Palsy

This study tested whether a robotic exoskeleton could help children aged 6 to 12 with severe cerebral palsy improve their walking and motor skills. Participants used the robot for 45-minute sessions three times a week over six months. The trial aimed to measure changes in movemen…

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study tested whether clemastine fumarate, an allergy medication, could improve eye movement problems in people with multiple sclerosis (MS). The trial planned to enroll 80 MS patients with a specific eye condition called internuclear ophthalmoparesis, but was terminated earl…

This early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…

This study tested whether a 12-week home-based resistance training program, supervised via telehealth, could improve strength and function in children aged 6–15 with cerebral palsy. Participants used elastic bands and weights during live-streamed sessions. The study aimed to see …

This study tested whether a motorized orthosis (Innowalk) that mimics walking is better tolerated by children with cerebral palsy than standard standing devices. The trial included 25 children aged 6-16 who had never walked. Researchers measured pain, muscle stiffness, and joint …

This study tested whether MYOBLOC, a botulinum toxin injection, can safely reduce muscle stiffness in the lower leg of adults with spasticity caused by stroke, brain injury, or spinal cord injury. About 40 participants received either a low or high dose of MYOBLOC or a placebo in…

This study tested a brace called CALIGALOC designed to correct foot drop (ankle varus) in people with hemiparesis after a stroke or other brain injury. The goal was to see if wearing the brace for 15 days improved walking speed and balance. Only 5 people took part, and the study …

This study tested a device called Agilik, a powered leg brace that helps children with cerebral palsy extend their knees while walking. The goal was to see if it improves gait, endurance, and speed. Only 9 children took part, and the study was stopped early, so the results are no…

This study compared two treatments for drooling in children with cerebral palsy: Botox injections into the salivary glands and scopolamine skin patches. Both groups also received rehabilitation therapy. The goal was to see which treatment reduced drooling more over 15 months. The…

This study tested whether a magnetic device (rTMS) placed on the scalp could help people who had a stroke regain movement in their arm. The trial planned to include 60 adults with recent ischemic stroke. However, the study was terminated early, so the results are not complete.

This small pilot study looked at whether adding functional electrical stimulation (FES) to reconstructive hand surgery can improve muscle strength and hand function in people with tetraplegia (paralysis of arms and legs). Fifteen adults with spinal cord injuries were enrolled. Th…

This study tested whether a single session of magnetic brain stimulation (called rTMS) over a specific brain area could improve pointing movements in people who had a stroke. Only one person took part, and the study was stopped early. The goal was to see if the stimulation could …

This study tested whether two gut hormones, GIP and GLP-2, could reduce bone breakdown in children with spinal muscular atrophy, cerebral palsy, or Duchenne muscular dystrophy who use wheelchairs. Participants received a liquid meal and then either a hormone injection or a placeb…

This study watched people with paraplegia who already use exoskeletons to see what daily tasks they can do at home. The goal was to find small home changes that could help them be more independent. Only 12 people took part, and the study was stopped early, so results are limited.

This study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…

This study looked at muscle samples from 7 children with brachial plexus birth palsy who had shoulder stiffness. Researchers wanted to understand why the shoulder gets stiff again after surgery, by checking for muscle wasting and scarring. The study was terminated early, so findi…