COLON CANCER

This study tested whether adding Celebrex to the experimental drug EPO906 could reduce severe diarrhea in people with advanced colorectal cancer. It involved 75 patients who had already tried standard treatments. The first phase found the safest dose, and the second phase looked …

This study tested a combination of three drugs (encorafenib, binimetinib, and cetuximab) given before surgery to people with a specific type of colorectal cancer that has a BRAF V600E mutation. Only 2 patients took part. The goal was to see how much the tumor shrank and to check …

This study looked at how well people aged 75 and older tolerate chemotherapy after surgery for stage III colon cancer. Researchers measured changes in daily living activities, side effects, and quality of life. The goal is to better identify which older patients can safely benefi…

This early-stage study tested a new drug called AZD6244 combined with standard chemotherapy in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researchers …

This study tested a device called Colovac 2 in 24 people having surgery for colon cancer. The device is placed inside the body to temporarily protect the new connection made between the remaining parts of the bowel. The goal was to see if the device stays in place and works safel…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with metastatic colon cancer that had certain gene types (KRAS/NRAS/BRAF wild-type). The goal was to see if the combo could shrink or stabilize tumors. The study is complete, but results are not…

This trial tested a new treatment for people with advanced gastrointestinal cancers that had spread and stopped responding to standard therapy. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to boost their cancer-fighting ability, and then infused th…

This early-stage study tested the safety of a new drug called COM902, given alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, or colon cancer that had stopped responding to standard treatments. The main goal was to find a safe dose and check for si…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the…

This study looked at a new test called OSNA to find free cancer cells in the belly fluid of 108 people with stomach or colon cancer who had no visible spread. The goal was to see if OSNA could detect cancer cells better than the usual lab method. If successful, this could help do…

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45-85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths compar…

This study tested whether offering a blood test (GuardantSHIELD) encourages more people to get screened for colorectal cancer compared to usual care. Over 2000 participants aged 45-75 who had not completed their screening were included. The main goal was to see if more people com…

This study tested two standard methods for controlling pain after colon or rectal surgery: a preperitoneal catheter that delivers local anesthetic directly to the surgical area, and an epidural catheter placed before surgery. Researchers measured pain scores and how much extra pa…

This study compared two ways to manage pain during and after colorectal surgery: a TAP block (an injection into the abdominal wall) versus epidural anesthesia (an injection near the spine). About 200 adults having elective colon or rectal surgery for cancer or diverticulitis took…

This study looked at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. The trial included 80 adults with a STOP…

This study looked at whether a supervised exercise program can help people with breast or colon cancer feel better and have a better quality of life. 78 patients took part, some of whom were also receiving chemotherapy, radiotherapy, or hormonal therapy. The program lasted 6 week…

This study tested a web app called PrehabPal that helps people aged 65 and older prepare for colon cancer surgery. The app creates a personalized exercise and health plan and offers coaching before surgery. Researchers compared it to written instructions to see if it helps patien…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study compared two common positions for digital rectal exams: lying on your side (lateral decubitus) versus lying on your back (supine). Researchers wanted to see which position allows doctors to perform a more complete exam. The study involved 320 men with conditions like c…

This study tested whether a website and text messages could help 50 colorectal cancer survivors make healthier food choices. Participants received a personalized diet report and tips via text for 12 weeks. The goal was to see if this approach was easy to use and could lead to bet…

This study looked at 70 adults with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it leads to more complications or longer hospital stays. Researchers measured muscle strength, mass, and physical performance. The goal is to find patien…

This completed study looked at 1,471 colon cancer patients to see how their tumor's DNA repair status (pMMR vs dMMR) relates to lymph node spread and survival. Researchers hope to identify patients who might not need extensive lymph node removal. The study is observational and do…

This completed study analyzed data from 1,500 colon cancer patients to see if a new way of classifying lymph node involvement—based on both the number and location of affected nodes and tumor deposits—can better predict survival than the current standard system. Researchers colle…

This study tested whether an educational session at a church could help Latino adults learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty Spanish-speaking participants watched videos and completed surveys. The goal was to understand barr…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. About 498 adults from Mexican-American households in Houston took part in interviews about their medical history, beliefs, and family communication.…

This study looked at how closely eight hospitals in Rome follow Enhanced Recovery After Surgery (ERAS) protocols for people having colon surgery for cancer or diverticulum. Researchers reviewed records from 1,000 patients to see which recovery steps were used and whether followin…

This study followed over 3,600 people with early to mid-stage colon cancer who had surgery to remove their tumor. Researchers tracked where cancer had spread to nearby lymph nodes and how much bowel and surrounding tissue was removed. The goal was to learn which surgical approach…

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested whether doctors can tell the difference between real endoscopic images and AI-transformed ones. 40 physicians with colonoscopy experience viewed different image styles. The goal is to help AI systems work better with various equipment. No treatment was given; it…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study looked at whether sending text message reminders helps more people finish a simple at-home colon cancer test (called FIT) compared to the usual phone call reminders. Over 1,200 adults from NYU family health centers took part. The goal was to see if texts could boost sc…

This study looked at over 7,000 people who had surgery for early-stage colon cancer to see how the tumor stage and lymph node involvement affect the chance of cancer returning and survival. Researchers grouped patients by tumor depth and lymph node status and tracked recurrence p…

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…