Can stem cell vesicles help rebuild brain blood vessels in moyamoya?
NCT ID NCT07065409
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new treatment for Moyamoya disease, a rare condition where major brain arteries narrow, raising stroke risk. The treatment combines a special muscle flap with injections of tiny particles from stem cells (iPSC-EVs) to encourage new blood vessel growth. Nine adults will be monitored for safety and early signs of improved blood flow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iPSC-derived extracellular vesicles (iPSC-EVs)
What this could lead to
If successful, this could lead to a new way to help the brain grow new blood vessels in Moyamoya disease, potentially reducing stroke risk.
What could go wrong
This is a very early phase 1 trial with only 9 participants, focused on safety. It is too small to prove effectiveness, and the treatment may not work or could cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tongji hospital
RECRUITINGWuhan, Hubei, 430030, China
Contact Phone: •••-•••-•••• Email: •••••@•••••