COLON CANCER

This study tests if giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer get all their planned treatments. About 232 adults with stable tumor genetics will be randomly assigned to standard care or the new approach. The goal is to see i…

This study looks at whether giving lidocaine (a numbing medicine) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can help the immune system recover better afterward. About 100 adults having colon cancer surgery will be randomly assigned to rec…

This study compares two surgical techniques for removing right colon cancer: laparoscopic (keyhole) surgery and open surgery, both using the complete mesocolic excision (CME) method. About 114 adults aged 18–90 with early-stage right colon cancer will be randomly assigned to one …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to target cancer cells while sparing healthy ones. The goal …

This study compares a new, less invasive procedure called endoscopic full-thickness resection (eFTR) to standard surgery for early colon cancer. About 434 people with small, early-stage colon tumors will be randomly assigned to one of the two treatments. The goal is to see if eFT…

This study tests giving chemotherapy plus an immunotherapy drug before surgery for locally advanced colon cancer. The goal is to see if this approach can completely eliminate the tumor before the operation and improve long-term survival. About 56 adults with a specific type of co…

This early-stage study tests a new drug, CBI-1214, for people with advanced colorectal cancer that hasn't responded to standard treatments. The drug aims to help the body's immune cells attack the cancer. About 80 participants will receive increasing doses to find the safest and …

This early-stage study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goals are to find a safe dose and ch…

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread too far. About 363 participants will receive either QL1706 or standard care to see if the drug can make the tumor disappear completely o…

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with a targeted therapy (bevacizumab) to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination ca…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with this cancer will receive the drug and be monitored for side effects and cancer response. The goal is to see if the drug alone can manage t…

This early-stage study tests a new drug called PHN-012, designed to deliver a powerful cancer-killing agent directly to tumor cells. It is for people with advanced colon, pancreatic, or lung cancer who have tried other treatments without success. The main goals are to check the d…

This study is for people with early-stage colon cancer (stage I) who currently need a standard surgery that removes part of the colon. The new approach uses a special dye to find and remove only the tumor and the first lymph node, leaving more of the colon intact. The goal is to …

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) who have run out of standard treatments. The goal is to find a safe dose and see if the drug can control the di…

This study tests whether giving immunotherapy before surgery can help completely remove T4 colon cancer in people whose tumors have a specific DNA repair problem (dMMR). About 18 adults aged 18-75 with this type of colon cancer will receive the treatment. The goal is to see if th…

This study looks at whether buying over-the-counter pain relievers and digestive aids can be an early warning sign for ten types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people recently diagnosed with cancer…

This study is testing a new type of PET scan that uses a tracer called 18F-FAPI-74 to see if it can find colon cancer that has spread to lymph nodes or other organs better than current scans. About 100 people with colon cancer, either newly diagnosed or with suspected recurrence,…

This study offers a free, supervised exercise program (online or in-person) for people who have or had cancer. The goal is to help them become more active and manage symptoms like fatigue. About 740 adults across Canada will take part in the 8 to 12-week program, which includes t…

This study looks at whether yoga and mindfulness can improve the emotional, social, and physical well-being of people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect how genes work. About 100 adults who finish…

This study is testing whether giving the numbing medicine lidocaine through a vein during colon cancer surgery can help patients feel less pain, use fewer strong painkillers, and have their first bowel movement sooner after the operation. About 100 adults with colon cancer who ar…

This study tests whether using virtual reality (VR) can reduce belly pain and improve daily life for people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. Researchers will track pain,…

This study looks at whether cleaning the bowel before surgery for colon cancer helps prevent infections. About 74 people having laparoscopic right colon removal will be randomly assigned to receive or skip bowel prep. The main goal is to see if bowel prep reduces surgical site in…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (called ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors (like breast, lung, or colon cancer) to see if the test spots signs of cance…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study follows 368 colorectal cancer survivors aged 25 to 65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, as well as any long-term side effects. The goal …

This study tests a new method to protect the ovaries of young women (ages 18-50) who need pelvic radiation for cancers like uterine or rectal cancer. Researchers will use daily CT scans to see if they can adjust the radiation beam to avoid the ovaries while still treating the tum…

This study aims to collect blood samples from 2,500 people with cancer or at high risk for cancer, along with their medical information, to create a large repository for future research. The goal is to develop and improve liquid biopsies—simple blood tests that may help detect ca…

This study follows up with people who previously received a type of gene therapy (using poxviral vectors) for cancers like prostate, liver, breast, colon, or lung cancer. The goal is to track their health for 15 years through yearly check-ups or phone calls to watch for any long-…

This study looks at how the bacteria in your gut and what you eat might affect diarrhea caused by chemotherapy in people with colon cancer. Researchers will collect stool samples and diet surveys from about 11 participants to find patterns. The goal is to better predict and manag…

This study aims to collect and analyze genetic information from 25,000 people who either have cancer or are at risk for it. Researchers will combine this genetic data with detailed health records to learn more about what drives cancer and how to personalize treatment. Participant…

This study looks at whether preserving the left colic artery during surgery for colorectal or ovarian cancer can improve blood supply to the remaining colon. About 50 adults will have their colon blood flow measured with and without clamping that artery. The goal is to see if thi…

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colon or rectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death occurs. The goal is …

This study collects stool and saliva samples from 2,500 people with colorectal cancer to look for genetic markers (microRNAs) and bacterial patterns. The goal is to improve how doctors diagnose and predict the course of the disease. Participants provide samples at key points duri…

This study aims to improve how doctors determine the stage of colon cancer before surgery and decide who should receive chemotherapy beforehand. Researchers are analyzing blood samples from 400 colon cancer patients to find specific molecules (exosomal microRNAs) that can be comb…

This study collects blood, tissue, urine, saliva, and stool samples from adults with cancer (and healthy volunteers) to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genetics and link results to patient outcomes. No treatment i…

This study tests a program called CARES that provides support, education, and resources to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with cancers like lung, breast, or colon cancer will take part. The…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…