Intracranial arterial disease

This study follows 118 people getting a special device called Pipeline Vantage to treat brain aneurysms. The device is placed inside the blood vessel to block the aneurysm and prevent rupture. Researchers will check how well it works and if there are any problems one year after t…

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial investigates whether a procedure to remove blood clots from arteries in the back of the brain can improve recovery in people who had a stroke more than 24 hours ago but within the last 7 days. Participants will either receive standard medication alone or the clot-remov…

This trial tests whether low-dose colchicine, an anti-inflammatory drug typically used for gout, can reduce stroke risk and artery plaque in people with intracranial atherosclerotic disease (ICAD). ICAD is a leading cause of stroke in Asia, and even with standard treatment, the r…

This study tests a metaverse-based surgical platform that uses extended reality (XR) to help surgeons precisely locate blood vessels during brain bypass surgery. The trial includes 30 adults with moyamoya disease or chronic cerebral ischemia who need an extracranial-intracranial …

This trial compares two endovascular procedures for treating unruptured wide-neck brain aneurysms: a flow diverter device (Pipeline) versus traditional stent-assisted coiling. About 266 adults aged 18–75 with these aneurysms will be randomly assigned to one treatment and followed…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study tests a device called Artisse, which is placed inside a brain aneurysm to block blood flow and prevent rupture. It involves 300 people aged 18-75 with wide-neck aneurysms that are either unruptured or recently ruptured. The main goal is to see if the device safely and …

This study is testing a new device called the Choydar flow-directed mesh stent for people with unruptured brain aneurysms—weak spots in blood vessels that could burst. The stent is placed inside the artery to block blood flow into the aneurysm, helping it heal. Researchers will f…

This trial investigates the safety and effectiveness of using a stent along with coil embolization to treat ruptured brain aneurysms. The procedure is performed within a week of the bleeding event in patients aged 18 to 80 with wide-neck aneurysms. Researchers are monitoring for …

This trial compares two types of surface-modified flow diverters—special stents used to treat unruptured brain aneurysms. The goal is to see which device causes fewer small brain injuries (seen on MRI) and fewer stroke-like symptoms after the procedure. About 196 people with unru…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 week…

This study looks at how well a device called WEB works for treating brain aneurysms (weak spots in blood vessels) in real-life medical practice. It will include 1,000 people of any age who have had this device placed. The main goals are to see if the aneurysm is sealed off at 12 …

This study tests whether a clot-busting drug called tenecteplase can help people who have a stroke affecting the back part of the brain. Participants must start treatment between 4.5 and 24 hours after their first symptoms. The goal is to see if the drug improves recovery and dai…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard posit…

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study looks at 180 adults with moderate to severe narrowing of brain arteries who have high LDL cholesterol. Researchers want to see if improving cholesterol management can lower the chance of having a stroke. Participants will not receive any experimental treatment; instead…

This trial tests a new device called the Surpass Elite with Guardian Flow Diverter for treating brain aneurysms that haven't ruptured. The device is a small mesh tube placed inside the artery to redirect blood flow and seal the aneurysm. About 183 adults aged 18-80 with specific …

This clinical trial is testing a device called the Contour Neurovascular System for people with wide-necked brain aneurysms. The device is placed inside the aneurysm to block blood flow and prevent it from rupturing. The study will enroll 250 participants and follow them for two …

This study tests whether sirolimus, a drug used to prevent organ rejection, can reduce harmful inflammation inside brain aneurysms. Researchers will give the drug to some patients before standard surgery or coiling and compare tissue and blood samples to those not receiving the d…

This study tests if a drug called indobufen works better than aspirin at preventing strokes and blood clots after a brain aneurysm is fixed with a stent or coil. About 2,500 people with unruptured brain aneurysms will take either indobufen or aspirin, plus clopidogrel, for 6 mont…

This study compares two ways to treat aneurysms in a specific brain artery: open surgery (clipping) and a less invasive procedure using catheters (endovascular). About 400 adults with this type of aneurysm will be randomly assigned to one treatment. The goal is to see which appro…

This study is testing a device called Pipeline Flex with Shield Technology to treat wide-necked brain aneurysms in adults aged 22 and older. The device is already approved for use, and researchers want to see how well it prevents blood clots. Ten participants will be enrolled at …

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before and after a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will be randomly assigned to receive either atorvastatin or a placebo. The goal …

This study tests a special stent (flow diverter) to treat brain aneurysms that are hard to treat with standard methods. About 164 adults aged 18-80 with certain types of aneurysms will receive the stent. The main goal is to see if the aneurysm is completely sealed one year after …

This study is testing a special stent coated with the drug rapamycin to treat narrowed brain arteries in people who haven't gotten better with medication alone. About 300 participants will receive the stent and be monitored for up to a year to see if it reduces the risk of stroke…

This study tests a new, remotely controlled guidewire called SmartGUIDE for treating unruptured brain aneurysms. It involves 30 adults who need a catheter-based procedure. The goal is to see if the new wire is safer and easier to navigate through blood vessels compared to standar…

This study tests whether bringing blood pressure down very quickly (below 120 mmHg) after a stroke clot removal procedure improves recovery. About 910 stroke patients will be randomly assigned to either intensive or standard blood pressure management. The goal is to see if this a…

This study tests a new stent (a small mesh tube) placed in brain arteries to prevent strokes in people whose arteries are narrowed by plaque. It includes 200 adults aged 18-75 who have had a stroke or mini-stroke despite medication. The main goal is to see if the stent is safe an…

This study tests a personalized approach to managing fluids during brain surgery for children with Moyamoya disease. Instead of standard blood pressure targets, doctors will use each child's baseline heart function to guide fluid delivery. The goal is to reduce temporary stroke-l…

This early study tests a new device called the LuSeed Aneurysm Embolization System for treating unruptured brain aneurysms. The device is designed to block blood flow into the aneurysm, reducing the risk of rupture. About 30 adults aged 18-80 with unruptured saccular aneurysms wi…

This study tests a new robotic surgical system (Symani) in 15 adults with Moyamoya disease, a rare condition that narrows brain arteries and raises stroke risk. The surgery aims to improve blood flow to the brain. Participants must have mild to moderate symptoms and agree to the …

This study tests a new drug-coated stent (NxiDIME) for people with severely narrowed brain arteries that have already caused a mini-stroke or stroke. The goal is to see if it keeps the artery open better than an existing stent. About 224 adults will be randomly assigned to get ei…

This early-phase trial tests a new treatment for Moyamoya disease, a rare condition where major brain arteries narrow, raising stroke risk. The treatment combines a special muscle flap with injections of tiny particles from stem cells (iPSC-EVs) to encourage new blood vessel grow…

This study tests a device called DERIVO 2heal, a small mesh tube placed in an artery to block blood flow into a brain aneurysm. The goal is to see if it safely and effectively seals the aneurysm over the medium and long term. About 158 adults with brain aneurysms will be enrolled…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study tests whether an artificial intelligence (AI) model can help doctors find brain aneurysms more accurately on CT scans. Over 6,400 adults in China will have their scans reviewed by radiologists with either a real AI or a sham AI that gives no real help. The goal is to s…

This study is testing a new type of MRI scan called eASL that measures blood flow in the brain without needing a contrast injection. It will include 50 children with conditions like Moya-moya or sickle cell disease that affect brain arteries. The goal is to see if eASL gives clea…

This pilot study tests whether a mild electrical stimulation applied to the spinal cord, combined with balance training, can improve stability and reduce fall risk in people who had a stroke over a year ago. Sixteen community-dwelling adults will be randomly assigned to receive e…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This pilot study tests whether a low-cost virtual reality (VR) system can help people recovering from a first-time stroke improve their arm movement. Researchers will compare VR therapy to standard care in 40 adults with moderate to severe arm weakness. Participants will use a Me…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study tests whether a scalp block (a numbing injection) can reduce severe headaches in patients who have had a brain aneurysm rupture. About 22 adults in intensive care will receive either standard care plus the scalp block or standard care alone. The goal is to see if the b…

This study is testing whether a special MRI technique, called 4D Flow MRI, can better detect and predict the growth of unruptured brain aneurysms. Researchers will follow adults with these aneurysms, using the advanced imaging to measure changes in the aneurysm's shape over time.…

This study tests whether a wireless sensor placed on the forehead can accurately measure oxygen levels in the brains of infants in the neonatal intensive care unit (NICU). The wireless device is compared side-by-side with the standard wired monitor in 20 newborns with conditions …

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be observed to understand the device's effects, but this study does not aim to cure or treat a disease directly.

This study looks back at medical records of up to 5,000 adults who had a brain aneurysm treated with special mesh tubes called flow diverters. Researchers want to see how well these devices work and how safe they are by checking things like successful placement, complications, an…

This study follows 1,000 people with small, unruptured brain aneurysms (3-7 mm) for three years. Researchers will use MRI scans to see if a specific imaging sign—wall enhancement—can predict which aneurysms grow. The goal is to create a safer, personalized monitoring plan so that…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This study is creating a large collection of medical data and biological samples from 1,100 people with brain aneurysms. The goal is to find better ways to predict which aneurysms are at risk of rupturing, which could lead to more personalized monitoring and treatment. Participan…

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This study aims to make brain aneurysm and AVM treatments safer and more effective by using computer models and artificial intelligence. Researchers will create detailed maps of each patient's brain blood vessels and simulate blood flow to help doctors plan procedures. The study …

This study tests whether a 3D simulation software called Sim&Size can help doctors plan treatments for unruptured brain aneurysms more accurately than current 2D methods. About 576 adults will be randomly assigned to use the software or standard planning. Researchers will compare…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study tests two methods of giving the anesthetic remimazolam during cerebrovascular bypass surgery in people with moyamoya disease. One method uses a computer-controlled pump (TCI), the other uses manual weight-based dosing. The goal is to see which approach uses less total …

This study is looking at families where someone has moyamoya disease, a rare condition that narrows brain arteries and raises stroke risk. Researchers want to find early warning signs in first-degree relatives using advanced MRI scans and biological samples like blood and saliva.…

This study compares a non-invasive continuous blood pressure monitor (ClearSight) to the standard arterial catheter in 50 adults undergoing coil embolization for unruptured brain aneurysms. The goal is to see if the non-invasive method can safely detect blood pressure changes and…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This small study tests a smartphone app that creates a 'digital twin' of the patient to help manage health after a stroke, moyamoya disease, or cerebral amyloid angiopathy. Twenty adults will either use the app plus standard care, or standard care alone. The goal is to see if pat…

This study will follow 1,000 people of all ages who are having endovascular procedures (minimally invasive treatments through blood vessels) for brain or spinal conditions like aneurysms or abnormal blood vessels. Researchers will record complications, recovery, and changes in th…

This registry is following 5,000 people who receive WallabyPhenox flow diverters or other devices to treat brain aneurysms, dissections, or perforations. Researchers are tracking safety, performance, and patient outcomes over time in routine hospital practice. The goal is to gath…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This observational study looks at proteins in tiny particles called extracellular vesicles from the blood of 120 people with brain aneurysms. Researchers will collect blood from different areas of the circulatory system during surgery to compare protein patterns. The goal is to f…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This study collects blood and tissue samples from 400 people with brain aneurysms (some ruptured, some not) and 200 healthy volunteers. Researchers will analyze the participants' genes to find variations linked to a higher risk of aneurysm rupture. The goal is to create a tool th…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real life, not just in controlled trials. No new treatments are being tested—just data gathe…

This study follows 150 adults with brain aneurysms who are treated with Sugita aneurysm clips. The goal is to see how safe and effective the clips are in real-world use over 5 years. Researchers will track how well the aneurysm is closed and any side effects. This is an observati…

This study explores whether a training program that mixes cognitive tasks (like memory and attention exercises) with physical therapy can improve recovery in people with post-stroke cognitive impairment or Moyamoya disease. Researchers will also use brain imaging to see how think…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study follows 2,000 adults who have had a brain aneurysm sealed with a coil or similar procedure. The goal is to track how often the aneurysm reopens over time and whether another treatment is needed. By collecting standardized data, researchers hope to improve follow-up car…

This study tests a new, remotely controlled guidewire called SmartGUIDE for treating unruptured brain aneurysms. The wire is designed to navigate blood vessels more easily without needing to be shaped by hand. Researchers will compare its safety and performance to standard guidew…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study is creating a large database of information from 20,000 people with brain aneurysms. Researchers will look at genetic, environmental, and other factors to better understand what causes aneurysms and how different treatments affect outcomes. Participants are not given a…

This study uses a virtual reality driving simulator to see how people with vision loss from a stroke steer a car. Researchers will compare driving accuracy between 40 participants with and without vision loss. The goal is to understand how the brain adapts to missing parts of the…

This study tests whether a fresh human placenta can be used as a realistic model for training neurosurgeons to repair brain aneurysms. The placenta's blood vessels closely resemble those in the brain, and researchers will create artificial aneurysms using a small catheter. The go…

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other brain blood vessel problems. Researchers will look at this data to find patterns that help predict recovery and compare different treatment…

This study compares general anesthesia (being fully asleep) versus local anesthesia (awake but numb) for repairing unruptured brain aneurysms with a flow diverter device. About 188 adults with small aneurysms will be randomly assigned to one of the two anesthesia methods. The goa…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study tracks 2,000 people in China with a rare brain aneurysm called a vertebrobasilar dissecting aneurysm (VBDA). Doctors will use different treatments—observation, stenting, or flow diverters—and follow patients to see which works best. The goal is to create clear guidelin…

This study looks at how knowing you have an unruptured brain aneurysm affects your mental health, and whether getting it treated or just monitoring it makes a difference. Researchers will follow 120 people with unruptured aneurysms, comparing those who have surgery or a less inva…

This study follows 100 people with severe narrowing of brain arteries to understand why some develop memory and thinking problems. Participants receive either standard medications or a procedure to open the artery. Researchers will track changes in memory and stroke risk over tim…

This study is collecting information from up to 10,000 people who receive BALT medical devices for conditions like brain aneurysms, stroke, and blocked arteries. Researchers will track how well the devices work and if any safety issues arise during routine care. The goal is to ga…

This study will follow 5,000 people who receive newer endovascular devices (like coils, stents, or flow diverters) to treat a brain aneurysm. Researchers want to see how often the aneurysm comes back and what factors, such as smoking, might play a role. The goal is to improve saf…