COLON CANCER

This study tests whether two immunotherapy drugs, cemiplimab and fianlimab, can safely shrink colon tumors before surgery in people with stage II-III colon cancer that hasn't spread. Participants get two IV doses before surgery, then are followed for up to three years. The goal i…

This study tests whether adding the drug QL1706 to standard chemotherapy and radiation can shrink liver tumors from colon cancer enough to allow surgery. About 30 adults with colon cancer that has spread only to the liver will receive targeted radiation, then a combination of QL1…

This early-phase study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, colon cancer) that have spread to the abdomen and haven't responded to standard treatments. The main goal is to check safety and find the best dose, while …

This study tests a new combination of drugs (iparomlimab, tuvonralimab, and chemotherapy) given before surgery to people with stage III colon cancer that has a stable genetic profile (MSS/pMMR). The goal is to see if this treatment can completely eliminate the tumor before surger…

This study tests a drug called fruquintinib in 88 adults with advanced colon cancer that has not responded to standard chemotherapies. The goal is to see if adding supportive care to manage side effects can help patients live longer without their cancer growing. Participants will…

This study tests whether a remotely supervised exercise program can help people with stomach, esophagus, pancreas, colon, rectal, or lung cancer better tolerate chemotherapy. Up to 120 adults will be randomly assigned to either a home-based aerobic and resistance exercise program…

This study will test a new way to create CT images for people with colon cancer. The method uses deep learning to make the images clearer. Researchers will compare the quality of these new images to standard ones. The goal is to see if this technique helps doctors see tumors bett…

This study tests whether a special dye (ICG) can help surgeons see lymph nodes during laparoscopic colon cancer surgery. About 25 adults with colon cancer will receive the dye during their operation. The goal is to see if the dye accurately marks all lymph nodes containing cancer…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study looks at where cancer spreads to lymph nodes in people with colon or rectal cancer. Researchers will examine tissue from 1200 patients who had surgery to remove their cancer. The goal is to find patterns that could help doctors better plan treatment in the future.

This study looks at why some people have ongoing loose stools after surgery for colon cancer. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affect qua…

This study aims to find out if people with metastatic breast or colorectal cancer produce antibodies that might also attack the heart, potentially causing dangerous heart rhythms. Researchers will test blood samples from 196 participants at the start of the study and again after …

This study looks at where colon cancer spreads to lymph nodes in the small bowel area for people with cecal or early ascending colon cancer. Researchers will examine tissue removed during surgery to find patterns of spread. The goal is to help surgeons decide how much bowel to re…

This study looks at whether a 6-month or 12-month follow-up colonoscopy is better for people who had a large colon polyp (20-50 mm) removed that was not cancerous. About 546 adults will be assigned to one of the two follow-up schedules. The goal is to see which timing finds any r…