COLON CANCER

This early-phase trial tests a new drug called CBI-1214 in 80 people with advanced colorectal cancer that has not responded to standard treatments. CBI-1214 is designed to connect the body's own immune T cells to cancer cells, helping the immune system attack the tumor. The main …

This study looks at two ways to treat colon cancer that has blocked the bowel. One option is emergency surgery to remove the cancer right away. The other is to first place a stent (a small tube) or create a stoma (an opening in the belly) to relieve the blockage, and then do surg…

This early-stage trial tests a new drug called 212Pb-DOTAM-GRPR1, which delivers a tiny dose of radiation directly to cancer cells that have a specific marker (GRPR). The study will include 48 adults with advanced cancers such as prostate, breast, lung, colon, cervical, or brain …

This study tests a drug called dostarlimab in 25 people with stage II or III colon cancer that has a specific genetic feature (dMMR). The drug is given before any surgery to see if it can shrink the tumor enough that surgery may not be needed. Participants receive the drug every …

This early-stage trial is testing an experimental drug called RSC-1255, taken alone or with hydroxychloroquine, in people with advanced solid tumors (such as lung, colon, or pancreatic cancer) that have stopped responding to standard treatments. The study has two parts: first, fi…

This early-stage trial is testing an oral drug called AUR107 in 50 adults with advanced solid tumors that have come back after prior treatment. The main goals are to check the drug's safety, find the right dose, and see how the body processes it. Researchers are also looking for …

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors like lung, stomach, colon, rectal, esophageal, or pancreatic cancer that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This study tests a less invasive surgery for people with early-stage colon cancer (stage I). Instead of removing a large section of the colon, doctors will remove only the tumor and a few nearby lymph nodes using a special dye. The goal is to see if this smaller surgery works as …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, or breast cancer) that have not responded to other therapies. The treatment uses specially engineered immune cells designed to kill cancer cells while leaving healthy cell…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study compares two types of surgery for right colon cancer: laparoscopic (keyhole) and open surgery, both using a special technique called complete mesocolic excision (CME). About 114 adults aged 18-90 with early-stage right colon cancer will be randomly assigned to one of t…

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread far. About 363 participants will receive either QL1706 or standard care. The goal is to see if QL1706 can eliminate more tumor tissue be…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor and then block that artery with tiny beads. This traps the c…

This early-stage trial tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancer that has stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a powerful cancer-killing agent directly to tumor cells…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests a new approach for people with a high-risk type of colon cancer that doesn't usually respond well to immunotherapy alone. The treatment combines low-dose radiation (sparing the lymph nodes) with chemotherapy and an immunotherapy drug (PD-1 inhibitor) before surge…

This study compares a new, less invasive treatment called endoscopic full-thickness resection (eFTR) to standard surgery for early colon cancer. About 434 adults with small, early-stage colon tumors will be randomly assigned to one of the two treatments. The goal is to see if eFT…

This study tests whether giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer complete their full treatment plan. About 232 adults with stable tumors will be randomly assigned to standard care or the new approach. The goal is to shrink…

This study tests a mix of immunotherapy drugs (sintilimab, IBI310, lenvatinib) to see if they can make certain stomach or colon cancers disappear without needing surgery. It includes 34 adults whose cancers have a specific genetic feature (dMMR/MSI-H) and have not spread. The goa…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This study tests whether giving immunotherapy before surgery can help doctors completely remove T4 colon cancer in people with a specific genetic feature (dMMR). About 18 adults with this type of cancer will receive the treatment and then have surgery. The goal is to see if the c…

This study tests giving chemotherapy and an immunotherapy drug before surgery for people with locally advanced colon cancer. The goal is to see if this approach can make the tumor disappear completely and improve long-term survival. About 56 participants will receive the treatmen…

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with bevacizumab to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this approach can control the cancer and…

This study tests a combination of two drugs (fruquintinib and FOLFIRI) in people with advanced colorectal cancer that has spread. It is for those who have already had one prior treatment. The goal is to see if this new combination can help control the cancer longer and with manag…

This study is testing a new blood test called EXoPred that uses artificial intelligence and a laser technique called Raman spectroscopy to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples…

This study is testing whether a blood test that looks at tiny genetic particles called microRNAs can help doctors more accurately stage colon cancer and decide who should get chemotherapy before surgery. Researchers will collect blood samples from 400 colon cancer patients and us…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study is testing a new type of PET scan that uses a special tracer called 18F-FAPI-74 to see if it can find colon cancer spread more accurately than current scans. 100 people with colon cancer, either at first diagnosis or with suspected return, will get this scan. The goal …

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This study tests if wearing surgical gloves during oxaliplatin chemotherapy can prevent nerve damage in the hands. About 84 adults with advanced colon cancer will be randomly assigned to wear gloves or not during treatment. The goal is to see if this simple, low-cost method reduc…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study is testing a supervised exercise program for people with cancer. Participants will take part in group exercise classes twice a week for 8 to 12 weeks. The goal is to see if the program helps improve physical activity levels and manage cancer-related symptoms. The study…

This study looks at whether yoga and mindfulness can improve the emotional, social, and physical well-being of people who have had lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect inflammation and gene activity. About 100 adults…

This study looks at whether aerobic exercise can help people with stage II or III colon cancer tolerate more of their planned chemotherapy. About 219 participants who have had surgery and are about to start chemo will be randomly assigned to an exercise program or a control group…

This study tests whether a special home-based program (ERAS 3.0) can help older, frail patients recover better after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance at home. Sixty participants will be randomly assigned to either the p…

This study tests whether giving lidocaine (a numbing medicine) through a vein during colon cancer surgery can reduce pain, lower the need for strong painkillers (opioids), and help the bowel start working again sooner. About 100 adults having elective laparoscopic colon resection…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether giving lidocaine (a numbing drug) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can improve the body's immune response and help patients recover better. About 100 adults having surgery for colon cancer will be randoml…

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This study looks at whether fecal microbiota transplantation (FMT) can reduce or prevent stomach and bowel problems caused by chemotherapy in people with advanced gastrointestinal cancers. About 90 adults with stage IV cancer who are about to start their 4th round of chemo will r…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to understand how these variants affect health, how people respond to the news, and whether they follow medical advice. Up to…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study looks at whether a specific dissolvable stitch (Monoplus) can lower the chance of a leak where the bowel is reconnected after colon cancer surgery. About 249 people having either keyhole or open surgery will take part. The main goal is to see if the leak rate within 30…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at how cancer and its treatments change taste and smell, and how that affects eating habits and nutrition. Researchers will follow 306 people newly diagnosed with certain cancers (mouth, throat, colon, or liver) to see if sensory changes lead to undernutrition. T…

This study is collecting stool and saliva samples from 2,500 people with colorectal cancer to look for patterns in bacteria and genetic material (microRNA). The goal is to improve how doctors diagnose and predict the course of the disease. Participants provide samples at key poin…

This study is looking at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, including pancreas, colon, and bile duct cancers. About 100 adults with these cancers will pr…

This study looks at why some people who had surgery for colorectal cancer develop lasting bowel issues like urgency or leakage. Researchers will compare 145 participants with and without these problems using advanced tests. The goal is to identify different types of bowel dysfunc…

This study explores how the bacteria in your gut and what you eat can influence chemotherapy-related diarrhea in colon cancer patients. Researchers will analyze stool samples and diet surveys from about 11 people receiving FOLFOX treatment. The goal is to create a tool that predi…

This study follows up with people who previously received a gene therapy or immunotherapy vaccine (using poxviral vectors) for cancers like prostate, liver, breast, colon, or lung cancer. No new treatment is given. Participants get annual health checks for 5 years, then yearly ph…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after treatment. No treatment is given as part of this study. Up to 1,750 participants will provide samples, which researchers will analyze to better understand…

This study looks at how a radiation treatment called Y90 works against liver tumors that started in the colon or rectum. Researchers will take small samples of the tumors after treatment to see how much damage the radiation caused. The goal is to learn how to make this treatment …

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study looks at whether keeping the left colic artery intact during colon or rectal cancer surgery helps maintain better blood flow to the remaining colon. About 50 adults with colorectal or ovarian cancer will have their blood flow measured with and without clamping this art…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study looks at whether a special nutritional supplement (HMB and vitamin D) combined with a structured exercise program can improve muscle strength and recovery in adults after colon cancer surgery. About 120 participants will be randomly assigned to different combinations o…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start and finish their cancer treatment faster. About 320 adults with solid tumors like lung, breast, or colon cancer wi…

This study follows 368 colorectal cancer survivors aged 25 to 65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being and look for late side effects linked to specific…

This study looks at whether cleaning the bowel before surgery for colon cancer reduces the chance of infection after the operation. About 74 patients will be randomly assigned to either receive or skip the bowel prep. The main goal is to see if there is a difference in surgical s…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma by studying families where more than one person has the disease. Researchers will collect DNA and blood samples from up to 500 participants, including patients and th…