Palsy

This study tests an implanted electrical stimulator to improve walking in people who have had a stroke. Six participants will first be screened, then receive the implant and use it at home. Researchers will compare advanced control settings to a simple trigger to see which works …

This study planned to test whether injecting botulinum toxin (Botox) into the salivary glands could reduce drooling in people with true bulbar palsy, a condition that causes swallowing problems after a brain stem injury. The trial was designed to compare the injections against st…

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study tests whether adding robot-assisted walking training to standard physical therapy helps children with cerebral palsy move better and breathe easier. Twenty-four children aged 8-18 will receive either standard therapy alone or standard therapy plus robotic walking sessi…

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study tests whether stem cells from donated umbilical cords can improve movement and thinking in children with cerebral palsy. 78 children aged 6 months to 3 years will receive either stem cells plus a special liquid (conditioned medium), stem cells alone, or standard therap…

This study tests whether a remote physiotherapy program, based on the neurodevelopmental treatment (Bobath) model, can improve gross motor skills and daily function in children with cerebral palsy. Twenty children aged 6 months to 6 years will participate, with a caregiver helpin…

This study tests whether a non-invasive brain-computer interface combined with mild electrical brain stimulation can improve facial movement in people with peripheral facial palsy. Thirty adults aged 18-70 with moderate to severe facial weakness will receive up to 20 sessions ove…

This study compares two treatments—special exercises called PNF and music therapy—to see which helps children with ataxic cerebral palsy improve balance, coordination, and daily activities. About 29 children aged 6 to 18 will take part, receiving either PNF or music therapy along…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tests an implanted stimulator and sensor that helps people with cervical spinal cord injury regain hand and arm function. Ten participants will use the device to perform everyday tasks like grasping objects. The goal is to improve independence and quality of life.

This study gave stem cell infusions to one person with severe cerebral palsy who had no other treatment options. The goal was to improve their quality of life, not to cure the condition. The person received 8 infusions of their own stem cells, taken from fat tissue.

This expanded access program gives one patient with a spinal cord injury at the C5-C7 level a single infusion of their own stem cells (HB-adMSCs). The stem cells are taken from the patient's fat tissue and grown in a lab before being given back. The goal is to see if this approac…

This pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…

This study compares two types of physical therapy for children aged 6 to 10 with diplegic cerebral palsy: scooter board activities and core stability exercises. The goal is to see which better improves trunk control and balance. Forty children will participate, and their progress…

This study compares two types of breathing muscle training in people who have had a lung transplant. One group does standard constant-resistance exercises, while the other adds short bursts of harder effort. The goal is to see which method better improves breathing strength and d…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests whether augmented reality (AR) games can improve walking and balance in children with cerebral palsy. Forty children will either do exercises wearing AR goggles or receive standard physical therapy. The goal is to see if the AR approach is more effective and enga…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This study tests whether personalized nutrition advice can improve nutrition, reduce stomach problems, and enhance quality of life in children with cerebral palsy. Fifty children aged 6 to 12 will be randomly assigned to receive either individualized dietary counseling or routine…

This study tests two different therapies—digital mirror therapy and action observation therapy—to see which better improves arm movement and grip strength in children with hemiplegia (one-sided weakness). Forty-five children aged 6 to 8 will participate. The goal is to find a sim…

This study compares a special exercise program called Coordinative Locomotor Training (CLT) to regular physiotherapy for children aged 8 to 12 with spastic hemiplegic cerebral palsy, a condition that causes stiffness on one side of the body. CLT uses running and skating movements…

This study looks at whether a very mild, unnoticeable electrical stimulation to the legs can help children and young adults with cerebral palsy (ages 10–21) maintain balance during everyday movements like standing up, walking, and turning. Participants will perform simple tasks w…

This study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…

This study tests whether adding a mild electrical stimulation to the diaphragm (the main breathing muscle) can improve lung function, head control, and sitting balance in children with severe cerebral palsy who cannot walk. Thirty children aged 5-18 will receive either standard r…

This study compares robotic exoskeleton training to traditional physical therapy for improving walking in adolescents and young adults with cerebral palsy. Participants undergo brain scans, mobility tests, and nerve tests before and after training. The goal is to see if the robot…

This study tests whether a structured walking therapy program can improve mobility in 120 adolescents and young adults with cerebral palsy. Participants undergo 24 gait training sessions over 8 weeks, with before-and-after tests of walking speed, brain activity, and muscle contro…

This small study tests whether adding robot-assisted walking training to regular physiotherapy can improve body composition (like muscle and fat) and daily function in children with cerebral palsy or similar conditions. Nine children will each receive both standard physiotherapy …

This study looks at whether using a passive kinesiotherapy device on the legs for 30 minutes can immediately reduce muscle stiffness (spasticity) and improve walking in people with conditions like cerebral palsy, stroke-related weakness, or spinal cord issues. About 80 participan…

This study tests whether early, intensive leg exercises, done by a physical therapist and a parent together, can improve walking and motor skills in children aged 8 months to 3 years who had a stroke around birth. The study compares this approach to usual care. The goal is to see…

This trial tests a robotic exoskeleton called the CPWalker to help children with cerebral palsy improve their walking. The device supports the child's weight and assists leg movements during walking practice. The study includes 30 participants aged 11 to 21 with spastic diplegia.…

This study looks at whether a special exercise method called blood flow restriction training can help children with hemiparetic cerebral palsy (CP) improve their hand grip strength. The method uses a cuff to lightly restrict blood flow during low-intensity exercises, which may bu…

This study tests whether a portable shoulder exoskeleton can help people who had a stroke move their arm and hand better. About 30 participants will perform tasks like reaching and picking up objects with and without the device. The goal is to see if the exoskeleton improves dail…

This study tests whether 3 months of intensive leg exercise (walking, kicking, jumping, and climbing with small ankle weights) can improve walking and daily function in 60 young children with spastic diplegia caused by prematurity. The exercise is done 1 hour a day, 4 days a week…

This study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …

This study tests whether a 12-week strength and functional exercise program, done at home via video calls with a physiotherapist, can improve walking, balance, and daily life in people with Hereditary Spastic Paraplegia (HSP). Twenty participants aged 16 to 70 will each experienc…

This study tests whether online group cognitive behavioral therapy (CBT) is a practical way to help adults with cerebral palsy who have chronic pain. Fourteen participants will attend weekly virtual therapy sessions for 12 weeks. The main goal is to see if people will stick with …

This study tests a gentle hands-on technique called Strain Counter-Strain to relax tight jaw and neck muscles in 30 children with spastic cerebral palsy, ages 4 to 8. The goal is to improve mouth opening, reduce drooling, and make eating easier. Results are measured after one mon…

This study compares two types of therapy for children aged 8 to 12 with spastic diplegic cerebral palsy. One group uses play-based activities like puzzles and arts and crafts, while the other uses standard exercises with resistance bands and weights. The goal is to see which appr…

This study tests whether an 8-week power wheelchair training program using the IndieTrainer system can help children with severe cerebral palsy improve their wheelchair skills and independence. Sixteen children who cannot walk or propel a manual wheelchair will participate. The t…

This study tests a program called MSE-PEACE, where parents and children with developmental disabilities (like autism or ADHD) attend 10 sensory sessions together. The goal is to see if it improves children's engagement and emotional control, and helps parents feel more confident …

This study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exer…

This study compares two physical therapy approaches for children aged 8-24 months with or at high risk for cerebral palsy. One method focuses on sitting, reaching, and problem-solving, while the other targets general motor skills. The goal is to see which therapy improves sitting…

This study looks at whether walking on a path with lights that show where to step can improve how children with spastic diplegia (a type of cerebral palsy) walk. Thirty children aged 5 to 8 with mild spasticity will walk on the light pathway, and researchers will measure changes …

This study tests a device called GaitBetter that combines treadmill walking with cognitive training (like thinking tasks) to help stroke survivors improve their walking and balance. About 76 people who had a stroke (either within 8 weeks or more than 6 months ago) will use the de…

This study tests a dual-task training program for children aged 6-8 with unilateral cerebral palsy. About 70 participants will be split into two groups: one doing balance exercises while also performing fine motor tasks, and the other doing single-task exercises. The goal is to s…

This study looks at whether adding tolperison to botulinum toxin injections helps reduce muscle stiffness and nerve pain in stroke survivors. About 40 adults with spastic hemiplegia (one-sided paralysis) will be followed. Researchers will measure spasticity and walking speed to s…

This study tests whether mirror therapy can help people who have had a stroke regain movement and reduce pain in a weak arm. Participants do arm exercises while watching the reflection of their good arm, which tricks the brain into thinking the weak arm is moving. The trial invol…

This study tests whether adding a mild electrical stimulation to the neck muscles can help people who recently had a stroke and now have trouble swallowing. Forty participants will receive either standard swallowing therapy or therapy plus electrical stimulation. The goal is to s…

This study tests whether adding Kabat rehabilitation or kinesiology taping to standard facial therapy helps people with Bell's palsy recover better. 38 adults with one-sided facial paralysis will receive one of the two extra treatments for 8 weeks. Researchers will measure change…

This study compares traditional balance exercises with video game-based exergaming (using Nintendo Switch Ring Fit Adventure) in stroke survivors with hemiplegia. Thirty participants will be split into two groups, both receiving standard physiotherapy plus either balance exercise…

This study tests an intensive group physical therapy program for children aged 7-17 with cerebral palsy who can walk. The program focuses on improving muscle strength, walking speed, and daily activities like climbing stairs. Researchers will measure changes in strength, balance,…

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This study looked at 60 children aged 6 to 10 with hemiplegic cerebral palsy to see which type of balance training works better: playing on a Wii Balance Board or doing reactive balance exercises. Both groups also did standard physical therapy three times a week for eight weeks. …

This study looks at whether three types of exercises—vestibular rehab, dynamic neuromuscular stabilization, and standard rehab—can improve balance and mobility in people with hemiplegia (paralysis on one side) after a stroke. About 45 adults who had a stroke at least a year ago a…

This study tests a 12-week play-based training program for children aged 2-5 with cerebral palsy. The program uses running frames and other assistive devices to improve mobility, fitness, and daily activity. Twenty children will participate in weekly group sessions plus home exer…

This study looks at whether doing arm exercises on a vertical surface (like a wall) or a horizontal surface (like a table) makes a bigger difference in hand skills and trunk control for children with bilateral cerebral palsy. Thirty children aged 5 to 8 will take part in a 3-mont…

This pilot study tests whether constraint-induced movement therapy (CIMT) can be effectively delivered via video in the homes of 10 children aged 4-10 with hemiplegic cerebral palsy. The therapy involves encouraging use of the weaker arm while restraining the stronger one. Resear…

This study tests whether adding light weights to the ankles can improve balance in children aged 7 to 13 who have ataxic cerebral palsy, a condition that affects coordination and stability. Researchers will measure changes using a special balance platform. The goal is to find a s…

This study tests whether adding a gentle, non-invasive nerve stimulation on the ear (taVNS) to standard physical therapy can reduce muscle stiffness, improve movement, and boost quality of life in children with spastic cerebral palsy. Eighteen children aged 8-18 will be split int…

This study tests a device called the Neuromechanical Gait Assist (NMGA) that combines a powered knee brace with muscle stimulation to help people who have difficulty walking after a stroke. Five veterans with leg weakness and a stiff-legged gait will use the device in a lab while…

This study compares two ways of delivering an intensive upper limb therapy program for children with cerebral palsy, ages 3 months to 4 years 11 months, and their caregivers. The goal is to see which method works better for improving hand function. The study involves 37 children …

This study looks at whether adding music to standard occupational therapy can help children aged 5-12 with conditions like cerebral palsy, encephalitis, or brain tumor recovery. Researchers will measure changes in walking, balance, and vital signs like heart rate and oxygen level…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study tests whether low level laser therapy can improve facial function in people with Bell's palsy, a condition that causes sudden facial weakness. Researchers will compare laser therapy to routine physiotherapy in 100 adults aged 18 to 80. The main goal is to see if laser …

This study looks at whether virtual reality games designed for hand-arm training can improve hand function in children with hemiplegic cerebral palsy. Seventeen children will either play VR games or do standard hand exercises for 40 hours over two weeks. Researchers will measure …

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study tests a robotic feeding device called Obi for people who cannot use their arms to eat on their own. About 50 participants, including patients, caregivers, and healthcare providers, will use the device at home or in care settings for one week. Afterward, they will fill …

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study investigates whether patients with pre-existing endothelial dysfunction (damage to the inner lining of blood vessels) are more likely to develop vasoplegia (a dangerous drop in blood pressure) after cardiac surgery using a heart-lung machine. Researchers will measure v…

This study follows 72 adults with cerebral palsy who had walking tests as children to see how their walking ability changes over time. Researchers measure joint movement, muscle activity, and blood markers related to metabolism and inflammation. The goal is to understand how walk…

This long-term study looks at children and adults with inherited nerve and muscle disorders that start early in life, like muscular dystrophy. Researchers will track symptoms over time and collect genetic samples from affected individuals, their family members, and healthy volunt…

This study is observing up to 198 people with rapid-onset dystonia-parkinsonism (RDP) or related genetic mutations. Researchers aim to identify affected individuals, document how common the disease is, and track its progression over time. Participants undergo assessments of sympt…

This study tests whether a special type of X-ray called DXA, taken while lying down, can measure spine curves as well as standard standing X-rays in people with scoliosis. About 20 participants will have both types of images taken, and researchers will compare the results and ask…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program can improve quality of life, diet, physical activity, and partner support. Only 6 participants were enrolled,…

This study tests a new way to measure how children move their arms using a special camera system that tracks reflective markers placed on the skin. Researchers will check if the method is reliable and easy to use in both healthy children and those with arm movement problems. The …

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study checks whether a play-based test of arm and hand movements, called the Melbourne Assessment-2, is reliable when done through telehealth for children with hemiplegic cerebral palsy. About 35 children ages 2 to 10 will attend one in-person visit and one telehealth visit,…

This study explores why constipation is common in children with cerebral palsy and what factors might be involved, such as diet, physical activity, and caregiver stress. Researchers will observe 100 children aged 4 to 18 and their caregivers using questionnaires and diaries. No t…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study follows 200 African American prostate cancer survivors and their partners to understand how daily stress, social support, and lifestyle choices like physical activity and diet affect each other. Participants wear an activity tracker and answer surveys on their smartpho…

This study aims to discover new genetic mutations that cause mitochondrial disorders by analyzing tissue samples from up to 6,900 participants. It includes people with suspected or known mitochondrial diseases, such as MELAS or Leigh's Disease, who lack a genetic diagnosis. The r…

This study looks at why people with cerebral palsy often feel very tired. Researchers will use EEG and PET scans to compare brain activity in 50 adults with mild versus severe fatigue. The goal is to find a brain network linked to fatigue, which could lead to better treatments in…

This study tests a new 3D imaging method to measure how much air the lungs can hold in people with suspected diaphragm weakness. About 100 adults will have two quick 3D scans while holding their breath. The goal is to see if this technique gives reliable results compared to stand…

This study looks at a possible side effect of a heart treatment called PFA for atrial fibrillation: injury to the phrenic nerve, which can paralyze part of the diaphragm and affect breathing. Patients get a special X-ray before and after the procedure to check diaphragm movement.…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…

This study looks at whether shoulder problems make balance worse for people who have had a stroke and have weakness on one side. Researchers will compare balance in 100 stroke survivors—some with shoulder pain and some without. The goal is to understand if treating shoulder issue…