Dementia

This study tests whether regular, one-on-one conversations with an AI can improve social confidence and engagement in adults aged 75 and older who have mild cognitive impairment and are socially isolated. Participants will have AI-led chats designed to stimulate thinking and soci…

This trial tests whether a specific acupressure routine, performed by trained caregivers three times a week for a year, can slow cognitive decline in older adults with early or mild Alzheimer's disease. Participants will be randomly assigned to receive either the full acupressure…

This trial explores whether a personalized system that combines gamma-frequency sound stimulation with cognitive training can improve thinking and memory in older adults with mild cognitive impairment or early dementia. Participants aged 60 and older will use the device during co…

This study will test whether providing acute hospital care at home, instead of in a traditional hospital, can help people with moderate to severe dementia spend more days at home after an acute illness. Researchers will randomly assign 200 participants to either receive home-base…

This study tests whether screening for elder neglect in primary care, combined with a caregiver support app, can reduce neglect in older adults with dementia. Researchers will compare three groups: one receiving screening alone, one receiving screening plus the SIRENS app, and on…

This trial tests whether home-based virtual reality cognitive exercises, done on a tablet, can help slow mental decline in people with mild-to-moderate Alzheimer's disease. Some participants will also have online sessions with a neuropsychologist. The study aims to find a practic…

This study tests whether a robotic surgical system can safely perform delicate microsurgery on deep lymph nodes in the neck of people with Alzheimer's disease. The idea is that improving lymph drainage from the brain might help clear harmful proteins linked to Alzheimer's. The tr…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

The EMBRACE trial will test whether a 12-month program combining Mediterranean diet advice, cognitive and language training, physical activity, and financial/digital literacy can help older adults at risk of cognitive decline. 120 participants will be randomly assigned to the pro…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests whether a drug called DAOIB, which boosts brain signaling, combined with omega-3 fatty acids can improve thinking and daily life in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive either the combo or a placebo for 24 week…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This early-stage trial tests whether a minimally invasive neck surgery, called lymphaticovenular anastomosis (LVA), is safe for people with Alzheimer's disease. The surgery connects tiny lymph vessels in the neck to nearby veins, creating a detour to help the brain drain harmful …

This study tests whether a natural compound from soy, called genistein, can slow down memory and thinking problems in people with mild cognitive impairment (MCI), often an early sign of Alzheimer's disease. About 150 adults over 50 with MCI will take either genistein or a placebo…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

Researchers at Assiut University are studying whether three different tests, a blood marker called GFAP, a brain MRI scan, and a brain wave recording (EEG), can together help doctors tell normal aging, mild cognitive impairment, and dementia apart. The study enrolls 75 adults age…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people aged 50-90 with mild memory problems. The goal is to see if a nurse-led screening tool can help get a diagnosis in months instead of over a year.

This study will check if a Greek version of the Montreal Cognitive Assessment (MoCA) test is reliable for spotting early memory problems. Researchers will enroll 250 Greek-speaking adults aged 55-85, including some with mild cognitive impairment or dementia. The goal is to give d…

Researchers are testing whether primary care doctors can deliver a brief lifestyle intervention to older adults at risk of dementia. The trial enrolls 300 people aged 60 and older with elevated dementia risk scores. Doctors at community health centers provide the intervention, an…

This study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This study tests whether an AI-assisted lifestyle program can help adults aged 40 and older without cognitive impairment maintain their memory and thinking skills. Participants receive personalized advice on diet, exercise, mental activities, and social engagement through an onli…

This study tests a 12-week remote program for adults aged 60-75 at risk of cognitive decline. The program includes aerobic exercise, cognitive training, and education on healthy aging, all delivered through a website. Researchers will measure whether the program improves memory, …

This study tests whether an AI-powered digital coach called BLAZE can help adults aged 40 and older improve their brain health. Participants will receive personalized tips and support through WhatsApp to reduce risk factors for dementia. The study will compare their progress to t…

This study tests whether a structured program of nutrition advice, physical exercise, brain games, social activities, and health monitoring can improve brain health in adults aged 60 and older who are at risk for memory problems. About 80 participants will either follow the full …

This pilot study tests whether a personalized lifestyle program combining workshops, remote coaching, and a smartphone app can help adults aged 55-75 at risk for dementia adopt healthier habits. 300 participants will either receive tailored guidance or standard advice. The main g…

Researchers at Indiana University are testing whether a home-based virtual reality program can help people with mild dementia practice everyday activities like preparing food, washing dishes, or managing money. Forty participants will be randomly assigned to either VR training or…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This trial tests a mobile app called Brain CareNotes Latino, paired with remote coaching, for Hispanic caregivers of people with dementia. The app helps create a care plan and tracks symptoms, while coaches offer personalized sessions. Researchers want to see if the intervention …

This trial tests a mobile app called the Social Reminder System, designed to help people with memory concerns stay socially engaged. The app sends reminders on a home tablet when a trusted friend or family member is nearby, potentially encouraging more visits and interactions. Re…

This study tests whether a six-week program of automated text or email messages can help reduce stress and burden for people caring for a loved one with dementia. Twenty care partners who previously took part in an observational study will receive educational tips, stress managem…

This study tests whether weekly group music therapy sessions can improve wellbeing, social connection, and relationship quality for people living with dementia and their informal carers. Over 10 weeks, participants attend sessions led by a registered music therapist at a day cent…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This early study tests whether a single session of focused ultrasound—using sound waves to gently stimulate a specific brain region—can safely reduce emotional symptoms like agitation, irritability, and anxiety in people with mild dementia. Fifteen participants aged 45 to 80 with…

This pilot study will test whether bright light therapy can help reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers plan to enroll 70 adults on inpatient units at Mayo Clinic. Participants will receive 60-minute sessions of light ther…

This study explores whether group music therapy is practical and helpful for people living with dementia and their companions in a rural community. Over 10 weeks, participants attend weekly music therapy sessions and complete surveys on quality of life, loneliness, and well-being…

This study tests whether giving home health aides extra training on dementia care can reduce troubling behaviors in older adults with dementia or mild cognitive impairment and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs …

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether a personalized virtual reality program that uses sights, sounds, smells, and tastes can reduce apathy in older adults with cognitive impairment living in nursing homes. Ten participants will attend weekly sessions for six weeks, reliving meaningful memori…

This study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to help with emotions, movement, and social connection. Forty pairs of adults aged 50+ and …

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests a new text messaging program called CAPTURE for caregivers of people with dementia after an emergency department visit. The program sends up to two tailored texts per day for 30 days, covering topics like symptom monitoring, caregiver well-being, and community re…

This pilot study will test a digital platform called the Dementia Journey Companion (DJC) that helps people with dementia and their caregivers plan future care. Researchers will enroll 150 participants with mild to moderate dementia living at home or in care facilities. The study…

This study tests whether an app called Health enSuite Caregivers can reduce distress in people caring for someone with moderate dementia. The app offers personalized tips on self-care, communication, and time management. Researchers will enroll 400 caregivers to see if using the …

This study tests a new digital education program called CARE-Dem for people caring for a loved one with dementia. The program includes videos, fact sheets, and activities to help caregivers understand dementia, communicate better, and find support. Researchers want to see if the …

This study tests whether playing interactive games with a social robot can improve thinking skills, mood, and quality of life in older adults with mild cognitive impairment or dementia. Researchers will randomly assign 80 participants to either 12 weeks of robot game sessions or …

This study tests whether an AI-powered smart electric vehicle can help people with Parkinson's disease or dementia improve their walking and reduce falls. The vehicle monitors gait, gives real-time feedback, and adapts to the user. Researchers will enroll 120 participants aged 50…

This study explores whether drinking beetroot juice twice a day is practical and acceptable for people with mild-to-moderate Alzheimer's disease. Thirty participants will take the juice for one week, with help from a caregiver, to see if they can stick with it and if it causes an…

This study tests a virtual reality program designed to help family caregivers of people with dementia find a better balance in their lives. Researchers will enroll 60 caregivers to see if the VR experience reduces stress and improves quality of life. The goal is to ease the emoti…

This study tests whether a computer-based stepping game, called Smart±step, can help older adults with mild cognitive impairment (MCI) improve their balance, thinking, and quality of life while reducing their risk of falling. About 70 participants will use the game, which combine…

This study tests whether laser acupuncture—using a pen-like device that shines light on specific points on the body—can improve behavioral and psychological symptoms in people with dementia. Sixty participants will receive either real or sham laser treatment three times a week fo…

Researchers at Tufts Medical Center are testing an advance care planning program for people 65 and older who have Alzheimer's disease or related dementias, or who face a higher risk of dying within a year. The program pairs participants with counselors and videos that explain car…

Researchers at Chang Gung Memorial Hospital are studying whether an interactive web-based training platform improves how gerontology students handle dementia care decisions. The study first interviews second-year students about the challenges they face when caring for people with…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study is developing and testing a screening tool for primary care doctors to spot signs of neglect in older adults with dementia, along with a mobile app called SIRENS that provides caregivers with expert-reviewed information and goal-setting features. The current phase will…

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study tests whether a 12-week blended training program can improve dementia knowledge and skills among primary healthcare providers in China. About 240 workers from community health centers will be randomly assigned to either the training or self-study materials. Researchers…

This study will adapt and test an online communication training program called CHATO for nursing home staff who care for people with dementia. The goal is to improve how staff interact with residents, which may reduce behavioral symptoms like agitation or rejection of care. Resea…

This study will follow over 3,000 older adults for three years to see how age-related hearing loss is connected to dementia. Researchers will use hearing tests, cognitive assessments, and blood markers to build a 'Hearing Health Clock' and early screening tools. The goal is to be…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This study aims to find out how many hospitalized patients in Iraq are malnourished, a problem that can lead to more complications and longer stays. Researchers will screen 300 adults in two hospitals using standard tools to identify those at risk. The goal is to gather data to i…

This study aims to understand how walking patterns, body composition, and a blood protein called BDNF differ between older adults with mild cognitive impairment and healthy older adults. Researchers will measure gait, handgrip strength, and cognitive function in 60 participants a…

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study is testing a digital toolkit that uses AI and wearable sensors to assess pain and distress in people with mild to moderate dementia. The goal is to see if the toolkit is easy to use and accurate. If it works, it could help caregivers better understand and respond to th…

This study looks at whether eye movement patterns can help detect early cognitive problems in people over 65. Researchers will use special glasses to track eye movements while participants perform visual tasks. The goal is to find a simple, non-invasive way to screen for mild cog…

This study tests whether a computer-based virtual trainer can improve how new home care workers talk to people with dementia. Researchers will measure changes in workers' knowledge, communication skills, and empathy. The goal is to see if this training method helps caregivers pro…

This study will follow 300 older adults (70+) who have mild cognitive impairment (MCI) for one year to see if feeling lonely makes them more likely to develop dementia. Researchers will track who progresses from MCI to dementia and compare loneliness levels. The goal is to unders…

This study aims to create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. Researchers will test the tool with 100 patients, caregivers, and clinicians to see if it reduces confusion and improves shared decision-…

This study tests a program designed to reduce stigma around dementia in rural Kenya. Researchers will train local health workers to lead group sessions that teach about dementia, correct myths, and build empathy through videos and discussions. The goal is to see if this approach …