COLON CANCER

This study looks at whether starting chemotherapy 10 to 14 days after surgery for stage III colon cancer is better than waiting the usual 2 weeks or more. About 300 patients are taking part to see if earlier treatment improves survival and lowers the chance of cancer coming back.…

This study tests a new fluorescent clip that glows under special light to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The g…

This study compares two methods for removing certain types of colon polyps (10-19mm adenomas or serrated lesions 10mm or larger) during a colonoscopy: cold snare piecemeal resection (CSPR) and cold snare endoscopic mucosal resection (Cold EMR). About 570 adults will take part to …

This study tests an oral drug called selpercatinib in people with advanced solid tumors that have RET gene alterations, including certain lung, thyroid, and colon cancers. The goal is to find the best dose and see if the drug can shrink tumors. About 857 participants are enrolled…

This phase 2 trial is testing a combination of two drugs, cabozantinib and nivolumab, in 48 people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can shrink or stabilize tumors. All participants have a type of …

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goals are to find the safest dose and understand how the drug works in the body. About 44 adults who…

This study looks at four different tools to help cancer survivors improve their diet, physical activity, and body weight. About 353 adults who have finished treatment for several cancer types will use these tools for up to 48 weeks. The goal is to see which tools work best to hel…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the treatment can shrink tumo…

This study tests whether giving chemotherapy before surgery (instead of after) helps people with locally advanced colon cancer live longer without the cancer returning. About 708 adults aged 18 to 70 with non-spreading colon cancer are taking part. The goal is to see if early che…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore healthy gut bacteria. About 30 adults scheduled for surgery will be randomly assigned to receive either the supplement or a placebo. The main goal is to see if the supplement improv…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with early-stage colon cancer that has not spread will receive the drug. The main goal is to see if the treatment is safe and effective at cont…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This early-stage trial tests a new drug called adagrasib combined with two existing cancer drugs (cetuximab and irinotecan) in people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effec…

This study compares giving 3 rounds of chemotherapy before surgery versus the standard approach of surgery followed by 8 rounds of chemo for people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo works just as well and may allow some patients to sk…

This study looks at whether giving chemotherapy both before and after surgery (perioperative) is better than only after surgery for people with advanced colon cancer. About 738 participants will be randomly assigned to one of two groups. The goal is to see if the perioperative ap…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with CEA-positive cancers (such as breast, colon,…

This study follows 150,000 adults in the U.S. who were prescribed the Cologuard stool test for colorectal cancer screening. Researchers want to see how many people get a follow-up colonoscopy after a positive result and how often cancer is found. The goal is to understand the rea…

This study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…

This early-phase study tests whether a green tea extract called EGCG can help prevent colon cancer from returning after surgery. About 51 adults with early-stage colon cancer who have not had other cancer treatments will take EGCG or a placebo before their surgery. Researchers wi…

This study tests ways to help more people complete a colonoscopy after an abnormal stool-based colorectal cancer screening test. The researchers will use team-based best practices in clinics and a patient app with enhanced instructions and navigation. About 2,000 adults who speak…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study tests whether using a FitBit and a mobile app after surgery for stomach, liver, colon, or other GI cancers can help prevent patients from being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will be randomly assigned to …

This study enrolls 4,000 people with breast, ovarian, or colorectal cancer to test a comprehensive genetic panel. The panel looks for inherited cancer risks and tumor mutations that may affect drug sensitivity. Researchers aim to validate these genetic findings to potentially gui…

This study analyzes data from over 45,000 people diagnosed with colon or ovarian cancer in England between 2016 and 2017. Researchers are looking for differences in how quickly people are diagnosed and what treatments they receive, based on their socioeconomic status. The goal is…

This study looks back at 193 people with stomach, appendix, or colon cancer who had surgery with or without heated chemotherapy (HIPEC). Researchers want to see if HIPEC affects how quickly the bowels start working again after surgery and whether it leads to more complications. T…

This study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…

This study looks at two different surgeries for a rare colon cancer located at the splenic flexure. About 140 patients will be split into two groups: one getting a smaller surgery (removing only the tumor section) and the other a larger surgery (removing more colon and lymph node…

This pilot study aims to develop new ways to diagnose colon cancer and predict if it will spread to the liver. Researchers will collect blood and liver tissue samples from 51 patients undergoing surgery for colon cancer or benign colon growths. The goal is to find biomarkers that…

This study examines DNA from over 21,000 cancer patients in New York to find inherited gene changes linked to cancers like breast, colon, and prostate. It is an exploratory project that aims to generate ideas for future research, not to test a treatment. Participants donated bloo…

This study looks at how exercise might stop colorectal cancer from returning in people who have already finished treatment. Researchers will measure changes in blood markers like inflammation and insulin resistance in 60 participants. The goal is to understand the biological proc…

This study brings together cancer experts to agree on standard definitions for key measurements used in cancer clinical trials, such as how long patients live without their cancer getting worse. Currently, different trials define these measurements in different ways, making it ha…

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. It includes 100,000 people of any age. The goal is to understand survival trends to help improve cancer care, not to test a new trea…

This study explores whether a special type of radiation planning can protect the ovaries of young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Researchers will use scans to see if they can adjust the radiation beam to avoid t…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study looks at whether a special payment model helps doctors coordinate care better for people with breast, colon, or lung cancer getting chemotherapy. Researchers will compare costs, quality of care, and use of hospital services between two groups. The goal is to see if thi…

This study aimed to find out if certain genes that affect bleeding can cause a false positive result on a stool test used to screen for colon cancer. Researchers planned to compare genetic markers in people who had a high test result but a normal colonoscopy with those who had no…