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Study probes why some get false alarms on bowel cancer test

NCT ID NCT05329870

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to find out if certain genes that affect bleeding can cause a false positive result on a stool test used to screen for colon cancer. Researchers planned to compare genetic markers in people who had a high test result but a normal colonoscopy with those who had normal results. The study was withdrawn before enrolling any participants, so no conclusions were reached.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Expected to start

May 2022

An estimate. Start dates often move.

Expected to finish

Nov 2023

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study would aim to enrol 150 participants. This would be in a 1:4 ratio, meaning 30 participants would have had a normal colonoscopy and a qFIT \>10 µg Hb/g and 120 participants would have a normal colonoscopy and a qFIT \<10 µg Hb/g.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who were symptomatic at the time of referral * Returned at least one qFIT sample * Underwent a complete colonoscopy, which did not identify any pathology * Willing to provide a saliva sample for genetic analysis * Are able to consent to the study Exclusion Criteria: * Age \< 18 * Previous colorectal cancer * Ongoing colonic polyp surveillance * Known inflammatory bowel disease * Taking anticoagulant medication (Aspirin, clopidogrel, warfarin or NOAC) * History of liver disease or known bleeding disorder * Incomplete colonoscopy * Unable to consent to the study

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colon cancer Colorectal cancer

Contacts and locations

Locations

  • NHS Lothian

    Edinburgh, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.