COLON CANCER

This study looked at whether starting chemotherapy 10 to 14 days after colon cancer surgery is better than waiting the usual 2 weeks. About 300 people with stage III colon cancer took part. The goal was to see if earlier treatment improves survival and lowers the chance of cancer…

This early-phase trial tests a new drug, adagrasib, combined with two existing cancer drugs (cetuximab and irinotecan) in 24 people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effects…

This study tests an oral drug called selpercatinib for people with advanced solid tumors that have a specific RET gene change. The goal is to see if the drug is safe and can shrink tumors. About 857 adults with cancers like lung, thyroid, or colon cancer are taking part.

This study tests whether giving chemotherapy before surgery (instead of after) can help prevent colon cancer from returning. It involves 708 adults with locally advanced colon cancer that has not spread to other organs. The goal is to see if this approach improves how long patien…

This early-phase study tests whether a green tea extract called EGCG can help prevent colon cancer from returning after surgery. About 51 people with colon cancer that can be removed will take EGCG or a placebo before their operation. Researchers will check for changes in DNA mar…

This study compares giving 3 cycles of chemotherapy before surgery versus the standard approach of surgery followed by 8 cycles of chemo for people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo works just as well and may allow some patients to sk…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore the natural balance of gut bacteria, which is often disrupted by the procedure. Researchers will compare changes in gut bacteria diversity between a group taking postbiotics and a g…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the drugs can shrink tumors. …

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goals are to find the safest dose and understand how the drug moves through the body. About 44 adult…

This study tests ways to help more people complete a colonoscopy after an abnormal stool-based screening test. It involves 2,000 adults who speak English, Spanish, or Cantonese and have had an abnormal FIT result. The approach combines team-based clinic practices and a patient ap…

This study tests a fluorescent clip that glows under special light to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The goal …

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy (a stoma on the belly for waste). About 70 adults with permanent or long-term ostomies will take …

This study compares two methods for removing medium-to-large colon polyps during a colonoscopy: cutting the polyp into pieces (CSPR) versus lifting and removing it in one piece (Cold EMR). Both methods use a cold wire snare, avoiding heat. The goal is to see which technique remov…

This study aimed to see if certain genes that affect bleeding can cause a stool test to show blood when the bowel is actually healthy. Researchers planned to compare genetic markers in people with a false-positive test to those with a normal test. The study was withdrawn before e…

This study searches for brand-new gene changes that appear in children but not in their parents, which might raise cancer risk. Researchers will compare DNA from 1,275 cancer patients (with breast, colon, or other cancers) and their healthy parents. The goal is to find these hidd…

This study is testing a new genetic test called the Gersom panel in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor changes that might guide treatment choices. Participants provide blood…

This study looks at whether a special payment model helps doctors coordinate care better for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who are getting chemotherapy. Researchers will compare quality of care, costs, and hospital use be…

This study looks at whether using a physical activity questionnaire, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors become more active and spend less time sitting. About 20 survivors aged 50 or older who finished treatment within the …

This study looks at whether a special website and a genetic counselor can help more family members of people with hereditary cancer get tested for cancer genes. About 205 adults who have a known cancer gene mutation and their close relatives will take part. The goal is to see if …