children with mild to moderate CP will be split into two…

This study tests if gentle electrical stimulation to leg muscles can help children with cerebral palsy walk more easily. About 65 children (ages 7-18) will walk on a treadmill while different stimulation settings are compared. The goal is to find which method works best to improv…

This trial compares two physiotherapy methods—Perception-Action Approach and Neurodevelopmental Therapy (Bobath)—for children aged 0 to 36 months with cerebral palsy or at high risk. Over 12 weeks, 24 participants will receive weekly therapy sessions and be assessed for motor fun…

This pilot study tests whether combining AI-assisted brain stimulation (tDCS) with hand-arm training can improve movement in children aged 6-17 with unilateral spastic cerebral palsy. Fifteen participants will receive either real or sham stimulation over 5 sessions. The goal is t…

This study will compare two common physical therapy approaches—Bobath (neurodevelopmental treatment) and functional physiotherapy—to see which one better improves upper arm strength and trunk control in children with cerebral palsy. Forty children aged 4 to 12 will receive one of…

This study compares a robotic glove to standard hand therapy for children with hemiplegic cerebral palsy, a condition where one side of the body is weaker. Seventy children aged 7-15 will receive either robotic or conventional therapy for 8 weeks. Researchers will measure hand fu…

This study tests a remote, 12-week program called PREP for teens with cerebral palsy and their caregivers. The program helps families set activity goals and overcome barriers at home, school, and in the community. Researchers will see if the program is practical and liked by fami…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with Bell's palsy recover facial movement and reduce symptoms like drooping. About 111 adults who have had Bell's palsy for 3 weeks to 6 months will receive either real o…

This study tests whether virtual reality training using the Nintendo Wii Fit can improve balance, walking, and agility in children aged 7-14 with cerebral palsy. Over 6 weeks, 56 kids will either play Wii Fit games or do standard physical therapy. The goal is to see if a fun, low…

This study looks at whether a combined program of 35 hours of therapy plus 15 hours of home practice works as well as 50 hours of standard therapy for improving how children aged 3 to 5 with cerebral palsy use both hands. About 66 children will take part. The goal is to make ther…

This study tests whether adding a gentle electrical stimulation to standard mouth exercises can help reduce drooling in children with cerebral palsy. About 30 children aged 4 to 17 will be split into three groups: one gets the real stimulation plus exercises, one gets exercises a…

This study tests whether a single session of a mental practice technique called PETTLEP-based Action Observation and Motor Imagery (AOMI) can immediately improve arm movement in stroke survivors. Participants will either watch and mentally rehearse a reach-to-grasp task or do a c…

This study tests whether adding functional electrical stimulation (FES) to task-oriented training helps stroke survivors with arm spasticity regain more movement than training alone. All participants receive Botox for spasticity first. The trial will enroll 40 adults who have had…

This study tests whether an intensive 15-day summer camp can improve movement and energy use in children with cerebral palsy. Thirty children aged 6 to 13 will take part in 90 hours of fun, guided exercises for their arms and legs. Researchers will measure changes in how their bo…

This study tests a new, smarter electrical stimulation system to help people who have had a stroke walk better. The system uses a computer to adjust stimulation in real time, aiming to correct footdrop (when the foot drags). About 20 participants will compare this new system to a…

This study tests whether an 8-day camp that combines sensory and motor training helps children with unilateral cerebral palsy use their affected hand better than motor training alone. About 26 children aged 5 to 15 will take part. The goal is to improve hand function and daily pa…

This study tests two types of nerve blocks for shoulder surgery to see which one is less likely to temporarily paralyze the diaphragm, the main muscle for breathing. About 70 adults having elective shoulder surgery will be randomly assigned to receive either a standard interscale…

This study will test two different physical therapy methods in 54 children aged 6 to 12 with spastic diplegic cerebral palsy. One group will walk on a treadmill with ankle weights, and the other will practice everyday tasks like stepping and balancing. Researchers will measure ch…

This study tests whether a gamified mobile app called HEMImprove 1.0 can help adolescents with unilateral cerebral palsy improve their arm function. Thirty-six teens will be randomly assigned to use the app at home or do conventional exercises from a manual, both for 30 minutes a…

This study tests whether adding a robotic glove to standard physical therapy can improve hand function in children aged 5-12 with unilateral spastic cerebral palsy. Forty children will be randomly assigned to receive either conventional therapy alone or conventional therapy plus …

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests a new robotic walking trainer called Rise&Walk InHome that stroke survivors can use at home. Twenty adults who had a stroke 3 months to 5 years ago will either use the device for 30 minutes, 4 times a week plus usual care, or just usual care. The goal is to see i…

This study compares two types of robotic hand therapy for people with chronic stroke and hand weakness. One group uses a robot that moves when the patient's brain waves show they are imagining the movement, while the other group uses a robot that moves automatically. The goal is …

This study tests whether combining two therapies—blood flow restriction training (using a cuff to partially restrict blood flow during exercise) and brain stimulation (rTMS)—can improve arm and hand function in people who have weakness on one side after a stroke. 69 adults will b…

This study tests a home-based digital rehabilitation program combined with a non-invasive spinal cord stimulation device to improve upper limb function in people with chronic tetraplegia. Nine participants will use a mobile app-guided exercise program with daily stimulation over …

This study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…

This study looks at whether adding exergaming (video games that require movement) to standard NDT-Bobath therapy can improve spinal mobility in children aged 10-15 with cerebral palsy. Forty-two participants will be split into two groups: one doing seated exergaming and the other…

This study compares two types of exercise training—task-oriented and group circuit training—to see which one helps children with quadriplegic cerebral palsy improve their movement and daily activities. About 36 children aged 7 to 12 will participate. The goal is to find better re…

This study tests two types of spiral arm straps (TheraTogs and TogRite) to see if they help children with unilateral spastic cerebral palsy use their affected arm and hand more effectively. Twenty-seven children aged 4 to 15 will be split into three groups: one gets rehab plus Th…

This study tests whether doing simple mental arithmetic before walking can improve gait speed and balance in people who have had a stroke. Seventeen participants will either solve math problems or watch a blank screen before walking. The goal is to see if this 'cognitive priming'…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This pilot study tests whether a home-based telerehabilitation system can help children with cerebral palsy improve their balance and hand function. Twenty-four children aged 6 to 18 will either use a digital therapy kit at home or follow a standard home exercise program. The goa…

This study tests whether adding virtual reality (VR) to standard Bobath therapy can improve leg muscle activity, balance, and motor function in children with spastic cerebral palsy. Thirty children aged 2 to 14 will be randomly assigned to receive either VR-enhanced Bobath therap…

This study tests whether allowing the pelvis to move freely during robot-assisted walking training helps stroke survivors walk better, improve balance, and reduce fear of falling. About 36 adults who had a stroke at least 6 months ago will receive either pelvic-free or pelvic-res…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard TENS therapy provides extra relief for shoulder pain after a stroke. Forty adults with hemiplegic shoulder pain will receive either TENS alone or TENS plus NMES, alongside their usual rehab. T…

This study looks at whether adding posture-oriented kinesio taping to standard rehab helps stroke patients improve their balance, coordination, and daily activities. Sixty adults who had a stroke at least one month ago will be randomly assigned to get either the tape plus rehab o…

This study compares three types of physical therapy for 90 children aged 6-12 with mild cerebral palsy: traditional therapy, active video games (exergaming), and exergaming with real-time muscle feedback. The goal is to see which approach best improves movement, balance, and moti…

This study tests whether a training program for therapists can help them use powered mobility devices with young children (ages 12-32 months) who have severe cerebral palsy. Therapists will learn how to use the devices during everyday routines at home or in early childhood settin…

This study compares carbon fiber ankle braces to standard plastic ones in 38 children with cerebral palsy aged 8-15. Each child will try both braces for 4 weeks to see which one improves walking, running, and jumping. The goal is to find out which brace helps kids be more active …

This study tests whether a special nerve block (PENG block) added to standard physical therapy can reduce shoulder pain and improve movement in people who have had a stroke. About 15 adults with stroke-related shoulder pain will receive the block or a placebo. The goal is to see …

This study tests whether a special strengthening and fatigue protocol using an isokinetic dynamometer can improve foot lift strength and walking more than standard rehab after Botox injections. Thirty adults with spastic foot drop will be randomly assigned to either the new proto…

This study compares two non-drug treatments—light therapy (photobiomodulation) and electrical stimulation—to see which better helps people with Bell's palsy regain facial movement. About 34 adults with moderate to severe facial weakness will receive one of the treatments along wi…

This study will test whether walking on a treadmill with body weight support can improve motor skills in children aged 5-12 with dyskinetic cerebral palsy. Twenty children will be split into two groups: one gets the treadmill training, the other gets standard Bobath therapy. Rese…

This study will test whether robotic-assisted therapy can improve hand function, grip strength, and wrist position sense in 32 children aged 6-9 with hemiplegic cerebral palsy. Participants will use a robotic device to perform repetitive, goal-oriented hand exercises. The goal is…

This early study tests whether delivering small electrical pulses over the skin above the spinal cord, alongside standard therapy, can help people with a recent spinal cord injury regain arm and hand function. Twenty participants will receive either active or sham stimulation dur…

This study will test whether special 'brain gym' exercises can improve thinking abilities and quality of life in 60 children aged 6 to 8 with spastic hemiplegic cerebral palsy. The children will do these exercises along with standard physical therapy for 30 minutes, three times a…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study will test whether a mild electrical stimulation applied to the lower back, combined with walking exercises, can improve mobility and balance in people with traumatic brain injury (TBI) who have weakness on one side. Thirty adults with a non-penetrating TBI at least two…

This study will use artificial intelligence and video analysis to assess how well children with cerebral palsy can walk and move. Researchers will collect data from 200 children aged 4 to 18 who can walk with or without help. The goal is to see if AI can accurately predict mobili…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This study examines patients who have internuclear ophthalmoplegia, a condition that causes trouble moving the eyes sideways, to see how many later develop multiple sclerosis (MS). Researchers will review medical records of 200 patients to identify factors that predict MS convers…

This study will check if an artificial intelligence (AI) system can accurately measure facial paralysis in people with Bell's palsy. Currently, doctors use subjective scales that can vary between observers. The AI analyzes facial movements using a camera and compares its scores t…

This study will look at how muscle stiffness and tone relate to balance in children aged 6 to 12 with spastic hemiplegia, a condition where one side of the body is tight and weak. Researchers will use a handheld device to measure muscle properties and a balance system to test sta…

This study follows 150 adults with paralysis from spinal tumors who undergo surgery to relieve pressure on the spinal cord. Researchers track how well patients recover movement, bladder and bowel function, and quality of life over one year. The goal is to identify factors that he…

This study will follow 42 children and teens with cerebral palsy who need surgery for scoliosis (a curved spine). Researchers want to see if the surgery helps them eat more and gain weight, since many have trouble eating and are underweight. The goal is to understand if the surge…

This observational study looks at 85 adults with Bell's palsy to see if worse facial muscle function is linked to higher anxiety, depression, and lower self-esteem. Researchers will measure facial movement and muscle activity, then compare those results with participants' answers…

This study tests a 6-week group bootcamp for caregivers of infants (3-15 months old) diagnosed with or at high risk for cerebral palsy. The program teaches parents how to better interact with and support their baby through physical and occupational therapy techniques. The goal is…

This study checks if a tool called the Hypertonia Assessment Tool (HAT) can correctly identify different types of muscle tightness in adults who have had a stroke. The tool was already tested in children with cerebral palsy, but not in adults after stroke. Researchers will test 6…

This study will look back at the medical records of 50 people with spinal cord injuries treated over the last five years. Researchers want to understand common causes of injury, levels of paralysis, and what complications patients faced, such as pressure sores or infections. The …

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This observational study will check if breathing strength and lung function are linked to hand use in 37 children aged 6–18 with hemiparetic cerebral palsy. Participants do simple breathing tests and hand skill tasks in one clinic visit. The goal is to see if rehab programs shoul…

This study will check how well motion-capture sensors track movements in 100 children and youth with cerebral palsy while they play active video games. Researchers will compare the sensors to a gold-standard system and a therapist's assessments. The goal is to see if these sensor…

This study looks at brain activity in children aged 5-15 with unilateral cerebral palsy (CP) compared to typically developing children. Using a special EEG cap, researchers measure brain waves while children watch and then perform simple actions like reaching for objects. The goa…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…