Prediabetes syndrome

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

Researchers are testing whether a daily probiotic supplement can improve blood sugar, blood pressure, and body composition in people over 65 who have prediabetes or type 2 diabetes and known heart disease. Participants take one probiotic capsule each morning for 60 days, while a …

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study is testing whether a healthy diet centered around beef can reduce inflammation and improve metabolic health better than a standard U.S.-style diet based on USDA guidelines. Researchers will enroll 56 adults with metabolic syndrome or pre-diabetes and assign them to one…

This study tests whether mirabegron (a bladder medication) and tadalafil (used for erectile dysfunction) can improve blood sugar control in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drug…

This trial tests whether taking 150 mg of grape seed extract (MegaNatural BP) daily for 6 weeks can lower blood pressure and improve heart health in adults aged 40 to 60 with elevated blood pressure and prediabetes. Researchers will measure changes in blood pressure, blood vessel…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests whether eating only during a specific window each day (time-restricted feeding) can improve metabolic health in postmenopausal women who have metabolic syndrome or are prediabetic. Researchers will measure changes in insulin sensitivity, body weight, and blood fa…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This trial tests whether a specific breathing exercise, called resonant frequency breathing with heart rate variability biofeedback, can improve how the body handles sugar in people with prediabetes. The training aims to calm the body's stress response by increasing heart rate va…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This study looks at whether eating lunch and dinner at a subsidized community dining site encourages older adults with prediabetes to walk more after meals and improves their blood sugar levels. Participants, aged 60 to 79, will spend six days eating at the community site and six…

This study compares two exercise programs—high-intensity interval training (short bursts of fast stair climbing) and continuous endurance training (steady walking)—in adults with prediabetes. The goal is to see which approach better improves blood sugar control, body mass index, …

This study tests whether a combination of special immune cells (Tregs) and a drug (rituximab) can delay or prevent type 1 diabetes in children aged 6–16 who are at high risk but still produce insulin normally. About 150 participants will be randomly assigned to one of four groups…

This study compares two types of keto diets—one high in saturated fat and one high in unsaturated fat (like canola oil)—against a standard low-fat diet in 175 adults who are overweight or have prediabetes or type 2 diabetes. Researchers will measure changes in cholesterol, blood …

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study tests whether taking a daily 30 mg zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Two hundred Amish adults aged 18–80 with prediabetes will be randomly assigned to receive either zinc or a placebo pill. Researchers will …

This phase 2 trial is testing whether mirabegron, a drug currently used for overactive bladder, can improve glucose tolerance and activate brown fat in people with prediabetes. Researchers will enroll 65 adults with a BMI of 27-45 and prediabetes. Participants will take mirabegro…

This trial tests whether intermittent dietary restrictions—either low-carb or calorie-restricted diets on two days per week—can reverse early signs of heart and metabolic problems in school-aged children aged 7 to 18. Participants have at least one risk factor like prediabetes, a…

This study looks at whether eating avocados regularly can improve how the body handles fats and sugar in people with prediabetes and insulin resistance. About 82 adults aged 40-70 with high triglycerides and insulin resistance will eat avocados as part of their daily diet. Resear…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests whether applying heat pads to the legs for 90 minutes a day can improve blood sugar control, muscle health, and physical function in older adults with prediabetes. Researchers will compare the effects to high-intensity interval training. The goal is to find a sim…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This study tests whether eating all meals within a 9-hour window each day for 12 weeks can improve insulin sensitivity and other heart health markers in 100 adults with obesity and prediabetes. Participants will be randomly assigned to either a 9-hour eating window or a 14-hour w…

This pilot study tests whether providing culturally appropriate food bundles and easy-to-read recipes can help adults with type 2 diabetes who face food insecurity. About 25 participants will receive food bundles and education, then complete surveys at 3 and 6 months. The goal is…

This study looks at whether eating pecans instead of snacks high in bad fats and sugar can improve blood sugar and heart health in people with prediabetes. About 147 adults aged 25-65 with prediabetes will either eat 1.5 ounces of pecans daily for 16 weeks or stick to their usual…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study tests whether exercising in the afternoon is better than the morning for improving blood sugar control in people with prediabetes. 48 participants will do high-intensity interval training three times a week for 12 weeks. Researchers will measure how the body stores and…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and have type 2 diabetes or are at risk. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The …

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study tests whether bitter melon peptide capsules can help control blood sugar in adults with prediabetes. About 12 people aged 30-65 will take the capsules three times daily before meals for 12 weeks. Researchers will measure blood sugar and HbA1c levels to see if the suppl…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study tests whether adding SMS reminders with diet and exercise advice to a standard lifestyle program helps people with prediabetes lose more weight. 300 participants in Réunion will be split into two groups: one gets the standard program alone, the other also receives 72 t…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests whether a daily collagen supplement called Nextida GC-B can improve blood sugar control in adults with normal blood sugar or prediabetes. Over 90 days, researchers will measure how the body handles sugar after meals and track changes in HbA1c. Sixty participants …

This study tests whether a supplement called AMPK Charge+® can help control blood sugar in adults with prediabetes or type 2 diabetes, both on its own and when combined with the drug semaglutide. About 90 participants will take the supplement daily, with some also receiving semag…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study looks at whether eating three servings of dairy each day (like milk, yogurt, and cheese) can help overweight teens (ages 15-18) and seniors (ages 60-80) improve their body weight, body composition, and blood sugar levels over six months. Participants are randomly assig…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This pilot study compares two approaches to reduce type 2 diabetes risk in 40 overweight adults with prediabetes. One group follows the standard Diabetes Prevention Program (DPP) focusing on diet and exercise. The other group uses an enhanced version (DPP++) that also includes a …

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This study tests whether a liquid supplement made from carob extract can improve blood sugar control in people with prediabetes. Thirty adults with prediabetes will take either the carob supplement or a placebo before meals for a period of time. Researchers will measure changes i…

This study tests whether giving a healthy food voucher to people with type 2 diabetes or prediabetes who have low income can improve their blood sugar control. About 390 participants will be randomly assigned to receive the voucher or not. The main goal is to see if hemoglobin A1…

This study tests whether limiting all eating to a consistent 10-hour window each day can improve blood sugar, cholesterol, and other health measures in people with metabolic syndrome or prediabetes. About 140 adults will either follow this eating schedule plus standard nutritiona…

This study tests whether a mobile app called PortionSize Ed can help recent stroke survivors who also have prediabetes or type 2 diabetes follow a Mediterranean-style diet. Forty adults aged 30 to 65 will be split into two groups: one gets the full app with dietitian support, the…

This study tests whether meal replacement products can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower blood sugar. Twenty participants will use meal replacements and be monitored for weight loss and blood sugar changes. The goal is to s…

This study tests whether watching virtual reality (VR) cycling videos can produce exercise-like benefits in 48 sedentary adults with prediabetes or high blood pressure. Participants will either do 20 minutes of real cycling or watch VR cycling, and researchers will measure change…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study tests whether a special high-intensity interval training (HIIT) program can improve heart health in school-age children who are at high risk for cardiovascular disease. The program involves short bursts of intense exercise, done several times a week. Researchers will t…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 people with pre-diabetes and coronary artery disease. The goal is to see which drug best slows or reverses the buildup of plaque in heart arteries over 24 month…

This study looks at whether adding baked potatoes (with skin) to a Mediterranean diet can improve blood sugar control, blood pressure, and cholesterol in adults aged 45-80 with pre-diabetes. Sixty participants will either get diet education alone or education plus pre-prepared ba…

This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests whether a supplement called dihydroberberine (DHB) can improve blood sugar control, appetite, and energy in adults with prediabetes. About 54 participants will take either DHB or a placebo daily for 6 weeks. Researchers will measure blood sugar, insulin, and GLP-…

This study tests whether adding a structured self-management program (DECIDE) to standard community health worker support helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either receive the enhanced progr…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This trial tests whether a community-based learning program can help prevent and control type 2 diabetes in rural Pakistan. Over 12,000 adults aged 20 and older will participate in group sessions focused on healthy behaviors. The study will measure changes in blood sugar levels a…

Researchers on Réunion Island are measuring blood sugar levels in 2,000 adults to estimate how many people have diabetes or pre-diabetes. Participants give a fasting blood sample and drink a 75g glucose solution, then give a second blood sample two hours later. The study also che…

This study aims to identify people at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Children and adults aged 1 to 45 who have a family member or close friend diagnosed with type 1 diabetes before age 45 can join. …

This study explores whether a simple finger-prick blood sugar test done during a routine dental visit can help find people with advanced gum disease who have undetected high blood sugar. Adults with severe periodontitis but no known diabetes will be tested at the dental clinic an…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study looks at whether doing a diabetes test right after giving birth (instead of waiting 4-12 weeks) helps more women get screened for type 2 diabetes after having gestational diabetes. It also asks women about their views on heart-health programs after pregnancy. About 104…

Researchers are testing a weekly family-based lifestyle program called Family DPP+ to see if it helps parents with prediabetes lose weight and adopt healthier habits. The trial enrolls African American and Hispanic parents and their children in Georgia. Parents attend sessions fo…

This trial tests whether two natural supplements—quercetin (from foods like apples and onions) and coenzyme Q10 (a substance your body makes)—can reduce inflammation and improve metabolic health in older adults. Over 12 weeks, participants aged 50 to 75 who are sedentary will tak…

This phase II trial tests whether a special form of nicotinic acid (a B vitamin) can reverse prediabetes and prevent type 2 diabetes. About 390 adults with prediabetes will take either a low or high dose of the drug or a placebo daily for 26 weeks, along with lifestyle advice. Th…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

Researchers are testing whether adding dapagliflozin to a lifestyle program can normalize blood sugar in people with prediabetes and protect their kidneys. The trial enrolls 170 adults aged 35 to 75 with prediabetes. Participants receive either dapagliflozin or a placebo for six …

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. Thirty women will be split into three groups based on their current blood sugar levels. They will follow the die…

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This trial tests a 4-week diet and exercise program called Small Steps for Big Changes in adults with prediabetes. Participants will attend supervised exercise sessions and learn to cut sugar and refined carbs while increasing vegetables. The study aims to see if this program can…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study tests whether a natural bile acid called 7-Ketolithocholic Acid, taken as a supplement, can lower blood sugar levels in 100 adults with prediabetes. Participants will also follow a healthy diet and exercise plan. The goal is to see if this supplement can help prevent o…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people with lactose intolerance who also have pre-diabetes. Researchers will compare regular milk to lactose-free milk over 12 weeks in 40 adults. They will measure changes in gut bacteria,…

This study tests whether a smartwatch-based program, combined with coaching from healthcare staff, can improve heart health in overweight or obese adults who have early signs of problems like high blood pressure or prediabetes. The program focuses on exercise and diet, and tracks…

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-generated health videos can help people with prediabetes control their blood sugar. Fifty adults aged 35 and older with prediabetes will wear a CGM and receive smartphone feedback. The goal is to …

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures fe…

This study tests whether extra lifestyle coaching plus medically tailored meals can help prevent type 2 diabetes in mothers who had gestational diabetes. Nearly 1,000 pregnant or recently postpartum women from home visiting programs will be randomly assigned to receive either enh…

This study looks at two different ways to help adults in rural communities prevent type 2 diabetes. Participants will either join group video sessions or follow a self-directed program. The goal is to see which method works better for weight loss and blood sugar control.

This study tests a community-based program in rural Kabul, Afghanistan, to help prevent and control type 2 diabetes. About 250 adults aged 20 and older will take part in group learning and action meetings. The goal is to see if this approach is practical and well-liked by the com…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This study tests whether adding reminders to electronic medical records helps doctors better manage pre-diabetes. About 6000 adults with pre-diabetes will take part. Some clinics will use the reminders, others won't. The goal is to see if the prompts lead to more blood tests, ref…

This study tests an online diabetes prevention program for UCLA undergraduates who are at risk for type 2 diabetes. The program includes short online lessons and aims to help participants lose weight and improve quality of life. Researchers will compare results between those who …

This study looks at whether eating a small handful of almonds (about 18 grams) 30 minutes before a meal can reduce the rise in blood sugar after eating. Researchers will test 25 adults with prediabetes, comparing blood sugar levels after meals with and without almonds. They also …

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study looks at whether walking in a natural setting (like a park) is better for reducing stress, anxiety, and improving mood compared to walking in a built-up commercial area. 216 adults with prediabetes will walk 150 minutes per week for six weeks in each environment, with …

This study looks at whether short-term beetroot juice (a source of nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in adults with prediabetes. Researchers will compare people who take metformin with those who do not. The goal is to find simpl…

This study looks at whether drinking whey protein twice a day can improve blood sugar and insulin levels in people with prediabetes or type 2 diabetes. Researchers will measure blood sugar control and appetite in 40 adults aged 50-70 over two 7-day periods. The goal is to see if …

This study tests whether easy home-based strategies—like wearing blue-light blocking glasses, standing for 10 minutes each hour, and not eating after 8pm—can reduce the negative health effects of evening screen time. Researchers will track 30 adults with obesity or prediabetes wh…

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study tests whether eating all meals within an early 8-hour window (and cutting calories by 25%) can improve blood sugar and heart health in people who are overweight and have prediabetes, type 2 diabetes, or normal blood sugar. Thirty participants will try either early or l…

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

This study looks at whether exercising in the morning or evening helps the body handle sugar better in people with prediabetes who have an extreme natural body clock. Twenty-eight adults with prediabetes and overweight will do a single cycling session at 9 AM, 5 PM, or no exercis…

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

This study looks at whether obese children with autism spectrum disorder differ from those without autism in fitness and heart health. Researchers will review medical records of 200 children aged 6 to 18, including step test results, handgrip strength, body measurements, and bloo…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study uses continuous glucose monitors (CGMs) to track blood sugar levels in the days right after a kidney transplant. It compares three groups of recipients: those with diabetes, those with pre-diabetes, and those without diabetes. The goal is to see if glucose patterns dif…

This study is testing whether a pharmacist-led program that uses continuous glucose monitors (CGMs) can help people with prediabetes better control their blood sugar and make healthier choices. About 40 adults with prediabetes will wear a CGM for 12 weeks and receive guidance fro…

This study investigates whether a key channel in insulin-producing cells becomes less active as type 2 diabetes progresses. Researchers will give a single 10 mg dose of glipizide, a drug that blocks this channel, to people with and without type 2 diabetes and measure their insuli…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study compares a continuous glucose monitor (CGM) worn on the skin to the standard oral glucose tolerance test (OGTT) for detecting diabetes in adults with cystic fibrosis. The OGTT is time-consuming and often skipped, so researchers want to see if the CGM is a simpler and e…

This study will screen 7,000 adults in China who are at high risk for diabetes but do not yet have it. Researchers will track blood sugar changes, eye health, and bone density over time. The goal is to find better ways to prevent diabetes and create a new model for managing high-…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at whether older adults with prediabetes have lower brain energy use and slower thinking compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can improve brain energy and processing speed. Twenty participants will under…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study looks at whether personality traits are linked to routine lab test results in 1,000 adults getting a health check-up. Participants fill out a personality questionnaire and provide blood samples. The goal is to see if certain personality types are more likely to have ab…

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This study looks at how lean pork loin and plant-based protein affect muscle building and blood sugar control in adults with prediabetes. Twenty participants aged 40-65 will eat prepared meals for three days. Researchers will measure muscle protein synthesis and glucose levels to…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study tests whether sending automatic WhatsApp reminders helps more women with gestational diabetes attend their postpartum glucose test. It also compares a newer one-hour blood sugar measurement to the standard two-hour test to see which catches prediabetes and diabetes ear…

This study looks at how the hormone glucagon affects insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high blood sug…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study uses the FreeStyle Libre 3 continuous glucose monitor to record blood sugar levels in 2,000 adults, both with and without prediabetes. The goal is to identify patterns that could help spot prediabetes earlier. Participants wear the monitor for a period while going abou…

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This study looks at how genetic differences in Mexican-Americans with prediabetes affect their response to semaglutide (Ozempic), a GLP-1 drug. Researchers will measure changes in insulin production and sensitivity, and analyze gene activity. The goal is to understand why some pe…

This study looks at how an 8-week exercise program changes the bodies and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers. They will also use advanced techniques to study immune cells and fi…

This study is following 1,250 people at higher risk for pancreas cancer, including those with new diabetes, pancreatic cysts, or a family history. Researchers will collect blood samples and health data twice a year for several years. The goal is to find early markers in the blood…

This study tests whether data from a smart ring, smartwatch, and smartphone app can identify people with prediabetes (higher-than-normal blood sugar) compared to healthy individuals. About 200 adults aged 45 and older who are overweight will wear these devices for 4 weeks and log…

This study tests whether wearing a continuous glucose monitor (CGM) helps adults with prediabetes improve their diet and physical activity compared to standard health coaching. 76 participants from a Singapore polyclinic will be randomly assigned to receive either a CGM plus coac…

This pilot study tests whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program (DPP) helps recruit and keep participants engaged. Twenty adults with prediabetes from two community health centers in Los Angeles will take part. The main goal is …

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will give a drug that blocks GLP-1 to see how it changes insulin and glucagon release. The goal is to understand why some people with prediabete…

This study looks at whether the artificial sweeteners aspartame and sucralose affect blood sugar control in adults aged 40 and older with prediabetes. Participants will receive either one of the sweeteners or a placebo as part of their diet for 8 weeks. Researchers will monitor b…

This study from Stanford University is looking for 100 volunteers to help understand why people's blood sugar levels respond differently to the same foods. Participants will wear a continuous glucose monitor and test various meals, supplements, and short exercises. The goal is to…

This study looks at how insulin and glucagon work together to control blood sugar levels when people are not eating. Researchers will give insulin and a fat emulsion to 60 volunteers with normal or impaired fasting glucose to see how their bodies respond. The goal is to better un…