Intracranial arterial disease

This study tested a new device called SINOMED IAS in 203 people with wide-necked brain aneurysms. The device is a stent placed inside the artery to block blood flow into the aneurysm, helping it heal. The main goal was to see if the aneurysm was successfully closed at 6 months af…

This study tested a special stent designed to divert blood flow away from brain aneurysms, helping them heal. It involved 143 people with unruptured, wide-necked aneurysms. The main goal was to see if the stent could completely seal the aneurysm within a year without causing majo…

This study tracked 723 people with brain aneurysms treated using MICRUSFRAME and GALAXY coils, sometimes with a PulseRider device. The goal was to see how well the coils blocked the aneurysm and kept it closed after 12 months. Researchers collected data from real hospital setting…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study tested a device called Trenza for treating brain aneurysms. It involved 150 people aged 18 to 80 with a single saccular aneurysm between 6 and 12 mm. The goal was to see if the device could safely block the aneurysm from blood flow and prevent strokes.

This study tested a special stent (Enterprise 2) used with coils to treat wide-neck brain aneurysms. Ten adults with this condition received the procedure. Researchers checked if the stent stayed in place, shortened, or narrowed over time. The goal was to see if this device can s…

This study tested a new medical wire, called the Tarvos Microguidewire, used during surgery on blood vessels in the brain. The wire helps doctors guide other tools to the right spot. Researchers looked back at records of 121 patients who had this wire used in their surgery for co…

This study tested two stent systems (Neuroform EZ and Neuroform Atlas) used with coils to treat wide-neck brain aneurysms. Wide-neck aneurysms are hard to seal because coils can fall out. The stents act like a scaffold to keep coils in place. 30 adults with unruptured, wide-neck …

This study tested whether a coated stent (Derivo 2 heal) causes less narrowing inside the artery than an uncoated stent after treating brain aneurysms. 21 adults with unruptured aneurysms in the internal carotid artery were randomly assigned to receive one of the two stents. Rese…

This study tested a temporary device called Comaneci that helps doctors place coils in wide-necked brain aneurysms. 90 patients were treated and followed for up to 6 months to check safety and how well the aneurysm was sealed. The goal was to see if the device works well in every…

This study tested a new stent called Tonbridge for treating brain aneurysms (weak spots in blood vessels). It involved 204 people aged 18 to 80 who needed a stent to help place coils inside the aneurysm. The goal was to see if the new stent works as well as an existing device at …

This study tested a new medical device called the Tonbridge flow diverter to treat brain aneurysms (weak spots in blood vessels). The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it heal. The trial included 142 people aged 18 to 80 wit…

This study tested a new expandable coil system for treating medium to large brain aneurysms (both ruptured and unruptured) in 13 adults. The goal was to see if the coil is safe and effectively blocks blood flow into the aneurysm. Results focused on serious side effects and how we…

This study looked at 528 adults who had a brain aneurysm fixed with a stent and coils. It compared taking two blood thinners for 6 months versus 12 months after the procedure. The goal was to see if the shorter course could prevent blood clots just as well while reducing bleeding…

This study compared two procedures for treating unruptured brain aneurysms: traditional coiling (using tiny coils to block blood flow) and a newer method using a flow diverter stent. 91 adults with specific types of aneurysms took part. The goal was to see which treatment works b…

This study looked at 51 stroke patients to see which therapy—constraint-induced movement therapy or task-oriented training—works better for arm function after a Botox injection. Both therapies aim to improve movement and reduce muscle tightness. The results help doctors choose th…

This study tested whether giving the drug tirofiban during stent or flow diverter procedures for unruptured brain aneurysms could reduce the number of small brain injuries seen on MRI after surgery. 192 adults aged 18-80 took part. The goal was to see if tirofiban works better th…

This study looked at 391 people with a type of stroke caused by a blockage in a major brain artery, treated 4.5 to 24 hours after symptoms started. Half got a clot-busting drug called tenecteplase followed by a mechanical clot removal procedure, while the other half had the proce…

This study looked at how safe and effective the OPTIMA coil system is for treating brain aneurysms. Researchers followed 300 patients across Europe for up to 12 months after the coiling procedure. They tracked complications like bleeding, blood clots, and the need for repeat trea…

This study tested whether a non-immersive virtual reality system (MindMotion GO) could help people with chronic stroke improve arm function better than standard occupational therapy. Twenty-six adults who had a stroke more than 6 months ago participated in 8 weeks of training. Th…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…

This study investigates whether people with late-onset Pompe disease have a higher risk of severe blood vessel problems in the brain and aorta. Researchers will collect medical and genetic data from adults with Pompe disease and from those who have had a brain aneurysm or bleedin…

This completed study looked at 208 people with cerebral aneurysms who were treated with clopidogrel, a blood thinner. Researchers wanted to find out how many patients are overly sensitive to the drug and what happens to them. The goal is to better understand risks and improve car…

This completed early-phase study looked at how sex and stress influence blood flow in the brain. Researchers gave 42 healthy young adults indomethacin (an anti-inflammatory drug) or a placebo to test whether a specific mechanism (COX signaling) explains differences between men an…

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study compared two types of anesthesia—propofol alone versus a mix of propofol and ketamine—in 46 adults having elective surgery for unruptured brain aneurysms. Researchers measured the diameter of the optic nerve sheath (a marker of brain pressure) at several points during …

This study looked at 481 stroke patients who had a procedure to remove a blood clot from their brain. Researchers compared those who received general anesthesia (fully asleep) versus sedation (awake but relaxed). They tracked death rates and recovery to see if one method was bett…

This completed study followed over 31,000 people in China who had unruptured brain aneurysms (a bulge in a blood vessel that hasn't burst). Researchers compared four approaches: simply monitoring the aneurysm, surgical clipping, coil embolization, or flow diversion. The goal was …

This study tested a 12-item checklist used by nurses to predict neurological complications like bleeding or re-blockage after endovascular therapy for stroke or aneurysms. Researchers compared 213 patients who were checked with the list to 213 who received standard care. The goal…

This study tested a software tool called AneurysmFlow that measures blood flow in brain aneurysms. The goal was to see if it can predict whether an aneurysm will fully close 12 months after a stent is placed. 132 adults with unruptured brain aneurysms participated. The tool is al…

This study looked at 21 children, teens, and young adults who had surgery for Moyamoya disease, a rare brain vessel condition. Researchers used questionnaires to measure anxiety, depression, attachment, and quality of life in patients and their parents. The goal was to understand…