Endometrial disorder

This trial explores whether a new type of radiotherapy called CT online-adaptive radiotherapy can safely deliver treatment for endometrial cancer in just 5 sessions over a week and a half, instead of the usual 25 sessions over 5 weeks. The study includes 30 adults who have had su…

This study compares two surgical techniques for ovarian endometrioma—standard cyst removal (cystectomy) versus a newer method using argon plasma coagulation (APC) to vaporize the cyst lining. The goal is to see which better preserves ovarian reserve, measured by antral follicle c…

This early-phase trial tests a one-time treatment called OPB-201, where a patient's own immune cells are modified in a lab to better recognize and attack cancer cells that carry a protein called PRAME. The study will enroll 30 adults with recurrent endometrial cancer or platinum-…

This phase 2 trial tests whether adding tirzepatide (a weight-loss injection) to a levonorgestrel intrauterine device (LNG-IUD) can eliminate precancerous or early-stage endometrial cancer in overweight or obese women. About 55 women who want to avoid hysterectomy will receive bo…

This study tests the safety of the immunotherapy drug dostarlimab when given together with standard chemotherapy (carboplatin and paclitaxel) as a first treatment for adults in India with advanced or recurrent endometrial cancer. Participants receive the drug combination initiall…

This trial tests whether fluzoparib plus bevacizumab works as well as the standard olaparib plus bevacizumab for maintenance therapy in women with HRD-positive advanced ovarian cancer after initial chemotherapy. The study enrolls about 120 participants and tracks how long they st…

This study looks at whether giving a GnRH agonist hormone treatment before a frozen embryo transfer can improve pregnancy and live birth rates in women with persistent chronic endometritis (a uterine infection that doesn't clear with antibiotics). About 150 women aged 20-40 will …

This Phase 3 trial tests a new biologic drug (PF-08634404) plus chemotherapy against the approved drug Keytruda plus chemotherapy in 600 women with advanced or recurrent pMMR endometrial cancer. The goal is to see if the new combination helps patients live longer without their ca…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This phase II trial tests whether combining elacestrant, a drug that lowers estrogen, with everolimus, which stops cancer cells from growing and cuts their blood supply, can control advanced or recurrent ER+ endometrial cancer. About 50 adults whose cancer has returned or spread …

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will receive either tirzepatide or no additional treatment for 4 weeks be…

This large Phase 3 trial will test a new drug called Rina-S, alone or with bevacizumab, against standard platinum-based chemotherapy for women with ovarian cancer that has returned after initial treatment. About 688 participants will be randomly assigned to receive either the new…

This phase II trial compares a new two-drug combination (sacituzumab govitecan plus bevacizumab) against standard chemotherapy (carboplatin, liposomal doxorubicin, and bevacizumab) in 87 women with platinum-sensitive ovarian cancer that has progressed after PARP inhibitor mainten…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy can better treat early-stage uterine cancer or pre-cancer in overweight women. About 30 participants will either get the standard progesterone IUD alone or the IUD plus tirzepatide. The g…

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. Instead of removing the whole cyst, doctors drain it and inject a solution to shrink it, which may better preserve a woman's egg supply. The study…

This phase 2 trial is testing a daily pill called Inavolisib in about 48 people with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The drug targets that mutation to try to shrink tumors or stop them from growing. Researchers will measure how ma…

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This study tests a new way to deliver radiotherapy for endometrial cancer after surgery. Using real-time MRI guidance, doctors can target radiation more accurately and reduce damage to nearby organs like the bowel and bladder. About 61 women will receive five high-dose sessions o…

This study compares two surgical approaches for early-stage endometrial cancer: laparoscopic staging (minimally invasive) and open staging laparotomy (traditional open surgery). Researchers will enroll 30 patients to see if laparoscopy is as safe and effective as open surgery, wi…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study tests whether adding FuKe Qianjin capsules, a Chinese herbal remedy, to standard antibiotics works better than antibiotics alone for chronic endometritis, a womb infection that can cause infertility and miscarriage. About 300 women aged 20-40 will take either the herba…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This study tests a combination of two drugs—CVL237 tablets and serplulimab injection—in people with advanced solid tumors that have lost or have low levels of a protein called PTEN. The trial aims to find the safest dose and see if the combo can shrink tumors or delay their growt…

This study compares two surgical approaches for women with early-stage, high-risk endometrial cancer that has a p53 gene mutation. One group will get the standard extensive lymph node removal, while the other gets a less invasive sentinel node biopsy. The goal is to see if the si…

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This study tests whether a combination of two drugs (fluzoparib and famitinib) can help keep advanced ovarian cancer from returning after successful initial chemotherapy. About 43 women with stage III-IV ovarian cancer who responded to platinum-based chemo will take these pills d…

This study tests two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair-deficient. The goal is to see if the treatment can make the cancer disappear or shrink enough to avoid surgery. Participants must…

This study tests whether adding letrozole to standard GnRH agonist therapy improves pregnancy rates in women with adenomyosis undergoing frozen embryo transfer. About 700 participants will be randomly assigned to one of two groups. The main goal is to see if more women have a hea…

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after standard treatments like immunotherapy. The drug works by targeting a protein on cancer cells to kill them. Researchers will measure how many pa…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests a new drug called BRY812 in people with advanced ovarian, endometrial, or ovarian clear cell cancers that have a specific marker (LIV-1). The goal is to see if the drug can shrink tumors and how safe it is. About 56 participants will receive the drug, and researc…

This Phase 3 trial tests whether adding the drug EG-007 to a standard combination of lenvatinib and pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without their cancer growing. About 450 participants will be randomly assigned to receive eithe…

This phase 2 trial tests whether adding a repurposed drug called EG-007 to the standard combination of lenvatinib and pembrolizumab is safe for people with advanced or recurrent endometrial cancer. The study will enroll 28 adults whose cancer has progressed after platinum chemoth…

This study tests a minimally invasive procedure that uses heat (radiofrequency or microwave) to destroy abnormal growths in the abdominal wall, such as cancer spread, desmoid tumors, or endometriosis. It involves 30 people who cannot have surgery or choose not to. The goal is to …

This study tests whether using an AI tool to analyze a patient's body composition from a CT scan can help doctors personalize chemotherapy dosing. The goal is to reduce severe side effects like low white blood cell counts in women with endometrial or ovarian cancer. About 294 par…

This phase 2 study tests whether adding the targeted drug fruquintinib to standard chemotherapy (paclitaxel and carboplatin) works better than chemotherapy alone for advanced pMMR endometrial cancer. About 128 participants will be randomly assigned to receive either the combinati…

This study tests whether adding nintedanib, a drug that reduces scarring, to standard progesterone therapy can improve live birth rates in infertile women with adenomyosis. About 328 women aged 20-38 with frozen embryos will take either nintedanib plus progesterone or progesteron…

This study tests a new radioactive tracer called 68Ga-FAPI-PSMA for PET/CT scans to see if it can find and stage solid tumors (like prostate, liver, and ovarian cancers) better than current tracers. About 20 adults with suspected or confirmed tumors will receive the tracer and ha…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can accurately detect these cancers compared to standard tests. About 300 women, some with c…

This study will test whether a special type of MRI called diffusion-weighted imaging can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) growths in the lining of the uterus. Researchers will compare the MRI results with the standard method—…

This observational study will test a new molecular test called CISENDO, which looks at DNA methylation in cells from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers wi…

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have non-atrophic endometrial changes and pain. Participants will be randomly assigned to take aspirin or not, a…

This study looks at whether a gel called Hyalosem can prevent scar tissue from forming inside the uterus after surgery. Researchers will review the medical records of 80 women who had uterine surgery and then received the gel. The goal is to see if the gel reduces adhesions and i…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study tests whether gentle belly massage can reduce period pain and improve quality of life in women with painful periods, with or without endometriosis. About 80 women will be randomly assigned to receive either real massage or a light touch (sham) over three menstrual cycl…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

This study tests whether a whole food, plant-based diet combined with behavioral education can improve quality of life and diet adherence in 60 women with metastatic breast or endometrial cancer. Participants are randomly assigned to either the plant-based diet with support or a …

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This observational study will follow 33 women with endometriosis who are taking relugolix combination therapy for pelvic pain. Researchers will track pain changes over 24 weeks using a standard pain scale, along with other symptoms and safety. The goal is to see how well this tre…

This study compares two standard radiation methods—proton therapy and photon therapy—for women with newly diagnosed cervical or endometrial cancer. The goal is to see which approach causes fewer stomach and bowel side effects. About 116 participants will be randomly assigned to o…

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This Phase 3 trial tests HMI-115, a monoclonal antibody, in 540 women with moderate to severe endometriosis pain. Participants receive either the drug or a placebo for 24 weeks, with a 28-week extension. The goal is to see if HMI-115 reduces menstrual and pelvic pain better than …

This study tests whether up to 9 sessions of electroacupuncture can reduce pelvic pain in women with suspected endometriosis who are scheduled for diagnostic surgery. 38 women aged 18-45 with moderate to severe pain will be enrolled. The goal is to see if this treatment can impro…

This study looks at whether following a Mediterranean diet can reduce inflammation and improve quality of life for women with endometriosis. Researchers will track pain, bloating, and fatigue in 104 women aged 18-45. The goal is to see if this anti-inflammatory diet helps manage …

This study looks at whether magnetic stimulation using a device called the 'Tesla chair' can help reduce pain in women with endometriosis. Many women still have pain even after surgery or medication, and painkillers may stop working. The study will include 30 women and measure pa…

This pilot study tests a new intravaginal device that uses gentle heat and stretching to help manage chronic pelvic pain in people with endometriosis. Twenty participants will use the device at home three times a week for 12 weeks. The goal is to see if it reduces pain and improv…

This study compares two advanced, minimally invasive hysterectomy techniques—TU-LESS (through the belly button) and vNOTES (through the vagina)—in 210 women with an enlarged uterus. The goal is to see which method leads to faster recovery, less pain, and shorter hospital stays. P…

This study compares total laparoscopic hysterectomy (removing the whole uterus including the cervix) with subtotal laparoscopic hysterectomy (keeping the cervix) in 500 women with benign conditions like fibroids or endometriosis. The main goal is to see which surgery leads to bet…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study compares immune cells, specifically natural killer cells, in women with deep endometriosis and those without the condition. Researchers will collect blood, tissue, and vaginal samples from 50 participants to look for differences that might explain the disease. The goal…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for two years. Those with a negative blood test may safely skip radiation, while others re…

This study will develop and test a free, cloud-based platform to educate women aged 18-45 with early-stage gynecologic cancer about fertility preservation options. Researchers will compare awareness, knowledge, and attitudes between a group using the platform and a group receivin…

This pilot study investigates how well a dual-wavelength diode laser can destroy endometriotic tissue inside ovarian cysts (endometriomas). Researchers will apply the laser to cyst walls removed during surgery and examine the tissue under a microscope to see if all abnormal cells…

This study compares two minimally invasive surgical methods for early-stage endometrial cancer: standard laparoscopy (small abdominal cuts) and vNOTES (surgery through the vagina with no visible scars). Researchers will enroll 160 women to see how well each method finds sentinel …

This study will ask 50 people aged 35 and older with abnormal uterine bleeding to collect daily urine samples and track their bleeding at home for several months. Researchers will use a home monitor to measure hormone levels and see if certain patterns are linked to uterine cance…

This study asks Black women aged 45 and older how they feel about using a vaginal fluid sample to test for DNA markers of endometrial cancer. The goal is to understand if women would accept this as a screening method. No treatment is given—just a 30-minute virtual interview to ga…

This study looks at two ways to measure endometriosis growths in the bowel before and during surgery. About 98 women will get both a standard vaginal ultrasound before surgery and a special ultrasound during their operation. The goal is to see if the during-surgery ultrasound giv…

This study looks at whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women with bowel endometriosis will have their surgery guided by ultrasound. The goal is to see if this approach r…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study will examine tissue samples from 30 women having surgery for bowel endometriosis to see if genetic changes in the affected bowel might increase the risk of colorectal cancer. The goal is to better understand any hidden connection and improve how doctors assess cancer r…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study looks at whether women with endometriosis who use AI tools like ChatGPT to prepare for their doctor visit have better or worse experiences. Researchers will compare satisfaction, treatment plan adherence, and communication quality between AI users and non-users. About …

This study is testing a new blood test that looks for tiny bits of cancer DNA (called minimal residual disease or MRD) in patients with endometrial or cervical cancer. The goal is to see if this test can find cancer coming back earlier than standard scans or exams. About 600 part…

This study aims to create a new lab model of human diaphragm muscle cells using tissue from women undergoing surgery for diaphragmatic endometriosis. Researchers will compare these cells to arm muscle cells to understand what makes the diaphragm unique. The goal is to provide a t…

This study will analyze tumor samples from 50 women with advanced or recurrent endometrial cancer to find biological markers that predict whether immunotherapy will work. Researchers will examine the tumor's DNA, epigenetics, and surrounding environment. The goal is to better und…

This study will test 20 people with endometrial cancer who also have a BRCA mutation in their tumor. Researchers will look for inherited (germline) gene changes using a blood test. The goal is to better understand genetic risks in this type of cancer. No treatment is given; it is…

This study looks at 100 women aged 18-45 with early-stage endometrial cancer who want to preserve their fertility. Researchers will analyze the tumor's molecular subtype (based on gene testing) to see how it affects response to hormone therapy and recurrence rates. The goal is to…

This study follows 100 women with deep endometriosis for 2 years to see if their lesions grow, shrink, or stay the same, and how this relates to symptoms and quality of life. Researchers will use regular ultrasounds and questionnaires to track changes. The goal is to learn whethe…

This study looks at how well patients do after surgery that removes both advanced gynecologic cancers and the major blood vessels they have grown into. Researchers will track 130 participants for up to 5 years to see survival rates and how long it takes for the cancer to return. …

This study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …

This study looks back at the medical records of 200 people treated for gynecological cancers (like ovarian, cervical, or uterine cancer) at Assiut University Hospital between 2022 and 2025. The goal is to measure how long patients survive after diagnosis and compare those numbers…

This study will examine tissue samples from 50 people with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to how aggressive the cancer is and how long patients live without th…

This study looks at fluid and tissue samples from the uterus and ovaries of women with moderate to severe endometriosis. Researchers want to find biological markers that explain why some women with endometriosis have trouble getting pregnant. The goal is to improve fertility trea…

This study will compare immune cells and gut bacteria in 40 women with and without endometriosis. Researchers will take tissue and blood samples during surgery and collect stool samples over a year. The goal is to find biological markers that could lead to better treatments for t…

This study will investigate whether exposure to persistent organic pollutants (POPs) like dioxins and PCBs is linked to more severe endometriosis. Researchers will analyze blood samples from 650 women with endometriosis living in the Ile-de-France region of France. The goal is to…